I think that with stimulants, overall, I've pushed myself physically to dangerous extents, more often than mentally.
There's many times on long stim binges where I've not drank water, nor eaten anything, obviously not slept, skipped my usual Benzos and Mirtazapine for days, and my heart rate and BP has been god only knows how close to overload, and the seizure threshold for abrupt benzo cessation. I have some kind of ability to 'listen to my body', I guess we all do, if we chose to 'tune in', so when the twitches started and things start to feel seriously bad with my heart rate and bp etc, I've been able to call time, and stop the binge, and take my usual meds, prescribed or otherwise, and force myself to drink some water. The relief has always washed over me as soon as those meds starting kicking in within 20 minutes or so. Probably and fortunately this happened extra fast due to my stomach being so completely empty.
I dunno how close I came to some form of death by misadventure. Probably quite close.
Mentally speaking, on stims, days into binges, whenever I started hearing non existent dragon flies buzzing round my head, and people crunching on the gravel outside the window of my enclosed back yard (I was too scared and paranoid to open the curtains to confirm the reality or otherwise of there actually being anyone there or not!

) that was always when I felt it was time to call an end to the session.
With the benefit of hindsight I think I I can say that I damaged my mental health more with excessive and prolonged use of cannabis at certain points, leading to a pretty severe 'nervous mental breakdown.' After which I was never quite the same, suffering from extreme anxiety, delusions, and paranoia etc etc. Although the nervous / mental breakdown term is no longer used in professional medical circles it perfectly describes what I felt happened to me. Also with mushrooms a couple of years earlier that also fucked my young head up quite a lot. The difference being that in time, (a year or 2) I fully recovered from that. Although perhaps those experiences left me more vulnerable to suffering mental damage from excessive use of cannabis later on.
Fortunately, the paranoia has gone, as have the delusions. (AFAIK

) But the anxiety looks to be here to stay.
I guess I was fortunate with stimulants that I was able to stop before anything very serious and public, involving mental health sectioning etc happened, but not so fortunate with cannabis. It was fucking peer pressure. I should have had the sense to distance myself from certain people, for at least a time, and maybe could have prevented all these permanent issues. But hindsight is a wonderful thing eh?