Nutmeg high

[Littana]

Yeah It basically Legal Weed If you use Fresh nuts and stay within 8 ~ 25g dose range, Since It a strong eCBRI. Just like how DXM is OTC DMT friom being a SNRI + Sigma-1 agonist + D2 agonism(From NDMA blockade) assuming 300 ~ 800mg.

Nutmeg & DXM might be the few Reuptake based Psychdelic hallucinogens.

well thats a load of bollocks

 

[bigjackaal96]

well thats a load of bollocks

So It trolling to point out that Nutmeg Is a eCBRI?. I hope your not getting sore that DXM still activates 5HT2A/5HT2C & 5HT1A through SERT, People have tried DXO on It own It basically Ketamine with a strong opioid effects nothing like what DXM adds. You do realise DMT is a SNRI at moderate to very high doses.

N,N-Dimethyltryptamine - Wikipedia

en.wikipedia.org

 

[Pfafffed]

Kaleida is an exponent of the unique and pleasant effects of nutmeg oil, so there's truly something for everyone. I'll take her word for it.

 

[bigjackaal96]

Nutmeg seems to be 4 different drugs like how DXM Is 3(SNRI, Sigma-1, NMDA).

Elemicin & Eugenol - Both boost 5HT2A giving LSD effects.

Licarin-A - Blocks FAAH & MAGL which leads to very high anandamide and 2-AG levels giving weed effects.

Myristicin - Inhibits acetylcholinesterase but seem to be mostly just stimulant effects. Which backs up the Deliriant effects are from CB1 & CB2 agonism not from a indirect pathway. Could give nicotine effects If It affects N-Receptors.

 

[The Holy Quadruplty]

Nutmeg seems to be 4 different drugs like how DXM Is 3(SNRI, Sigma-1, NMDA).

Elemicin & Eugenol - Both boost 5HT2A giving LSD effects.

Licarin-A - Blocks FAAH & MAGL which leads to very high anandamide and 2-AG levels giving weed effects.

Myristicin - Inhibits acetylcholinesterase but seem to be mostly just stimulant effects. Which backs up the Deliriant effects are from CB1 & CB2 agonism not from a indirect pathway. Could give nicotine effects If It affects N-Receptors.

I've done a lot of research and it seems to be a decent GABA A, and B agonist, and positive modulator. It may not be true, but it seems like it to me. Oh yeah and opioid agonist mostly Kappa, and I'm not saying anything that I'm saying is true forsure please don't forget that. Lol

I've also heard it's like Mescaline, and MDMA which doesn't seem wrong to be at all.

Possible sigma antagonist tho?!...

I really wish I knew if it really metabolized into MMDA, or not. It does feel like Molly, or LSD as mentioned.

I've heard it metabolizes to other amphetamines especially with chocolate, and black pepper possibly?!

I'm on it right now, and never done it without opioids, benzos, 1st generation antihistamines mostly Diphenhydramine's, and Chlorpheniramine. Oh yea menthol cigarettes, and potent weed as usual too.

I m probably on anywhere from 15 to 30 grams of it with all the other stuff as usual, and been doing Nutmeg everyday for a few months now.

I love it.

 

[bigjackaal96]

I've done a lot of research and it seems to be a decent GABA A, and B agonist, and positive modulator. It may not be true, but it seems like it to me. Oh yeah and opioid agonist mostly Kappa, and I'm not saying anything that I'm saying is true forsure please don't forget that. Lol

I've also heard it's like Mescaline, and MDMA which doesn't seem wrong to be at all.

Possible sigma antagonist tho?!...

I really wish I knew if it really metabolized into MMDA, or not. It does feel like Molly, or LSD as mentioned.

I've heard it metabolizes to other amphetamines especially with chocolate, and black pepper possibly?!

I'm on it right now, and never done it without opioids, benzos, 1st generation antihistamines mostly Diphenhydramine's, and Chlorpheniramine. Oh yea menthol cigarettes, and potent weed as usual too.

I m probably on anywhere from 15 to 30 grams of it with all the other stuff as usual, and been doing Nutmeg everyday for a few months now.

I love it.

It about as dirty as a TCA antidepressent binding/sub-compound effect wise. With eCBRI being the core effect with everything else being just strong side targets. If It 5HT2A/SRI effects are 2nd strongest that alone could add delirium since Psychedelics produce psychosis that very noise drenched intoxication at high doses. Even DXM feels like this since It SNRI.

 

[painfulstate]

It works for rls

 

[Allylbenzene]

This post has some clarification on nutmegs FAAH inhibitors, anxiety-inducing sedative trimyristin fat and volatile allylbenzenes (elemicin, myristicin, safrole).

People looking for cleaner psychoactive effects prefer the essential oils or allylbenzene isolates. The mace covering tends to contain more allylbenzenes than the nutmeg seed.

There are 2 possible ways which allylbenzenes can be metabolised into nitrogen-containing metabolites (active drugs).
A controversial area still up for debate.

The reddit post mentioned above overlooks the role of allylbenzene metabolites. Nutmeg/mace oil contain zero Licarin yet can produce psychedelic/psychoactive effects under the right circumstances.

 

[Vanilla_Incense]

I know this thread is old but for anyone who sees this just don't do it. The high is shit, lasts too long and if you do too much your gonna have a bad time

 

[Allylbenzene]

To anyone interested, someone on dmt-nexus made a cleaner feeling drink based on nutmeg, "Space Booze".

oilman:

The thing is, space paste is more like really heavy oral THC than space booze. Space booze, for some reason, is different and reminds me more of a classic psychedelic at a low dose (the closest thing I can think of is shrooms). I don't have any explanation as to why I feel that way. They are both good.

A much simpler approach by downwardsfromzero:

But I've always soaked my freshly ground kernels in ethanol (70+%) for a week or more. I'd test the potency by working up in dropwise increments, then a teaspoon's worth put in coffee or something. Start early in the day, the effects last for a long time.

Using a tincture or the nutmeg/mace oil avoids the toxic, sedative & anxiogenic trimyristin and sedative FAAH inhibitors.

Mace arils have higher allylbenzene content than the inner nutneg seed.

 

[Esperighanto]

4 grams of nutmeg in matcha ice cream felt like whacked out, long lasting Benadryl. Pretty unimpressive, hit it with enough acid to not see through the fractals and it overwhelmed the nutmeg feeling dramatically.

 

[paranoid android]

4 grams of nutmeg in matcha ice cream felt like whacked out, long lasting Benadryl. Pretty unimpressive, hit it with enough acid to not see through the fractals and it overwhelmed the nutmeg feeling dramatically.

Long lasting benadryl sounds absolutly fucking horrible to me lol. Fuck nutmeg its one thing i was smart enough not to do

 

[Allylbenzene]

It helps to avoid ingesting large quantites of nutmegs sedative & anxiogenic (likely toxic) trimyristin fat and the sedative FAAH inhibitors. Hence a basic nutmeg/mace tincture or essential oil is preffered. Dose responsibly.

 

[Esperighanto]

Long lasting benadryl sounds absolutly fucking horrible to me lol. Fuck nutmeg its one thing i was smart enough not to do

Yeah I was maybe like, a month or two into having ever touched a serotonergic, had just read PiHKAL and TiHKAL and was rereading OCaaSL, just taste testing ethnobotanicals at a wild pace during that phase of my life. Benadryl is only nice in combination with DXM for me personally, counterflipping is strangely euphoric.

 

[nostarmane]

I still don't understand why nutmeg even at 7g gives me dry mouth, eyes and complete loss of ability to sweat. Cannabis does not cause that for me at all.

Licarin A is main component of nutmeg power and is a significant FAAH and MAGL inhibitor. This raises Anandamine in your brain which is an endocannabinoid. The encyme inhibition is very long lasting and probably explains the possibility of 36 hour trips.

Source: https://pubmed.ncbi.nlm.nih.gov/31595522/

Full text:

Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase - PMC

The study aimed to identify nutmeg compounds that indirectly interact with the endocannabinoid system through inhibition of the fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) enzymes. Thirteen compounds were screened for FAAH ...

pmc.ncbi.nlm.nih.gov

Anandamine inhibits alpha7 nicotinic acetylcholine receptor function (alpha7 nAChR). This is completely different to classical deliriants which antagonist muscarinic acetylcholine receptors (mAChR).

Source: https://pubmed.ncbi.nlm.nih.gov/12766252/


Anything higher than 7g or 3 teaspoons (non heaped) of nutmeg causes sensations of suddenly not knowing what happened some moment ago. Like a sudden confusion and reset feeling. The nicotinic acetylcholine receptos are important for memory function.

Low dose nutmeg at 3 g is very anxiolytic for me and does not result in any hangover or long sleep. The positive effects on mood are impressive.

 

[Esperighanto]

I still don't understand why nutmeg even at 7g gives me dry mouth, eyes and complete loss of ability to sweat.

This likely indicates something to do with cholinergic, nicotinic, muscarinic, or histamine responses but they all exist as separate components of a biochemical cascade that can be tricky to separate sometimes.

 

[nostarmane]

This likely indicates something to do with cholinergic, nicotinic, muscarinic, or histamine responses but they all exist as separate components of a biochemical cascade that can be tricky to separate sometimes.

Short term memory is definitely impacted even at low dose of 1 teaspoon nutmeg for me. But it doesn't feel like a delirium at all. Maybe something affects nicotinic acetylcholine receptors unlike classical deliriants which target muscarinic ACh receptors.

 

[Allylbenzene]

Several nutmegs volatile terpenoids are acetylcholinesterase inhibitors which increases acetylcholine.

Here's a study on the psychoactive effects of myristicin:

The pharmacologic and toxic effects of myristicin have been examined in laboratory animals in order to estimate its safety in man. Myristicin is assumed to be the principal active ingredient of nutmeg powder. In 400mg doses, myristicin produced mild cerebral stimulation in human subjects. This effect is much less than that produced by 15g of nutmeg powder, which was taken by one of the authors in order to describe its psychopharmacologic action. Removal of the volatile components of nutmeg eliminates the psychic action but not all of the side effects. It appears that myristicin does not reproduce the entire activities of whole nutmeg.

https://www.erowid.org/references/texts/show/7158docid6486

After some animal testing, 10 human subjects were given either 400mg of myristicin or a placebo. The administration was orally in capsules. Out of 10 subjects, 4 had confirmed effects from this does. 2 had doubtful but possible effects from myristicin orally. The other 4 either had placebo or no reaction. To see how this differed from actual nutmeg, one of the authors took 15g of nutmeg himself, and reports on the experience. 3 authors then take 10g of nutmeg with the volatile oils removed - they did not get hallucinogenic effects but some did get either sedation or stimulation (suggesting that the fixed oils - i.e. trimyristin - may have some effects which differ in different subjects).
This is the first study on nutmeg that I can find in the literature.
It's not a new phenomenon. According to the study, published in 1961, myristicin - and possibly all allylbenzenes - are active in only about 40% of the population if administered orally as the sole ingredient in a capsule. No wonder so many people think this is BS. Most people don't get effects orally from straight allylbenzenes. But in nutmeg, which contains about 20% trimyristin by weight as well as a lot of other compounds, it is active in almost everyone.