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  • BDD Moderators: Keif’ Richards

Methiodone IC-26. New opioid, pretty much perfect.

Oreon

Bluelighter
Joined
Oct 5, 2025
Messages
26
Had a recent opportunity to test out IC-26, aka Methiodone. It is great. How does it compare to methadone? Well first off, the intial 1 hour and the come up of Methiodone is a lot more like Oxycodone, while the overall longevity and potency is like Methadone, it has best of both worlds effect wise.
Very happy with results.

-O
 
I suppose it is purchased over the dark web. The Chinese makers do not sell to individuals right?
 
I mentioned this before but there is no information on the dinor metabolite of IC-26. It's known that the dinor metabolite of methadone is cardiotoxic BUT as physiological pH, dinormethadone can form an internal imine which isn't cardiotoxic. That isn't possible with dinor IC-26 and while we don't know the metabolism of IC-26, isn't it more logical to assume sequential N-demethylation will be a major metabolic pathway of IC-26 so we should at least have reason to question if the stuff is MORE cardiotixic that methadone?

This is a case where survivorship bias means exactly what it says. People who consume IC-26 and suffer a heart attack aren't likely to post about their experience?
 
I mentioned this before but there is no information on the dinor metabolite of IC-26. It's known that the dinor metabolite of methadone is cardiotoxic BUT as physiological pH, dinormethadone can form an internal imine which isn't cardiotoxic. That isn't possible with dinor IC-26 and while we don't know the metabolism of IC-26, isn't it more logical to assume sequential N-demethylation will be a major metabolic pathway of IC-26 so we should at least have reason to question if the stuff is MORE cardiotixic that methadone?

This is a case where survivorship bias means exactly what it says. People who consume IC-26 and suffer a heart attack aren't likely to post about their experience?
Great point. Rx Drugs that come out of a pharmacy (except Suboxone) are in general safe to take everyday. These RC's are known and reported in the drug production field faster than the public finds about them. It is their business to know.

When I hear about these RC, I want to try them but know it might not turn out to well for me personally. I just have to stick with what I know.
 
@Them Witches - Yes, in the UK we still use 'yellow cards' (although I understand a digital option now exists) but if a medication results in a serious unexpected side-effect, it will trigger yellow card warnings from prescribing clinicians.

In the case of methadone, I knew one person who suffered a fatal heart attack at the age of 28 after they stopped using H and were prescribed (quite a high dose of) methadone. A second person suffered a heart attack and survived... but they were on BL but disappeared about a year ago with nobody knowing what happened to them.

The cardiotoxicity of methadone is known and yet it's not standard practice to provide regular EEGs. I suspect the logic is that compared to the harms associated with H use still means methadone vastly more likely to save life, but that toxicity is directly related to dose so someone prescribed 5 or 10mg two or three times a day is at a much lower risk than someone prescribed high doses intended to stop AWS for a full 24 hours. I might be wrong but I think the person who died was on 120 or 130mg/day.

While I am loathe to aid anyone producing what is potentially a toxic product, I believe that just as dipipanone swaps the N,N-dimethyl moiety of methadone for a piperidine ring, the sulfone analogues can likewise allow the introduction of a piperidine moiety (page 162). I would even suspect a morpholine homolologue would also be active, although the paper does not specify that compond.



Of course, given that the enantiomer responsible for analgesic activity is the non-toxic isomer, the alternative would be to resolve the product which means half the yield but the product has twice the activity. But the truth is that nobody seems to have researched the ethylsulfone analogues of methadone much and I always remind people that drug manufacturers are not required to publish human trials. So who knows if a trial took place?

BTW My suggestions MAY offer a safers product but no data on those resolved compounds or on the homologue with a piperidine (or indeed a morpholine) were ever tested for safety, as far as I can tell. Sadly, you would really need animal models to discover if the modifications offer increased safety... and then it's often the case that animal models do not find toxicity demonstrated in humans.
 
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The cardiotoxicity of methadone
I was on 180mg from the age 24-28. Then from age 33-48 dosages have varied from 80mg and 40mg. Now currently at 40mg daily.

I have blood work done at least once per year and most years 2-3qty times. I am doing fine.

I also take Roxicodone and have been from ages 32-48. I am doing fine.

I dissolve Roxicodone under my tongue and it does not effect my teeth. Hydromorphone buccal hurts the teeth almost instantly (Exalgo taken buccal).
 
@Them Witches - I don't claim to be an expert on methadone toxicology but I read that the dinor metabolite can increase the QTc interval. I do wonder if an initial EEG say 28 days after methadone being prescribed would demonstrate if a person is subject to that mode of toxicity.

It was the long-acting methadone deriavtive ORLAAM that proved to be the most dangerous and I assume is why it is no longer in use. In that case there is no ketone so the internal imine cannot form. I still maintain that derivative 1c of R-4066 could be of huge importance in the treatment of people dependent on highly potent opioids. It's duration of action is far longer than methadone and it's analgesic potency is around x106 methadone (in animal models of analgesia).

But it seems that buprenorphine is currently seen as the most PROFITABLE treatment if new formulations can recieve their own patent protection. It bugs me because I'm almost certain that the use of 1c for treatment of opioid dependence WOULD be patentable.


Obviously it would require investment but I have a feeling that at some point in the future buprenorphine will be recognized as the wrong treatment option, especially when people have an issue with fentanyl-class or nitazene-class opioid (as examples). I've not heard much but the little I do hear suggests that for treament of fentanyl dependent clients, buprenorphine is a BAD option.
 
Those are all really good points @4DQSAR

The question of the ¨right treatment¨ for the Fentanyl-age is running through my mind constantly. Case in point here, up in Canada, there are people who can access what I would define as oodles and oodles of free, pharmaceutical grade, injectable Hydromorphone tablets. See, when I was using Heroin, if someone had told me, ¨hey, just stop using Heroin and I´ll give you free Hydromorphone¨ I would have jumped at the chance.

What we see now though are many cases of these users selling their tablets so they can go buy Fentanyl with the money. I know this is a downer, but, here in the United States, we have not even begun to consider an option of this magnitude and likely won´t in the near future. The point, Canada did years ago and it´s starting to look like they were already too late in rolling out this program.

For the record, the common dose for Methadone was historically 80mg-120mg per day. Anything less, you´d be considered on the ¨lighter¨ side and any more, you´d probably consider that a ¨heavier¨ dose.

Since Fentanyl really took hold, I´ve seen people at the Methadone clinic get raised up to previously unheard of levels. I have seen very few people ¨get better¨ from this practice. I think it was the only thing they had available that could possibly make a difference. Methadone previously was only enough to take the place of Heroin and fix your life if you also were willing to put the work in on yourself.\

So many of these people are out on the street, hustling and freezing every waking moment, it´s not like they have an easy way of sitting down and being mindful of their lives. For those of them who haven´t sold their medicine, I feel it has just raised their tolerance to Opioids in general and made things worse.

We used to talk about withdrawing from 100mg Methadone in jail like the ultimate hell a person could experience in this life. Now you´re on 300mg Methadone, using Fentanyl and maybe even drinking Alcohol too... fuck... how are you supposed to fix that problem.

There needs to be something drastically implemented very soon or many of these people are going to die, whether it´s freezing, starving, seizing or dying from a terrible injection-related infections. Yea, this topic gets me worked up. When you see all of these people in wheelchairs and shit because they couldn´t stop injecting this poison. How does that not piss you off when other countries have literally ¨solved¨ their Heroin problem i.e. Switzerland. The politicians swear they would change it if they could, if only they had the answer, well, someone does have the answer and they´ve been there and done that decades ago.

If we would have implemented a Heroin prescribing scheme before Fentanyl, who knows how this could have gone.
 
I believe that a meta-analysis of methadone progams showed that 90-95mg/day seems to produce the best outcomes i.e. more people stayed in the progam and did not consume other drugs. I suggest that they discovered that it may well be reasonable to help a client reduce to that dose but reducing futher showed increase drop-out.

To be clear, their are no extant trials of the compound I flagged but in fact there are several compounds with that high potency and long duration of action. It's just the case that methadone is so cheap. But cheap is nothing if it doesn't work. The compound I flagged is far more costly to make BUT you need a hundred times less of it and it appears that a single dose MAY provide 48 hour relief which in itself would be a cost saving, I assume.


I don't know if nor-ORLAAM or dinor-ORLAAM are clinically significant and evidence suggests that dinor-ORLAAM is responsable for the toxicity of the medication (and it's subsequent withdrawal) but when compared to compound 1c in the previous post, it does seem reasonable to believe a 3 dose per week protocol may be possible. With ORLAAM a given dose was given on Mondays, Wednesdays and then on Friday a larger dose was given, avoiding the need for a Sunday dose.
 
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Those are all really good points @4DQSAR

The question of the ¨right treatment¨ for the Fentanyl-age is running through my mind constantly. Case in point here, up in Canada, there are people who can access what I would define as oodles and oodles of free, pharmaceutical grade, injectable Hydromorphone tablets. See, when I was using Heroin, if someone had told me, ¨hey, just stop using Heroin and I´ll give you free Hydromorphone¨ I would have jumped at the chance.

What we see now though are many cases of these users selling their tablets so they can go buy Fentanyl with the money. I know this is a downer, but, here in the United States, we have not even begun to consider an option of this magnitude and likely won´t in the near future. The point, Canada did years ago and it´s starting to look like they were already too late in rolling out this program.

For the record, the common dose for Methadone was historically 80mg-120mg per day. Anything less, you´d be considered on the ¨lighter¨ side and any more, you´d probably consider that a ¨heavier¨ dose.

Since Fentanyl really took hold, I´ve seen people at the Methadone clinic get raised up to previously unheard of levels. I have seen very few people ¨get better¨ from this practice. I think it was the only thing they had available that could possibly make a difference. Methadone previously was only enough to take the place of Heroin and fix your life if you also were willing to put the work in on yourself.\

So many of these people are out on the street, hustling and freezing every waking moment, it´s not like they have an easy way of sitting down and being mindful of their lives. For those of them who haven´t sold their medicine, I feel it has just raised their tolerance to Opioids in general and made things worse.

We used to talk about withdrawing from 100mg Methadone in jail like the ultimate hell a person could experience in this life. Now you´re on 300mg Methadone, using Fentanyl and maybe even drinking Alcohol too... fuck... how are you supposed to fix that problem.

There needs to be something drastically implemented very soon or many of these people are going to die, whether it´s freezing, starving, seizing or dying from a terrible injection-related infections. Yea, this topic gets me worked up. When you see all of these people in wheelchairs and shit because they couldn´t stop injecting this poison. How does that not piss you off when other countries have literally ¨solved¨ their Heroin problem i.e. Switzerland. The politicians swear they would change it if they could, if only they had the answer, well, someone does have the answer and they´ve been there and done that decades ago.

If we would have implemented a Heroin prescribing scheme before Fentanyl, who knows how this could have gone.
Now we have xylazine thrown in there too just in case hell on earth wasn’t hot enough.
 
Hello, posting back on Methiodone experince, 2 days later.
After a mere 35mg dose, which is typically standard, for Methadone recreational dose, the Methiodone IC-26 took me to places.
I was absolutely Opioided for 48 hours after 1 dose. 48h of Nodding non-stop. The intial high faded after 1 hour, the for 47h, just nodding in and out. First time that I've tried an opioid that lasts that long. Whatever it is, it is clearly stronger than regular Methadone, as regular Methadone is not that long lasting or strong.
 
@Oreon - one of the reasons IC-26 wasn't developed was it's unreliable pharmokinetics. In some individuals it was as potent as methadone, in others far less active. That long duration only suggests that the potentially toxic dinor metabolite accumulates.

If there wasn't a large body of evidence demonstrating the cardiotoxicity of related compounds (dinor-methadone and dinor-ORLAAM) then I wouldn't have mentioned the potential risk.

As I pointed out, in this case the term 'surivorship bias' could mean exaxtly what it says - people who die don't post on that outcome.
 
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