Allylbenzene
Bluelighter
- Joined
- Jul 25, 2025
- Messages
- 984
This post is for anyone who regularly takes amphetamines (adderall, vyvanse, meth, speed) and wants to make things a bit more sustainable.
It turns out that amphetamines increase an enzyme called Carbonic anhydrase.
So what does Carbonic anhydrase do?
Carbonic anhydrase catalyses a naturally occurring reaction, and simply speeds it up many fold in order to shuttle between the various forms of CO2 (be it CO2 in gaseous form, carbonic acid, or bicarbonate). In short, Carbonic anhydrase promotes the conversion of CO2 into bicarbonate (in tissues) or bicarbonate back into CO2 (in lungs).
CO2 is largely overlooked by modern medicine which calls it a "waste gas" yet it plays several crucial physiological roles which are outlined in the quote at the end of the post. The idea is that any interference with the enzymes that regulate CO2 are likely to have an undesirable disruptive influence, particularly if this interference occurs regularly (eg using an amphetamine-type substance daily).
Since amphetamine induces (increases) the activity of Carbonic anhydrase this will plausibly affect the regulation of CO2. If someone is taking adderall/vyvanse or speed/meth on a daily basis, the effect on CO2 regulation might become problematic. Using a Carbonic anhydrase inhibitor will help to mitigate this effect of amphetamine (which does the opposite: it activates the enzyme).
Examples of common carbonic anhydrase inhibitors: thiamine, aspirin, niacin.
(thiamine = vitamin B1, niacin = vitamin B3)
Here are some reasonably low dose ranges:
• For thiamine, 30-100mg max with a meal.
• For niacin make sure to keep the doses very low, around 50mg, with a meal.
• For aspirin, a very low dose of 10-50mg. If using aspirin over a long period of time it's recommended to combine it with a small amount of vitamin K2.
On CO2's important physiological role. This provides some context on why it's inappropriate to interfere with the enzyme that regulates CO2 - and if this should occur then to at least mitigate it.
It turns out that amphetamines increase an enzyme called Carbonic anhydrase.
So what does Carbonic anhydrase do?
Carbonic anhydrase catalyses a naturally occurring reaction, and simply speeds it up many fold in order to shuttle between the various forms of CO2 (be it CO2 in gaseous form, carbonic acid, or bicarbonate). In short, Carbonic anhydrase promotes the conversion of CO2 into bicarbonate (in tissues) or bicarbonate back into CO2 (in lungs).
CO2 is largely overlooked by modern medicine which calls it a "waste gas" yet it plays several crucial physiological roles which are outlined in the quote at the end of the post. The idea is that any interference with the enzymes that regulate CO2 are likely to have an undesirable disruptive influence, particularly if this interference occurs regularly (eg using an amphetamine-type substance daily).
Since amphetamine induces (increases) the activity of Carbonic anhydrase this will plausibly affect the regulation of CO2. If someone is taking adderall/vyvanse or speed/meth on a daily basis, the effect on CO2 regulation might become problematic. Using a Carbonic anhydrase inhibitor will help to mitigate this effect of amphetamine (which does the opposite: it activates the enzyme).
Examples of common carbonic anhydrase inhibitors: thiamine, aspirin, niacin.
(thiamine = vitamin B1, niacin = vitamin B3)
Here are some reasonably low dose ranges:
• For thiamine, 30-100mg max with a meal.
• For niacin make sure to keep the doses very low, around 50mg, with a meal.
• For aspirin, a very low dose of 10-50mg. If using aspirin over a long period of time it's recommended to combine it with a small amount of vitamin K2.
On CO2's important physiological role. This provides some context on why it's inappropriate to interfere with the enzyme that regulates CO2 - and if this should occur then to at least mitigate it.
Last edited:
shut-eye ! 