Owsley's wife and James Fadiman (inventor of microdosing) don't seem to approve of MDMA

[pupnik]

yes if amphetamine works this could substitute it, but the dose should be lower than 15mg and it should be taken every 3-4 hours orally - max 30 mg day spread out - otherwise it is too rough for every day

 

[4DQSAR]

I loved speed, (amphetamine), MDMA has some of that, but something else too, kinda raunchy like speed, but cleaner too, cleansing even.

For a while we played around with ring-substituted aminorex derivatives. We mostly stuck with labile groups as an even longer DOA wouldn't suit most (hence para fluoroaminorex not being popular) and we found that a para methyl resulted in an compound that was an SRI. But the meta was mostly a DRI. So a 2:1 ratio of the two was like MDMA, but more potent.

We even got to the point of thinking of a name - Empathy.

Then the PSA turned up so we had to stop.

 

[pupnik]

good bunnies!

 

[burn out]

I don't approve of MDMA either.

 

[Skorpio]

Do you think it has potential as an ADD medication?

I think it would be a pretty bad idea. Taking serotonin releasers daily, even at reasonable doses, is going to cause heart valve fibrosis in a good portion of the population taking it (even Shulgin needed new valves).

Personally MDMA makes me both really social and really dumb at like 100 mgs, I’m not sure if lower doses would retain some of that effect (like forgetting what I’m saying and generally mentally feeling scrambled and unable to access ideas).

Finally it’s abuse potential is pretty high, so we’d need to exist in a very different legal paradigm regarding drugs that are fun.

 

[red22]

And how do you feel about classical amphetamines in modest doses? And how comparable are they to MDx in your opinion?

 

[pupnik]

I love them, but I no longer dream about them. or of cocaine.
just glad I never fell in love with opiates.

maybe to access them you need to graduate in a course of delayed gratification and body mind integrity.
black belt in martial arts perhaps.

 

[Pissed_and_messed]

I think it would be a pretty bad idea. Taking serotonin releasers daily, even at reasonable doses, is going to cause heart valve fibrosis in a good portion of the population taking it (even Shulgin needed new valves).

Personally MDMA makes me both really social and really dumb at like 100 mgs, I’m not sure if lower doses would retain some of that effect (like forgetting what I’m saying and generally mentally feeling scrambled and unable to access ideas).

Finally it’s abuse potential is pretty high, so we’d need to exist in a very different legal paradigm regarding drugs that are fun.

People report they start suffering horrible comedowns of microdose regimen that theoretically shouldn't do that if linear increase/decrease of all effects and after-effects related to dose is assumed. It is hypothesized MDMA causes much worse depletion of serotonin if same amount of molly is consumed in several microdoses, say, over a month, instead of in two proper doses with month interval.

 

[red22]

I'm very interested in the idea of using lower doses of MDMA with MAOIs. The idea is that you'll only get the minor negative effects of the lower doses while amplifying the perceived effects to that of the higher doses. Maybe that's just a fanciful idea, i.e., the amplification goes both ways… Another way to put it: the MAOI carries the weight of the MDMA, as opposed to leaving it to your bare brain.

Apparently MDMA is safe with MAOIs as long as the dose is kept low. See these posts of mine for anecdotes and more details. ↓ Also, in the case of harmala MAOIs, one may be protected from the negatives of MDMA because harmalas have a neurogenesis effect—just like their tryptamine cousins.*

Using MDMA as a substitute for DMT in ayahuasca

https://www.bluelight.org/community/threads/how-is-that-even-possible-945930/

https://www.bluelight.org/community...drug-combo-you-ever-did.948196/#post-16296742

https://www.bluelight.org/community/threads/a-second-look-at-maois.729458/post-16303894


*findings from therapeutic research

 

[Skorpio]

And how do you feel about classical amphetamines in modest doses? And how comparable are they to MDx in your opinion?

Classical amphetamine (ie d-amph or mixed salts or amphetamine sulfate) are pretty decent at modest doses.

If I was planning on taking them daily for a super long time I’d probably look into NDRIs like methylphenidate, because VMAT2/TAAR based releasers increase cytoplasmic dopamine, but there is a lot of clinical data showing modest amphetamine consumption is well tolerated.

I'm very interested in the idea of using lower doses of MDMA with MAOIs. The idea is that you'll only get the minor negative effects of the lower doses while amplifying the perceived effects to that of the higher doses. Maybe that's just a fanciful idea, i.e., the amplification goes both ways… Another way to put it: the MAOI carries the weight of the MDMA, as opposed to leaving it to your bare brain.

Apparently MDMA is safe with MAOIs as long as the dose is kept low. See these posts of mine for anecdotes and more details. ↓ Also, in the case of harmala MAOIs, one may be protected from the negatives of MDMA because harmalas have a neurogenesis effect—just like their tryptamine cousins.*

Using MDMA as a substitute for DMT in ayahuasca

https://www.bluelight.org/community/threads/how-is-that-even-possible-945930/

https://www.bluelight.org/community...drug-combo-you-ever-did.948196/#post-16296742

https://www.bluelight.org/community/threads/a-second-look-at-maois.729458/post-16303894


*findings from therapeutic research

I don’t think harmalas driving neurogenesis compensates for MDMA serotonergic toxicity. MDMA causes neurogenesis on its own.

MDMA toxicity occurs through dopamine / alpha methyl dopamine uptake by SERT, where the serotonin neurons can’t handle the cycling between catechol and quinone that dopamine does, generating oxidative elements.

 

[Observer01]

Do you think it has potential as an ADD medication?

No, only because MDMA is not something you can take regularly and get positive effects. I suppose you could argue that you could "learn" something and then implement that might help ADD, but that's debatable.

I would argue however, that psychs like mushrooms could be beneficial for something like OCD, and I believe there are studied cases of people going through heroic sessions of psilocybin and having it virtually cure that their OCD.

 

[4DQSAR]

The strange case of the man who took 40,000 ecstasy pills in nine years

· Usage increased to 25 tablets a day at peak· Memory problems and paranoia may be lasting

www.theguardian.com

Be aware, some pills in the UK reached quite ridiculously low doses of MDMA. I used to know people who were around the Dutch MDMA distribution scene and they would make 'export' pills with far, far less active that those intended to be used in The Netherlands.

 

[red22]

Quote ↓

Hi, Daniel. I have extensive experience, knowledge and insight.

First, fast and ready rules that are cut and dried are not to be credited, such as what you've been led to believe with Starseeds.

Secondly, no substance you name, but one, gets you anywhere beyond the astral level, which is 4D and is just a mess of intelligences and influences that are adept at tricking you into thinking you're getting something of psychological or "spiritual" benefit. You're already WAY beyond 4D, so unless you just want to have some fun on them, they're not going to do anything for you like you think. Ibogaine, by the way, is an exception, because of the power of its intrapersonal insights.

MDMA was synthesized through a man by a demon. That man didn't know it. It's designed from the ground up to keep people from reaching anywhere at all, but because it has such wonderful touchy-feely stuff going on with it, and since humans are such slaves to sensation, it makes them believe they're getting something from it. I once utterly tornado'd a home in the mountains where people went there, paid $300 for a weekend, used it, and then came away thinking they'd gotten something. My presence destroyed it, the couple got divorced, and sold the cabin.

Now, for the big one. 5 MEO DMT is absolutely sacred. You produce it every night. Babies at birth have 1000 times as much of it in their blood as adults, and people at their death also have 1000 times as much as a healthy adult. It's the current through the Door of Brahma. If you go into a cave that is absolutely black and stay there for weeks, after about the 9th to 11th days, you'll begin producing it prodigiously. At that point, you don't even need eyes, as second-awareness is fully active. It does blast through the chakras, but we have tools here that will do that. If it's pure 5 MEO, you won't' go on any sort of trip. If you have the right person to administer and "sit" with you, and you both properly prepare, it can show you Creation's Core, but you won't behold that as you. You are gone. You will have no concept of self, and you won't see anything at all. You have to be gone, since you are incapable of apprehending what that is from the "couch" of a 3D body.

Now, having said that, it doesn't lift you and leave you there. It's short, pedestrian, wonderful, orgasmic, the connection to Earth, as an example, afterward is astounding, but if you're looking for permanent results and insights and being raised to another level of being, not one plant ally or its processed version will get you there. And by you, I mean YOU. People of lower order frequencies, such as Earthlings native to this experiment, could use them to get where YOU are.

Alchemy, made by an Alchemist, will, however, get you where you need to go, and by that I mean, not necessarily where you THINK you need to go. In the Cosmic order of things, very few people have even an inkling of what they need to see to the treading of their highest and least cluttered path.

J.D. Aliix (Jason Davis), 2021-07-29, https://blueemerald-social.com/forum/topics/the-effects-of-psychadelics


Background info:

Blue Emerald Alchemy is a company based in the Salt Lake City area of Utah. Orbiting around our "sphere" are many people: researchers, superhealers, superseers, technology and health product pioneers, and entrepreneurs located variously in the US, with feedback and support from people all over the world.

We have developed and implemented some big and fun and impactful things over the years, which culminates in this, the latest incarnation of The Blue Emerald and everything that will bloom from it. The possibilities are endless and we'll be expanding in many directions soon enough.

In addition to the Blue Emerald Alchemy company and website property, we have:

Merlin Power Stones - Powerful talismanic instruments to clear your highest path and set you firmly on it.

Imagi - an online manifestation engine that's very powerful, and which can program anything - including you - with your intents.

We're wide open to team up for anything, any project, any product, what have you. We get found by some very able people.


Blue Emerald Alchemy
PO Box 40743 611
Grand Junction, CO 81504
801.874.6243 - Mary Cell
marybetts at blueemeraldalchemy dawt com


How We Got Started

The first incarnation of this effort was Zeropoint Technologies in 1999, which I (Jason Davis) built from the ground up and later sold it to a friend. I had no intention at the time to start another company like that but the infinite mind had other plans for me and Blue Emerald Alchemy was born at the end of 2008.


The products and services we offer

Spiritual Development
Health & Wellness

Source: https://www.alignable.com/fruitvale-co/blue-emerald-alchemy

 

[red22]

I'm very interested in the idea of using lower doses of MDMA with MAOIs. The idea is that you'll only get the minor negative effects of the lower doses while amplifying the perceived effects to that of the higher doses. Maybe that's just a fanciful idea, i.e., the amplification goes both ways… Another way to put it: the MAOI carries the weight of the MDMA, as opposed to leaving it to your bare brain.

Apparently MDMA is safe with MAOIs as long as the dose is kept low. See these posts of mine for anecdotes and more details. ↓ Also, in the case of harmala MAOIs, one may be protected from the negatives of MDMA because harmalas have a neurogenesis effect—just like their tryptamine cousins.*

Using MDMA as a substitute for DMT in ayahuasca

https://www.bluelight.org/community/threads/how-is-that-even-possible-945930/

https://www.bluelight.org/community...drug-combo-you-ever-did.948196/#post-16296742

https://www.bluelight.org/community/threads/a-second-look-at-maois.729458/post-16303894


*findings from therapeutic research

Psychedelics Today uploaded this video this morning, which featured a comment I made on one of their IG posts. They just took the video down and blocked me.

6.32 MB file on MEGA

mega.nz

My comment:

I would never take MDMA again without harmalas. Seems to be a rather dangerous and superficial substance without something "spiritual" to give it a base and some substance. Murple was a fan of the aforementioned combo.

⇨ Using MDMA as a substitute for DMT in ayahuasca [Bluelight]

"I think that more and more people will increasingly understand that a vine heavy brew, with relatively small amounts of DMT, is about the best preventive medicine a human being can ever take."

Julian Palmer. Articulations: On the Utilisation and Meanings of Psychedelics. 2014. Chapter 4. Ayahuasca / The Religion of Ayahuasca

 

[red22]

The title of this article argues against what Fadiman said:

MDA, MDMA, and other “mescaline-like” substances in the US military's search for a truth drug (1940s to 1960s)

 

[Innerpeace]

The title of this article argues against what Fadiman said:

MDA, MDMA, and other “mescaline-like” substances in the US military's search for a truth drug (1940s to 1960s)

That link doesn't work

 

[Themailman]

MAPS, that works on what it calls “the careful uses of psychedelics and marijuana”, claims that marijuana and MDMA are psychedelics in the same way any other mind-altering substance or activity is. “Dreams are psychedelic, meditation can be psychedelic. Non-drug techniques like Holotropic Breathwork, hyperventilation, ecstatic dancing — all sorts of things are psychedelics,” says Rick Doblin, the MAPS founder, in a video clip.

Fadiman does not agree. He insists that MDMA is not a psychedelic. “It is not even a borderline psychedelic,” he says, “[but] is often confused or classed with psychedelics because most of the work done with it, therapeutically, is done by MAPS that also works with psychedelics.”

"In pursuit of altered states of consciousness". Momina Manzoor Khan and Manal Khan. The Herald. Originally published as "Mind over matter" in December, 2018.


With LSD, you take microdoses, not even one milligram. I don’t think people get that you need to only take so little LSD to get a psychedelic effect. It’s tiny, and therefore it doesn’t have a negative effect like MDMA and ketamine. It doesn’t raise the blood pressure like MDMA and doesn’t cause cardiac arrhythmias. MDMA is not a psychedelic, it’s an amphetamine. The “A” in MDMA stands for “amphetamine.”

Rhoney Gissen Stanley. The Secret History of the LSD Trade. Annie Oak Harrison. 2023-04-15. Lucid News.


MDMA is certainly damaging after 25 years of empirical research: a reply and refutation of Doblin et al. (2014). Parrott, A. Human Psychopharmacology: Clinical and Experimental, 29(2), 109–119. DOI: 10.1002/hup.2390

Fadiman.... Claiming you "invented" microdlsing is incredibly dubious... thats like saying you invented the number 0.1.... microdosing itself is dubious and borderline pseudoscience anyways.

And he says MDMA is "not psychedelic at all"? Has he ever done drugs before or does he just read books?

I dont like this guy and I would either call him an ego driven moron and/or punch him in the face if I ever met him.