Coming off Invega/Xeplion (paliperidone) injections v 12

They're just suggestions of things that might help accelerate or slow recovery, you might wake up one day and realise things aren't as bad as they once where without doing anything but it's probably good to do things that will make things better rather than just waiting. It's important to remember that I'm just a random person on the internet and don't know shit but regardless to answer that deep question, Some people say something along the lines of the past is the past & it's impossible to be the same person you where 10 or 20 years ago. You can move forward and become a new version that's still true to your old self & better and happier than todays self. "The only constant is change". Who knows if that's right though. If you used to be a endurance runner and then you got put on invega and didn't run for a year, it would make sense that to run a marathon again you'd need to train up again. idk though.
I am.more worried about the cognitive aspects of personality recovering than physical aspects. Also worried about drive and motivation. Dont want to be the person i was 20 years ago, only want to be the person i was before invega injections, is that realisticallu possible based on evidence?
Why do you think weed can be harmful during recovery?
 
Last edited:
Overuse. With reduced positive effects people tend to overuse. Overuse blunts response to dopamine. So reduced benefits and increased opposite of benefits. Low dose THC is medicinal but high dose is harmful except maybe for epilepsy.
Also people that where on here saying its a P-Pg substrate so it clears invega quicker might be wrong. I'm just a random guy on the internet that doesn't know shit but to me it looks like being a P-Pg substrate would mean that it's eliminated by P-Pg, so it would take up bandwith and slow clearance. But clearance is relatively quick it's just release that's slow so trying to speed up clearance would really only take a few days off recovery time if anything. but idk. and given your last injection was june 17 2025 it would already be eliminated so it's pretty irrelevant.

Cognition & motivation need to be trained too. Excercise probably helps immensly with this aswell as novelty, learning, goal oriented tasks with immediate feedback, mindfulness / attention training and sleep. Neurons that fire together wire together. There's something called "reward prediction error" that's probably relevant. While the brain is not a muscle the analogy still works as there are some similarities: both change with use (plasticity vs hypertrophy), both weaken with disuse, both require energy, oxygen, and recovery, both improve performance through training. However the mechanisms are completely different. what the brain needs is contrast, timing, rest, and meaningful error signals.

Here's a learning task if you are interested and have computer access. Some people are hyper-focused on receptors or "not having enough dopamine" without understanding either concept. So as a pretend assignment zoom out a tiny bit and develop a basic understanding of synapses.
Diagram 1
Diagram 2
https://neurolaunch.com/dopamine-synapse/
Grab the 2 diagrams and put them at the top of a word document on one half of your screen. Open the neurolaunch article and put it on the other half of the screen. Type up an explanation of synapses like it's a paper your going to submit as an assignment for a class (ignore the numbers in circles and the arrows between them in diagram 1). Don't submit anything though just do it as a fun learning activity.
Try to remember what you learnt tomorrow without reading. Open just the diagrams without the article and explain them to yourself.
You might enjoy it, find it interesting and decide to learn more.
If it was already eliminated, wouldnt the side effects and symptoms of invega disappear as well? I think weed does reduce the efficacy of invega.

What i need an opinion is, does the personality, quirks, love, hobbies, empathy and memories before the injections all come back eventually or do you need to do something in order for it to come back?
 
Here's my list. It's pretty thereotical but behavioral factors are likely going to have the best results. When done for a couple months they should also induce neuroplasticity and gene expression changes in the right direction. Gene expression happens over weeks and takes months to lock in gains so theoretically keep up healthy habits for a few months and you're good.
Helpful:
Low dose stimulants/buproprion (if perscribed)
Ketamine therapy (if perscribed)
MAOIs should only be used short term (if perscribed)
Even low dose alcohol/cannabis infrequently
Drug based interventions only work when paired with behavioral factors during plasticity windows like:
Exercise (Aerobic, high intensity short duration 30-60 minutes. Think running, cycling. Maybe start with daily walks, then powerwalks and work up to it over a few weeks)
Novelty & learning
Goal-oriented tasks with immediate feedback
Mindfulness / attention training
Deep consolidated sleep

Harmful:
High dose stimulants
Chronic exposure to MAOIs
Poor sleep
Chronic or high dose alcohol/cannabis
Caffeine/Nicotine

The Thr75 thing i posted suggested forskolin will dephosphorylate Thr-75 but that's in glass not in body and would probably not be helpful and be harmful to try to use it.
Thr-75 is probably much worse on partial antagonists and its only theoretical.
How is caffeine harmful. Did doctors not say this injection shrinks the brain,low dose stimulant won't help that much,you need something like vyvanse
 
If only there was a complete opposite of this drug,not like stimulants or dopamine agonists but to a higher extent. What if there is a reverse antipsychotic that can be injected and last in our body several months.
 
I haven’t found single person who gets worse after 5 months, its only people who dont recover, i almost cry everyday from this torture and to be honest my friend all im thinking is finish my self so i dont take this pain anymore, i really cant wait for one year when i cant sleep or do anything during the day, i just wake up from 6 am and doing nothing until its night and i sleep for 3 hours and thats it, how am i supposed to cope like that
Hey man. I’m someone who has gotten worse as time goes on. You’re not alone. I also have insomnia, the pressure in my head, mental akathisia, anhedonia. I don’t have any words of encouragement as I’m in a bad place. But I can say, we have to hold on to see what will happen.
 
Music is still enjoyable for me and I can sway and float away on music while on Abilify
 
If I still feel this way in a month, I’m going to finish it. Hell on earth.
please hold on, it’s still early days, what happened to waiting until October? take riampficin to eliminate the medication from your system, cerebroyslin as well
 
If I still feel this way in a month, I’m going to finish it. Hell on earth.

We are going through this hell but there are things we can do to to alleviate this pain. We can pay attention to the recovery stories. Take it as easy as you can. Stay distracted with whatever you can, play games or whatever distracts you best. If things get too hard, there are drugs like rifampicin, that can reduce the efficacy of invega in blood. There are other options too.
 
NO, just trying to find out why antipsychotics prevent a person from feeling the effects of weed, alcohol, caffeine, nicotine etc.. finding the answer to why may lead to a solution
I’am not a researcher and those who are refuse to do research about the damage these antipsychotics do to the brain.
 
LEO-POINTING-MEME.jpeg

A long acting injectable psychotic! I love the idea!


Vyvanse is low dose. Git gud noob.
quote-i-was-banging-seven-gram-rocks-because-that-s-how-i-roll-i-have-one-speed-i-have-one-charlie-sheen-62-52-90.jpg
Vyvanse is the most efficient among them and it has helped people in this thread
 
If only there was a complete opposite of this drug,not like stimulants or dopamine agonists but to a higher extent. What if there is a reverse antipsychotic that can be injected and last in our body several months.
Anti-antipsychotic, a new drug used to threat post antipsychotics injections syndrome developed due to a wrong/false diagnosis that harmed the patient?

Then they should more selective to those who they decide They would inject, so they lose profits.

Then they have to make an extended study and research on how these injections affects the brain and body, in order to manufacture a “counter-drug”.

But then they will discover how harmful these antipsychotic were to the body and brain, and they will be BANNED as the old lobotomy, so They will lose tons of profits.

Rockfeller once said “a patient cured it’s a customer lost, we have to threat them for the entire life, not cure them”.

If you don’t know he is the head of our modern medicine, do some research if you want.
 
What exactly does vyvanse do? Does it lift blunted emotions, anhedonia, or improve drive?

Imo amphetamines are not going to be a cure all. When i was on abilify and had come off invega i shot up alot of coke and besides helping my mood coke didnt really do much to help. Ive never had vyvanse but i have had dexedrine and vyvanse is basically long acting deedrine. Dexedrine is nowhere near as intense as IV coke and i still had blunted emotions and shit on it. I got a helleva rush but ended up shooting more just to feel something and eventually had a seizure. Well i had a few mini seizures but only one i ended up going to the ER for. I had 1 or 2 een after i got out of the ER.

One thing i will say is that if your a guy get your testosterone levels checked. My test levels where fucking tanked and i blame that on the abilify and invega injections. My opiate use no doubt ddnt help but i never got ED from opiates at all. On invega and abilify i didnt get a erection for 2 goddamn years and had zero sex drive. Since going on testosterone replacement therapy i feel absolutely great and am in the best shape of my life at 44 years old. I am in better shape now then when i was 20 and doing bricklaying 12 hours a day.

S ya if your a guy get your doc to gie you a blood test for both test and also estradiol thats your e2.
 
Imo amphetamines are not going to be a cure all. When i was on abilify and had come off invega i shot up alot of coke and besides helping my mood coke didnt really do much to help. Ive never had vyvanse but i have had dexedrine and vyvanse is basically long acting deedrine. Dexedrine is nowhere near as intense as IV coke and i still had blunted emotions and shit on it. I got a helleva rush but ended up shooting more just to feel something and eventually had a seizure. Well i had a few mini seizures but only one i ended up going to the ER for. I had 1 or 2 een after i got out of the ER.

One thing i will say is that if your a guy get your testosterone levels checked. My test levels where fucking tanked and i blame that on the abilify and invega injections. My opiate use no doubt ddnt help but i never got ED from opiates at all. On invega and abilify i didnt get a erection for 2 goddamn years and had zero sex drive. Since going on testosterone replacement therapy i feel absolutely great and am in the best shape of my life at 44 years old. I am in better shape now then when i was 20 and doing bricklaying 12 hours a day.

S ya if your a guy get your doc to gie you a blood test for both test and also estradiol thats your e2.
What do you suggest we take for emotions, or do we just wait? Do all emotions eventually come back? Did your emotions for your loved ones get blunted by invega and did they come back?
 
What do you suggest we take for emotions, or do we just wait? Do all emotions eventually come back? Did your emotions for your loved ones get blunted by invega and did they come back?

The emotions came back fully for me. Honestly what i suggest is just waiting and doing stuff to help like exercise. It took me almost a year to get akll my emotions back fully. But i think the latuda i was on hindered my recovery. I think would have recovered much faster if not for that
 
The emotions came back fully for me. Honestly what i suggest is just waiting and doing stuff to help like exercise. It took me almost a year to get akll my emotions back fully. But i think the latuda i was on hindered my recovery. I think would have recovered much faster if not for that
How exactly do emotions start coming back? Little by little every month or like a flood gate opening? Or do the emotions fluctuate and come and go?
 
Last edited:
LEO-POINTING-MEME.jpeg

A long acting injectable psychotic! I love the idea!


Vyvanse is low dose. Git gud noob.
quote-i-was-banging-seven-gram-rocks-because-that-s-how-i-roll-i-have-one-speed-i-have-one-charlie-sheen-62-52-90.jpg
Vyvanse is the most efficient among them
Imo amphetamines are not going to be a cure all. When i was on abilify and had come off invega i shot up alot of coke and besides helping my mood coke didnt really do much to help. Ive never had vyvanse but i have had dexedrine and vyvanse is basically long acting deedrine. Dexedrine is nowhere near as intense as IV coke and i still had blunted emotions and shit on it. I got a helleva rush but ended up shooting more just to feel something and eventually had a seizure. Well i had a few mini seizures but only one i ended up going to the ER for. I had 1 or 2 een after i got out of the ER.

One thing i will say is that if your a guy get your testosterone levels checked. My test levels where fucking tanked and i blame that on the abilify and invega injections. My opiate use no doubt ddnt help but i never got ED from opiates at all. On invega and abilify i didnt get a erection for 2 goddamn years and had zero sex drive. Since going on testosterone replacement therapy i feel absolutely great and am in the best shape of my life at 44 years old. I am in better shape now then when i was 20 and doing bricklaying 12 hours a day.

S ya if your a guy get your doc to gie you a blood test for both test and also estradiol thats your e2.
Vyvanse is a stimulant and it was people use to feel better in this threads like the other guy.
 
Top