I have a close close friend who started using meth about 5 weeks ago after a few years of sobriety from various substances. I am from central PA, about 1.5 hours outside of Philly. We did test the product and get positives for Fentanyl and one for Xylazine. The friend cut back on the meth usage to prepare to quit over the next few days and randomly had two major seizures in the kitchen resulting in two bone breaks in the right leg that now needs surgery. The hospital staff told me more and more people are coming thru detoxing off of meth and having violent, severe withdrawal symptoms from Xylazine/Tranq. I am wondering if anyone else has experienced this recently or heard of it? It’s wild to me as I only used heroin in the early 2000s when it was still just heroin and the only withdrawal that caused seizures was benzos and alcohol. Ugh.
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BDD Moderators: Keif’ Richards
Fentanyl/Xylazine in meth and seizures during withdrawal
- Thread starter pattiXann
- Start date
This is a troubling development for a few reasons. Of course, we already know that Xylazine is contanimating drugs beyond just the Opioid supply. It has been found in everything from dope, to Cocaine, to Meth and even (now this is not something I would worry about) Cannabis. We know that Xylazine is really not fit for human consumption. In short, it would seem that this drug is known to be highly poisonous/corrosive. This is "acceptable" when you're dealing with livestock that will likely not live for longer than a few years. Humans can live for 100 years. We have people using Xylazine for the same amount of time that a livestock animal will live.
For those who are not yet aware, Xylazine is an A2 adrenergic receptor agonist. For the sake of reference, Clonidine (Catapres) is also an agonist of the same family. The two substances lower blood pressure and to a lesser extent, pulse rate dependent upon dosage. Being that these drugs are antihypertensive agents, tolerance to said drugs leads to a dependency upon the drug for the maintenance of homeostasis. As we know from general laws of pharacology, if you will, the human body is not limited in its ability to become tolerant to and adapt to the presence of drugs. Follow me here.
If a person is sufficiently tolerant to either of these drugs, sudden withdrawal from high doses can produce Hypertensive Crisis. This is typically experienced as a sensation of extreme physical tension accompanied by feelings of sheer panic, temperature insensitivity and a general breakdown in a person's functionality. People who are out there heavily using these combination dope products faces a twin withdrawal of both Fentanyl and Xylazine. Think if a miserable hell were merged with the feeling of your ribcage being squeezed in a vice while you consistently feel like you're about to have a heart attack. That's neither here nor there though.
Methamphtamine as a powerful central nervous system stimulant is paired greatly with Xylazine from a business perspective. Methamphetamine users are often trying to shed the excess body load and tension as a result of high dose usage. Xylazine and/or Clonidine is a logical addition for anyone trying to achieve this. The issue is, as a person uses higher and higher quantities of Meth laced with Xylazine, they could be completely unaware of what is happening behind the scenes to their circulatory system.
The same amount of Xylazine that would easily knock another person out might only cause transient subjective feelings in a Methamphetamine user. Once the Xylazine intake stops, they are then left with a massive tolerance to the Xylazine. The withdrawal from Xylazine is stated to come on rapidly. It is not out of the question to think that a person could have a sudden attack of hypertension that would leave them potentially on the floor or worse.
This is something we really need to keep following. I would advise everyone to test their drugs. There is a good reason for a dealer to include Xylazine in their stimulant drugs, so I'm not surprised that they do. Good information.
For those who are not yet aware, Xylazine is an A2 adrenergic receptor agonist. For the sake of reference, Clonidine (Catapres) is also an agonist of the same family. The two substances lower blood pressure and to a lesser extent, pulse rate dependent upon dosage. Being that these drugs are antihypertensive agents, tolerance to said drugs leads to a dependency upon the drug for the maintenance of homeostasis. As we know from general laws of pharacology, if you will, the human body is not limited in its ability to become tolerant to and adapt to the presence of drugs. Follow me here.
If a person is sufficiently tolerant to either of these drugs, sudden withdrawal from high doses can produce Hypertensive Crisis. This is typically experienced as a sensation of extreme physical tension accompanied by feelings of sheer panic, temperature insensitivity and a general breakdown in a person's functionality. People who are out there heavily using these combination dope products faces a twin withdrawal of both Fentanyl and Xylazine. Think if a miserable hell were merged with the feeling of your ribcage being squeezed in a vice while you consistently feel like you're about to have a heart attack. That's neither here nor there though.
Methamphtamine as a powerful central nervous system stimulant is paired greatly with Xylazine from a business perspective. Methamphetamine users are often trying to shed the excess body load and tension as a result of high dose usage. Xylazine and/or Clonidine is a logical addition for anyone trying to achieve this. The issue is, as a person uses higher and higher quantities of Meth laced with Xylazine, they could be completely unaware of what is happening behind the scenes to their circulatory system.
The same amount of Xylazine that would easily knock another person out might only cause transient subjective feelings in a Methamphetamine user. Once the Xylazine intake stops, they are then left with a massive tolerance to the Xylazine. The withdrawal from Xylazine is stated to come on rapidly. It is not out of the question to think that a person could have a sudden attack of hypertension that would leave them potentially on the floor or worse.
This is something we really need to keep following. I would advise everyone to test their drugs. There is a good reason for a dealer to include Xylazine in their stimulant drugs, so I'm not surprised that they do. Good information.
hellinabucket77
Greenlighter
We have to figure out how to destroy this xylazine bs. Its a shame. I know it will never happen but I wish the government (u.s) would just legalize so people wouldn't have to use this BS. Pain patients turn to the streets because they can't get actual pain relief meds anymore and then they run into this garbage. Its sad how things have gone downhill so fast. I have been trying to come up with ways to stop that traq bs but I guess some people like it and as long as that happens and at least 60% of users stop buying until its just an opiate and nothing else then everything is going to keep getting more f***Ed. Thank you for the info, that is another bit of info I was unaware of.
hellinabucket77
Greenlighter
Damn, I am sorry for your loss. This is insane. I feel so bad for the younger users getting involved. Back in the day, first timers would sniff a little or smoke it and just get nausea and feel better after but now its take a tiny amount and you are incoherent then either dead or addicted to a substance with no euphoria and barely any pain killing properties due to the formulation.