Opioids Oxycodone hit or miss. What's going on?

[Automator]

I feel like shit daily. Seasonal depression hitting hard. One night last week, it was the best I've felt since starting these. Since then, crap, crap, crap.

 

[Them Witches]

@Automator -- what brand are you taking? Mallinckrodt or KV-tech ? Those are the only two brands worth a shit.

If you are still on 2 doses per day, you need to be moved to every 4-6hrs. This is just how Oxycodone IR release works.

I am not a fan of ER Oxycotin every 12hrs.

 

[Automator]

@Automator -- what brand are you taking? Mallinckrodt or KV-tech ? Those are the only two brands worth a shit.

If you are still on 2 doses per day, you need to be moved to every 4-6hrs. This is just how Oxycodone IR release works.

I am not a fan of ER Oxycotin every 12hrs.

KV - sometimes I'll feel decent, most of the time I feel like garbage. Sad, depressed.

I take it 4 times a day now. Usually every 4-6 hours.

I just don't understand the varying feelings. Back in the day it made me feel great. Never abused, just the dose in general. I took my afternoon dose 2 hours ago and am finally starting to come back to center.

 

[paranoid android]

I prefer extended release opiates for the pain i have. I been on just about everything from tramadol to the fent patch. Im on mscontin now which works great. I just shot 60mg's of it actually. That dose had a rush to it.

Fent s great for pain but sucks balls for getting high. Also it wasent covered under my insurance and was rather expensive. So that combined with the total lack of euphoria made me go back to morphine.

I kiked the oxy instant release back in the day tough. The oxycontins where ok but i preferred the IR's

 

[Them Witches]

KV - sometimes I'll feel decent, most of the time I feel like garbage. Sad, depressed.

I take it 4 times a day now. Usually every 4-6 hours.

I just don't understand the varying feelings. Back in the day it made me feel great

Chronic pain is persistent pain (lasting 3+ months), while Chronic Pain Syndrome (CPS) is a more complex condition where that long-lasting pain significantly impacts emotions (like depression, anxiety) and daily function, creating a cycle where physical pain and emotional distress feed each other, often with changes in the nervous system. About 25% of people with chronic pain develop CPS, which involves more than just the pain itself.

Chronic Pain

• Definition: Pain that lasts beyond the expected healing time, typically more than 3 to 6 months.
• Focus: Primarily on the prolonged physical sensation, which can stem from an injury, illness, or nerve damage.
• Nature: Can be a symptom of an underlying issue that hasn't fully resolved.

Chronic Pain Syndrome (CPS)

• Definition: A condition where chronic pain is accompanied by significant psychological and functional issues, creating a self-perpetuating cycle.
• Symptoms Beyond Pain: Includes depression, anxiety, sleep problems, fatigue, irritability, loss of sexual desire, and reduced ability to function.
• Nervous System Changes: The nervous system can get "stuck" in a pain-signaling pattern, even after the initial injury heals.
• Impact: Affects physical health, emotions, relationships, and work, making it harder to treat than simple chronic pain.

Analogy

• Think of chronic pain as a persistent fire (the pain signal).
• Chronic Pain Syndrome is when that fire sets off smoke alarms (anxiety, depression) and makes the whole house (your life) unlivable, even if the initial source of the fire is addressed.

Treatment Focus

• Chronic Pain: May focus on the specific physical cause (medication, physical therapy for the injury).
• Chronic Pain Syndrome: Requires a holistic, interdisciplinary approach including counseling, stress management, and physical/mental reactivation to break the pain-distress cycle.

Oxycodone, for that matter all opiates/opioids; long-term opiate/opioid therapy requires significant "tuning if you will." It requires addressing all "areas" of the patient :

-- around 3-4 years a single opioid will not be enough. especially if a "IR" has been the primary treatment. each patient is different thus "tuning" is needed to develop a personal patient profile

-- some patients do well with a primary higher extended release opioid and a secondary IR "break-thru" opioid.

-- I prefer a primary IR opioid : 4hrs and a secondary "long half-life" IR opioid example. Roxicodone 30mg IR : 4hrs & Methadone 10mg IR : 6-8hrs

-- if your doctor is not willing to prescribe a 2nd opioid, then I it maybe time to find another doctor.

-- adding medications to help with pain, mood, sleep makes the world of difference like Clonidine, Ativan, Valium, Cyclobenzaprine, Zanaflex, Vistaril PAM, Busbar, Zoloft, Lunesta, Gabapentin, Lyrica

-- creating a personal daily routine makes a world of difference in mood and response to medications

I would suggest talking to your doctor about what is going on. I would refrain from saying things or describing things that trigger the doctor's response of "the pain medications are destroying the patient"... Unless that is the honest that the pain medications are creating a "dark cloud" and/or "preventing progress"

I hope you start to feel better. Increasing the Oxycodone dosage will not change much mentally and will not create euphoria at this point unless it is a drastic change. And that too "feeling" will lessen quickly b/c of dependence and tolerance.

 

[moonyham]

Tried the sublingual administration today. That's a no no for me. Definitely hit like a ton of bricks and freaked me out thinking I overdid it. Old me would have found it incredibly enjoyable. I don't know why my body doesn't tolerate opiates anymore. I NEED them though. My life sucks, lol.

Don't know if this is whats happening but I kinda became 'allergic' to opiates. Even weak ones like tramadol or codeine. I get the most upset stomach and will start vommiting, feel feverish, and generally hate my existence if I do any opiates. This happened to me after smashing oxycodone(real ones, from a pharmacy) for a few months. Found out a couple years later when I did some codeine for an injury, and then found out again when I did heroin and tramadol a while later. My body just rejects it now completely. Makes for never becoming an opiate addict really easy but besides that, kinda sucks because if I get injuries I just have to kinda bare the pain.

 

[Automator]

UPDATE - going on 60mg OxyContin x 2 and 6 10mg IR for breakthrough. Start in a month, wish me luck! Will report back.

I still feel like garbage almost daily, anxiety is awful. Pain is even worse.