Has anyone with schizophrenia/schizoaffective disorder tried to get high while taking cobenfy?

beyondabove

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Hey has anyone tried to get high on drugs while taking the antipsychotic Cobenfy? I am looking to see what sort of experience people had when taking cobenfy because antipsychotics usually block out most drugs. But the thing about cobenfy is that it works on different receptors than all other antipsychotics so I am thinking you may actually be able to feel some euphoria on drugs again. Please reply if you have tried.
 
Had to look up Cobenfy..how long have taken Cobenfy? I take Vraylar so I'm curious about your experience taking Cobenfy especially if you are able to hallucinate from psychedelics. If you are up to it I am interested in your findings.
 
Had to look up Cobenfy..how long have taken Cobenfy? I take Vraylar so I'm curious about your experience taking Cobenfy especially if you are able to hallucinate from psychedelics. If you are up to it I am interested in your findings.
I just got prescribed cobenfy. I probably won't try psychedelics to find out if I can trip. Im pretty sure I won't be able to. My doctor said weed might work better than the AP I was taking. Im curious if stimulants will work better in terms of euphoria since cobenfy doesnt work directly on the dopamine receptors.
 
Hey has anyone tried to get high on drugs while taking the antipsychotic Cobenfy?
This medication... is fascinating to me. I had no idea about this.

This is a treatment for schizophrenia???

This is a highly unusual drug. It is entirely atypical of all other antipsychotics which act on serotonin and dopamine receptors. This is a combo of a muscarinic and antimuscarinic drug?? I had no idea those receptors were implied for schizoid conditions... very unusual...

but to answer your question, yes you should be able to get high with no issues on all drugs while taking this antipsychotic. It only works on muscarine receptors, it's not going to block any drug from working.

However, it may have some unpleasant side effects in combination with a lot of drugs, so take caution, but it should not stop any specific drug from working... except maybe certain antihistamine drugs, heh.

With all that said, please take care, because people with schizoid type conditions should really not be getting high on stimulants or psychedelics.
 
This drug... is fascinating to me. I had no idea about this.

This is a treatment for schizphrenia???

This is a highly unusual drug. It's a combo of a muscarinic and antimuscarinic drug??

Sorry I'm just really interested in this, very unusual...

but to answer your question, you should be able to get high with no issues on all drugs while taking this antipsychotic. It only works on muscarine receptors, it's not going to block any drug from working.

However, it may have some unpleasant side effects in combination with a lot of drugs, so take caution, but it should not stop any specific drug from working... except maybe certain antihistamine drugs, heh.

With all that said, please take care, because people with schizoid type conditions should really not be getting high on stimulants or psychedelics.
I have schizoaffective depression disorder, I disagree with your assessment that people with schizophrenia should not be getting high on stimulants and psychedelics. What are your sources to back this assumption?
There are no studies or research claims that psychedelics and/or stimulants are harmful to people diagnosed with schizophrenia. Hell might as well include the entire human race that psychedelics are harmful. They tried this during prohibition.
This is war on drugs propaganda.
 
I have schizoaffective depression disorder, I disagree with your assessment that people with schizophrenia should not be getting high on stimulants and psychedelics. What are your sources to back this assumption?
My own experience, experience with friends of mine, common sense, as well as various reports/studies that are easily googleable.

Please don't take offense, I'm not speaking down, I'm speaking as a peer.

It is generally not a good idea for people with those conditions to take stimulants or psychedelics.
 
My own experience, experience with friends of mine, common sense, as well as various reports/studies that are easily googleable.

Please don't take offense, I'm not speaking down, I'm speaking as a peer.
Do you mind explaining how psychedelics affected you negatively? Was it long term or temporary? Did you benefit from the experience?
 
Do you mind explaining how psychedelics affected you negatively? Was it long term or temporary? Did you benefit from the experience?
I’m trying to show that psychedelics are beneficial even to people with a history of psychosis. Psychedelic treatments are prohibited to people with schizophrenia and or history of psychosis. I disagree with this because there is no data or research on this. It is wrongfully assumed that psychedelics causes schizophrenia type symptoms.
 
I’m trying to show that psychedelics are beneficial even to people with a history of psychosis. Psychedelic treatments are prohibited to people with schizophrenia and or history of psychosis. I disagree with this because there is no data or research on this. It is wrongfully assumed that psychedelics causes schizophrenia type symptoms.

I dont have schizophrenia but i have had psychosis and shrooms didnt give me any symptoms similar to psychosis. However schizophrenia is more complicated then just psychosis. If your going to trip you want a benzo on hand just in case things go bad

Cobenfy is fascinating and as someone who has had psychosis as well as dramamine induced delirium i can say that a muscarinic makes sense to treat psychosis as dramamine delirium is very similar if not identical to psychosis
 
Do you mind explaining how psychedelics affected you negatively?
I can only speak as someone who has experienced drug induced schizophrenia, and stimmy/psychy drugs made my experience worse. I've written a lot about it on this website a few years ago, it's a long story I don't feel like recounting right now.

I am just saying, from my experience, it's generally not a good idea. That's my experience, that's my opinion.
 
Cobenfy is fascinating and as someone who has had psychosis as well as dramamine induced delirium i can say that a muscarinic makes sense to treat psychosis as dramamine delirium is very similar if not identical to psychosis
it's definitely a fascinating pathway, and it does make sense to treat delusions in some way, but it's super interesting how there is both an agonist and antagonist... I imagine the antagonist is the main drug and the agonistic muscarinic drug might act in a superfluous manner such as bupe/naloxone preparations.

I need to read more about this drug... inherently interesting working on muscarinic receptors for psychosis
 
it's definitely a fascinating pathway, and it does make sense to treat delusions in some way, but it's super interesting how there is both an agonist and antagonist... I imagine the antagonist is the main drug and the agonistic muscarinic drug might act in a superfluous manner such as bupe/naloxone preparations.

I need to read more about this drug... inherently interesting working on muscarinic receptors for psychosis

From my understanding its method of action comes from acting as a muscarinic agonist. The antagonist part is just to mediate side effects i think
 
From my understanding its method of action comes from acting as a muscarinic agonist. The antagonist part is just to mediate side effects i think
That makes sense.

Also makes sense that muscarinic agonism could lead to decreased delusion.

Maybe it has no effect on hallucinations, it just pushes the brain to recognize them as error and mediate accordingly.

I am very curious how this drug fits into the dopamine and serotonin psychosis hyphothesis
 
That makes sense.

Also makes sense that muscarinic agonism could lead to decreased delusion.

Maybe it has no effect on hallucinations, it just pushes the brain to recognize them as error and mediate accordingly.

I am very curious how this drug fits into the dopamine and serotonin psychosis hyphothesis

I think the serotonin hypothesis is junk. No psychedelic ive taken is anything like psychosis. However dramamine was near identical to psychosis from what i can remember
 
I think the serotonin hypothesis is junk. No psychedelic ive taken is anything like psychosis. However dramamine was near identical to psychosis from what i can remember
No drug I've ever taken was anything like psychosis, there are only drugs that have interacted with or produced my psychosis and/or made it worse.

I agree in that high doses over DPH has been the only experience I've had that mimicked the confusion and delirium of real psychosis.

I want to know how an antagonist might reduce someone's psychosis. Seems logical but the brain is never that simple...
 
I’m going to ask my provider if she will prescribe Cobenfy and compare that with Vraylar (currently taking)
 
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