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Miscellaneous Most anxiolytic psychedelic drugs

LucidSDreamr

LucidSDreamr

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5HT receptors agonists are stimulating mostly and not relaxing feelings .

MDxx in the most sedating psychedelic drug. And not due to its psychedelic properties.

What’s that one mdxx analogue that only releases serotonin and zero dopamine? Maybe this. Is this compound a 5HT agonist?

Is there any actual 5HT agonist like drug that is anxiolytic at all?
 
MDAI is the only one I can think of, though it was better combined with something that releases dopamine. The two samples I had were brown and looked like dirt, and I always questioned purity though the source was reliable. I almost fell asleep the first time I tried it without combining it with something stimulating.
 
I'm not sure I'd go so far as to call it anxiolytic, but 2C-C ticks the box of being pretty much a straight 5HT agonist (rather than a reuptake inhibitor / releaser) while being fairly calming.
 
If we’re including 2Cs as well, I recall 2CT4 being weirdly sedating. It was a long time ago so my recollection is dim, but I’m hoping I can find another sample some day to refresh my memory.
 
LucidSDreamr said:
Salvia? You’ve gotta be kidding me. scariest drug there is
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Nah it's one of the most relaxing psychedelics I've ever touched in my life. Smoked some yesterday alongside some MDMB-4en-PINACA and melted right into my chair like I was on ketamine and a few dabs. Forgot to mention smoked Amanitas, which feel like chilled out Ambien in many ways.
 
LucidSDreamr said:
5HT receptors agonists are stimulating mostly and not relaxing feelings .

MDxx in the most sedating psychedelic drug. And not due to its psychedelic properties.

What’s that one mdxx analogue that only releases serotonin and zero dopamine? Maybe this. Is this compound a 5HT agonist?

Is there any actual 5HT agonist like drug that is anxiolytic at all?
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Bk-MDMA was even more sedating then MDMA, wow i thought.
Tiil experiencing 6-APB, where i actually only moved to pee or get a drink.
MDAI as @General alcazar wrote, is ime a sedative.

100 mg, had me flat for hours. Just a moan here and there.
Didn t hate nor like it. The dose felt overwhelming high.
Like 6-APB also felt as to much, 100 mg both ordinary dosages att.
That was what i thought, MDAI in low dose could be a Anxiolytic.

Anyone who tried a low dose could say more, that 100 was so strong.
i was so shocked after my experience can t remember taking it after.
 
LucidSDreamr said:
Yea but are you talking threshold doses?

Not +++ or ++++?

I don’t melt into anything it get ripped open and r dragged up universal stairs through chaotic Armageddon shit
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I've used it from straight leaf up to 180x extract. When using high doses of extract, that feeling of dissolving into the universe is on par with the peace I get from 15+ tabs of acid, nbomes and monstrous doses of pharmahuasca. I'm not sure that I've ever experienced anxiety, or catastrophized before in my life, may be why I act this way.
 
I rarely get anxiety or panic attacks. But I have taken low dose LSD once or twice and that worked well.
 
Esperighanto said:
I've used it from straight leaf up to 180x extract. When using high doses of extract, that feeling of dissolving into the universe is on par with the peace I get from 15+ tabs of acid, nbomes and monstrous doses of pharmahuasca. I'm not sure that I've ever experienced anxiety, or catastrophized before in my life, may be why I act this way.
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Nbome are probably the least anxiogenic psychedelics I’ve ever tried. That’s a good answer. Feeling sober with just powerful visuals is nice.

All the other ones have some sense of stress to them even though I did tons of them and have always been fascinated with their effects so I was willing to do them all.

Dissociatives are anxiolytic at times but I don’t count them as psychedelics like this sub forum does
 
LucidSDreamr said:
Dissociatives are anxiolytic at times but I don’t count them as psychedelics like this sub forum does
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Yeah, I think that this sub is moreso the "hallucinogen" sub since we also hold onto deliriants, salvinorin, and imo it'd be the best place to talk about synthetic cannabinoids too since they're blatantly psychedelic (or deliriant) for most people. Cannabis having its own is nice, but those aren't people who drink a large amount of Banisteriopsis caapi tea and smoke 1.5-2.5g of dabs like I was frequently doing for a while, as that's a blatantly psychedelic experience that would send your average stoner right into a straightjacket. Imo dissos can be hit or miss for anxiolysis, I was watching Scooby Doo & The Witch's Ghost with this guy once and the ketamine became ketamean, he asked to turn it off because it was too scary then spent about 3 days barely able to move or speak.
LucidSDreamr said:
Nbome are probably the least anxiogenic psychedelics I’ve ever tried. That’s a good answer. Feeling sober with just powerful visuals is nice.
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For me psychedelics are about the headspace and the visuals are kind of the accompany that, like how a light show accompanying a band can be nice but it's not the main course, if that makes sense. My fiance always tells me that if a drug is widely or universally disliked, I'll probably enjoy it, hahaha.
 
Esperighanto said:
For me psychedelics are about the headspace and the visuals are kind of the accompany that, like how a light show accompanying a band can be nice but it's not the main course, if that makes sense. My fiance always tells me that if a drug is widely or universally disliked, I'll probably enjoy it, hahaha.
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Yea the headspace is definitely something but with classical psychs I just preferred the ones that made music sound amazing and the lights pretty.

For really reality shattering experiences I preferred the dissociative headspace (let’s say an MXE hole) vs say a strong DMT trip.
 
LucidSDreamr said:
For really reality shattering experiences I preferred the dissociative headspace (let’s say an MXE hole) vs say a strong DMT trip.
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That's definitely understandable, I prefer the whole fact of still being able to get up and walk and think straight, I'm a big fan of taking monstrous doses of acid, DOM, etc. and just walking around the city back when I lived in one. The more sedative something is too, the less I enjoy it, I fucking despise ketamine and DCK compared to 3-MeO-PCP or 2-FXE/2F-DCK because of that. I'm just naturally in a super low energy, depressed state all the time, so being able to escape that is very meaningful for me.
 
LSD is kinda anxiolytic for me, once you pass the 2nd or 3rd peak. Probably just the dopamine.
 
Any 5-HT1a agonist could have anxiolytic effects much like serenic medications like buspirone. Unlike buspirone, it may be that they display those serenic qualities acutely instead of requiring weeks for demonstrated clinical relevance. I learned at Psychedelic Sciences 2025 last week that several novel psychedelics are being explored clinically for just this reason, so I guess we'll find out if that's true soon enough.

5-MeO substituted tryptamines tend to be more selective for 1a than 2a according to Lankri's research at Columbia. 5-MeO-DMT/MET are a little more selective for 1a while 5-MeO-PiPT is much more selective for 1a. Maybe that's why I get a "warm dissociative comfort" from it. Who can say?
 
Every psych I’ve tried has had some rather anxiety inducing moments. I’m of the opinion that throwing booze/benzos/opioids in with any trip is the key to finding a more somatic experience that I enjoy. Mushrooms and Psilacetin after the come-up is over tend to feel very relaxing especially in conjunction with benzos and opioids.

I guess I just prefer to dose higher with my psychs and force the anxiety away with downers. I’m a naturally anxious person though and the older I get the less interested I am in the most intense of psychedelic effects.
 
Pfafffed said:
Any 5-HT1a agonist could have anxiolytic effects much like serenic medications like buspirone. Unlike buspirone, it may be that they display those serenic qualities acutely instead of requiring weeks for demonstrated clinical relevance. I learned at Psychedelic Sciences 2025 last week that several novel psychedelics are being explored clinically for just this reason, so I guess we'll find out if that's true soon enough.
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Interesting to hear that novel psychedelics are perhaps being explored clinically. I'd certainly like to know more about that. Has anything been published yet? Or was it just shared at the conference?

I will add that to the extent that 5-HT2B activation enhances natural serotonin release, it's likely that such activation may also have anxiolytic consequences that counter (to some extent) the effects of 5-HT2A activation. At the same time, many if not most psychedelics have affinity at adrenergic receptors (particularly alpha adrenergic) as well, where they should induce either stimulate or inhibit adrenergic activity.

When I experimented with salvia, I never experienced any anxiety. I've had a variety of doses and a variety of "tiers" of experience. A first tier experience is just kind of stoning. A second tier experience is like taking a lung-full N2O, except a lot more "twisted". Basically, dimensionality begins to break down and one witnesses the deformation of reality including oneself. A third tier experience is rather like dreaming vividly. By comparison, serotonergic psychedelics can definitely make me feel anxious, but some are a lot worse than others. I sometimes have to "work through the experience" to avoid getting stuck in a bad anxious place.
 
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