Harm Reduction Does taking a benzo with an amphetamine reduce cardiotoxicity?

[PenguinWithNapalm]

Just wondering.

 

[6apebillen]

I'm not an expert but I would say not significantly. Cardiotoxicity of stimulants is caused by more than just increasing blood pressure and heart rate, and benzos might reduce those specific effects, but they're not polar opposites.

Similar thing to when people drink alcohol and then take cocaine they might feel more sober because some of the effects counteract eachother, but you're still putting stuff in your body, youknow.

Maybe somebody with more knowhow on the specifics on how this cardiotoxicity works can chip in.

 

[KurtAurelius]

In an instance maybe? But it’s not a long term protective measure.. but if your doing crazy things like IV Coke or similar id definitely recommend a benzo for both blood pressure, keeping sane and being able to sleep but again only when absolutely needed, Benzos are demonic as everyone knows.

I think Raw Olive Oil, Ginger and Garlic, Taurine, Agmatine, Magnesium, Tocotrienols and Bentofiamine and other similar food: supplements are agents for more Sustainable blood pressure lowering and cardio protection.

Using superior stimulants like Methylphenidate over Cocaine or Dextroamp/Dextrometh over practically any other kind of stimulant preferably in pharmaceutical form,

Methylphenidate- 72-108mg ER a day- 20mg IR every 2 hours up to 60-100mg
Dextro amp- around 40mg a day or 70mg Vy/Elvanse one pop
Dextrometh- max 25mg, better to have in just one dose

These are the closest approximation for a maxium usage of each agent safely but this is very idealistic considering it, but that with your usual cookie cutter whole foods, exercise sleep and then supplements will be the best way to protect your heart.

If you can, monitor your pulse and blood pressure and also get a ekg or whatever but this is best case scenario.

 

[shreddedlettuce]

Just wondering.

IMO (and I could be wrong), but I think it would be the opposite - it would increase Cardiotoxicity if anything.

again - I could be wrong

PS. taking it once the stimulant has worn off is a different story

 

[TheFunkeeJunkee]

Yes, but only partially—and only in certain situations.

Amphetamine isn’t uniquely cardiotoxic. Like most stimulants, it stresses the heart mainly by activating the sympathetic nervous system (SNS). This means increased heart rate, higher blood pressure, and vasoconstriction. Over time, or in a massive overdose, this can strain the heart and circulation, sometimes leading to arrhythmias, heart attacks, or long-term heart muscle problems.

Amphetamine can also be directly toxic to heart cells, especially with chronic or high-dose use. It can cause oxidative stress, damage mitochondria, and contribute to structural changes in the heart (remodelling), which can eventually lead to cardiomyopathy. This is most well-documented with heavy methamphetamine use; standard prescription doses or infrequent use are much less risky in healthy hearts.

Benzodiazepines do reduce CNS and SNS activity, which can lower heart rate and blood pressure in the short term. However, they don’t protect against the direct, long-term damage amphetamine can cause to heart cells.

Practically speaking, benzodiazepines also blunt the psychoactive effects of amphetamine. So if the goal is reducing heart strain, a much safer strategy is simply using less amphetamine, rather than relying on a benzo to “protect” your heart.

 

[PenguinWithNapalm]

Yes, but only partially—and only in certain situations.

Amphetamine isn’t uniquely cardiotoxic. Like most stimulants, it stresses the heart mainly by activating the sympathetic nervous system (SNS). This means increased heart rate, higher blood pressure, and vasoconstriction. Over time, or in a massive overdose, this can strain the heart and circulation, sometimes leading to arrhythmias, heart attacks, or long-term heart muscle problems.

Amphetamine can also be directly toxic to heart cells, especially with chronic or high-dose use. It can cause oxidative stress, damage mitochondria, and contribute to structural changes in the heart (remodelling), which can eventually lead to cardiomyopathy. This is most well-documented with heavy methamphetamine use; standard prescription doses or infrequent use are much less risky in healthy hearts.

Benzodiazepines do reduce CNS and SNS activity, which can lower heart rate and blood pressure in the short term. However, they don’t protect against the direct, long-term damage amphetamine can cause to heart cells.

Practically speaking, benzodiazepines also blunt the psychoactive effects of amphetamine. So if the goal is reducing heart strain, a much safer strategy is simply using less amphetamine, rather than relying on a benzo to “protect” your heart.

Ah gotcha.

 

[notsmokeymcpot42088]

I always wondered that myself and personally take the benzos if I take amph or coke in an effort to ease the heart / jitters / comedown *second dose usually* (Which doesn't happen anymore but I was cool once)