Hello good people of Bluelight,
I'm happy to see that we have not yet been completely eliminated by President Trump's ICE Wars. I'm gonna skip the jokes and get serious. First, I understand that we have a new population of Kratom users crawling around the site; that's right, the kind of people with relatively little previous history of illicit/recreational drug use. The vacuum that has been created in pain management, that is, the only folks receiving anything stronger than Acetaminophen in this country are those with extremely severe, debilitating conditions, those with cancer and/or hospice patients.
There is no level of relief available for the law-abiding American citizen with a severely fucked lower back who just wants to make it to retirement so his family remains fed. There is no Codeine for those with severe COVID who just want a few hours of sleep each night and a relief from the coughing. Doctors fucked up once, they sold out en-masse, colluded with organized crime (the FDA) to fill their pockets writing ridiculous, unlimited scripts for extremely potent Opioids. They got caught. They again did the wrong thing by denying patients the right to pain relief even in situations that are deserving. Here we are now, Kratom has rushed in to fill the void that Codeine successfully handled for 100 years. The only difference is, Codeine was highly-regulated even in its day. These products are the very definition of dubious in content.
Given that we likely have a lot of "normies" looking in on our graft right now, I feel it is helpful to define some basic terms that many of us already understand quite well. Forgive me for the lack of brevity, this is important stuff.
Definitions
Bioavailability - This is a number, a percentage that tells you, of a given dosage of a medication, how much of that medication will ultimately be absorbed and produce desired effects. If a drug's Bioavailability is 76%, then we know that 76% of that drug will be absorbed and used by the body. A closely-related term we need to know is "Route of Administration".
Route of Administration - This is the way in which a drug enters our body, then blood stream and eventually the brain. These include oral, rectal, pulmonary (smoking, vaporizing), sublingual (under the tongue), buccal (through the membranes of the mouth) and of course injection via vein, muscle, epidural (injected in the dura) and intrathecal (injected directly into the spinal cord), transdermal (absorbed through the skin) and I'm sure, some that I have forgotten.
For our purposes here at Bluelight, the most relevant ROA's are oral, pulmonary, injection etc. Each route of administration will almost always lead to a corresponding difference in BA.
For example, a typical case would be Heroin.
Oral - ~30%
Insufflated/Nasal - 60%
Rectal - ~60%
Injection/Pulmonary - 99%-100%
Kratom - Kratom is a tree native to Southeast Asia, Malaya to be more specific though it is used also in Thailand. It becomes less popular in places like former Indochina where it is often not used in favor of Opium products.
Mitragynine - Mitragynine is the primary active alkaloid of the Kratom plant. Mitragynine is this the chemical substance most responsible for the effects produced by Kratom products.
7-Hydroxymitragynine - This is what is known as an "Analog" of Mitragynine. Think of an Analog as any drug that is chemically based on the same "skeleton" if you will, but with modifications made at crucial points. Thus, 7OH, as it is known colloquially, is an Analog of Mitragynine and also the most well-known.
->7OH is found in non-commercially viable quantities within Kratom and is responsible for a portion of the drug's effects. However, 70H can only be produced synthetically if it is to be commercially usable as a substance. There is nothing natural about 70H products. They are purely a capitalist venture made to take advantage of a highly-vulnerable population. They chose to market 70H solely because there is brand recognition among users. Many users already take Kratom for a "natural" alternative to Opioids and the marketing of 70H intends to capitalize on this.
Mu Opioid Receptor (MOR) - There are 3-4 named Opioid receptors found in the body, mostly in the gut and the brain. The MOR is the Receptor that mediates all of the traditional, well-known and
Dosage Conversion to Morphine Milligram Equivalency (MME)
First, let's talk about Mitragynine itself.
Mitragynine is an atypical Opioid in that it is only a partial agonist of the Mu Opioid Receptor. Think of this as a sort of "halfway" activation. A common drug used both in pain management, but more often in addiction medicine is called Buprenorphine. It is often stated that it is less "recreational" due to its own partial agonist qualities. Kratom has often been touted as less addictive, less potent, less extreme; this lack of extremity also lends itself to a more stable experience with the drug in the long term.
Mitragynine has been shown to substitute for 400% of the same amount of Morphine in mice. This is the best we have to go on right now, though inter-species conversions are rife with difficulty (mice are often the closest). Mitragynine, in other words, could be said to be 25% the potency of the same amount of Morphine. However, bear in mind that Mitragynine is only a partial-agonist. It cannot be substituted without taking this into account.
7-Hydroxymitragynine can be 0.01%-0.04% of the total weight of Kratom leaf. Let's take an average and assume we have 0.02% 70H
Mitagynine is found within Kratom at concentrations ranging from 2%-20%. For our purposes, let's say we have a batch that is right in the middle at 10%
Now, let's say we have a gram of this not so bad, not so good Kratom leaf product.'
10% of 1g = 100mg/.25 (Morphine Conversion) =25mg MME. Remember, this is a partial agonist. In the name of calculating our MME's we will cut this in half and call it 12mg MME
0.2% of 1g = 2mgx10 (Morphine Conversion) = 20mg MME
Using our janky, suppositional math, we have arrived at the sum of 32mg Morphine Milligram Equivalent per gram of Kratom. This can be higher and it can be lower. This is supposed to be our average. 32mg Morphine is enough to make most naive individuals intoxicated. However, I can see someone who uses Kratom for a couple of months easily working their way up to this kind of dosage and higher. We've all seen it.
Kratom has developed something of a better reputation among other Opioids over the years. It is natural, less-dangerous and occupies a vacuum that is totally unaddressed in our healthcare system, that is, the treatment of pain. Doctors were willing to sell you into addiction for money. They're willing also to let legitimate patients suffer needlessly due to their own selfishness; being concerned that they may get in trouble, as opposed to standing up for their patients. Doctors, insurance, pharmacy in this country, they are all positively grotesque caricatrures of what the might once have been. I digress...
70H is either semi-synthetic or more likely, made entirely synthetically. It is sold by manufacturers intending to use what little trust and good feelings the populace has toward Kratom in a scheme to sell highly-potent Opioids to current or future addicts.
In conclusion:
7OH is potentially 13x more potent than Morphine. There is not a lot of information out there regarding routes of administration. I'd be unsurprised if say, the rectal route of administration led to a more potent effect.
We can add to this and discuss it. I just wanted there to be a clearing house for all of this Kratom conversion stuff.
I'm happy to see that we have not yet been completely eliminated by President Trump's ICE Wars. I'm gonna skip the jokes and get serious. First, I understand that we have a new population of Kratom users crawling around the site; that's right, the kind of people with relatively little previous history of illicit/recreational drug use. The vacuum that has been created in pain management, that is, the only folks receiving anything stronger than Acetaminophen in this country are those with extremely severe, debilitating conditions, those with cancer and/or hospice patients.
There is no level of relief available for the law-abiding American citizen with a severely fucked lower back who just wants to make it to retirement so his family remains fed. There is no Codeine for those with severe COVID who just want a few hours of sleep each night and a relief from the coughing. Doctors fucked up once, they sold out en-masse, colluded with organized crime (the FDA) to fill their pockets writing ridiculous, unlimited scripts for extremely potent Opioids. They got caught. They again did the wrong thing by denying patients the right to pain relief even in situations that are deserving. Here we are now, Kratom has rushed in to fill the void that Codeine successfully handled for 100 years. The only difference is, Codeine was highly-regulated even in its day. These products are the very definition of dubious in content.
Given that we likely have a lot of "normies" looking in on our graft right now, I feel it is helpful to define some basic terms that many of us already understand quite well. Forgive me for the lack of brevity, this is important stuff.
Definitions
Bioavailability - This is a number, a percentage that tells you, of a given dosage of a medication, how much of that medication will ultimately be absorbed and produce desired effects. If a drug's Bioavailability is 76%, then we know that 76% of that drug will be absorbed and used by the body. A closely-related term we need to know is "Route of Administration".
Route of Administration - This is the way in which a drug enters our body, then blood stream and eventually the brain. These include oral, rectal, pulmonary (smoking, vaporizing), sublingual (under the tongue), buccal (through the membranes of the mouth) and of course injection via vein, muscle, epidural (injected in the dura) and intrathecal (injected directly into the spinal cord), transdermal (absorbed through the skin) and I'm sure, some that I have forgotten.
For our purposes here at Bluelight, the most relevant ROA's are oral, pulmonary, injection etc. Each route of administration will almost always lead to a corresponding difference in BA.
For example, a typical case would be Heroin.
Oral - ~30%
Insufflated/Nasal - 60%
Rectal - ~60%
Injection/Pulmonary - 99%-100%
Kratom - Kratom is a tree native to Southeast Asia, Malaya to be more specific though it is used also in Thailand. It becomes less popular in places like former Indochina where it is often not used in favor of Opium products.
Mitragynine - Mitragynine is the primary active alkaloid of the Kratom plant. Mitragynine is this the chemical substance most responsible for the effects produced by Kratom products.
7-Hydroxymitragynine - This is what is known as an "Analog" of Mitragynine. Think of an Analog as any drug that is chemically based on the same "skeleton" if you will, but with modifications made at crucial points. Thus, 7OH, as it is known colloquially, is an Analog of Mitragynine and also the most well-known.
->7OH is found in non-commercially viable quantities within Kratom and is responsible for a portion of the drug's effects. However, 70H can only be produced synthetically if it is to be commercially usable as a substance. There is nothing natural about 70H products. They are purely a capitalist venture made to take advantage of a highly-vulnerable population. They chose to market 70H solely because there is brand recognition among users. Many users already take Kratom for a "natural" alternative to Opioids and the marketing of 70H intends to capitalize on this.
Mu Opioid Receptor (MOR) - There are 3-4 named Opioid receptors found in the body, mostly in the gut and the brain. The MOR is the Receptor that mediates all of the traditional, well-known and
Dosage Conversion to Morphine Milligram Equivalency (MME)
First, let's talk about Mitragynine itself.
Mitragynine is an atypical Opioid in that it is only a partial agonist of the Mu Opioid Receptor. Think of this as a sort of "halfway" activation. A common drug used both in pain management, but more often in addiction medicine is called Buprenorphine. It is often stated that it is less "recreational" due to its own partial agonist qualities. Kratom has often been touted as less addictive, less potent, less extreme; this lack of extremity also lends itself to a more stable experience with the drug in the long term.
Mitragynine has been shown to substitute for 400% of the same amount of Morphine in mice. This is the best we have to go on right now, though inter-species conversions are rife with difficulty (mice are often the closest). Mitragynine, in other words, could be said to be 25% the potency of the same amount of Morphine. However, bear in mind that Mitragynine is only a partial-agonist. It cannot be substituted without taking this into account.
7-Hydroxymitragynine can be 0.01%-0.04% of the total weight of Kratom leaf. Let's take an average and assume we have 0.02% 70H
Mitagynine is found within Kratom at concentrations ranging from 2%-20%. For our purposes, let's say we have a batch that is right in the middle at 10%
Now, let's say we have a gram of this not so bad, not so good Kratom leaf product.'
10% of 1g = 100mg/.25 (Morphine Conversion) =25mg MME. Remember, this is a partial agonist. In the name of calculating our MME's we will cut this in half and call it 12mg MME
0.2% of 1g = 2mgx10 (Morphine Conversion) = 20mg MME
Using our janky, suppositional math, we have arrived at the sum of 32mg Morphine Milligram Equivalent per gram of Kratom. This can be higher and it can be lower. This is supposed to be our average. 32mg Morphine is enough to make most naive individuals intoxicated. However, I can see someone who uses Kratom for a couple of months easily working their way up to this kind of dosage and higher. We've all seen it.
Kratom has developed something of a better reputation among other Opioids over the years. It is natural, less-dangerous and occupies a vacuum that is totally unaddressed in our healthcare system, that is, the treatment of pain. Doctors were willing to sell you into addiction for money. They're willing also to let legitimate patients suffer needlessly due to their own selfishness; being concerned that they may get in trouble, as opposed to standing up for their patients. Doctors, insurance, pharmacy in this country, they are all positively grotesque caricatrures of what the might once have been. I digress...
70H is either semi-synthetic or more likely, made entirely synthetically. It is sold by manufacturers intending to use what little trust and good feelings the populace has toward Kratom in a scheme to sell highly-potent Opioids to current or future addicts.
In conclusion:
7OH is potentially 13x more potent than Morphine. There is not a lot of information out there regarding routes of administration. I'd be unsurprised if say, the rectal route of administration led to a more potent effect.
We can add to this and discuss it. I just wanted there to be a clearing house for all of this Kratom conversion stuff.
)
