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Most pleasurable & euphoric Benzodiazepine ?

krkkhed said:
replying to a sort of old post here...but i am wondering how you would describe IV midazolam and lorazepam if you could? How do they compare? also how do they compare to IVing other downers like opioids for example.
Is there a nod?? Also I swear I read somewhere about Midazolam causing hallucinations in some people or in high doses or when IVd, kinda like zolpidem or zopiclone. Have you experienced that? Ill have to look into it myself..
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The nod? Thing you couldn't control in the beginning and now we chasing it lol.

The lorazepam iv was in hospital after a car accident and while in recovery shit went side ways. Calmed down instantly and weird feeling, very blissful. Depending on dose you gonna sleep especially if you already on another cocktail of meds.

And iv midazolam made id say more euphoric but also had me in a trance like state. This was for a toe op under local anesthetic

As for comparing it to the rush or high from downers like H. Not close.

Also to note both times I had these two benzos iv'd I also already had opioids in my system.
 
Coffeeshroom said:
The nod? Thing you couldn't control in the beginning and now we chasing it lol.

The lorazepam iv was in hospital after a car accident and while in recovery shit went side ways. Calmed down instantly and weird feeling, very blissful. Depending on dose you gonna sleep especially if you already on another cocktail of meds.

And iv midazolam made id say more euphoric but also had me in a trance like state. This was for a toe op under local anesthetic

As for comparing it to the rush or high from downers like H. Not close.

Also to note both times I had these two benzos iv'd I also already had opioids in my system.
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interesting, thanks for the insight :)
 
^Was prescribed temaz for awhile and that is my #1 non RC benzo probably. Pharmacy literally accused my of forging the script and it was a big thing (my doctor was pissed at the pharm, I just requested somethin more common). But it was a compromise
 
notsmokeymcpot42088 said:
^Was prescribed temaz for awhile and that is my #1 non RC benzo probably. Pharmacy literally accused my of forging the script and it was a big thing (my doctor was pissed at the pharm, I just requested somethin more common). But it was a compromise
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I agree, I love temazepam.
My new doctor (old one closed his office so sent me to him) decided to take me off temazepam and re-evaluate....annoying but I will most likely get it back
 
Personally I experienced the most euphoria from triazolam. I was getting a root canal done and told the endodontist that I had a pretty bad dental phobia, thinking he would offer nitrous gas. For whatever reason his office didn't have nitrous but he said he would give me some "Halcion" - my ears perked right up, as I had always wanted to try it but never could find any. I only got two 0.5mg tablets but it was pretty much super nice. A few years later I ran into someone who was in the hospital and got discharged with a script for #90 0.25mg triazolam *score* and he gave me about 6 or 8
 
Brotizolam was the nicest benzo I've tried yet.
Pretty much the only benzo I got real euphoria from apart from Clonazolam.

I also really liked the short duration. Felt normal the next day.
 
#1 Clonazpam/Klonopin' .. quote similar to Valium but longer lasting, I don't get sleepy or "high" - just nicely chilled out and I can think clear AF and focus on stuff like an old mofo. I'm always hyped up so k- pins slow down this merry go round of life I'm stuck on. #2 Diazapam/Valium nice like Clonaz' but hits a little harder and makes me tired. I like these for sleeping or couching it. I don't care for any of the rest. The worst ? Xanax. Hits me like hammer, lasts about an hour then a uncomfortable weird crash and game over. I hate the shit but it seems popular. I take my low dose k pins with low dose oxy and it's my perfect mix with 1 or 2 beers. My last doc pulled me off clonaz', the bitch, and it took me almost a year to find another doc who was cool with scripting benzos and opioids together. BTW, I'm 67 and take them for pain relief (ice hockey player for years) but also enjoy how it increases my quality of life. Any REAL DOCTURD' WITH HALF A BRAIN CAN READ MY CHARTS AND LOOK AT MY CTs, MRI, XRAYS, etc and easily see my body has been beaten up pretty bad. All those injuries in your youth come back to get you. And BTW, I was playing ice hockey at 5 years old, into college, not good enough to catch any scouts eyes, but played in Men's Leagues until I was 65. The Men's League were pretty much 20 to 45 years old "kids." I still played aggressive and still threw the gloves off when it was needed. I finally had to hang up the skates and it sucks not being able to play. My mind says go, but body says no.
 
Side note, I have no clue to the new ones or all the other benzos available from RC, etc. I'm in the USA.
 
marcoman said:
#1 Clonazpam/Klonopin' .. quote similar to Valium but longer lasting, I don't get sleepy or "high" - just nicely chilled out and I can think clear AF and focus on stuff like an old mofo. I'm always hyped up so k- pins slow down this merry go round of life I'm stuck on. #2 Diazapam/Valium nice like Clonaz' but hits a little harder and makes me tired. I like these for sleeping or couching it. I don't care for any of the rest. The worst ? Xanax. Hits me like hammer, lasts about an hour then a uncomfortable weird crash and game over. I hate the shit but it seems popular. I take my low dose k pins with low dose oxy and it's my perfect mix with 1 or 2 beers. My last doc pulled me off clonaz', the bitch, and it took me almost a year to find another doc who was cool with scripting benzos and opioids together. BTW, I'm 67 and take them for pain relief (ice hockey player for years) but also enjoy how it increases my quality of life. Any REAL DOCTURD' WITH HALF A BRAIN CAN READ MY CHARTS AND LOOK AT MY CTs, MRI, XRAYS, etc and easily see my body has been beaten up pretty bad. All those injuries in your youth come back to get you. And BTW, I was playing ice hockey at 5 years old, into college, not good enough to catch any scouts eyes, but played in Men's Leagues until I was 65. The Men's League were pretty much 20 to 45 years old "kids." I still played aggressive and still threw the gloves off when it was needed. I finally had to hang up the skates and it sucks not being able to play. My mind says go, but body says no.
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Hockey's big where I'm from in Maine, most people who play it just smoke weed and drink though, they all find opioids and benzos to be too performance affecting. I could always play hockey on benzos but opioids, no way.

Edit: For context I'm 26, and am talking about having played pickup games of ice hockey.
 
While I appreciate it unlikely that anyone will get to sample it, we found pynazolam to be the most euphoric. The reaon being that it is a 'frustrated α1 ligand i.e. it buns to the α3,α5 & and α5 subunits so it has reasonably potent anxiolytic activity, it's also a serotonin releaser. A potent serotonin releaser.

ALL nitrobenzodiazepines are serotonin releasers although one or two (such as clonazepam), it's serotonin releasing action isn't encounterd at theraputic doses. We noted that nimetazepam is the most favoured benzodiazepine in nations where it is available. People would consume nimetazepam before socializing - not typical for a benzodiazepine.

We asked ourselves the simple question, to whit 'Why were all the early benzodiazepine hypnotiic nitrobenzodiazepines?' and so we decided to design a 'frustrated α1 ligand' i.e. it would LOVE to fit into the α1 subunit but the pendent aromatic being a pyridyl ring, it cannot. So we noted that it had notable seratanogenic activity (hence sociability of nimetazepam) overlaid with the usual action produced by the α3 and α4 subunits i.e. anxiolytic but not hypnotic.

THAT is why nitrobenzodiazepines were noted for their hypnotic activity. Both their α1 affinity AND their SRI activity combine to induce sleep.

None of us had ever tasted methaqualone but a few older memers of the cohort did make direct comparisons with methaqualone. You just want to sit down and enjoy the experience. Higher dises intesify the seratonegenic activity and the anxiolytic activity but we were still minded to remember than nitrobenzodiazepines are more toxic in overdose than other benzodiazepines. Later we discovered that pynazolam is essentially exreted unchanged. Hydroxylayion of the 2 methyl being the only metabolite and that was only found in small quantities. It being the metabolites of nitrobenzodiazepines that are toxic - still, discression is the better part of valour.

So 5mg was nice, 10mg was great but we didn't go any further. We had sufficient to either go higher or to test chronic use i.e. on consecutive evenings. Only after about a week did we note any reduction in the intensity of the effects so knowing tolerance is the 'yellow warning' that dependence would soon follow, we stopped.

Only eight people tasted pyrazolam, pyeyzolam AND pynazolam and what was of most interest to me was when asked which of the three was preferred, without a moment's thought, they all agreed that pynazolam was the best.

Luckily there are now a number of two step reactions that replace an aryl halide (the -Br of pyrazolam) with an aryl nitro moiety. I believe at bench scale pynazolam was synthesized from pyrazoam via the boronic acid route. Nott practical to scale and of course you need a ready supply of pyrazolam to hand. Luckily, that was not an issue for us.

So 5-10mg reliably produced extremely social evenings followed by restful sleep and no hangover.

But that's the thing isn't it? Nobody is going to offer an RC where 10mg is a dose when crazy stuff like flunitrazolam are far more potent and far simpler to produce. In the case of flunitrazolam, norflunitrazepam --> northionitrazepam --> flunitrazolam. Easy.
 
4DQSAR said:
While I appreciate it unlikely that anyone will get to sample it, we found pynazolam to be the most euphoric. The reaon being that it is a 'frustrated α1 ligand i.e. it buns to the α3,α5 & and α5 subunits so it has reasonably potent anxiolytic activity, it's also a serotonin releaser. A potent serotonin releaser.

ALL nitrobenzodiazepines are serotonin releasers although one or two (such as clonazepam), it's serotonin releasing action isn't encounterd at theraputic doses. We noted that nimetazepam is the most favoured benzodiazepine in nations where it is available. People would consume nimetazepam before socializing - not typical for a benzodiazepine.

We asked ourselves the simple question, to whit 'Why were all the early benzodiazepine hypnotiic nitrobenzodiazepines?' and so we decided to design a 'frustrated α1 ligand' i.e. it would LOVE to fit into the α1 subunit but the pendent aromatic being a pyridyl ring, it cannot. So we noted that it had notable seratanogenic activity (hence sociability of nimetazepam) overlaid with the usual action produced by the α3 and α4 subunits i.e. anxiolytic but not hypnotic.

THAT is why nitrobenzodiazepines were noted for their hypnotic activity. Both their α1 affinity AND their SRI activity combine to induce sleep.

None of us had ever tasted methaqualone but a few older memers of the cohort did make direct comparisons with methaqualone. You just want to sit down and enjoy the experience. Higher dises intesify the seratonegenic activity and the anxiolytic activity but we were still minded to remember than nitrobenzodiazepines are more toxic in overdose than other benzodiazepines. Later we discovered that pynazolam is essentially exreted unchanged. Hydroxylayion of the 2 methyl being the only metabolite and that was only found in small quantities. It being the metabolites of nitrobenzodiazepines that are toxic - still, discression is the better part of valour.

So 5mg was nice, 10mg was great but we didn't go any further. We had sufficient to either go higher or to test chronic use i.e. on consecutive evenings. Only after about a week did we note any reduction in the intensity of the effects so knowing tolerance is the 'yellow warning' that dependence would soon follow, we stopped.

Only eight people tasted pyrazolam, pyeyzolam AND pynazolam and what was of most interest to me was when asked which of the three was preferred, without a moment's thought, they all agreed that pynazolam was the best.

Luckily there are now a number of two step reactions that replace an aryl halide (the -Br of pyrazolam) with an aryl nitro moiety. I believe at bench scale pynazolam was synthesized from pyrazoam via the boronic acid route. Nott practical to scale and of course you need a ready supply of pyrazolam to hand. Luckily, that was not an issue for us.

So 5-10mg reliably produced extremely social evenings followed by restful sleep and no hangover.

But that's the thing isn't it? Nobody is going to offer an RC where 10mg is a dose when crazy stuff like flunitrazolam are far more potent and far simpler to produce. In the case of flunitrazolam, norflunitrazepam --> northionitrazepam --> flunitrazolam. Easy.
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This is fascinating to hear, while analyses of the SAR are always welcome at BL, we do ask that synthesis is kept off of publicly viewable avenues for the sake of legal reasons. I think this is fine here, but if it were to go deeper, it may be a little far (trust me, I wish it did, I have a million questions pertaining to this synthesis).

What RoAs were preferred for these compounds?
 
We just had 5mg tablets made.

BTW when I said 'Easy', that's irony - it's not at all easy given the OTHER precursors which I did not list. It's just that the product is an order of magnitude more potent AND you can just read the patents and academic papers to find the details of the synthesis. We didn't publish ANYTHING and thusfar (a decade later) nobody has been able to produce them. There is 1 detail which took us ages to work out... but we figured that not sharing would protect our work.
 
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4DQSAR said:
We just had 5mg tablets made.

BTW when I said 'Easy', that's irony - it's not at all easy given the OTHER precursors which I did not list.
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Interesting, I wonder how vaporization would've treated these. Etizolam oral/sublingual is a totally different beast when compared to nasal sprays or vaporization in my experience. I bet the same may extrapolate out to other substances such as pynazolam.
 
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