Thank you for the information here! It's very appreciated.Mirtazapine has nothing to do with my inability to use/enjoy THC. THC just took a turn on me in my mid 20's or so. It now triggers anxiety/panic attacks pretty regularly. I have been able to enjoy it with a tolerance, but now that my tolerance is at zero it's hard to get it back up to be able to enjoy the effects again. I do enjoy high CBD and low THC buds though.
I like mirtazapine as an anti-depressant. It's not as extreme in it's effects as venlafaxine. Venlafaxine I found to be a pretty good anti-depressant. It helped me get thru a point in my life where I was suicidal. I had to stop due to some extreme side effects. Mainly the fact that the sexual dysfunction was so bad and my body was unable to even release itself through nocturnal emissions It got to the point where I had blue balls 24/7. It hurt to wake up, couldn't get comfortable trying to sleep. couldn't sit without pain, couldn't walk without pain. I'd only ever take it again as a last resort (if my life depended upon it)
Mirtazapine I like. It's not in your face and the changes are subtle. It's not as chemical feeling as SSRI/SNRIs. Reuptake inhibitors have that robotic feeling. Like being unable to feel sad when you should, just this mask of "happy" that feels unnatural and not human. Mirtazapine feels a bit more natural. It's leveled out my mood enough that I've been able to make positive changes like picking up reading again, going on long walks often. It's also great for sleep and helps anxiety quite a bit. The main downside for me is weight gain. The munchies that it can cause are crazy. I have an appointment later this month and I'm going to talk to my doctor about the possibility af adding Bupropion with my Mirtazapine. I suspect that I have ADHD so I think the combo of the 2 will be pretty effective for me. I guess the main part about Mirtazapine that I dislike the most is that I can no longer have spur of the moment psychedelic trips. I now have to plan them out so I can taper off. On that note, does anyone have any idea how long I should be off of mirtazapine before being able to take a psychedelic? I'm on a pretty low dose (15mg)
While I don't have an answer to your question about how long before tripping after discontinuing mirtazapine, I do want to mention that Bupropion's been a serious lifesaver for me. I'm missing all but ~6 feet of intestines in my body, and it's just ileus, so I absorb food super poorly. My default state is sleeping as much as possible all the time, as I can barely ever absorb meaningful amounts of calories from food. Bupropion is a few steps separated from amphetamine/methamphetamine as far as its structure, and it has an effect that would warrant the name "Ritameth" if it were to ever need a new brand name, as it feels like a stunningly high dose of Ritalin with characteristics of low doses of oral methamphetamine.
It tends to last 20-30 hours for me, and it can keep me up at night if I took too much (or took it too late), the shivering and wide eyes are very meth-like as well. It has more of a Ritalin-ish feel though, and it functions similarly as an NDRI. It also has a gang of other interesting effects, it blocks nicotine from functioning, hence its use as a smoking cessation aid for example. Be wicked careful about mixing bupropion with other drugs that may have a stimulating effect, as it will potentiate them. Harmalas are also obviously a big no-go, as this is far too close to amphetamine. Once, 300mg of harmaline with 300mg of bupropion and 5 tabs of acid damn near killed me at a Lake Street Dive show. I find it interesting that a very long and verbose alternative name for Bupropion, to further elucidate its chemical structure, could be 3-chloro-beta-keto-N-tert-butyl-methcathinone.
Edit: Sorry for the rant, actively buped up hahaha.