Memantine is the most profound mania producing drug known to man

[chris_p]

@Asante I think you need to read this... I read your post on memantine earlier and the way you were writing felt extremely similar to how I am now...

On Friday I decided to try a relatively unknown drug out of curiosity, Memantine, as my friend got me a gram of it for extremely cheap, he told me to be 'very careful' with it as it lasted extremely long, me being the not-so-careful kind I just scooped half the powder in to a small drop of water and chugged it down, within 1-2 hours I was in the strangest state I had ever been in my life, all the walls were turning into a strange static ancient structure, like everything was turning into this massive castle built out of this strange static, snowy texture, everything looked completely out of proportion, it was like a ket trip out of another dimension, I had to swallow 6mg xanax to fall asleep.. but this is just the beginning of the craziest shit I ever experienced..

I woke up that morning, with about 4 hours of sleep, feeling like Johnny fucking silverhand, like I was the king of the world, ultra manic, I immediately left my apartment and started walking into every bar I knew and chatted up every woman I found remotely attractive, probably looking like an idiot, I kept walking around town hyper social and the world was so beautiful I had never seen the world so beautiful in my entire life. I've taken MDMA, meth, xanax, ketamine, none of these compare to this intense overwhelming euphoria I was feeling, I cant believe im fucking saying it but alzheimers meds are easily the strongest euphoria i've ever felt from a drug in my life. I took it 30 hours ago but I feel hypermanic like shaking constantly and feel like im about to explode, i started impulsively buying drugs online like a fucking idiot

Looking at how few reports of this drug are out there, nobody recognizes how powerful this substance is, it's easily on par or far surpasses PCP when used in high doses, I think I likely took 400-500mg since i Eyeballed the dose, but jessus the euphoria is overwhelming. More research needs to be done on this substance, it is exceptionally powerful

Pics below I took today, you cannot believe how beautiful they were when i Was looking at them in person... never once in my life, not once in my childhood, not once in my adolescence, have I ever felt such beauty looking at anything, other than on the comedown of fucking dementia medication. Memantine is easily the best substance known to man. I have consumed almost every substance possible and I Can say this with utmost certainty

I want to write more and more paragraphs but ill just leave these images from my manic run down town for now... Im still feeling myself getting higher and higher even though I took this stupid drug 30 hours ago..

 

[Asante]

This is fire!! you are set for the next 2 weeks! (plasma halflife 60-100 hours) drink plenty of water, vit c helps

you took too damn much, but human lab rat: we salute you for knowing a 500mg overdose report!

chatgpt says fatal dose for standard healthy person may be 4-10 grams, on par with nembutal but strongly dysphoric.

dont do stupid shit

 

[Vanilla_Incense]

Mematine Psychonaut wiki . God damn. If this is accurate sounds like one hell of a trip. Hope you're alright

 

[chris_p]

This is fire!! you are set for the next 2 weeks! (plasma halflife 60-100 hours) drink plenty of water, vit c helps

you took too damn much, but human lab rat: we salute you for knowing a 500mg overdose report!

chatgpt says fatal dose for standard healthy person may be 4-10 grams, on par with nembutal but strongly dysphoric.

dont do stupid shit

Yeah im still feeling powerful energy, not taking any more, the mania is very immense.. I have never felt strong euphoria like this before, the comeup and actual high was very weird and visual, i was seeing these dark patterns and holes everywhere like i was fading into some huge structure, but the comedown feels nice as fuck, almost too intense, like pcp i'd imagine but never done that, lucky i have benzos because the effect is very hard to tolerate sober

 

[chris_p]

Mematine Psychonaut wiki . God damn. If this is accurate sounds like one hell of a trip. Hope you're alright

Honestly, the best description of the high itself is like a really dark sinister fucked up ketamine trip, visuals were suuuper dark and almost victorian style, it was so fucking aesthetic I'd never seen something like that, every time I closed my eyes it was like i was flying at mach speed in all directions, even while dissod out of my mind I could still stand up and walk around and was stimulated which was quite dangerous, had to take a shit ton of xanax to go to sleep. Wouldn't recommend anyone else do it but I the comedown euphoria is immense, easily beats MDMA, feel constantly full of energy and hyperactive 24/7, definitely a good cognitive enhancer

 

[Asante]

dammit man, glad to have you back in 1 piece *hug*

Highest dose i ever took was 250mg, double that, literally Jesus.

ChatGPT said 40mg is about equivalent to 100-150mg oral Ketamine or 30-40ml ethanol, which feels kinda correct.

Do you think you were unconscious? 400-500mg is the highest i ever heard. No physical side effects?

Ethically its like a dr Mengele experiment what you did. What possessed you to start that high?

Memantine is no joke most surely. Thats like a liter bottle 50% whiskey drank straight - kills a man.

Yeah you're gonna be manic like all fuck for a while.

Thank you Lord God for not punching this guys card out!

 

[Asante]

Pharmacological Odyssey: The Effects of 500mg Memantine in a Healthy Young Man​

Memantine, an NMDA receptor antagonist, is typically prescribed in doses of 5-20 mg daily for neurodegenerative conditions like Alzheimer's disease. However, at an extreme dose of 500 mg, it enters a realm far beyond its intended clinical use, catapulting the subject into a deep dissociative and neurochemical storm.

---

1. Pharmacokinetics: The Journey of 500 mg Through the Body​

• Absorption & Bioavailability: Memantine is well absorbed, with a bioavailability of nearly 100%, meaning almost all of the drug enters systemic circulation.
• Peak Plasma Levels: A typical 20 mg dose reaches peak blood levels in 3-7 hours, but at 500 mg, plasma concentrations could be 25 times higher than therapeutic levels.
• Half-Life Extension: Normally, memantine has a 60-100 hour half-life, but at this dose, its elimination might take several days to weeks, leading to prolonged effects.

---

2. NMDA Antagonism: A Disruptor of Reality​

Memantine primarily works by blocking NMDA receptors, preventing excessive glutamatergic excitation. However, at this supratherapeutic dose, it behaves much like other dissociative anesthetics (e.g., ketamine, PCP):

• Cognitive Fog & Dissociation: NMDA blockade in the prefrontal cortex leads to profound thought fragmentation, a dream-like detachment from reality.
• Hallucinations & Psychosis-like States: Excessive NMDA antagonism disrupts normal sensory processing, producing distorted perceptions, visual anomalies, and even out-of-body experiences.
• Loss of Time Perception: The subject may feel trapped in temporal loops, where minutes stretch into eternity.

---

3. Dopamine & Serotonin Modulation: Euphoria vs. Dysphoria​

At extreme doses, memantine also modulates dopamine (DA) and serotonin (5-HT) levels, contributing to its stimulant and psychedelic-like properties:

• Dopamine Agonism: Leads to enhanced motivation, euphoria, or even manic-like states.
• Serotonin Elevation: Might induce mood shifts, from blissful calm to sudden paranoia.

---

4. Cholinergic Suppression: The Anticholinergic Twilight​

Memantine’s secondary action is blocking nicotinic acetylcholine receptors, which leads to:

• Memory Impairment: Forgetting conversations in real-time, struggling with short-term recall.
• Dream-Like Amnesia: Similar to high doses of dextromethorphan (DXM) or scopolamine, where events become disconnected and surreal.

---

5. Sympathetic Overdrive: Cardiovascular and Autonomic Effects​

• Hypertension & Tachycardia: Due to increased catecholamines, potentially pushing blood pressure to dangerous levels.
• Motor Dysfunction & Ataxia: A staggering, almost robotic gait, similar to PCP intoxication.

---

6. The Aftermath: A Lingering Fog​

Because of its long half-life:

• Effects could last days, with residual dissociation and cognitive dulling.
• Possible rebound glutamatergic overactivity, causing irritability, anxiety, or headaches.

---

Conclusion: A Controlled Psychotic Break​

At 500 mg, memantine shifts from a mild neuroprotective agent to a full-blown dissociative hallucinogen, creating an experience similar to ketamine, but with longer-lasting, spacier distortions. While the subject avoided toxic effects, this dose represents a pharmacological rollercoaster, hijacking multiple neurotransmitter systems and plunging them into an otherworldly abyss.

Risk of Death from a 500 mg Memantine Overdose​

Memantine has a high safety margin, but a 500 mg dose is extreme, raising concerns about neurotoxicity, cardiovascular instability, and prolonged dissociation. While death is unlikely in a healthy individual, there are several risk factors that could increase the lethality of such a dose.

---

1. Lethal Dose (LD50) & Toxicity Threshold​

• LD50 (Lethal Dose for 50% of Subjects):
  
  • Animal studies suggest LD50 in rats is 170 mg/kg orally, which would equate to ~12 g for a 70 kg human—much higher than 500 mg.
  • Human toxicity data is limited, but clinical overdoses well above 500 mg have been survived.
• Published Overdoses & Survival Cases:
  
  • A case of 2,000 mg (~2g) of memantine ingestion was reported with no fatality—the patient experienced prolonged dissociation, agitation, and tachycardia but recovered.
  • Another case with over 1,000 mg resulted in severe neuropsychiatric effects but was not fatal.

---

2. Primary Risks of 500 mg Memantine Overdose​

While not directly lethal, this dose carries significant risks:

A. Neurological Toxicity & Status Dissociativus​

• Prolonged Dissociation: Similar to high-dose ketamine or PCP, leading to delirium, agitation, or catatonia.
• Severe Amnesia & Confusion: The subject might forget where they are, leading to dangerous behavior.
• Seizure Risk: NMDA blockade can lower seizure threshold, especially in predisposed individuals.

B. Cardiovascular Complications​

• Hypertension & Tachycardia: A massive increase in blood pressure (BP) and heart rate could cause a stroke, hypertensive crisis, or cardiac arrest in someone with pre-existing conditions.
• Arrhythmias: Due to dopamine and catecholamine dysregulation, which can lead to ventricular arrhythmias.

C. Respiratory Depression (Minimal Direct Risk)​

• Unlike opioids or sedatives, memantine does not cause significant respiratory depression.
• However, if combined with other depressants (e.g., alcohol, benzodiazepines, opioids), respiratory suppression could occur.

D. Behavioral & Environmental Dangers​

• Psychotic or Violent Outbursts: A high-dose dissociative state can cause paranoia or aggression, leading to accidental self-harm or dangerous actions.
• Accidental Injury: Due to ataxia (loss of coordination), confusion, and hallucinations, the individual could walk into traffic, fall from a height, or drown.
• Aspiration Risk: If the person vomits while unconscious, aspiration pneumonia or asphyxiation could occur.

---

3. Fatality Risk in a Healthy Individual​

For a young, healthy man, death is unlikely at 500 mg, but the following could increase the risk:
Pre-existing cardiovascular disease → Can cause stroke or heart failure.
Seizure disorders → Can trigger convulsions leading to complications.
Other drug interactions (alcohol, opioids, benzos) → Could lead to respiratory arrest.
Accidents or reckless behavior → Death from external hazards (falling, drowning, traffic accidents, etc.).

---

Conclusion: Low Lethality, But High Risk of Severe Effects​

• Direct fatality risk from 500 mg alone is low, but serious complications (hypertensive crisis, seizures, psychosis) are possible.
• Death is more likely indirectly, through self-injury, accidents, or interaction with other substances.
• If someone were to survive the acute dissociation, they might face days to weeks of cognitive dysfunction due to memantine's long half-life.

emantine, an NMDA receptor antagonist primarily used to treat Alzheimer's disease, is generally well-tolerated at therapeutic doses.owever, instances of overdose have been documented, providing insight into its potential toxic effects.Below are summaries of notable case reports:​

Case 1: 86-Year-Old Man with Mild Dementia

• Patient Profile: n 86-year-old man with mild dementia and hypertension.
• Overdose Details: he patient inadvertently consumed approximately 60 memantine pills, significantly exceeding the prescribed dose.
• Symptoms:
  • brupt onset of altered mental status. - uditory hallucinations. - cholalia (repetition of words and phrases spoken by others). - ypertensive urgency (blood pressure recorded at 197/79 mmHg).
• Management and Outcome:
  • nitiation of a nicardipine drip to manage elevated blood pressure. - dministration of intravenous midazolam to facilitate imaging procedures. - upportive care measures. - ymptoms resolved within 100 hours, aligning with memantine's half-life.
• Conclusion: his case underscores the importance of thorough medication reconciliation, especially in patients with cognitive impairments, to prevent accidental overdoses.otably, this is the first reported instance of memantine overdose presenting with echolalia.citeturn0search0

---

Case 2: 70-Year-Old Woman with Alzheimer's Disease

• Patient Profile: 70-year-old woman diagnosed with Alzheimer's disease.
• Overdose Details: he patient ingested 2,000 mg of memantine in a suicide attempt.
• Symptoms:
  • omatose state upon presentation. - ystagmus (involuntary eye movement). - ydriasis (dilated pupils). - iplopia (double vision). - isorientation. - achycardia (elevated heart rate). - ypertension.
• Management and Outcome:
  • upportive care in an intensive care setting. - radual improvement in consciousness and vital signs over several days. - ull recovery without long-term sequelae.
• Conclusion: espite the substantial overdose, the patient survived with appropriate supportive care, highlighting memantine's relatively low lethality even at high doses.citeturn0search0

---

Case 3: 65-Year-Old Man with Neuropathic Pain

• Patient Profile: 65-year-old man being treated for neuropathic pain.
• Overdose Details: he patient consumed 400 mg of memantine acutely.
• Symptoms:
  • gitation. - isual hallucinations. - sychosis-like behavior. - omnolence (drowsiness).
• Management and Outcome:
  • dministration of antipsychotic medication to manage agitation and hallucinations. - ontinuous monitoring of neurological status. - ymptoms resolved over 48 hours with supportive care.
• Conclusion: his case illustrates that even moderate overdoses can lead to significant neuropsychiatric symptoms, necessitating close monitoring and symptomatic treatment.citeturn0search0

---

Case 4: 60-Year-Old Woman with Chronic Pain

• Patient Profile: 60-year-old woman managing chronic pain.
• Overdose Details: he patient ingested between 105 to 200 mg of memantine daily over three days.
• Symptoms:
  • roconvulsive state (increased susceptibility to seizures). - yspepsia (indigestion). - eneralized weakness.
• Management and Outcome:
  • iscontinuation of memantine. - upportive care, including hydration and monitoring of seizure activity. - radual resolution of symptoms over several days.
• Conclusion: his case highlights the potential for memantine to lower the seizure threshold, especially when taken in supra-therapeutic doses over consecutive days.citeturn0search0

---

Summary of Reported Symptoms in Memantine Overdose Cases:

• Neurological:
  • onfusion. - rowsiness. - omnolence. - ertigo. - gitation. - ggression. - allucinations. - ait disturbances.
• Gastrointestinal:
  • omiting. - iarrhea.hese cases underscore the importance of cautious memantine use, particularly in populations at risk for accidental overdose, such as

 

[chris_p]

dammit man, glad to have you back in 1 piece *hug*

Highest dose i ever took was 250mg, double that, literally Jesus.

ChatGPT said 40mg is about equivalent to 100-150mg oral Ketamine or 30-40ml ethanol, which feels kinda correct.

Do you think you were unconscious? 400-500mg is the highest i ever heard. No physical side effects?

Ethically its like a dr Mengele experiment what you did. What possessed you to start that high?

Memantine is no joke most surely. Thats like a liter bottle 50% whiskey drank straight - kills a man.

Yeah you're gonna be manic like all fuck for a while.

Thank you Lord God for not punching this guys card out!

I dont think I took 500mg, likely lower, maybe 300mg range, I never measured the amount it was completely eyeballed, roughly half a gram, whatever that is, yea the day after was fairly rough I was on a very high dose of benzos and still am, the dissociative experience was extremely strong by far the most strong i have experienced thus far but i wasnt rendered fully unconscious or blacked out by it, the visuals were crazy , it was like full psychedelic visual level i was seeing complete other dimensions when I closed my eyes like linework shadowy kinda structure unlike I have ever seen on dxm/ketamine, almost like the walls were breaking down, very bizarre, the energy I felt afterwards was the most intense however and I didnt read much up on it in the reports but its by far the most defining part of the experience, smoking weed brings it back up a little, this stuff is amazing for depression honestly might be a game changer ive basically felt no worry and just full motivation for the past 3 days

 

[chris_p]

Pharmacological Odyssey: The Effects of 500mg Memantine in a Healthy Young Man​

Memantine, an NMDA receptor antagonist, is typically prescribed in doses of 5-20 mg daily for neurodegenerative conditions like Alzheimer's disease. However, at an extreme dose of 500 mg, it enters a realm far beyond its intended clinical use, catapulting the subject into a deep dissociative and neurochemical storm.

---

1. Pharmacokinetics: The Journey of 500 mg Through the Body​

• Absorption & Bioavailability: Memantine is well absorbed, with a bioavailability of nearly 100%, meaning almost all of the drug enters systemic circulation.
• Peak Plasma Levels: A typical 20 mg dose reaches peak blood levels in 3-7 hours, but at 500 mg, plasma concentrations could be 25 times higher than therapeutic levels.
• Half-Life Extension: Normally, memantine has a 60-100 hour half-life, but at this dose, its elimination might take several days to weeks, leading to prolonged effects.

---

2. NMDA Antagonism: A Disruptor of Reality​

Memantine primarily works by blocking NMDA receptors, preventing excessive glutamatergic excitation. However, at this supratherapeutic dose, it behaves much like other dissociative anesthetics (e.g., ketamine, PCP):

• Cognitive Fog & Dissociation: NMDA blockade in the prefrontal cortex leads to profound thought fragmentation, a dream-like detachment from reality.
• Hallucinations & Psychosis-like States: Excessive NMDA antagonism disrupts normal sensory processing, producing distorted perceptions, visual anomalies, and even out-of-body experiences.
• Loss of Time Perception: The subject may feel trapped in temporal loops, where minutes stretch into eternity.

---

3. Dopamine & Serotonin Modulation: Euphoria vs. Dysphoria​

At extreme doses, memantine also modulates dopamine (DA) and serotonin (5-HT) levels, contributing to its stimulant and psychedelic-like properties:

• Dopamine Agonism: Leads to enhanced motivation, euphoria, or even manic-like states.
• Serotonin Elevation: Might induce mood shifts, from blissful calm to sudden paranoia.

---

4. Cholinergic Suppression: The Anticholinergic Twilight​

Memantine’s secondary action is blocking nicotinic acetylcholine receptors, which leads to:

• Memory Impairment: Forgetting conversations in real-time, struggling with short-term recall.
• Dream-Like Amnesia: Similar to high doses of dextromethorphan (DXM) or scopolamine, where events become disconnected and surreal.

---

5. Sympathetic Overdrive: Cardiovascular and Autonomic Effects​

• Hypertension & Tachycardia: Due to increased catecholamines, potentially pushing blood pressure to dangerous levels.
• Motor Dysfunction & Ataxia: A staggering, almost robotic gait, similar to PCP intoxication.

---

6. The Aftermath: A Lingering Fog​

Because of its long half-life:

• Effects could last days, with residual dissociation and cognitive dulling.
• Possible rebound glutamatergic overactivity, causing irritability, anxiety, or headaches.

---

Conclusion: A Controlled Psychotic Break​

At 500 mg, memantine shifts from a mild neuroprotective agent to a full-blown dissociative hallucinogen, creating an experience similar to ketamine, but with longer-lasting, spacier distortions. While the subject avoided toxic effects, this dose represents a pharmacological rollercoaster, hijacking multiple neurotransmitter systems and plunging them into an otherworldly abyss.

Risk of Death from a 500 mg Memantine Overdose​

Memantine has a high safety margin, but a 500 mg dose is extreme, raising concerns about neurotoxicity, cardiovascular instability, and prolonged dissociation. While death is unlikely in a healthy individual, there are several risk factors that could increase the lethality of such a dose.

---

1. Lethal Dose (LD50) & Toxicity Threshold​

• LD50 (Lethal Dose for 50% of Subjects):
  • Animal studies suggest LD50 in rats is 170 mg/kg orally, which would equate to ~12 g for a 70 kg human—much higher than 500 mg.
  • Human toxicity data is limited, but clinical overdoses well above 500 mg have been survived.
• Published Overdoses & Survival Cases:
  • A case of 2,000 mg (~2g) of memantine ingestion was reported with no fatality—the patient experienced prolonged dissociation, agitation, and tachycardia but recovered.
  • Another case with over 1,000 mg resulted in severe neuropsychiatric effects but was not fatal.

---

2. Primary Risks of 500 mg Memantine Overdose​

While not directly lethal, this dose carries significant risks:

A. Neurological Toxicity & Status Dissociativus​

• Prolonged Dissociation: Similar to high-dose ketamine or PCP, leading to delirium, agitation, or catatonia.
• Severe Amnesia & Confusion: The subject might forget where they are, leading to dangerous behavior.
• Seizure Risk: NMDA blockade can lower seizure threshold, especially in predisposed individuals.

B. Cardiovascular Complications​

• Hypertension & Tachycardia: A massive increase in blood pressure (BP) and heart rate could cause a stroke, hypertensive crisis, or cardiac arrest in someone with pre-existing conditions.
• Arrhythmias: Due to dopamine and catecholamine dysregulation, which can lead to ventricular arrhythmias.

C. Respiratory Depression (Minimal Direct Risk)​

• Unlike opioids or sedatives, memantine does not cause significant respiratory depression.
• However, if combined with other depressants (e.g., alcohol, benzodiazepines, opioids), respiratory suppression could occur.

D. Behavioral & Environmental Dangers​

• Psychotic or Violent Outbursts: A high-dose dissociative state can cause paranoia or aggression, leading to accidental self-harm or dangerous actions.
• Accidental Injury: Due to ataxia (loss of coordination), confusion, and hallucinations, the individual could walk into traffic, fall from a height, or drown.
• Aspiration Risk: If the person vomits while unconscious, aspiration pneumonia or asphyxiation could occur.

---

3. Fatality Risk in a Healthy Individual​

For a young, healthy man, death is unlikely at 500 mg, but the following could increase the risk:
Pre-existing cardiovascular disease → Can cause stroke or heart failure.
Seizure disorders → Can trigger convulsions leading to complications.
Other drug interactions (alcohol, opioids, benzos) → Could lead to respiratory arrest.
Accidents or reckless behavior → Death from external hazards (falling, drowning, traffic accidents, etc.).

---

Conclusion: Low Lethality, But High Risk of Severe Effects​

• Direct fatality risk from 500 mg alone is low, but serious complications (hypertensive crisis, seizures, psychosis) are possible.
• Death is more likely indirectly, through self-injury, accidents, or interaction with other substances.
• If someone were to survive the acute dissociation, they might face days to weeks of cognitive dysfunction due to memantine's long half-life.

emantine, an NMDA receptor antagonist primarily used to treat Alzheimer's disease, is generally well-tolerated at therapeutic doses.owever, instances of overdose have been documented, providing insight into its potential toxic effects.Below are summaries of notable case reports:​

Case 1: 86-Year-Old Man with Mild Dementia

• Patient Profile: n 86-year-old man with mild dementia and hypertension.
• Overdose Details: he patient inadvertently consumed approximately 60 memantine pills, significantly exceeding the prescribed dose.
• Symptoms:
  • brupt onset of altered mental status. - uditory hallucinations. - cholalia (repetition of words and phrases spoken by others). - ypertensive urgency (blood pressure recorded at 197/79 mmHg).
• Management and Outcome:
  • nitiation of a nicardipine drip to manage elevated blood pressure. - dministration of intravenous midazolam to facilitate imaging procedures. - upportive care measures. - ymptoms resolved within 100 hours, aligning with memantine's half-life.
• Conclusion: his case underscores the importance of thorough medication reconciliation, especially in patients with cognitive impairments, to prevent accidental overdoses.otably, this is the first reported instance of memantine overdose presenting with echolalia.citeturn0search0

---

Case 2: 70-Year-Old Woman with Alzheimer's Disease

• Patient Profile: 70-year-old woman diagnosed with Alzheimer's disease.
• Overdose Details: he patient ingested 2,000 mg of memantine in a suicide attempt.
• Symptoms:
  • omatose state upon presentation. - ystagmus (involuntary eye movement). - ydriasis (dilated pupils). - iplopia (double vision). - isorientation. - achycardia (elevated heart rate). - ypertension.
• Management and Outcome:
  • upportive care in an intensive care setting. - radual improvement in consciousness and vital signs over several days. - ull recovery without long-term sequelae.
• Conclusion: espite the substantial overdose, the patient survived with appropriate supportive care, highlighting memantine's relatively low lethality even at high doses.citeturn0search0

---

Case 3: 65-Year-Old Man with Neuropathic Pain

• Patient Profile: 65-year-old man being treated for neuropathic pain.
• Overdose Details: he patient consumed 400 mg of memantine acutely.
• Symptoms:
  • gitation. - isual hallucinations. - sychosis-like behavior. - omnolence (drowsiness).
• Management and Outcome:
  • dministration of antipsychotic medication to manage agitation and hallucinations. - ontinuous monitoring of neurological status. - ymptoms resolved over 48 hours with supportive care.
• Conclusion: his case illustrates that even moderate overdoses can lead to significant neuropsychiatric symptoms, necessitating close monitoring and symptomatic treatment.citeturn0search0

---

Case 4: 60-Year-Old Woman with Chronic Pain

• Patient Profile: 60-year-old woman managing chronic pain.
• Overdose Details: he patient ingested between 105 to 200 mg of memantine daily over three days.
• Symptoms:
  • roconvulsive state (increased susceptibility to seizures). - yspepsia (indigestion). - eneralized weakness.
• Management and Outcome:
  • iscontinuation of memantine. - upportive care, including hydration and monitoring of seizure activity. - radual resolution of symptoms over several days.
• Conclusion: his case highlights the potential for memantine to lower the seizure threshold, especially when taken in supra-therapeutic doses over consecutive days.citeturn0search0

---

Summary of Reported Symptoms in Memantine Overdose Cases:

• Neurological:
  • onfusion. - rowsiness. - omnolence. - ertigo. - gitation. - ggression. - allucinations. - ait disturbances.
• Gastrointestinal:
  • omiting. - iarrhea.hese cases underscore the importance of cautious memantine use, particularly in populations at risk for accidental overdose, such as

I did notice increase heart rate and still have but not substantial compared to some substances, I think cardiovascular risk is overblown

 

[Asante]

Did you have "reverie" experiences, ie occasionally drifting into a closed eye daydream with vivid audio hallucinations? I get these on high doses.

 

[chris_p]

Did you have "reverie" experiences, ie occasionally drifting into a closed eye daydream with vivid audio hallucinations? I get these on high doses.

Yeah, in fact it was sometimes hard to tell if my eyes were closed or not or where I was, I would be in this strange shadowy place constantly, sound was extremely flanged and distorted and staticky, almost felt like my entire body was melting into it, very vivid pictures of people/women/structures made of kind of like an ink linework felt like i was becoming part of it, I would start seeing these holes and kind of lines and noise appearing all over the walls in repeated textures too, very unique dissociative with a bit of a sinister twist to it

 

[Asante]

with me, the reverie periods came over me with audio hallucinations fading in, i'd close my eyes and -be there- and seconds later drift out of thewm into a waking state. very reminiscents of how Mayhem With Mercy by Venom (a PCP band) enters and exits.

I wjsh Sangomas and other witchdoctors had access to this dreamtime stuff, they could store it in a dark bottle in their hut, dose it by the knifepoint and it would be good for a couple decades stored that way.

I'm a witchdoctor, a spirit medium, and it opens the gate to the spirit world without scopolamine toxicity or opium addictiveness if you are Entheogenic or otherwise a spiritworker. I essentially prefer it over psychedelics or other dissociatives.

What sinister side did you experience?

Listen to this, sounds like slipping in and out of a memantine reverie.



to me, what mescaline/peyote is to psychedelics, memantine is to dissociatives.

Relatively benevolent, full spectrum, lasts all day, not more-ish.

If it were tabletted for entheogenic purposes, a 80mg tablet you can take 1/4-2 of is ideal.

 

[chris_p]

with me, the reverie periods came over me with audio hallucinations fading in, i'd close my eyes and -be there- and seconds later drift out of thewm into a waking state. very reminiscents of how Mayhem With Mercy by Venom (a PCP band) enters and exits.

I wjsh Sangomas and other witchdoctors had access to this dreamtime stuff, they could store it in a dark bottle in their hut, dose it by the knifepoint and it would be good for a couple decades stored that way.

I'm a witchdoctor, a spirit medium, and it opens the gate to the spirit world without scopolamine toxicity or opium addictiveness if you are Entheogenic or otherwise a spiritworker. I essentially prefer it over psychedelics or other dissociatives.

What sinister side did you experience?

Listen to this, sounds like slipping in and out of a memantine reverie.



to me, what mescaline/peyote is to psychedelics, memantine is to dissociatives.

Relatively benevolent, full spectrum, lasts all day, not more-ish.

If it were tabletted for entheogenic purposes, a 80mg tablet you can take 1/4-2 of is ideal.

Many visions of strange entities made of holes and strings, they werent scary necessarily but it felt like the energy could quickly go negative luckily it was a positive experience throughout, they were much different from the kind I see on psychedelics which are hyperreal entites that are constructs of my own mind, these ones seemed more autonomous or like they existed in the real world, ha yes that windy sound is very reminscent, like the static is pulling me away from the real world, this stuff is truly amazing especially the mania promoting effects.. a high dose every 2 weeks could possibly result in significant intelligence/motivation increase, a drawback I am noticing is very large amounts of pent up energy even now, next time i will possibly get a scale to get accurate dosing, the actual dissociative experience was very strange and bizarre luckily I am used to those experiences and did not get too out of it and was still aware it was all a drug induced state, next time i might try it with some shrooms, this stuff is very cheap surprisingly (30 euro for a g) and you only need to take it very infrequently for long term effects, from my experiments I've found one of the strongest most powerful entheogens here, but yet to try pcp..

 

[deficiT]

All dissociative have that mania inducing potential, I've found the PCP based ones to be worse for that, but they can all do it.

Yeah, definitely get a scale, and use it. Potent drugs like that will cause more problems than they solve if you treat them like toys.

That's insane, I'm glad you're alright.

Have you come down yet?

 

[chris_p]

All dissociative have that mania inducing potential, I've found the PCP based ones to be worse for that, but they can all do it.

Yeah, definitely get a scale, and use it. Potent drugs like that will cause more problems than they solve if you treat them like toys.

That's insane, I'm glad you're alright.

Have you come down yet?

Still highly manic and motivated, work is very easy, strong antidepressant effects still, but this is likely a result of multiple drugs interacting at once including MAOIs I have been using, memantine has likely weaned down already quite a bit but it's hard to tell what's affecting me at the moment, feeling great though

 

[Asante]

Dude if you start to get psychotic features (paranoia, delusions, all-too-wild hallucinations) ask your doctor or the ER for 5mg of haldol for a few days. Its no shame and wouldnt be unheard of in the throes of a massive dissociative event. If the going gets rough or you are fed up, call a doctor. in any case drink plenty of non drug fluids and if you can, a level teaspoon or 3 1 gram vitamin c tablets 1-3x a day (yes i'm saying 3-9gr in one day with plenty of fluid intake, adding juice and milk) to acidify your urine to pull a lot more memantine out of your system if you get seasick or want to get out faster.

 

[ageingpartyfiend]

@chris_p please get a scale man ffs...am not only referring to this thread

you can get some quite decent mg scales for around $60 thesedays.

even if you dgaf about yourself, your trip reports for benefit of community would be much more 'scientific' (something you have said you semi-aspire to) and helpful if we knew the exact-ish doses you take in your alarming combos (and it could save your ass ofc)

 

[chris_p]

@chris_p please get a scale man ffs...am not only referring to this thread

you can get some quite decent mg scales for around $60 thesedays.

even if you dgaf about yourself, your trip reports for benefit of community would be much more 'scientific' (something you have said you semi-aspire to) and helpful if we knew the exact-ish doses you take in your alarming combos (and it could save your ass ofc)

Not gonna lie here, I'd have to fight a lot of demons to convince myself to spend $60 for a scale, but I'll write it down somewhere on my list

 

[chris_p]

Dude if you start to get psychotic features (paranoia, delusions, all-too-wild hallucinations) ask your doctor or the ER for 5mg of haldol for a few days. Its no shame and wouldnt be unheard of in the throes of a massive dissociative event. If the going gets rough or you are fed up, call a doctor. in any case drink plenty of non drug fluids and if you can, a level teaspoon or 3 1 gram vitamin c tablets 1-3x a day (yes i'm saying 3-9gr in one day with plenty of fluid intake, adding juice and milk) to acidify your urine to pull a lot more memantine out of your system if you get seasick or want to get out faster.

Yea i was quite close to psychosis or at least mania but I still held my chill throughout, I've definitely had much heavier experiences than that, I always carry xanax no matter what, does the trick every time

 

[Asante]

I hope its tapering for you, so many days of mania sounds exhausting. Try to sleep well!