Dissociatives DXM (1st plateau) as a mood stabiizer

[dopamimetic]

I feel that a threshold dosage of DXM (120mg in my teens @ 60kg, now 180mg @ 80kg) stabilizes me more than anything else, I've tried various prescriptions and mood stabilizers like lamotrigine, sodium valproate, pregabalin and of course SSRIs, moclobemide, antipsychotics and a bunch of other pills even morphine in high doses. They aren't even close, most do nothing just side effects but every time I binge on low dose DXM I am stable as fuck, positive, energized, wanting to do things and stuff. Time passes easier and stuff feels way more interesting, I need to invest less mental energy to begin things etc. There is next to no dissociation at this dosage. I tried to convince myself that it was just addiction speaking, me wanting to repeat the experiences but I really honestly think there is something special to DXM. I've tried most drug classes and while many were interesting and fun so had none the same feeling of therapeutic potential that DXM comes with. Methoxetamine would be next but that one is long gone and I don't have access to the new arylcyclohexylamine dissos.

Anybody else feeling something similar?

I had a bottle of BupropiDex over the last week and definitely want to use daily again. I know this isn't safer use but I am desperate and it fucking works. Just that my gf with whom I live together doesn't want me to do drugs and wouldn't approve me taking supratherapeutic dosages of a cough suppressant when I'm not sick, sigh, I needa talk with her but don't know how to start.

 

[Esperighanto]

I'm ~100kg (220 lbs) and threshold DXM for me is somewhere between 25 and 40mg, the fact that it's so high for you is fascinating. Think it may be tolerance related? And are you taking it all at once, or broken up over the day? Have you considered trying to mimic Auvelity with bupropion and DXM, perhaps? Also I'm sure your girlfriend will be understanding if you talk to her about these things.

 

[SuperPsych]

I also get great benefit for NMDA antagonists which lead me to dose nearly every day when I have them available. I don't know if I'd call it mood stabilization, at least in my case. They do reliably leave me feeling more optimistic, improve my ADHD symptoms and ability to focus, plan and act out tasks. They ease my everlasting feeling of anhedonia and enable me to enjoy old hobbies again and they cause me to become fascinated with different concepts, so I find myself going down long research rabbit holes because my brain feel malleable and thirsty for information.

I have always thought that there was something very special about DXM. I haven't done it in years except for one experience about 2 years ago that was very intense because I mixed it with huge doses of O-PCE and was also in a bad place mentally. I did it a ton as a teenager though, and to this day DXM has led to some of the most profound mystical experiences of my life. I suspect that the sigma receptor may play a role in the feeling of mysticism. I will probably attempt another DXM experience within the next year or so. DXM + Tobacco and followed by Cannabis is quite possibly the most euphoric combination that I have ever experienced. The euphoria doesn't feel forced and chemically induced like cathinones, amphetamines/MDMA. It feels almost natural. Like the euphoria isnt caused by a flood of neurotransmitters but rather due to the mind and body tapping into some cosmic well of knowledge and emotion.

As a kid and leading into my teenage years I had a profound fear of death. My mother got diagnosed with cancer when I was young and she fought it until I was 17 when she finally passed. As a Elementary school kid I had insomnia because I would be tossing and turning all night, scared for my mother. I knew that she was dying and I didn't want her consciousness to just go to blackness or enter some kind of empty purgatory. When I was 16 I had a DXM experience that was a really high dose. I think it was 700-800mg thru the course of the night. At one point I went to the bathroom then went back to my bed room and after a while I heard what sounded like water dripping. I went back to the bathroom to see and the sink had flooded and the water was pouring over the counter and onto the floor. I cleaned it in a hurry before any of my family saw me and had questions that I'd be unable to answer in that state. My sister had a hair straightener with some exposed wiring that was covered hastily with electrical tape. It had gotten wet during this ordeal. I went back to my room and started freaking out. I was convinced that she would wake up in the morning, plug it in and get electrocuted to death. In my head there were only 2 options, either she could plug it in and die, or I can go plug it in and die. It didn't cross my mind that I could leave a not telling her not to plug it in.

I started thinking about what would happen if she plugged it in. I had vivid mental images of our lives leading up to this moment, her plugging it in and dying, then the following weeks and years of our family after losing her. Then I had vivid mental imagery of what would happen if I plugged it in. Same thing, our lives leading up to this point, me plugging it in and dying, me seeing what would happen to my family after they lost me. After comparing the two I had decided that it would be better for my family if I was the one who passed away. That it would be hard for them but that ultimately the family would stick together and persevere. If she passed I had seen that the family would be devastated and become fragmented. So without fear I went to the bathroom, grabbed the wet hair straightener, counted to 3 and plugged it in. Obviously I did not pass away, but the fear of death never came back. That night was the end of my tossing and turning every night terrified of the unknowns of what happens to someone after death. I'm just about to be 31 and the fear has not come back.

Since that experience, I fit into two separate beliefs in what happens after death. I now have a fairly strong belief that reincarnation is a possibility. This is due to a vivid and profound dream that I had about a year ago. The other belief that I have is due to my most recent psychedelic trip off of copious amounts of 3-me-PCP and 150ug LSD and a little bit of weed. What I got from that trip is that the big bang is the collapsing of this universe and the resulting big bang that follows. This cycle of universe death and rebirth has probably always gone on and will always continue. The exact same material make up is within the universe at all times and following each big bang that is the rebirth, the universe begins growing again with the same materials at the same rate. We will all be born again once the universe reaches this point that we're in again, and we will all die again. We will all experience the same joys and sorrows. Humans will have the same breakthroughs and wars. The same societies will be born and collapse. This will happen time and time again. We have all lived this exact same life that we are experiencing now and we will all experience it again. Maybe there will be slight differences, maybe not. This may sound like ramblings of a madman who has consumed too many psychedelics and dissociatives and that may be xcactly all that it is. But during this trip I watched this exact scenario play out a dozen times. Watched all of my loved ones live and die, watched myself be born and pass, watched the universe collapse and explode back into life and it just made sense to me at the time and it still makes sense to me now

 

[dopamimetic]

I'm ~100kg (220 lbs) and threshold DXM for me is somewhere between 25 and 40mg, the fact that it's so high for you is fascinating. Think it may be tolerance related?

Yeah I do indeed have tolerance. Both from using other dissociatives (mostly DCK) and also does morphine seem interestingly to have cross tolerance with DXM for me. Also do opioids ruin the dissociative experience, they make it more psychotic and less enjoyable. I have been sober from opioids for ~2 years now and from dissociatives for 3 years. Tolerance is still not down to baseline but almost. With the morphine I was at a point where 600mg DXM had zero dissociation, only psychotic side effects. The latter seem to have vanished now.

The lowest dose of DXM which had effects to me were 75mg when I was on venlafaxine and also when I was less heavy back in my teens.

And are you taking it all at once, or broken up over the day?

All at once, but staggering works as well.

Have you considered trying to mimic Auvelity with bupropion and DXM, perhaps?

I have accidentally experienced this combo years ago when I was prescribed bupropion and took DXM for a cold. 2x 50mg XR DXM a day had a strong effect, mostly stimulation but also some dissociation. I think the bupropion potentiates the DXM to some extent but also changes the overall experience, I don't like the excess norepinephrine and bupropion exacerbates my tinnitus which I dislike too. DXM alone is less potent but also more mellow.

.I also get great benefit for NMDA antagonists which lead me to dose nearly every day when I have them available. I don't know if I'd call it mood stabilization, at least in my case. They do reliably leave me feeling more optimistic, improve my ADHD symptoms and ability to focus, plan and act out tasks. They ease my everlasting feeling of anhedonia and enable me to enjoy old hobbies again and they cause me to become fascinated with different concepts, so I find myself going down long research rabbit holes because my brain feel malleable and thirsty for information.

Oh I get those effects as well but there is some definite mood stabilizing effect. DXM is literally everything I would wish from a prescription psychiatric pill but none of those delivered. DXM also has little side effects. I sweat a bit more and in the past did I get insomnia, that one has been absent now. I seem to get slightly confused when I overshoot the right dosage, which does not worry me but my gf notices it and she is somewhat hypochondriac. I think the confusion might add to the antidepressant effects I get because it distracts me from my ruminating thoughts. The same for the dissociation.

I have always thought that there was something very special about DXM.

Indeed. It was by coincidence my first drug I ever took, even before alcohol, and it had a profound impact onto my life. I experienced how it is to live free of depression and anxiety for the first time in a very long time. Later should I experience other dissociatives, the first being MXE, then K and eventually DCK, O-PCE, 3-MeO-PCE etc. and while I loved them all so does DXM seem to be more therapeutic, more of a medicine than just a psychotropic drug. Its long duration might add to this but I guess it's not the only effect, after DCK I always had a bad comedown but with DXM there is an afterglow. I am now day 2 without DXM and feel okay, I miss its effects but that's it, no psychotic effects or bad feelings. Also I never had problems to stay with a certain dosage with DXM while with DCK I experienced compulsive redosing. I do have difficulties not to take DXM at all when I have sone around tnough,

I suspect that the sigma receptor may play a role in the feeling of mysticism.

All dissociatives have a mystsic edge imho, but I wonder about the effects of sigma agonism as well. I have done two sigmaergic drugs / cough suppressants, pentoxyverine and noscapine, of the latter a whole box and they had zero effects though so I am unsure about sigma.

I also believe that dissociatives taught me some spiritual lessons, when I dosed higher.

The euphoria doesn't feel forced and chemically induced like cathinones, amphetamines/MDMA. It feels almost natural. Like the euphoria isnt caused by a flood of neurotransmitters but rather due to the mind and body tapping into some cosmic well of knowledge and emotion.

Definitely. The euphoria from dissociatives feels very natural to me too, but 4,4'-dimethylaminorex was similar, which is a triple releaser like MDMA but also a MAO inhibitor. It is my #2 top drug of all times, after DXM. I also feel that dissocicatives induce some wacky feelings which I never experienced while sober, and they are awesome. The most pronounced one was when I did the first dose of DXM last week and was a bit tired so I went to bed and began nodding somewhat in and out of consciousness, and always when I faded I felt such an amazing unknown emotion.

 

[dopamimetic]

The afterglow is over and I am craving the DXM heavily. This is such a double edged sword. Before I was okay with being sober, I was fighting some symptoms but I forgot the intensity of disso cravings,

 

[dopamimetic]

Back to taking low dose DXM daily. 120mg 1-2x a day. It helps me a ton even when I don't really like some of its effects specially in higher dosages (the 120mg are pretty benign) and I am aware that I am becoming dependent again (anybody else getting withdrawals from dissos?) but NMDA antagonists just help me way more than any other drug or medication ever did and I've tried a ton. And most prescriptions are dependency-forming (looking at you, SSRIs). Even morphine was just a trainwreck after I became dependent. It's a shame that DXM use is illicit and not on prescription. I am having a hard time in my life and the DXM helps me tremendously with coping. I am just more calm and focused. I wake up earlier but the DXM doesn't interfere with my sleep at this regimen, it is also the most sedative dissociative I've encountered so far, most are manic and very stimulating while DXM slightly sedates me so I take some caffeine.

I really feel that DXM has legit therapeutical potential, like slow released MXE would have too. They should be studied and approved, I think ketamine gets used more widely in the US now but most countries require ridiculous supervision while administration and all sorts of regulation which hinder a prescription.

Wonder whether I will run into tolerance and need to adjust the dosage endlessly like with other drugs. But somehow I feel that the mood stabilizing effect might be different from the recreational dissociation and last for longer time. I hope it. Just placed an order for 8 bottles of BupropiDex.

 

[Esperighanto]

Back to taking low dose DXM daily. 120mg 1-2x a day. It helps me a ton even when I don't really like some of its effects specially in higher dosages (the 120mg are pretty benign) and I am aware that I am becoming dependent again (anybody else getting withdrawals from dissos?) but NMDA antagonists just help me way more than any other drug or medication ever did and I've tried a ton. And most prescriptions are dependency-forming (looking at you, SSRIs). Even morphine was just a trainwreck after I became dependent. It's a shame that DXM use is illicit and not on prescription. I am having a hard time in my life and the DXM helps me tremendously with coping. I am just more calm and focused. I wake up earlier but the DXM doesn't interfere with my sleep at this regimen, it is also the most sedative dissociative I've encountered so far, most are manic and very stimulating while DXM slightly sedates me so I take some caffeine.

I really feel that DXM has legit therapeutical potential, like slow released MXE would have too. They should be studied and approved, I think ketamine gets used more widely in the US now but most countries require ridiculous supervision while administration and all sorts of regulation which hinder a prescription.

Wonder whether I will run into tolerance and need to adjust the dosage endlessly like with other drugs. But somehow I feel that the mood stabilizing effect might be different from the recreational dissociation and last for longer time. I hope it. Just placed an order for 8 bottles of BupropiDex.

DXM tolerance is absolutely intense and once it forms it often takes multiple months to go back down for me at least. I'd ask others to see their experiences with it too, though.

 

[Nonyascaline]

I'm ~100kg (220 lbs) and threshold DXM for me is somewhere between 25 and 40mg, the fact that it's so high for you is fascinating.

The dose for coughs, y'know like normal people take, is 30mg. Even though I haven't done dex in a hot minute I remember taking 180-210mg for first plat. (with a small amount of disso permatolerance ofc)