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Misc Lamotrigine (Lamictal) thread

B

bvc

Bluelighter
Joined
Aug 26, 2025
Messages
378
I wanted to start a thread for Lamotrigine (Lamictal). Maybe it's unnecessary but I've had amazing effects from Lamictal that have changed my life. I want to create a sort of journal and/or discussion about Lamictal. I think Lamictal has been both beneficial and/or harmful for different people. I want to talk about drug studies, too.
 
Today I had what might have been muscle spasms in my limbs (arms and legs) after taking a higher dose of Lamotrigine this morning. I came close to dropping some things, and I almost fell. I'm going to look at stabilizing myself and figure out how to make sure that this doesn't happen in the future.
 
Jnowhere said:
Basically
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Yep. I just didn't expect that symptom. Lucky it was my limbs and not my torso (heart) I guess. Haven't been that scared since I had my first episode of sleep paralysis from laying laying on my arm. Thought for a little while I'd had a stroke. It's stopped now, thank fucking christ.

Edit: My cat's looking at me. She's very disappointed in me. :(
 
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Am I the only one to look at the chemical structure of lamotrigine and wonder if anyone has calculated if detonation would result in an exothermic reaction?

Yes, I am aware it's a pretty bizarre thought but you would be amazed how many insensitive explosives weren't even known to BE high explosives until someone did the calculations. After all, one isn't likely to accidentally subject a medicine to the conditions required to detonate an IHE but this has happened before.
 
4DQSAR said:
Am I the only one to look at the chemical structure of lamotrigine and wonder if anyone has calculated if detonation would result in an exothermic reaction?

Yes, I am aware it's a pretty bizarre thought but you would be amazed how many insensitive explosives weren't even known to BE high explosives until someone did the calculations. After all, one isn't likely to accidentally subject a medicine to the conditions required to detonate an IHE but this has happened before.
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Wow. I had no idea. That's cool.
 
4DQSAR said:
Am I the only one to look at the chemical structure of lamotrigine and wonder if anyone has calculated if detonation would result in an exothermic reaction?

Yes, I am aware it's a pretty bizarre thought but you would be amazed how many insensitive explosives weren't even known to BE high explosives until someone did the calculations. After all, one isn't likely to accidentally subject a medicine to the conditions required to detonate an IHE but this has happened before.
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You should ask @Rectify or @MedicinalUser247 about this. They might know.
 
4DQSAR said:
Am I the only one to look at the chemical structure of lamotrigine and wonder if anyone has calculated if detonation would result in an exothermic reaction?

Yes, I am aware it's a pretty bizarre thought but you would be amazed how many insensitive explosives weren't even known to BE high explosives until someone did the calculations. After all, one isn't likely to accidentally subject a medicine to the conditions required to detonate an IHE but this has happened before.
Click to expand...
Ah, a prescription bottle bomb 💣. Shhhh, there are possible terrorists watching.lol
 
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If there was a total collapse of the government and a second Civil War.

I WANNA BE THE FIRST EVER TO THROW A MOLOTOV LAMICTAL!!!! AT HIPPIES.
 
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Well, I suggested lamtragine might be an iIHE, that's an insensisitve high explosive. Those typically require an appropriate primer and gain to make them detonate. I take no interest in the chemistry of explosives or poisons but I seem to recall the first IHEs were initially classed as being flammable i.e. they would burn but not expode. I'm unclear on how it was worked out that in the right conditions they would detonate but it's either going to be a very dull calkculation OR a spectacular accident.
 
4DQSAR said:
Well, I suggested lamtragine might be an iIHE, that's an insensisitve high explosive. Those typically require an appropriate primer and gain to make them detonate. I take no interest in the chemistry of explosives or poisons but I seem to recall the first IHEs were initially classed as being flammable i.e. they would burn but not expode. I'm unclear on how it was worked out that in the right conditions they would detonate but it's either going to be a very dull calkculation OR a spectacular accident.
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I wish I knew chemistry and physics, etc. better so I could understand the molecule threads those two do.
 
bvc said:
I wish I knew chemistry and physics, etc. better so I could understand the molecule threads those two do.
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Well, Sci Hub, Google Scholar & PubChem combine into a very powerful (free) learning tool.

If you can find and afford an old copy (version 11 seems best) of ChemOffice, that's amazingly powerful. But if not, ChemSketch and the other on-line tools that ACD/Labs are free and are still jolly useful.

I suppose if money is no object, a Reaxys licence that includes unlimited searches is the MOST powerful tool but is costly. I specified older versions of ChemOffice because I'm told the newer versions link you to Elsevier and other publisher so yes, you can read the paper almost instantly, but unlike using Sci Hub, it bills you! Few things are more upsetting than spending anywhere from $30-$80 for a paper only to reaslize that only one sentence is of value.

I believe there are also some more advanced tools but they really are designed to extract the maximum amount of money out of researchers.

As a class, I suggest that the phenethylamines represent the easiest class of psychoactive to explore. Isomer Design even has a search engine in which you provide the basic scaffold and it displays every compound in it's database that contains said scaffold.

But I would estimate that as with everything, it's 1% inspiration, 99% perspiration. It's so easy to just draw a chemical and assign a name and theoretical activity. Part of that 99% is working out a facile synthesis.

I don't feel it's hard, but it takes a long time and get ready for doubt. Because as Karl Popper noted, an experiment can only disprove a theory.

If all else fails, ask. But do the 'all else' first as being asked something that a Google search will find in ten seconds can be frustrating. But we are all learning. Nobody can legitimately claim to know more than a fraction of all of one science, let alone all of the sciences that intersect with chemistry. So there really are vistas of information that has yet to be extracted from data.
 
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Took 800mg dose about an hour ago (400, then 400 2 minutes later): currently undergoing racing thoughts and high mood.
 
bvc said:
Wow. I had no idea. That's cool.
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Yeah that is cool.
bvc said:
I wanted to start a thread for Lamotrigine (Lamictal). Maybe it's unnecessary but I've had amazing effects from Lamictal that have changed my life. I want to create a sort of journal and/or discussion about Lamictal. I think Lamictal has been both beneficial and/or harmful for different people. I want to talk about drug studies, too.
Click to expand...
What is it you like about it?
 
Feeling gggggoooooooooooooooooooooooooooooooooooooooo!!!!!!!!!!!!!!!
DXM about 2 hours ago, but the 900 mg of lamictal I took about 4 hours ago probably helped too.
I'm about to get wasted, bitches!!!
Maybe the case I'm working on abuot the raped woman will get taken seriously!!!! YaaYYYYYYaaa!
 
4DQSAR said:
Am I the only one to look at the chemical structure of lamotrigine and wonder if anyone has calculated if detonation would result in an exothermic reaction?

Yes, I am aware it's a pretty bizarre thought but you would be amazed how many insensitive explosives weren't even known to BE high explosives until someone did the calculations. After all, one isn't likely to accidentally subject a medicine to the conditions required to detonate an IHE but this has happened before.
Click to expand...
One interesting example of being both a medical and explosive use of a substance would be nitroglycerin. It would be completely wild if Lamictal were to have a similar profile.
 
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