Opioids Tapentadol Megathread

[silver_lining]

I have been taking Tapentadol off & on for about 2 years now. Not my favorite opiate, but a damn good one when it comes to pain. Recreational use is a bit strange, I find it best used with Soma & Valium as by itself I find it quite speedy, which is not my speed at all. I like it down slow. I guess i'm lucky i can kinda pick it up and sit it down when ever on more of a pain related basis than a recreational choice. If I just want to get high and escape I've found that Soma alone will scratch the itch and not nearly the physical dependence and addiction that benzo or Opiod use leaves me in. I guess I don't like tapentadol just enough to not want to abuse it, but enjoy it when i do? Human Strange,.

 

[silver_lining]

I have been taking Tapentadol off & on for about years now. Not my favorite opiate, but a damn good one when it comes to pain. Recreational use is a bit strange, I find it best used with Soma & Valium as by itself I find it quite speedy, which is not my speed at all. I like it down slow. I guess i'm lucky i can kinda pick it up and sit it down when ever on more of a pain related basis than a recreational choice. If I just want to get high and escape I've found that Soma alone will scratch the itch and not nearly the physical dependence and addiction that benzo use leaves me in. I guess I don't like tapentadol just enough to not want to abuse it, but enjoy it when i do? Human Strange,.

200 mg Tapentadol, 350 Soma, 20 Valium was my midnight snack a few nights ago. All at once. Lots of nods, lots of blackouts, ended up at a Casino playing Texas Hold'em and won $200 lol then nodded and was in bed. Horrible HR, sticking to Soma and Hash for a bit, maybe the occasional Benzo & a bath, that's nice.

 

[Azed]

200 mg Tapentadol, 350 Soma, 20 Valium was my midnight snack a few nights ago. All at once. Lots of nods, lots of blackouts, ended up at a Casino playing Texas Hold'em and won $200 lol then nodded and was in bed. Horrible HR, sticking to Soma and Hash for a bit, maybe the occasional Benzo & a bath, that's nice.

Man oh man. I loved the combination of tapentadol, soma, and clonazepam. I substituted the clonazepam with diazepam or bromazolam and it just wasn't as good. I normally just blackout watching YouTube videos and wake up an hour or two later confused as hell about what I'm watching haha.

 

[Rikbikboo]

Blimey. I must have a few hundred of these in 100mg from laying around the house. Literally boxes and boxes of them They don’t seem to do a thing for me. Maybe I’ll give them another go and see what’s what after reading this thread.

 

[Highbiatch]

OP: "Hi all, just acquired some Tapentadol and wondered what it was like in not therapeutic doses? Got 100mg orange tablets.

I’ve tried Tramadol for pain but replaced with this and wondered if there was any experiences with Tapentadol?"

______________________________________

Dosage Info from Psychonautwiki.org




Tapentadol has an oral bioavailability of about 32%. Tapentadol is metabolized by the Cytochrome P450 system in the liver and is excreted by the kidneys in urine as well as in feces. Unlike most opioids, tapentadol is also a norepinephrine reuptake inhibitor and also has weak serotonergic effects as well.

Tapentadol is an orally available, synthetic benzenoid that acts as an agonist for the mu-opioid receptor (MOR) and inhibits the reuptake of noradrenaline, with potential anti-nociceptive activity. Upon oral administration, tapentadol binds to the MOR which enhances MOR-mediated signaling, interferes with the sensation of pain and results in an analgesic effect. Tapentadol also inhibits the reuptake of noradrenaline, which increases the levels of noradrenaline (NA), activates the inhibitory alpha-2 receptors and results in an analgesic effect.

Tapentadol and its metabolites are excreted almost exclusively (99%) via the kidneys. Approximately 70% (55% O-glucuronide and 15% sulfate of tapentadol) is excreted in conjugated form. A total of 3% of drug was excreted in urine as unchanged drug.

- @deficiT 9/22

It is similar to tramadol in its dual mechanism of action; namely, its ability to activate the mu opioid receptor and inhibit the reuptake of norepinephrine.

Unlike tramadol, it has only weak effects on the reuptake of serotonin and is a significantly more potent opioid with no known active metabolites.

Tapentadol is not a pro-drug and therefore does not rely on metabolism to produce its therapeutic effects; this makes it a useful moderate-potency analgesic option for patients who do not respond adequately to more commonly used opioids due to genetic disposition (poor metabolizers of CYP3A4and CYP2D6), as well as providing a more consistent dosage-response range among the patient population.

The potency of tapentadol is somewhere between that of tramadol and morphine, with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects.

How do most people take it? What’s the usual ROA?

 

[Azed]

How do most people take it? What’s the usual ROA?

I've only ever done oral route. The orange tablets are all I've ever had and they are disgusting. Could not possibly imagine snorting or chewing them. Oral worked fine for me. Wouldn't recommend taking more than 400 mg at once; pharmaceutical max is around 500 mg. Would definitely start low and work your way up.


Best wishes and stay safe!

 

[Psilanaut]

There are some manufactures that even combine Carisoprodol and Tapentadol into one pill! I like to take them separately because the Carisoprodol seems to be under-dosed (especially the Pain-O-Soma brand). I would love to try Oxy, but its so damn expensive. I find Kratom and O-DSMT to be underwhelming in my opinion. I finally decided to purchase some more Tapentadol since the Flubromazepam I ordered a month or so ago appears to be bunk. Strangely enough, yesterday I took some taps after work and this morning I had no nausea when I woke up. A very welcome surprise since normally I wake up feeling sick as a dog. I'll take what I can get.


Best wishes!
Azed

Unfortunately that has resulted in deaths. I can't remember the details of the autopsy reports in this particular case. It happened in one of the Nordic countries. I do remember something about seizures leading to death but I could be wrong. One thing I do remember though is that the patient had told his docs that he had scored "Oxy" tablets from India. He gave them a sample of the tabs and their lab analysis showed it was Carisoprodol and Tapentadol (exact quantity/ratios unknown). The company that produced them is known to folks who order through our main "Indian Pharma Export" site (I can't mention the name of the site but the "company" was Royal).

 

[LucidSDreamr]

Man I take methadone for pain
Tapentadol worked a charm but at about 200 mg
I would descend into a dreamlike state; I would fall unconsciouos mid sentence
completely lose my train of thought mid gesture; more like a brain fart than a total nod; then I would come to and try to recall what the fuck I was saying, without being too obviously impaired. pretty sure I was indeed obviously impaired!
I gave up my script as I would just blow thru it in a week.
If I took enough also I felt like I was floating with no sensation of having legs; but feeling wobbly like a baby giraffe in those cases.
It really made me too fucked up even compared to hydrocodone but given that ones hard to feel as strongly being on methadone too

How much methadone were you taking for pain?

Then u took the tapentadol on top of the methadone (…did it add to the pain releif vs only methadone alone ?)

 

[lolis my thesis]

60mgs/day plus tapentadol 75mgs. I feel it as a high, better than oxy or vicodin
currently at 15mgs/no breakthru tablets on methadone

 

[LucidSDreamr]

60mgs/day plus tapentadol 75mgs. I feel it as a high, better than oxy or vicodin
currently at 15mgs/no breakthru tablets on methadone

Thanks for the feedback. What do you mean 15mgs/no? I don’t understand that last sentence regarding breakthrough pain

It’s crazy because I’m only on 10 mg of methadone per day which handles my pain well.

But the other day my pain was so bad I added 300 mg of tapentadol(rectal).

It didn’t feel like it helped a lot with the pain but it just was one trial so far and i was basically tripping balls from that 300mg dose. So the hallucinations and stress didn’t let me fee of there was much pain releif.

 

[lolis my thesis]

I was saying I gave up breakthru pain meds
Only taking 15mg/day of methadone

 

[Liminality]

Did 125mg rectally
Times are all added to the start i.e. if it says 90 mins then that is from the initial dose
At 20-30 minutes it starts kicking in
At 90 mins, warmth and comfort rising from stomach
At 2 hrs some nodding/tiredness
At 3 hrs I think it's starting to wear off

Edit: Yeah it burns a bit via rectal roa. Depends on the dose as well as to how much to dilute it.
And yeah, the duration could just be my personal tolerance.

 

[Esperighanto]

Blimey. I must have a few hundred of these in 100mg from laying around the house. Literally boxes and boxes of them They don’t seem to do a thing for me. Maybe I’ll give them another go and see what’s what after reading this thread.

I am notoriously sensitive to mu opioid agonists and 400mg of tapentadol alongside a gram of carisoprodol felt far less intense than 20mg of 7-OH alongside half a gram of carisoprodol, in my opinion. The stimulation of tapentadol is pretty fucking awesome though.

Did 125mg rectally
Times are all added to the start i.e if it says 90 mins then that is from the initial dose
At 20-30 minutes it starts kicking in
At 90 mins, warmth and comfort rising from stomach
At 2 hrs some nodding/tiredness
At 3 hrs I think it's starting to wear off

I noticed Taps (alongside Soma) lasting more like 4-6 hours total personally, but it was almost impossible to nod off of, it would however induce some slurred speech at points, especially if I was railing lines of Tizanidine or mixing it with benzos at the time). Tapentadol felt a lot better if I took it in 75-125mg doses every thirty minutes as opposed to 100-200mg every hour or two, I suspect that I may be a poor metabolizer of tapentadol personally.

On an unrelated note, while carisoprodol wasn't very impressive when combined with tapentadol, but tizanidine, promethazine and benzos (etizolam, flualprazolam, and bromonordiazepam specifically) all potentiated tapentadol significantly more for some reason. All of these are also wonderful alongside carisoprodol without any opioids, but in general I much prefer kratom leaf (2-5g at most), Hydromorphone, Oxycodone, or 7-OH-Mitragynine/Mitragynine Pseudoindoxyl/Mitragynine when compared to tapentadol though.

 

[Smyth2]

I got some a few days ago. Been taking 300mg per day of the ER formulation.

It's better than taking nothing but I did not get a strong euphoric high or any stimulant effects at this dose.

 

[Smyth2]

I took my fifth daily dose this morning on an empty stomach.

I started feeling very anxious on it as if 300mg ER was an overdose.

Not sure why this is as the other doses I have done were not this strong.

I looked in the mirror and had completely pin point pupils.

Be careful dosing on an empty stomach as it hits so much harder. It's not even a euphoric feeling just generalized anxiety.

I'm drinking some fluids now to help me excrete the dose.

 

[Esperighanto]

I took my fifth daily dose this morning on an empty stomach.

I started feeling very anxious on it as if 300mg ER was an overdose.

Not sure why this is as the other doses I have done were not this strong.

I looked in the mirror and had completely pin point pupils.

Be careful dosing on an empty stomach as it hits so much harder. It's not even a euphoric feeling just generalized anxiety.

I'm drinking some fluids now to help me excrete the dose.

I too found tapentadol to seem weak at first, until I'd been daily dosing it with carisoprodol for about 4-5 days. Maybe there's a metabolite that builds up? Idrk. I personally enjoyed the stimulation, but I also don't really get anxious ever. Highest I pushed the dose was a half gram at once after daily dosing 200mg for 3 days, and it reminded me a lot of high doses of 7-OH-Mitragynine.

 

[gletterz]

Got myself some 200mg IR’s and take bupenorpherine also so that would camel some of the high yeah?they both have a ceiling effect so which one has the dominant ceiling,

 

[SwissArmy]

I love Taps, best opiate I have had, they are like gold dust to get though. They are called " Palexia" here, 100mg slow release.

 

[silver_lining]

I love Taps, best opiate I have had, they are like gold dust to get though. They are called " Palexia" here, 100mg slow release.

Interesting you say it's like gold dust to get, I find it's the safest and easiest to obtain. They come in blister packs so it's guaranteed it is what it's supposed to be. I wish i could tell you the source, but we are not allowed to post that info. Super cheap tho, 200 pills usually comes to $65.

I didn't like them at first, would only use it occasionally for breakthrough pain rather than more oxy or hydrocodone. But now it's the only opiate i take, I ingest orally 100mg per dosing, not the slow release formula. Most days it's 2 -3 times. If I find myself taking 4 per day, i usually start the next day with 150mg dose and then only 50mg one more time during the day. I've been using them daily for the most part for 6+ months now. Definitely have become physically dependent but the side effects are very minimal compared to all other opiates, and i've tried them all.

They also go very well with my prescribed Valium, that takes all the speedy effects away and definitely gets me nodding if I accidentally re dose the valium.

Throw Soma into the mix and you got one hell of a cocktail, but this is not encouraged or advised.

Feel free to message me if you want to chat, i like tapentadol buddies

 

[Esperighanto]

Throw Soma into the mix and you got one hell of a cocktail, but this is not encouraged or advised.

Soma is the best sedative hands down imo, it mixes so well with everything. 7-OH-Mitragynine felt even better alongside it than tapentadol did honestly. I had 200 100mg doses of tapentadol in my possession as well as 200 500mg Pain-O-Somas, and I was shocked that after putting down about 50 Somas and every one of the tapentadols in ~3 weeks, there were no withdrawls at all. I'm not sure if that would apply to other people, and I was using many other drugs at the time (mostly NEP, 3-HO-PCP and 2C-B) so that may have complicated things too.

I am incredibly opioid sensitive too, but I found tapentadol to feel weaker than even morphine orally. Maybe it has to do with enzymatic quirks or something but I suspect the batch I got (from India) may have been underdosed. A quarter of a tablet would cause pupillary dilation, normal opioid sweats, etc but I could just eat them like candy and the high never really intensified, it just took longer to wear off, almost as if redosing only touched duration but left intensity alone if that makes sense. I much prefer 7-OH-Mitragynine as it's more of an "in my face" sort of high, but goddamn is tapentadol a unique drug. It found use with me as predominantly a stimulant.