Opioids Meals that make my meds kick in harder...

[Mastermind830]

A little about me. I am 42, a little heavy, but healthy. Sugar levels are great. Blood pressure and cholesterol are within range. Here is my thought. I am prescribed 120 Percocet per month. I have noticed that if I take my dose on an empty stomach and then follow it with a high-carb meal like pasta, my medicines kick in wayyyyy harder. Anyone else notice this or any other food that seem to kick your meds?

 

[moonyham]

A little about me. I am 42, a little heavy, but healthy. Sugar levels are great. Blood pressure and cholesterol are within range. Here is my thought. I am prescribed 120 Percocet per month. I have noticed that if I take my dose on an empty stomach and then follow it with a high-carb meal like pasta, my medicines kick in wayyyyy harder. Anyone else notice this or any other food that seem to kick your meds?

I have noticed this with every drug basically. I feel super slow and weighed down if I eat a carb heavy meal even when I'm sober.. I think drugs just make us more aware or amplify it.

 

[Mastermind830]

I have noticed this with every drug basically. I feel super slow and weighed down if I eat a carb heavy meal even when I'm sober.. I think drugs just make us more aware or amplify it.

That's possible. The only other meds I am on are asthma medicines so I never really noticed. But when taking my usual dose of Oxy, just a general feeling of pain freeness, but no nod. With pasta or tacos? Nod city.

 

[Jnowhere]

 

[Gridlink]

I've never heard about high carb meals making opiates kick in harder. But when I used to do oxymorphone, I would eat a meal high in fats and then take the pills immediately afterwards. Something about the lipids seemed to make the oxymorphone absorb faster and have a higher bioavailability compared to taking them on an empty stomach.

 

[PenguinWithNapalm]

I know kinda on the other end that if I’m hungry then I don’t feel the effects of most drugs

 

[Deleted member 578389]

so if you take the percs and just keep fasting, you get less high than a carb heavy meal???

 

[moonyham]

That's possible. The only other meds I am on are asthma medicines so I never really noticed. But when taking my usual dose of Oxy, just a general feeling of pain freeness, but no nod. With pasta or tacos? Nod city.

Honestly, probably just getting older and into pre-diabetic territory. Thats why all the dads and uncles at family gatherings would be falling asleep/sleeping after a meal. Loading up on food these days puts me to sleep depending on what I've eaten that day etc

 

[moonyham]

I know kinda on the other end that if I’m hungry then I don’t feel the effects of most drugs

100% on weed for this one.. If I eat before I smoke, the high is substantially more chill and lethargic. If I don't eat before... The high is mild.

 

[Mastermind830]

so if you take the percs and just keep fasting, you get less high than a carb heavy meal???

Yeah. Kind of weird. Didn’t notice it until I got into percs from norcos. I’ve tried with and without food but for some reason the carb foods just make me get higher.

 

[PenguinWithNapalm]

100% on weed for this one.. If I eat before I smoke, the high is substantially more chill and lethargic. If I don't eat before... The high is mild.

Yes. Weed, stimulants and opioids (not taken orally) eating before benzos though really blunts the effects; most pills for that matter

 

[Dextro .45]

Certain drugs yes and no…..

Ritalin (Methylphenidate) taking with a light fatty meal enhances and speeds absorption. In addition, co-consumption of Methylphenidate with Ethanol increases levels of the active isomer d-threo-MPH (Focalin) by 40% significantly enhancing euphoric / mood-boosting effects in all human study participants

Note: it also produces the inactive metabolite levo-threo-Ethylphenidate (which is NOT the desirable isomer d-Ethylphenidate which is VERY euphoric & pleasurable…..in addition to Ritalinic Acid


Pregabalin (Lyrica) is another significant example…….taken on a fasted state C-Max is achieved in 1.5 hours ……after a full meal, C-Max is achieved in 4 hours ………a significant amount of time. I take my oral Brompton Cocktail on an empty stomach including Lyrica (Pregabalin) it’s full onset kicks in 30min easy …45min to 1h I’m completely lit

Methadone 100 - 125mg
Ritalin (Methylphenidate) 50-70mg IR
Lyrica (Pregabalin) 300-450mg
Diazepam (Valium) 30mg
Alprazolam (Xanax) 1mg
Ethanol / Alcohol - 2.oz per drink X 3-5 drinks over 4 hours or son

Due to chronic pain from RA at age 25 ……I’ve built my tolerant up to a very high and robust level of tolerance, in every drug class, opioids, benzodiazepines, Gabapentinoids, dopaminergic stimulants, others GABA-A agonists

 

[saduncan]

Yeah, that can happen. Empty stomach + carbs can change how fast stuff gets absorbed, so it can feel stronger. Just be careful though, that spike can also mean harder crashes and more side effects.

 

[Mastermind830]

Thanks for all the replies and sharing of your experiences as well. I love this community. It has been here for me throughout my 15 year journey. I did not start posting until a few years ago, but all of the posts and replies have always made me felt like I was not alone in this. Love and light to everyone!

 

[marcoman]

I'm a lightweight and glad. One beer with one k pin and one beer. Never more than one beer. And I munch on chips and high end cheeses waiting for it to kick in. My daily ritual.

 

[thehayzzz]

Certain drugs yes and no…..

Ritalin (Methylphenidate) taking with a light fatty meal enhances and speeds absorption. In addition, co-consumption of Methylphenidate with Ethanol increases levels of the active isomer d-threo-MPH (Focalin) by 40% significantly enhancing euphoric / mood-boosting effects in all human study participants

Note: it also produces the inactive metabolite levo-threo-Ethylphenidate (which is NOT the desirable isomer d-Ethylphenidate which is VERY euphoric & pleasurable…..in addition to Ritalinic Acid


Pregabalin (Lyrica) is another significant example…….taken on a fasted state C-Max is achieved in 1.5 hours ……after a full meal, C-Max is achieved in 4 hours ………a significant amount of time. I take my oral Brompton Cocktail on an empty stomach including Lyrica (Pregabalin) it’s full onset kicks in 30min easy …45min to 1h I’m completely lit

Methadone 100 - 125mg
Ritalin (Methylphenidate) 50-70mg IR
Lyrica (Pregabalin) 300-450mg
Diazepam (Valium) 30mg
Alprazolam (Xanax) 1mg
Ethanol / Alcohol - 2.oz per drink X 3-5 drinks over 4 hours or son

Due to chronic pain from RA at age 25 ……I’ve built my tolerant up to a very high and robust level of tolerance, in every drug class, opioids, benzodiazepines, Gabapentinoids, dopaminergic stimulants, others GABA-A agonists

Where do or better question HOW do you guys even get to where you have all this to begin with? I have three prescriptions that I've had forever and even each of them took forever to be prescribed. Also they won't give more than 30 a day here of meds unless the meds are more than once a day ..I recently moved and found some real addicts living there. They are all crack but have other meds that's how i tried lyrica. I've never done crack and now been doing for like a week and never done lyrica or any type of Gabas so i ended up OD in hospital last night and can't figure out which combo or drug did it.
It just could have been the sheer amount because it's happened to me before but we were snorting lines of all my stuff which is methylphenidate, clonazepam, Zoplicone and I'm not used to drinking but there have been some nights of that plus each night crack. I've never felt so euphoric either.. any opinions? Or just general experiences?