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MDMA + mescaline

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doubledog

Bluelighter
Joined
Aug 22, 2024
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Hi guys, I am new here and would like to find some info about combination of MDMA with mescaline.
I have some experience with both of them separately and currently I am considering to take them together. My idea is that MDMA could make first hours more intense and interesting, then mescaline could provide more serious and natural psychedelic content/mindspace and also make comedown from molly smoother, without significantly changing it.
I would probably take 50mg of MDMA and 150 mg of mescaline.

I was not able to find any report or comment about this combo, so my conclusion is that it is probably not worth it.
Anybody with experience or any comment?
 
Both of them are pretty rough on your sert receptors. If you do just don't add other serotonergic drugs.
 
doubledog said:
Hi guys, I am new here and would like to find some info about combination of MDMA with mescaline.
I have some experience with both of them separately and currently I am considering to take them together. My idea is that MDMA could make first hours more intense and interesting, then mescaline could provide more serious and natural psychedelic content/mindspace and also make comedown from molly smoother, without significantly changing it.
I would probably take 50mg of MDMA and 150 mg of mescaline.

I was not able to find any report or comment about this combo, so my conclusion is that it is probably not worth it.
Anybody with experience or any comment?
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Welcome to Bluelight.

50mg of MDMA will not be enough to produce a typical MDMA experience.
It will surely change how the Mescaline feels but I never tried such a low dose so would not be able to say specifically how.

I will just say to be careful with dosage as the MDMA + Hallucinogen combo can be beautiful but also overwhelming.

So while 50mg MDMA might be too low, don't take a large dose either.
 
I've taken Mescaline in combination with 2C-B, MDMA, MDA, LSD, DMT, Ketamine, usually separately of course :D

When I combined it with other phenethylamines/amphetamines, I almost always took the other compound in low dose and the mesc at typical dose (330mg HCL) But... I never really had any glowing experiences with combining the mescaline with either phenethylamines, amphetamines, or tryptamines. The mescaline was usually the dominant part of the experience, and the enactogens never really did more than just kinda alter the mescaline trip for a bit. I did enjoy the mescaline and MDA experience, but I think I would rather just have one or the other. Once I ate a lot of peyote and smoked DMT several times on the plataeu and my visions went from geometric and smooth, to very chaotic, fast moving, colorful, and somewhat unfriendly. I never tried for a full breakthrough, but I never found the need to.

The mescaline LSD combo however was extremely rich in every sense, visually, mentally, emotionally/spiritually. It was a glowing trip and well balanced in everyway. I find mescaline alone can be quite dreamy, and the LSD kept it sharper/lucid.

I would repeat that, and I don't take LSD frequently at all. That gave me true hallucinations where I saw and communicated with someone who wasn't real*.

If you do end up taking that combo, we'd love to hear a report.
If I only have a little bit of mescaline, I'd be asking similar questions.

In general I am going to say mescaline is best on it's own or with a lysergamide.
 
Never mixed mescaline with MDMA, but I've mixed allylescaline with MDMA, MDA and 6-APB on separate occasions. It's really neat, there's a calmer feeling when the allylescaline is in the mix, and it feels like the already somewhat empathogenic nature of allylescaline amplifies dramatically. I think I was ~80-100mg of MDA, ~125 with MDMA and the 6-APB I think didn't exceed 65mg when I tried them. I can find the exact doses if I dug through my notes for a while, those are just trying to remember off the dome. People tend to refer to mescaline with MDMA as "loveflipping", and as far as my empathogen + allylescaline experiences, I definitely get why the name exists.
 
Thanks guys for the answers.
My goal is to find sweet spot in dosing where both substances cooperate without either one being dominant, that's the reason for half doses (my normal dose of MDMA is 80-100mg, for mescaline 250-300mg). I may start with even lower amounts.
It seems that no serious risk of some unwanted interaction is involved, so I will give it a try. Will report back.

I read a lot that combo with lysergamide is great, but I am not a big fan of LSD (it's emotionally cold and distant for me, my last time was 25 years ago) and also have no easy access to it. But I can easily imagine that for people, who like LSD, it is really enjoyable.
 
doubledog said:
Thanks guys for the answers.
My goal is to find sweet spot in dosing where both substances cooperate without either one being dominant, that's the reason for half doses (my normal dose of MDMA is 80-100mg, for mescaline 250-300mg). I may start with even lower amounts.
It seems that no serious risk of some unwanted interaction is involved, so I will give it a try. Will report back.

I read a lot that combo with lysergamide is great, but I am not a big fan of LSD (it's emotionally cold and distant for me, my last time was 25 years ago) and also have no easy access to it. But I can easily imagine that for people, who like LSD, it is really enjoyable.
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btw welcome to bluelight! All 1st hand experiences are very much appreciated and welcome. We'd love to hear the outcome of your trials. Travel well!
 
Hi, I am back with the report.

I tried this combination few days ago, but in a different way that I originally planned. It was 130 mg mescaline and after 2 hours when it kicked in, added 100mg of MDMA. I thought that mescaline will take some time to start working, but I took it dissolved in some beer and it started quicker than expected.

It was quite good, I liked it, both effect merged smoothly, no complications, even at that low dose mescaline added some psychedelic depth and mood to MDMA, negative aspect was that it also somehow diminished molly's euphoric effects.

The best outcome was that mescaline provided some kind of "protection" against next days bad mood, mescaline afterglow dominated over any MDMA after effects. Here I have to say that I have never had strong bad after effects from molly, just very slight melancholy sometimes.

In general, I was surprised that mescaline felt stronger and molly felt weaker in that doses, but will definitely repeat it some day, but will stick to original plan and take it at the same time.
 
I don't remember the dosages, but I mixed MDMA with Mescaline once and I spent the whole trip wishing that I had taken one or the other. I think the MDMA dose was maybe just a bit short of what I typically am looking for in a roll. I'm sure that at the right doses that the experience can be great, but I feel like there are better psychedelics for MDMA combos. 2CB, 4 subbed tryptamines, LSD, etc. Mescaline is just fine on it's own. I haven't tried it yet but I imagine that allylescaline would be great with MDMA/MDA/5-APB/6-APB
 
Agree, this combo is nothing super special or worth to experience, I just wanted to try it and was curious. There are definitely better combinations out there.
 
If you do this, use the MDMA as a primer, then four hours into MDMA once it’s mostly gone, take Mescaline. This is how more rewarding 2cb experience tend to be when combined with MDMA.

Much of the reports of stacking end up being negative.

Thanks for your trip report! As others seem to mention, stacking is not rewarding.
 
Leprechaun said:
If you do this, use the MDMA as a primer, then four hours into MDMA once it’s mostly gone, take Mescaline. This is how more rewarding 2cb experience tend to be when combined with MDMA.

Much of the reports of stacking end up being negative.

Thanks for your trip report! As others seem to mention, stacking is not rewarding.
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Would agree aside from mescalines long duration. I was surprised but taling 2c-b post MDMA was definitely the best way to combine the two. Stacked em once alligning the peaks and while i had a good/great experience, i could feel extra strain on my cardiovascular system so ive yet to repeat
 
Didgital said:
Would agree aside from mescalines long duration. I was surprised but taling 2c-b post MDMA was definitely the best way to combine the two. Stacked em once alligning the peaks and while i had a good/great experience, i could feel extra strain on my cardiovascular system so ive yet to repeat
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Yes, MDMA and 2C-B stacked don't meet each other. Did MDA -> LSD @ 1:30h and would absolutely want to do it later around say @3:30h or even @4h. Same with MDMA -> LSD.

The other way around is also possible LSD -> MDMA and LSD -> MDA at the tail end. However, I would expect this would take away quite a bit from the light and easy LSD afterglow.

LSD for me feels great the next day after some sleep, little residue and good spirits.

If I miss the nights sleep, the next day and following week will have irritability due to lack of sleep, then compensating sleep which puts the weeks schedule off.

So I prefer to do this on a Saturday afternoon or morning.

With me running around 10k every Saturday morning, I can mix low doses with the run.
 
Leprechaun said:
LSD for me feels great the next day after some sleep, little residue and good spirits.

If I miss the nights sleep, the next day and following week will have irritability due to lack of sleep, then compensating sleep which puts the weeks schedule off.
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Would agree that missing the sleep is main cause of LSD "hangover" more than the drug itself.

I would say the same applies to many long lasting psychedelics.

2c-e while main trip is 8bhrs long, im generally not sleeping until 16 hrs (i really enjoybthe afterglow), but then i usually dont aleep for 48 hrs and then require a full 24 hrs to feel normal.
 
The combo of these two substances could be very pleasant,but all is about the dose,the current condition of Ur spirit,set and setting and so on.got experience from 100mg mdma plus a kilo of fresh San Pedro-highly stimulated feeling,without visuals...got some nausea,lacrimation......strong...no joke
 
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Combining MDMA and mescaline can be intense; it's wise to start with low doses and allow plenty of time between them. Everyone reacts differently, so listening to your body and staying hydrated can help. Have a safe experience.
 
I have hippy flipped and/or candyflipped and I would imagine a medium lsd or a hefty shroom dose being a great combo BUT I have yet to try mescaline..Hopefully soon.

I noticed timing and of course dose is very important so you actually get the benefit of both, instead of let's sayy LSD outweighing whatever shroom dose you may had coupled with.

I realized I CAN NOT take a roll after or toward the end of my lsd trip, I mean I can but the chemical euphoria(so to speak) makes it complete shit and actually ruins my current LSD euphoria. That said - if I take a modest roll and THEN dose lsd about 2-3 hrs later - fucking magical.

Anyhow, I am just giving my personal experience about timing and drugs outweighing the other if not taken at the perfect time.

I can see rolling on mdma while waiting for mescaline to kick in to work great but possibly not given mescaline's strong empathogenic properties already?
 
Opana313 said:
I realized I CAN NOT take a roll after or toward the end of my lsd trip, I mean I can but the chemical euphoria(so to speak) makes it complete shit and actually ruins my current LSD euphoria. That said - if I take a modest roll and THEN dose lsd about 2-3 hrs later - fucking magical.

Anyhow, I am just giving my personal experience about timing and drugs outweighing the other if not taken at the perfect time.
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Hopefully not too off-topic but just responding to this as the common 'wisdom' when combining mdma and lsd is to take the mdma when the lsd peak begins to diminish (so maybe 5 hours ish after dropping the acid), so the opposite of what works for you

The thinking behind this is (amongst other notions) the fact that dropping the acid while the mdma is fading may well not be the ideal (mind) set for dropping (your joy is fading), and also because lsd lasts significantly longer.

The only time I've ever done the combo was the opposite to that advice, and more like your preferred timeline. Took (excellent) mdma at a big outside party, had a great time, dropped some lsd (perhaps 5 hours after the mdma) and proceeded to have a dysphoric, nasty-ass few hours, ugh. My only really unpleasant lsd experience in fact, out of maybe 30-ish trips over the years. The party was also in a real paradidse, right out in the hills, awesome vibes maybe around 1k people in a beautiful location by waterfalls etc, and the lsd was genuine.
 
ageingpartyfiend said:
Hopefully not too off-topic but just responding to this as the common 'wisdom' when combining mdma and lsd is to take the mdma when the lsd peak begins to diminish (so maybe 5 hours ish after dropping the acid), so the opposite of what works for you

The thinking behind this is (amongst other notions) the fact that dropping the acid while the mdma is fading may well not be the ideal (mind) set for dropping (your joy is fading), and also because lsd lasts significantly longer.

The only time I've ever done the combo was the opposite to that advice, and more like your preferred timeline. Took (excellent) mdma at a big outside party, had a great time, dropped some lsd (perhaps 5 hours after the mdma) and proceeded to have a dysphoric, nasty-ass few hours, ugh. My only really unpleasant lsd experience in fact, out of maybe 30-ish trips over the years. The party was also in a real paradidse, right out in the hills, awesome vibes maybe around 1k people in a beautiful location by waterfalls etc, and the lsd was genuine.
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I must say that my experience is that you are spot on with the L at peak then add Mdma. It brings you right back up and adds a soft psychedelic effect to the trip, which then goes another 4 or 5 hours. Very nice. Especially if you're having a trip where, when you start to come down, you're like, oh no, it going away, I don't want it to end. Before you get there the mdma brings you back up so sweetly and lets you down gently, grateful for the whole experience... Ime...
 
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