Methyl-K has popped up. Predictions on effects?

[SuperPsych]

Methyl-K has become available. It's a chemical synthesized by Alexander Shulgin and described in Pihkal. The description in Pikhal makes it seem not very worthwhile, but my guess is that they never found the proper dose as the highest they tested was 100mg. Methyl-J sounds pretty nice so my hope would be that this has some worthwhile activity. I don't plan on getting any, I just saw it pop up and the name caught my attention and got me interested in it as I have never heard of it until now.

From Wikipedia:
"N-Methyl-1,3-benzodioxolylpentanamine (MBDP; Methyl-K, UWA-091), also known as 3,4-methylenedioxy-α-propyl-N-methylphenethylamine, is a psychoactive drug of the phenethylamine chemical class. It is the N-methyl analogue of 1,3-benzodioxolylpentanamine (BDP; K). Methyl-K was first synthesized by Alexander Shulgin ("Sasha" Shulgin). In his book PiHKAL ("Phenethylamines i Have Known And Loved"), the minimum dosage is listed as 100 mg, and the duration is unknown. Very little is known about the pharmacology, pharmacokinetics, effects, and toxicity of Methyl-K."

From Pihkal:
"QUALITATIVE COMMENTS: (with 100 mg) There were no effects. I was busy and totally wound up and didn't sleep until 3 AM, but this was probably unrelated to the Me-K."

That is the only entry in Pihkal. I'm curious as to if that was a threshold dose and if a dose like 250mg might result in a proper and worthwhile experience. I'm curious if anyone has any thoughts or predictions. The temptation to get some and guinea pig is definitely there. It's been 10 years or more since I was one of the first to try a new substance. There's a certain thrill in exploring the unknown.

 

[3DQSAR]

One on one hand the report says it had no effect and then goes on to say the taster went on to feel 'wound up' all day and not being able to sleep until 3AM.

That's not QUITE the placebo effect, but it's an example of someone not finding the expected effects (entactogenic I presume) and ignoring what the stuff was actually doing.

It's a DRI - possibly one that hasn't got much oral bioavailability.

 

[SuperPsych]

One on one hand the report says it had no effect and then goes on to say the taster went on to feel 'wound up' all day and not being able to sleep until 3AM.

That's not QUITE the placebo effect, but it's an example of someone not finding the expected effects (entactogenic I presume) and ignoring what the stuff was actually doing.

It's a DRI - possibly one that hasn't got much oral bioavailability.

That's what I was thinking. Being 'wound up' and kept up until 3am definitely sounds like it had some activity going on. Is it known to be a DRI or is that just a prediction. I haven't been able to find any solid answers into exactly what it does. Would be interesting to see some reports on it effects insufflated, rectally, or smoked. It popped up in the last week or so, so I'm sure reports will be popping up on reddit soon.

 

[3DQSAR]

Prolintane is the closest medicine and that is described as a 'mild stimulant'.

Pyrovalerone is a prolintane derivative and MDPV is actually mentioned in the pyrovalerone patent,* so it seems very likely that the 3,4-MD will likewise increase activity.

But the optimal chain length is 5. Yes, those with 6 were active, just less so.

I bet the dimethyl amine derivative is more potent.

*In the case of MDPV, my belief is that the p-Me was chosen instead partly due to cost but more importantly, because that p-Me acts as a sacrificial moiety. The body can easily oxidize that methyl with non-specific blood enzymes thus the metabolic fate is much easier to determine and it's most unlikely that there won't be some genetic trait that results in metabolism leading to anything potentially toxic.

 

[Esperighanto]

This is just the non-beta keto version of the old pentylone, it seems to be unpopular based on what reports I've seen but maybe it has potential in the right mix, or a certain set & setting.

 

[3DQSAR]

This is just the non-beta keto version of the old pentylone, it seems to be unpopular based on what reports I've seen but maybe it has potential in the right mix, or a certain set & setting.

Prolintane is less potent that analogues with a benzylic ketone (or bioisostere) but it's still pretty active. I'm not a stimulant user but am aware that those analogues with said ketone do appear to produce more compulsive redosing. I suspect it's at least in part due to the much faster onset.

 

[Esperighanto]

Prolintane is less potent that analogues with a benzylic ketone (or bioisostere) but it's still pretty active. I'm not a stimulant user but am aware that those analogues with said ketone do appear to produce more compulsive redosing. I suspect it's at least in part due to the much faster onset.

I find it interesting that the more flat/stimulant-y cathinones are quicker to come up and leave, whereas beta-keto-2C-B (and I'm assuming other bk-2C-X's) is often reported as having a pretty long come-up time and being gentler on redose urges.

 

[KhaoticK]

Yea I would avoid this chem at all costs, I took 80mg to start then only 20mg redose and sent me to the er then hospital, had a hypertensive episode and I do not at all have any heart conditions or in my family, extremely experienced with rcs and the regular drugs with over 160 drugs tried, this was the only stim that did that to me, luckily no heart attack they ran an ekg but felt like I was having one, my arms and legs were going numb and blood pressure very high, could almost not get up to leave to the hospital, had to call an ambulance. I could barely talk at that point, felt like I had to force words out just to talk from the panic attack and hr attack that put me in. My heart just would not stop pounding bpm was probably 180+ max hr 190, sitting up felt like I was gonna pass out, I’m very experienced with mdma and all the flourinated amphetamines, this one please avoid. Luckily I had some Pyrazolam powder, sublingualed an unknown amount out of panic as ik they were gonna give me iv benzos anyway, Pyrazolam wasn’t too strong but I reached for the quickest thing near me, moving felt like an instant heart attack imminent, still wasn’t enough to stop the hr and blood pressure surge. At the er they had to IV me with ativan and Valium 3 times and maybe cause of panic in the body my heart rate was still climbing up to 170+ bpm. It eventually calmed down from the iv benzos but my hr was like that for probably the whole peak of the drug, roughly 3-4 hours. Absolutely crazy as you may think this won’t happen to you but it can. What’s weird is that it started out calm and I had entactogenic effects, but that’s about it then the umcomfortable seizure like stimulations crept in like I was injected with adrenaline, felt like I was gonna seize any moment, I had to concentrate on breathing as I wasn’t getting enough oxygen from the quick hr, this was more intense than any high intensity workout. I’m 25 and this was the only stim I’ve done that had this sort of reaction, took it on an empty stomach which probably wasn’t a great idea but I had ate food only like 30 mins later, but that wouldn’t have mattered if it were any other stim, this has toxicity forsure, cardio toxicity and im also active and workout regularly, heart was in shape. I was the Guinea pig for the night and felt like I was gonna die, please avoid this, its the parent drug of pentylone, which was known to cause ods and death, and now I see how and why