Hi everyone! It’s been almost a year since I last visited this forum.
So... I’m going to tell you briefly about my BEFORE and AFTER Invega Sustenna. I had already been hospitalized in a psychiatric clinic for a few months, and I was in a mixed state. A little depression and a lot of hypomania... No medication could get me out of that state. That’s when I was prescribed Invega. I took the initial pills, and nothing bad happened... But 2 days after taking the injection, I crashed from hypomania into a MAJOR and very severe depression. I remember that on that second day, while hospitalized, I had a session with the psychologist, and I—who used to be 'way too talkative'—couldn't open my mouth to speak a well-formed sentence. It felt like I had severe cognitive problems.
N After that, it was nothing but Major depression, total anhedonia, lack of interest in things, and the presence of suicidal thoughts. (Detail: I’ve had a bipolar diagnosis for 12 years and had never attempted suicide, but in 2025 I attempted it 4 times. Result: Invega completely took my life away.
Right now, I’m going through moderate depression, as it is more linked to GAD (Generalized Anxiety Disorder), which is stagnant. Seriously, I don’t react to the world because of the anxiety I feel; it's so brutal that it causes me pain and a 'tearing' sensation in my heart.
Result: I, who before Invega took 30mg of Vyvanse and felt extremely energetic, without anxiety, and even with euphoria similar to ecstasy or MD... After Invega, I went to my 'escape valve' by taking 30mg, and I felt absolutely nothing (believe it)! The only thing that remained was a decrease in anxiety.
Result: I went straight to the 70mg dose and felt a 'slight,' almost imperceptible effect of acceleration.
That’s when I moved up to 2, and NOTHING; I went up to 3 Vyvanses of 70mg, and that’s when I felt something (close) to the 30mg Vyvanse, but still, FAR from being my old 30mg Vyvanse in terms of euphoria and total energy!
I’m telling you this and questioning it at the same time. This happened in October 2024 (Invega Sustenna).
My biggest question is: is this 'resistance' to Vyvanse normal after 1 year and 3 months have passed?
What do you make of this issue?
Is it permanent? Is there still Paliperidone in my system? Did Paliperidone permanently affect my brain regarding psychostimulants? What would you tell me?
Thanks in advance, guys!!