RCs Gamma-Decalactone / 4-Hexyl-Gamma-Butyrolactone

[Allylbenzene]

I've known people smoke the herb from which valporate was isolated and they noted a slight sedation, likely because of the rapid transport of valporic acid to the brain.

Btw valporate (2-propylvaleric acid) is a derivative of valeric acid (pentadoic acid) from Valerian; it also contains valerenic acid (a sesquiterpene), isovaleric acid and isovaleramide which are all reported to be GABA-A PAMs.

 

[4DQSAR]

Well, it was the herbal form so who knows what actives are in there. But it stinks (smelly socks), it tastes awful and it make you cough, I only got it because Kokopelli was going to throw it into a bin and each staff member was offered as much as they wanted, gratis.

The effects were marginal.

Isovaleramide reminds me of a 1950-1960s era sedative/hypnotic Alpronal, Bromisoval, Carpatral and similar open-ring barbiturite-like drugs (ureides). That first one has an allylic side-chain, the others ethyl side chains, Anyone who had built a training-set of barbiturates will appreciate the fact that the -Br increases potency but less well understood is swapping from an ethyl to an allyl. Genetally they are more potent, have a shorder duration of action BUT have a larger TI. The larger TI being the important thing.

For YEARS I have wanted to resolve glutethimide (as the two enantiomers have different activities and form different (and in one case a more potent than parent) metabolites. That done, comparing the 4 different isomers would actually provide a huge amount of valuable data. Glutethimide (Dordien) was infamous in the US when someone discovered that the (raecemic) glutethimide was a potent CYP2D6 inducer - a VERY rare and powerful activity. How did they discover it? Well, it means the human body converts almost 100% of any codeine in the body into morphine (normally it's only about 10%). So the infamous 'Fours and Dors' cocktail im which users took 'loads' which depending on where you read, was two x 500mg glutethimide (Doriden) and anywhere from two to four Tylenol #4 (60mg codeine phosphate in each)... but I SUSPECT someone just discovered it by accident. Mixing to classes of CNS depressent isn't a wise move.

I never got the chance to try it but it's more than likely that only one of the two glutethimide enantiomers is responsible for enzyme induction (so chiral synthesis could make just that one isomer) and the (uncontrolled anywhere but the UK) allyl homologues of the above compounds MAY enable us to find a compound that if consumed in isolation, has no psychoacitive effects on their own BUT if consumed because a person takes a codeine-containing product.... would produce a morphine-like activity.

Now THAT would be neat as even the infamous PSA would not cover a compound that isn't psychoactive when taken alone...

But the dose makes the poison so if 10mg of the highly bioavailable codeine phosphate were combined with an inducer, it could provide all the benefits of morphine without most of the side-effects.

 

[Allylbenzene]

But it stinks (smelly socks), it tastes awful and it make you cough

Yup, isovaleric acid:

Cheese, dairy, acidic, sour, pungent, fruity, stinky, ripe fatty and fruity notes

...and valeric acid:

Acidic and sharp, cheese-like, sour milky, tobacco, with fruity nuances

Ironically I've read that Valerian root essential oil inhibits then induces CYP2D6. The oil is pretty cheap.

Myrrh? Fairly inexpensive...

In ancient times, myrrh has been used as analgesics, which is possibly due to bioactive constituents present in them acting as pain relievers (El Ashry et al. 2003).
Two sesquiterpenoid compounds, furanocudesma-1, 3-diene, and curzerene present have been reported to be acting on the receptors opioid in the central nervous system, bringing about anesthetic activity.

In 1983, Carl Heinz Brieskorn* and Pia Noble at the University of Würzburg (Germany) identified furanoeudesma-1,3-diene and two other aroma compounds in the essential oil of myrrh. Thirteen years later, Jose R. Pedro and co-workers at the University of Valencia (Burjassot, Spain) described the stereoselective synthesis of furanoeudesma-1,3-diene from the drug santonin. The synthetic product was identical to furanoeudesma-1,3-diene obtained from C. myrrha.

Also in 1996, Piero Dolara and colleagues at the University of Florence (Italy) reported that furanoeudesma-1,3-diene and other myrrh components exhibited analgesic effects in laboratory mice.
They showed that the compound binds to opioid receptors in brain membranes and that the analgesic effect was completely reversed by administering naloxone.

Furanoeudesma-1,3-diene - American Chemical Society

Myrrh is a resin that occurs in some species of trees in the genus Commiphora that grow in Asia, Africa, and South America.

www.acs.org

Frankincense...

4.1. Chemical Constituents of the Combination​

The chemical composition of the combination formed by frankincense and myrrh is different from the chemical composition of the two single-flavor drugs, but it is not a simple addition of the chemical components of the two drugs. The complex physical and chemical changes before and after the combination of frankincense and myrrh make the proportion and content of each component in the compound change to a certain extent.
While some original components may be lost, other new components may be produced.
...
The pharmacological properties of the combination are mostly synergistic, including synergistic anti-inflammatory activity, synergistic anticancer, synergistic analgesic, synergistic antibacterial, and synergistic blood-activating effects.

Seeing the Unseen of the Combination of Two Natural Resins, Frankincense and Myrrh: Changes in Chemical Constituents and Pharmacological Activities - PMC

For the treatment of diseases, especially chronic diseases, traditional natural drugs have more effective therapeutic advantages because of their multi-target and multi-channel characteristics. Among many traditional natural medicines, resins ...

pmc.ncbi.nlm.nih.gov

 

[emkee_reinvented]

Spreek gewoon Rotterdams, het loont de moeite om de idiomen van die stad te begrijpen.

Maar dan snapt 90 % niets van wat ik schrijf.

Jij bent een uitzondering die ene die de regel bevestigt.
En ik had een 5 of 6 voor Nederlands, Engels een 8.
[eind-exames]

 

[emkee_reinvented]

Dat is een duister pad om te kiezen!

I never painted shit Purple honestly, i used a Spray-can.
Lazy, and hygienic. And efficient !

 

[emkee_reinvented]

Btw valporate (2-propylvaleric acid) is a derivative of valeric acid (pentadoic acid) from Valerian; it also contains valerenic acid (a sesquiterpene), isovaleric acid and isovaleramide which are all reported to be GABA-A PAMs.

Post a scientific link, and convince me. I don t believe it.
Your link don t link them, VPA/ Valarian and Valerenic Acid

Imo the only resemblance is the name. Valproic Acid was a medium used as.
To put a possible medicine in, a solvent, a.o. a lucky coincidence discovery.

And VPA a GABA-a, not ime.

 

[emkee_reinvented]

Dat is een duister pad om te kiezen!

Welk pad ? Die nauwe die leidt naar Zion ?

 

[emkee_reinvented]

@emkee_reinvented - my bad.

I mentioned that I had obtained some valarian root in Amsterdam and a couple of (desparate) friends tried smoking it. Their reports were sort of 'well, it does SOMETHING' but neither could realy say what. But neither asked for more and in the end I just threw it away. I might add that my cat LOVED it.

My Cat too, and still don t get it. As i know Cat s get high true their olfactory s.
Smelling Catnip, which smell s way better imo, the cat get s a 15 minute:

OPiOID high along Hallucination s, about what, was my next thought.
on Catnip !

 

[emkee_reinvented]

Btw valporate (2-propylvaleric acid) is a derivative of valeric acid (pentadoic acid) from Valerian; it also contains valerenic acid (a sesquiterpene), isovaleric acid and isovaleramide which are all reported to be GABA-A PAMs.

So Valproate doesn t, like the most supllement don t contain [enough] Valerenic Acid.
But that does indecate they are related, i didn t know that.

I assumed it was the name only, Valproic -Valerian -Valepotriaten.
So that was wrong they are related, Valproic a derivative of.
Learned something, Allylbenzene.