"Isotonitazene" IV Trip Report

[secretMotel]

Isotonitazene Review
Intro to "Isoto"nitazene​

I had an idea but wasn't entirely sure what to expect since most descriptions I'd read of nitazenes were vague: most zenes have a strong rush, then some are sedating while others are weirdly stimulating for an opioid. Duration varies from ~1hr-1day+. As for isoto specifically, it's reportedly one of the shortest-acting yet most euphoric zenes.

The potency of zenes is hard to estimate, but isoto is often compared to fentanyl, which puts it at ~100×Morphine. But at first I operated under the assumption it's 500ᴍᴍᴇ since it was likely an analogue, and the strongest is ~300-500ᴍᴍᴇ. After titrating up my dose, I found 100ᴍᴍᴇ to be more accurate, but I think it's a little stronger. Though I hate to contribute to opiophobic propaganda, I'd never handled an ultra-potent chemical weapon "research chemical" like this before, and idk the cops might be kinda right about the dangers of ambient fentanyl molecules.

So, needless to say, volumetric dosing is required. Annoyingly, zenes tend to be poorly water soluble, so the solution was cloudy even when filtered. It was a bitch to IV until I learned the addition of benzyl alcohol dissolves it. Using the powder would've been more fun. I think it was mainly due to a cut, not the chemical itself, but it looked and smelled exactly like powdered sugar. Honestly thought I got ripped off, but there was only one way to find out… and well, it turns out powdered sugar is a hell of a drug.

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Trip Report​

The rush is obscenely long, consisting of an opioid-like⑴ and a stimulant-like⑵ phase:

1. The initial onset is near instantaneous, but it creeps up very slowly at first. It's just gentle warmth, accompanied by a sweet taste in the back of my throat, which might be the most enjoyable thing about it tbh. Oddly it's the chemical taste of artificial sweetener, not powdered sugar.
2. Then out of nowhere, it hits like a truck—not in a good way, it's a bait and switch—escalating from warm to HOT!! like, dripping sweat, I feel like an oven. Vision gets much darker/hazier than with other opioids. Plus INTENSE nausea for exactly 1nanosecond. Then waves of dizziness that gradually subside after a few minutes. At higher doses, it feels like you'll pass out rather than fall into an opioid-induced sleep.

There isn't much of a high afterwards, just mild physical relaxation and mental stimulation that linger for 1-2hr. Nowhere near nodding and/or tweaking, it feels more subtle and balanced. The combined effect is speedy yet mellow, reminding me of low-dose kratom or the energy boost from buprenorphine, though it's distinct from either of them.

Discussion​

The closest comparison I can make is to a knock-off speedball that only has intensity, no euphoria... except for the euphoric sugar rush you get from the taste, lol. Ignoring the fact that everything happens in reverse order, fent + coke could almost replicate this, if you add just enough coke that you'll feel like shit but not quite enough to enjoy it. Or better yet, replace the coke... with nicotine, roflmao. Alternatively, I think hydromorphone must be similar since both have a very short-lived high after a rush so strong it's almost overwhelming.

It goes without saying that I binged it like the off-brand, opposite day speedball it is. So in a few years when the "nitazene epidemic" is in full swing, just remember: I did it before it was cool. Isoto is comparatively easy on you both physically and mentally, which is a good thing but also isn't. Zene tolerance/dependence supposedly is disproportionately brutal relative to potency, which says a lot as most are even stronger than fent. So just because you can, doesn't mean you should.

Isoto is definitely one of the more fiendish drugs I've encountered. Somehow the raw intensity keeps you chasing despite how overwhelming and unpleasant it is. Devoid of any real euphoria, I was driven to keep redosing not so much by compulsion as by boredom: I did it because it was something to do, then do again, and again, and... This problem lasted only as long as my supply did. Since there are so many better drugs that fill the same niche, it was valuable only for its novelty. Not to mention, I don't wanna find out about the withdrawal.

Verdict​

Given the unexpected absence of euphoria induced by what is supposed to be one of the most euphoric drugs of its kind, I will concede that one possible explanation for my underwhelming experience is that perhaps I was unlucky enough to be sold some particularly dogshit analogue. But all "iso"s are similar afaik, so I think more likely it's just a dogshit drug, and by extension a dogshit class.

Blows fent out of the water, but still trash compared to H. Sinfully bingeable, but the fun begins and ends there. It seems safe to assume the long-acting zenes are similarly disappointing, as a bupe/fent-like high is lackluster no matter the duration. Zenes give so little yet have the potential to take so much. Good thing I'm only stupid enough to get addicted once or twice.

Overall, isoto hardly felt anything like an opioid. Compared to the typical experience, everything about this wannabe speedball is fucked all the way up, inside out and upside down, ass backwards and topsy-turvy, just so wrong on so many levels. I think this must be Dr Frankenstein's drug of choice because it's a miserable mismatched monster, an amalgam of only the worst qualities of opioids and stimulants.

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Footnotes​

Isotonitazene is in quotes in the heading because I'm pretty sure isoto proper doesn't exist anymore, but it made no difference to me since the iso- analogues are supposed to be close enough. And even if not, I just wanted to try any zene, I didn't really care which.

 

[Deleted member 507397]

Is it possible to smoke or snort it

 

[notsmokeymcpot42088]

Damn I admire your fortitude -- I have been waiting for an IV nitazene trip report for awhile.

After the description I tend to lean towards what is being distributed (Grey powder) on the streets has A LOT of nitazene effects -- the profuse sweating the odd lack of euphoria for an opi.

I chalked it up to fent/xylazine (Which still a reasonable theory) -- But this feels to track better. ( I doubt there is any H in that H tbh, maybe some fent if lucky ).

Good thing it is not packed away for euphoria as much as "Worst case scenario"

Speaking of insanely long rushes I have good indicator that Dimethocaine IV is like a 2-3 minute (Coke-esque) rush. Longest rush would be an interesting thread topic haha

 

[4DQSAR]

It's worth knowing that the prototype of the class, etonitazene, was produced illegally in Russia during the 90s with the nickname китайский карлик (Chinese dwarf) and in the end they figured out that mixing it with tobacco and smoking was the only safe(ish) way to consume it. I mean, Russians are fairly gung ho when it comes to drugs but in this case even they worked out how dangerous it is.

My hypothesis is that Ciba abandoned development because it's effects were unreliable between people. I don't know that, I just know that they published papers on the syntheses and a couple on animal models and stopped.

BTW I think one reason they are now being produced in China is that in the late 1970s someone published a telescoped synthesis. Someone also published a telescoped synthesis of carfentanil which is why I think that specific highly potent homologe is the one that has turned up.

We know SO LITTLE about the effects of this class of compound so trip reports will, I'm certain, turn up as evidence in some future paper. I'm glad to read it but that possibility of unreliable pharmokinetics might mean the stated potencies taken from animal models don't hold true for humans.

Stay safe.

 

[Tronica]

Hey @secretMotel

Just wondered whether you knew what flavour of isotonitazene it was, e.g. N-desethyl isotonitazene - there's just been a paper published a few days ago about this flavour found in Portugal.

 

[notsmokeymcpot42088]

It's worth knowing that the prototype of the class, etonitazene, was produced illegally in Russia during the 90s with the nickname китайский карлик (Chinese dwarf) and in the end they figured out that mixing it with tobacco and smoking was the only safe(ish) way to consume it. I mean, Russians are fairly gung ho when it comes to drugs but in this case even they worked out how dangerous it is.

My hypothesis is that Ciba abandoned development because it's effects were unreliable between people. I don't know that, I just know that they published papers on the syntheses and a couple on animal models and stopped.

BTW I think one reason they are now being produced in China is that in the late 1970s someone published a telescoped synthesis. Someone also published a telescoped synthesis of carfentanil which is why I think that specific highly potent homologe is the one that has turned up.

We know SO LITTLE about the effects of this class of compound so trip reports will, I'm certain, turn up as evidence in some future paper. I'm glad to read it but that possibility of unreliable pharmokinetics might mean the stated potencies taken from animal models don't hold true for humans.

Stay safe.

Why was mixing it with tobacco the only safe(ish) way? (Sorry if I missed something in there that explained it!) -- I mean it doesn't matter I'm never gunna run across the stuff -- just wondering theoretically

 

[4DQSAR]

Why was mixing it with tobacco the only safe(ish) way? (Sorry if I missed something in there that explained it!) -- I mean it doesn't matter I'm never gunna run across the stuff -- just wondering theoretically

In Russsia, like most Eastern European nations, you can buy little machines that make what look like normal ready made cigarettes (UN nickname is 'tailor maide') but it means the width is uniform. So people would just smoke whatever they considered 'enought' and stop.

Obvioualy it began with people IVing the stuff but the death rate was just astounding. People would use a given dose one time and be fine and the OD next time. That was from the SAME etonitazene each time. One assumes they would have at least tried just putting less and less into the barrels but who knows? Maybe sometimes it wouldn't be 'enough'. So they settled on the cigarettes as a solution.

I only know this much because a German (?) BLer years ago explained it to me. They had been working in Russia around the time. I gave you the Russian nickname because an internet search will yeild more information. I'm the first to admit that this is woeful in terms of evidence but right now, all of those novel nitazenes are being trialled in the people who take them. I doubt the makers in China have performed animal models.

That's why I ended by saying 'stay safe'.

 

[notsmokeymcpot42088]

oh I have no interest in actually touching such substance -- just musing theoretically.

Sounds like truly scary and horrible stuff --- the same dose not doing the same thing (Before tolerance introduction) would be maddening to an IV'er I imagine -- not enough in the barrel no rush and you prolly can't get another for x hours or w/e.

A category to avoid but makes for interesting read -- and it does seem like the dope is likely contaminated with it.

 

[secretMotel]

Hey @secretMotel

Just wondered whether you knew what flavour of isotonitazene it was, e.g. N-desethyl isotonitazene - there's just been a paper published a few days ago about this flavour found in Portugal.

I have no idea, sorry. I wish I would've sent a sample off for lab testing, but since I didn't, I have no way of knowing 100% for sure what it was. I honestly can't even be completely certain that it actually was a nitazene at all, I just have to assume based on what it was advertised as. But as I confessed in the footnote, I strongly suspect it was falsely advertised. That being said, I asked some nitazene users for opinions on what this substance might have been, and a few people responded that subjectively, the effects and duration matched pretty closely with NDI. So maybe that's which analogue it was, but it's anyone's guess, really.

I plan to probably try isotonitazepyne relatively soon, so if and when I do so, I'll be able to compare to isopyne at least. I'm definitely going to send a sample of the isopyne off for lab testing if I can, so that way I'll know for sure what it is that I'm trying next. I'll write a detailed experience report on it and post it in a new thread when the time comes. The lack of descriptive user reports on these substances has been one of the most irritating things for me while I've been trying to research nitazenes. So I want to try as many as possible and contribute my findings, but unfortunately I think I'm a little too late; nitazenes are already becoming much harder to acquire as the law is cracking down and banning them all. Oh well, it's too bad. This particular class of opioids is so interesting to me.

 

[Tronica]

I have no idea, sorry. I wish I would've sent a sample off for lab testing, but since I didn't, I have no way of knowing 100% for sure what it was. I honestly can't even be completely certain that it actually was a nitazene at all, I just have to assume based on what it was advertised as. But as I confessed in the footnote, I strongly suspect it was falsely advertised. That being said, I asked some nitazene users for opinions on what this substance might have been, and a few people responded that subjectively, the effects and duration matched pretty closely with NDI. So maybe that's which analogue it was, but it's anyone's guess, really.

I plan to probably try isotonitazepyne relatively soon, so if and when I do so, I'll be able to compare to isopyne at least. I'm definitely going to send a sample of the isopyne off for lab testing if I can, so that way I'll know for sure what it is that I'm trying next. I'll write a detailed experience report on it and post it in a new thread when the time comes. The lack of descriptive user reports on these substances has been one of the most irritating things for me while I've been trying to research nitazenes. So I want to try as many as possible and contribute my findings, but unfortunately I think I'm a little too late; nitazenes are already becoming much harder to acquire as the law is cracking down and banning them all. Oh well, it's too bad. This particular class of opioids is so interesting to me.

Yes I think once China cracked down, everything changed. But as usual, there will be other subclasses that will become more popular to take its place.