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Nootropics Psilocybin for neuroplasticity

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rehm2k3

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Mar 12, 2025
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Hi all,

I have been using 4aco DMT pills to enhance my learning ability and focus more on personal growth and so far I have seen great benefits.

Now that I have ordered psilocybin, I want to use it only and for the sole purpose of self development and learning new skills.

How often should I dose?

I heard that microdosing works well if you are someone who is looking for the goals that I mentioned but I am concerned about tolerance building up.

I heard that 2 weeks is when psilocybin tolerance resets but I hear different from many people.

Any ideas?
 
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The jury is kind of out on whether microdosing actually stimulates neuroplasticity. It also kind of depends on what you actually mean by microdosing.

We do know for sure however that full dosage trips do stimulate neuroplasticity, and that there seems to be a window of plasticity after the trip that varies in length somewhat in proportion to the duration of the psychedelic's effects. So for example mushrooms might give a 5-7days window of neuroplasticity, LSD might give 10 days, iboga might be a couple of weeks.

I think once every 2-4 weeks with a full-ish dose of mushrooms might be around optimal based on what we know. That will give you plenty of windows of neuroplasticity, and give you time to integrate and reset tolerance. You could push it to once a week for short periods, but most people wouldn't want to trip that often. You don't need to loosen the connections all the time, it's also important to let things gel.

Welcome @rehm2k3
 
perpetualdawn said:
The jury is kind of out on whether microdosing actually stimulates neuroplasticity. It also kind of depends on what you actually mean by microdosing.

We do know for sure however that full dosage trips do stimulate neuroplasticity, and that there seems to be a window of plasticity after the trip that varies in length somewhat in proportion to the duration of the psychedelic's effects. So for example mushrooms might give a 5-7days window of neuroplasticity, LSD might give 10 days, iboga might be a couple of weeks.

I think once every 2-4 weeks with a full-ish dose of mushrooms might be around optimal based on what we know. That will give you plenty of windows of neuroplasticity, and give you time to integrate and reset tolerance. You could push it to once a week for short periods, but most people wouldn't want to trip that often. You don't need to loosen the connections all the time, it's also important to let things gel.

Welcome @rehm2k3
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Thanks for the response.

What's a "fullish" dose of shrooms?

and the idea that microdosing doesn't stimulate neuroplasticity comes from where?

Surely the effects are gradual, as with most things. I don't see why the neuroplasticity would be stimulated above a specific higher threshold.

And I would be more than happy to trip once a week, it's just that tolerance would build quite quickly.
 
rehm2k3 said:
What's a "fullish" dose of shrooms?
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Depends on the individual but I'd say 1.5-3g is what I'd target. Maybe a wider range, like 1-5g

and the idea that microdosing doesn't stimulate neuroplasticity comes from where?
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It's sort of the other way around - the question to ask is "the idea that microdosing *does* stimulate neuroplasticity comes from where?". We assume the null hypothesis. So far there haven't been a lot of convincing studies showing that it does, and more studies show that it's likely placebo. On the other hand a lot of people feel that microdosing mushrooms etc has been very beneficial to them, so there could be something there that's hard to pick up in studies. Or it really could just be placebo - which isn't a bad thing either! I've done lots of microdosing (or probably more honestly mini-dosing - just past threshold) and found it very enjoyable and useful.

Surely the effects are gradual, as with most things. I don't see why the neuroplasticity would be stimulated above a specific higher threshold.
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Yes but similar to the upper limit concept, from the current research - there could be a bottom threshold that you need cross to get any neuroplasticity effects. Other things in nature are like that - like water - it's completely solid until you raise the temperature above 0C
 
rehm2k3 said:
and the idea that microdosing doesn't stimulate neuroplasticity comes from where?
Click to expand...

The idea that microdosing does anything at all is bollocks according to the latest study - think it said microdosing is pure placebo. I've microdosed in the past and noticed slight effects but not much. I think the trip itself is key to any positive effects.
 
I can only speak to my own experience, not research or anything... I found that microdosing shrooms was not useful for virtually anything. No anti-depressant effect, no anxiolytic effect (if anything felt a bit worse), no enhanced novelty, no changes to my thinking. I used as much as 100mg at a time. For me, it's only full on psychedelic doses that work. I suspect it's because microdoses do not reach sufficient saturation levels to trigger changes to neural architecture.

I have used low dose ketamine for depression (12mg or less) and I found that type of microdosing infinitely more useful than psilocybin species at the same dosing level. It may be because ketamine only targets a small family of receptors, so it does not require high quantities to be activating; whereas mushrooms work synergistically and in a more broad spectrum way on 5ht receptors, so they require higher dosing to reach full saturation. But then you have something like LSD which is at the microgram dosing level, and it taps them all and beyond. So I'm not sure my assumptions even work.

There is a major movement in my part of the world to use psilocybin microdoses as treatments. A non-clinical community is doing that kind of work here. Informally, most people I have talked to have said that it does not work.

So I dunno... I can't make sweeping statements, but I am leaning towards it not being an effective treatment.
 
Interesting about the ketamine Foreigner - never thought of microdosing it. I struggle with larger doses - they make me ill for 2 or 3 days afterwards but I do notice an antidepressant effect.

I've been finding creatine, NAC and NR are great for brain fog and depression tho - havn't had a headache since I started taking them a couple of months ago. Before that I was waking up every morning and taking paracetomol to try and clear the brainfog.
 
I find Metocin (4-HO-MET) helpful, although unable to trip Metocin I believe helped me overcome depression enough to stop taking a strong antidepressant without withdrawal symptoms
It also reduced side effects from anti psychotic medication withdrawal
 
Ismene2 said:
The idea that microdosing does anything at all is bollocks according to the latest study - think it said microdosing is pure placebo. I've microdosed in the past and noticed slight effects but not much. I think the trip itself is key to any positive effects.
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For real OP listen close. They say what? 500-750mg of mushrooms is a "threshold" but for real Ismene2 speaks the truth...placebo unless you are a mushroom cubensis virgin, THEN maybe some benefit but truly whatever effect you receive would not continue passed the first week in my opinion..you are better off dosing Lyons mane everyday...unless you are using the most potent mushrooms you can find, like pan cyan, these are super potent and zero body load..this might punch through tolerance if you were micro dosing cubensis and decided to switch it, idk maybe possible but even this mad idea in my opinion wouldn't last long and probably just wasting great medicinal tool

I have been dosing psychedelics in my teens and tripped MUCH LESS OFTEN than I do now but I started with 1gram, then 1.5; so .5g increase until I was ready for heroic doses(anything above 5grams).
BUT now they made their way back into my life and tripping is Very very much on the regular.
for the past year and a half to help with my addictions and overall my well being..it leaps bounds when you focus on going at a heroic dose alone on the weekends with any cubensis strain to help you better understand yourself, improve, and the best part is the brighter outlook on life..which I think is part of what helps rewire neuron pathways and helps with ptsd, and depression.

Look its not "cool" to trip everyday (not that you would obviously) and its barely cool to trip once a week even after say an LSD weekend binge...not because I don't want to trip, but because of tolerance. The 2 week rule truly shines and more so if you wait a month.

Pan Cyan is incredible to me atm. 1 gram and I am visually sitting near a 3.5 or 4g trip(or 5g) they really do seem to be like "what acid wishes it could do" but do not get confused I love LSD but that quote I read is spot on because the visuals have me enamored and zero body load but yeah something about cubes does seem to have a much more spiritual aspect, even though there will be a body load and need more to trip.

Now that I am older MY ENTERTAINMENT (which is also plays a vital role in my addiction/taper process from maintenance opioids)...
I enjoy tripping ballz on a couple tabs of acid on a Friday night or heroic doses of shrooms and a dark room, in the comfort of my own home VS the average fuckhead headed to the BAR to get plastered - fucking they body and mind up with toxic alcohol... Mushrooms will not hurt you(in the sense of correct mushroom species/strain). The worst that will ever happen is thinking you poisoned yourself while high which help's spiral you into a difficult or what some call a "bad" trip, which is where I think we all benefit the most..

Get to know them with low doses first then when you are ready, the courage and fear met with a heroic dose can be life changing,
 
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When it comes to psychedelics how they affect one person may be totally different on another person. A lot has to do with genetics and state of mind before, during and after the experience. If you expect a positive experience and outcome you will likely get what you want.
 
Ismene2 said:
o. I've microdosed in the past and noticed slight effects but not much
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I mean there can be a whole discussion on whether said benefits are even benefits at all even if you can't notice them.

You don't have to notice everything to know if something is good for you.

Your lack of attention to something doesn't diminish its effects, even if minimal.

My only concern here was growing tolerance, i rlly wanna experience the full effects :)
 
M!$TER-ED said:
When it comes to psychedelics how they affect one person may be totally different on another person. A lot has to do with genetics and state of mind before, during and after the experience. If you expect a positive experience and outcome you will likely get what you want.
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That's what I find so fascinating about psychedelics,. you can delude yourself with the right expectations in mind.. and ofc a massive dose lol

which is why i want to use it for personal growth, i can set who i want to be and let the pyschs change my brain.
 
sure, what you choose to think and the decisions you make makes the future you truly desire. The problem with this concept most people don't know themselves well enough to make the type of decisions it takes to change themselves into what ever they want to be
 
M!$TER-ED said:
sure, what you choose to think and the decisions you make makes the future you truly desire
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It's not that I need psychs to achieve this but rather help me in the process which I'm already in

I don't see the costs of using psilocybin

It promotes neurogenesis and neuroplasticity, why would I not take that?
 
There is always a cost when you use psychedelics, fortunately the reward is greater than the sacrifice. Psychedelics can help cross over the gap between what you think you know and what you can know.
 
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