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Help! Serotonergic drugs never last very long for me

SotPoker1012

SotPoker1012

Bluelighter
Joined
Feb 12, 2025
Messages
91
From mushrooms, to DMT, to LSD and mdma, I find serotonergic drugs to be very short acting.

This is independent of what I've eaten and my tolerance.

LSD lasts about 8 hours if I take a big dose and about 6 if I just take one tab.

Mushrooms last between 2-6 hours depending on how much I took.

MDMA is the quickest of them all, only lasting about 2 hours if I don't redose. Then I can get about 4 hours.

What do you guys think could cause this? Could it just be my body/brain chemistry, a sign of a neurological issue, or what?

Anyone else experience this, and what can be done to extend these drugs for people like me?

I've also found that these drugs tend to make me tired. Even MDMA makes me sleepy after the peak.
 
someguyontheinternet said:
Yea those sound pretty normal to me. MDMA peak usually lasts about 2hr after ~1hr come up
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Do you get an extended comedown?
I go from rolling to mildly stimmed up within a half hour or so of the peak. Other psychedelics, aside from LSD for some reason, never really have a comedown for me. I feel like I leave the headspace very soon after peaking.
Glad my times are roughly normal though.

It's very possible this is a matter of perception. I am prone to abusing drugs, so maybe it's just my mind desperately wanting the peak back convincing me that I'm sober.
 
SotPoker1012 said:
Do you get an extended comedown?
I go from rolling to mildly stimmed up within a half hour or so of the peak. Other psychedelics, aside from LSD for some reason, never really have a comedown for me. I feel like I leave the headspace very soon after peaking.
Glad my times are roughly normal though.

It's very possible this is a matter of perception. I am prone to abusing drugs, so maybe it's just my mind desperately wanting the peak back convincing me that I'm sober.
Click to expand...
Are you on any medications or have you ever been on an SSRI? Do you always reagent test your drugs? There's a lot of stuff that gets sold as MDMA
 
SotPoker1012 said:
LSD lasts about 8 hours if I take a big dose and about 6 if I just take one tab
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This is fairly normal.

In my experience

75ug - 6hr
100ug - 8hr
150ug - 10-11hr
200ug - 12hr-14hr+

These days your average tab of acid is around 75ug, but some are even less than that.

Shrooms lasting 2hr is a bit strange.

By the way, are you describing the total duration of effects, or just the peak and/or the main experience?
 
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someguyontheinternet said:
Are you on any medications or have you ever been on an SSRI? Do you always reagent test your drugs? There's a lot of stuff that gets sold as MDMA
Click to expand...
I was on Lexapro 10 years ago, from ages 14 to 16. I am currently 25. I didn't begin experimenting with these drugs until my early 20s, so I really don't have a frame of reference for how (if at all) my prior use is ssris would effect it. It was my assumption that after a few months your brain chemistry went back to normal though.

I've recently kicked a mild benzo dependence (officially one week clean yesterday, hence me taking some MDMA last night)
However, I experienced this with psychedelics prior to ever taking benzos, during my benzo use*, and now after it.

I haven't always tested, but the last two years I've been getting some high quality crystal MDMA and I've been testing it since then. Prior to that I was getting it from street dealers and people at parties, and not testing it. So who knows what I really got then, but I'm fairly confident in my current supply being high quality. All the tests have come back good so far.

*I knew not to take benzos immediately before the trip too. I would take my benzo dose before bed and whatever psych I was on early in the day. 12 or so hours apart.
fairnymph said:
I think that sounds a little unusual at least. Have you ever been diagnosed with any mental conditions? Or do you suspect that you have any?
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I'm currently diagnosed with autism, though I've had a depression/anxiety diagnosis in the past that probably still applies.

I suspect I may have ADHD, as I have the majority of common symptoms, but I've never been tested.
Quasimoto said:
This is fairly normal.

In my experience

75ug - 6hr
100ug - 8hr
150ug - 10-11hr
200ug - 12hr-14hr+

These days your average tab of acid is around 75ug, but some are even less than that.

Shrooms lasting 2hr is a bit strange.

By the way, are you describing the total duration of effects, or just the peak and/or the main experience?
Click to expand...
Supposedly my current batch of LSD gel tabs are 180ug, but they don't feel very strong at all. I took two (for a total of 360ug) and only then got any visuals.

I'm not too upset about them being under dosed though as I know they're LSD and I plan on candy flipping later this year. A smaller dose of LSD is desirable for experimenting.

Total duration, not counting the period of no effect before the come up begins.
 
SotPoker1012 said:
I was on Lexapro 10 years ago, from ages 14 to 16. I am currently 25. I didn't begin experimenting with these drugs until my early 20s, so I really don't have a frame of reference for how (if at all) my prior use is ssris would effect it. It was my assumption that after a few months your brain chemistry went back to normal though.

I've recently kicked a mild benzo dependence (officially one week clean yesterday, hence me taking some MDMA last night)
However, I experienced this with psychedelics prior to ever taking benzos, during my benzo use*, and now after it.

I haven't always tested, but the last two years I've been getting some high quality crystal MDMA and I've been testing it since then. Prior to that I was getting it from street dealers and people at parties, and not testing it. So who knows what I really got then, but I'm fairly confident in my current supply being high quality. All the tests have come back good so far.

*I knew not to take benzos immediately before the trip too. I would take my benzo dose before bed and whatever psych I was on early in the day. 12 or so hours apart.

I'm currently diagnosed with autism, though I've had a depression/anxiety diagnosis in the past that probably still applies.

I suspect I may have ADHD, as I have the majority of common symptoms, but I've never been tested.

Supposedly my current batch of LSD gel tabs are 180ug, but they don't feel very strong at all. I took two (for a total of 360ug) and only then got any visuals.

I'm not too upset about them being under dosed though as I know they're LSD and I plan on candy flipping later this year. A smaller dose of LSD is desirable for experimenting.

Total duration, not counting the period of no effect before the come up begins.
Click to expand...
Neurodivergent people have weird brains - I know I certainly do. I also wouldn’t be surprised if being on Lexapro at that age had some effect. I need higher doses with a lot of drugs/meds and it’s very common for them to not last as long for me as for others, though I’m not as extreme as you.
 
Honestly, you sound like you are in the normal range. Drugs last longer for some people than others, but your numbers aren't unusual. It can even differ from drug to drug. DOC lasts 12-24hrs for people. For me, it lasts 12hrs at a common dose. Mescaline and LSD at common doses last longer for me.

It could have something to do with your body's normal liver enzyme levels. Or that could have nothing to do with it at all.
 
Pfafffed said:
Honestly, you sound like you are in the normal range. Drugs last longer for some people than others, but your numbers aren't unusual. It can even differ from drug to drug. DOC lasts 12-24hrs for people. For me, it lasts 12hrs at a common dose. Mescaline and LSD at common doses last longer for me.

It could have something to do with your body's normal liver enzyme levels. Or that could have nothing to do with it at all.
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Thanks for the reply.
I think I just fall on the lower end of the normal range for these drugs and just had an inflated idea of how long these drugs are "supposed" to last at the dosages I typically take. For example, I had been under the impression that the stimulation effect of MDMA was supposed to last longer than it does, yet I can nap an hour or so after the peak just fine and don't get any kind of long comedown.

If there is anything to it aside from just my own chemistry, being on the spectrum seems like a decent theory. I know people with ADHD require higher doses of stimulants to get a recreational effect from them. Perhaps autism also has some interaction with drugs, and it's not super uncommon for people to be diagnosed with both. (Both due to "comorbidity" - I don't like using that term for something that isn't morbid but I don't know an apopriate alternative and sometimes crossover in symptoms that leads to one being diagnosed as the other)
 
SotPoker1012 said:
Thanks for the reply.
I think I just fall on the lower end of the normal range for these drugs and just had an inflated idea of how long these drugs are "supposed" to last at the dosages I typically take. For example, I had been under the impression that the stimulation effect of MDMA was supposed to last longer than it does, yet I can nap an hour or so after the peak just fine and don't get any kind of long comedown.

If there is anything to it aside from just my own chemistry, being on the spectrum seems like a decent theory. I know people with ADHD require higher doses of stimulants to get a recreational effect from them. Perhaps autism also has some interaction with drugs, and it's not super uncommon for people to be diagnosed with both. (Both due to "comorbidity" - I don't like using that term for something that isn't morbid but I don't know an apopriate alternative and sometimes crossover in symptoms that leads to one being diagnosed as the other)
Click to expand...
It’s common for people with Asperger’s like myself to require high doses. And yes, there is significant overlap with ADD/ADHD.
 
While I'm not neurodivergent due to development, I've had 12-15 concussions, as well as brain/nerve damage from having seizures while under general anesthesia during surgery. I also have ~1/8 of my intestines left. I have the inverse experience as OP, I can feeel incredibly low doses of psychedelics compared to what people claim the threshold dose to be, and I prefer dosing usually multiple times over the norm, LSD in the 1.5-3.5mg range is beautiful, as are fungi between 8-12 grams, and 2C-B above 60mg. I've never had a bad trip, idk if I even can. I wonder what separately determines the lower and upper bounds of doses you can feel and work with?
 
Shinji Ikari said:
Sounds normal tbh. You have to take a lot of acid for it to last 12 hours. I'm usually on the tail end after about 8 hours with 2 or 3 tabs.
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I've taken one gel tab of some fire at 8am and been feeling it when I go to bed at midnight sometimes. Might be a tolerance thing, and to be fair I didn't test it, but 'good' (in my experience) acid lasts all day for me.
 
daturetard said:
I've taken one gel tab of some fire at 8am and been feeling it when I go to bed at midnight sometimes. Might be a tolerance thing, and to be fair I didn't test it, but 'good' (in my experience) acid lasts all day for me.
Click to expand...
I drank a vial of idk, like 15mg of LSD? It was about 4 days afterwards that I could smoke weed again without being rocketed to the ~5mg zone of LSD again, and the initial effects wore off within maybe 36 hours of dosing, maybe more like 40-48 hours. Acid lasts a very long time. Many times when people claim acid lasted 4-6 hours, I've asked them how the tabs tasted and they've consistently said "Bitter, of course!" as if acid has a taste. 25X-NBXX compounds are fun and all, but misconstruing the 25X-NBXX experience (and utility) with LSD's is wild.
perpetualdawn said:
I think you get sensitized to psychedelics/serotonergics if you have taken them a lot over many years without abusing them into heavy tolerance. I've noticed this with myself and other people I've talked to as well.
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I've definitely noticed this, but it's not like the upper limit got any lower, the lower limit (threshold dose) certainly got lower though.
 
There are several, PhenethylAmines and Tryptamines with legs.

Not my preference, kinda annoying drugs that won t even stop
with monster doses of trip killers. And Psychedelics working on or emphatogens are two different groups with some overlap.

But DOx long lasting phenethylamines, aMT same but Tryptamine.
For a long lasting emphatogen 6_APB, more like MDA though.

But this is known info, ready to find, wanna know is it worth it ?
Imo no, LSD is ime to long for my liking/ wasn t it that i love it,

all the legged ones, aMT 6-APB and DOC, i tried where subpar
too the shorter ones . My current constitution leaves me one,
Lysergic s.
 
the drug probably stays your system about just like with everyone else, you just develop tachyphylaxis, serotonin receptor downregulation, bit faster than me, for example. I find effects of LSD to be easily distinguished even after 12 hours, single dose molly for 6 hours, and I can trip with shrooms having only one day off in between trips, just fine.

I always consume cannabis while tripping, which extends the high, essentially. I don't find last hours of molly that interesting if I have not toked or taken edible.

Actually I consider trip lasting until I go to sleep, I think particularly with weed enhancing afterglow and restoring high, certain kind of mindspace lasts even after the drug has been eliminated from the system.
 
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