Misc Ritalin/methylphenidate users, experience accounts, what works for you, etc?

[JohnBoy2000]

I had a thread going on methylphenidate versus amphetamines.

After getting good perspective and trialling an amphetamine RX, I can firmly say methylphenidate works far better for me.

Releasers like amphetamine simply don't have a positive effect on me.

With that being said, ritalin, concerta, ritalin LA, and dosing;

I'd be interested to hear what works for those who use this, and what doesn't?

I'm currently using ritalin IR, which kicks well initially but that kick doesn't last. It then has about a 4 to 6 hour affect before redosing for the second half of the day is necessary.

BTW, I'm currently using it for pain and low mood brought on by said pain (dental pain, waiting for a root canal treatment or extraction).
I don't have ADHD, but fatigue, poor concentration and motivation brought on by low mood is an issue.

 

[JohnBoy2000]

I have also never tried cocaine, no interest as it has no therapeutic value for mood disorders or treating pain via oral ROA (I know it's used topically however as an anesthetic and vasoconstrictor).

 

[Dextro .45]

Ritalin (Methylphenidate) is AMAZING lol....considered in medical literature a "Classic Amphetamine" nearly identical in its MOA to Cocaine (both being Inverse Agonist at the monoamine transporters)

Ritalin-DAT>NET
Cocaine-DAT>SERT>>NET

Ritalin causes 3-4X more dopamine release over norepinephrine and is close to double the potency of Cocaine at the DAT (ED-50) Effective Dose to inhibit 50% of DAT - required to experience euphoric mood-boosting properties

Ritalin (Methylphenidate) is also rapid acting lasting 3-4h and has the most desirable safety profile cardiovascular speaking ....very little stress on HR & BP

I take 50mg XR capsules and IR formulation......taken with a meal it enhances/speeds absorption (oral bioavailability) and co-ingestion with Ethanol increases d-MPH (Focalin) by 40% enhancing its euphoric properties in all study participants in a medical journal study I read. Its a very effective dopaminergic stimulant with excellent safety profile.

....a little uncommon to be scripted Ritalin for dental work....they inject a numbing agent into gums and you can't feel your face for 7 hours.....then maybe, MAYBE .....TEC's (Oxycodone 5mg / Acetaminophen 325) but now weak ass T3's ohhhh 30mg of Codiene lmao. Me and my brother both had wisdom teeth removed age 15 and 13, both got Percs TEC 60 tablet jars lol.....wtf? Before the Sackler family fucked Oxycodone for the entire world, medical care, and REAL patients in genuine pain who require an effective Opioid analgesic with a set of balls......Oxycodone's only fault is its capabilities to reliably induce profound euphoric bliss.

Oxycodone (Eukadol) original German patent pre WWII stated its narcotic like euphoric properties...unlike the sleep inducing Morphine, Dilaudid, etc......Oxycodone is actually uplifting, energizing, Significantly Euphoric, and a VERY effective & potent Opioid analgesic painkiller .....Best ever. Excellent oral bioavailability and speed of onset / duration of action.

....Dilaudid & Diamorphine (super potent & rapid acting) only IV/IM/SC injection.....oral Methadone also invaluable as a long acting, potent Opioid analgesic with great oral bioavailability.

The only 2 drugs to ever give me true euphoria were oral Oxycodone & Ritalin (Methylphenidate) significant mood-boosting properties and pleasurable euphoria

 

[emkee_reinvented]

My opinion is bit the opposit. It does have the resemblence with Coke.
Definetly not like Amphetamines. So same goes for the HR an BP.

Both get raised a lot more by MPH then Amphetamine. YMMV.
Now is that no longer a med since they discovered the d-isomere had less side-effects.
And ime causes no Euphoria, maybe you need the levo for that.
Your dr. obliged to check anyway as thats protocol when prescribing stims.
Not that all do it, but they should.

MPH is imo trash, kiddie-Coke. Irredic kinetics, a 5 mg dose felt like a hearth attack.
And 2 hours later gone, and the if you don t keep redosing. The rebound, irritating to others.
You probably won t notice, maybe only ADHD-ers get em but only on MPH.

It stressed my hearth/ cardiovascular system and affected my appetite, big time.
And then there was a long list of side effects, btw i can sleep fine on dextro-Amphetamine.
That should be first line treatment, but isn t poor kids.

Co-ingestion with Ethanol forms l-MPH no the desired d-MPH, which is brought on the market.
For the same reason as dextro-Amphetamine. Less side effects.
So if you like the side effects then Ethanol is a good tool.

And Opiods for normal wisdom teeth removal is just saying to young people:
"You are a Pussy" no-one gets Opioids for dental work, they are not that eager for addicts.
That it outweighs profits.

 

[Dextro .45]

My opinion is bit the opposit. It does have the resemblence with Coke.
Definetly not like Amphetamines. So same goes for the HR an BP.

Both get raised a lot more by MPH then Amphetamine. YMMV.
Now is that no longer a med since they discovered the d-isomere had less side-effects.
And ime causes no Euphoria, maybe you need the levo for that.
Your dr. obliged to check anyway as thats protocol when prescribing stims.
Not that all do it, but they should.

MPH is imo trash, kiddie-Coke. Irredic kinetics, a 5 mg dose felt like a hearth attack.
And 2 hours later gone, and the if you don t keep redosing. The rebound, irritating to others.
You probably won t notice, maybe only ADHD-ers get em but only on MPH.

It stressed my hearth/ cardiovascular system and affected my appetite, big time.
And then there was a long list of side effects, btw i can sleep fine on dextro-Amphetamine.
That should be first line treatment, but isn t poor kids.

Co-ingestion with Ethanol forms l-MPH no the desired d-MPH, which is brought on the market.
For the same reason as dextro-Amphetamine. Less side effects.
So if you like the side effects then Ethanol is a good tool.

And Opiods for normal wisdom teeth removal is just saying to young people:
"You are a Pussy" no-one gets Opioids for dental work, they are not that eager for addicts.
That it outweighs profits.

Ethanol with Methylphenidate forms the inactive metabolite Ritalinic Acid and l-Ethylphenidate (NOT d-Ethylphenidate, which is just as active & euphoric as Methylphenidate at inhibiting the DAT)

Ritalin is 50% dextro-threo-Methylphenidate & 50% levo-threo-Methylphenidate.

Focalin is 100% dextro-threo-Methylphenidate (the only isomer out of the possible 4 that has binding affinity to the DAT/NET) its often stated Focalin is an example of an "over engenered drug"

Ritalin (Methylphenidate) is perfectly fine as it is......

Are you sure this was Ritalin 5mg ? ....as this dose is well tolerated in small children. CIBA Pharmaceuticals marketed Ritalin in the 50/60's as a safer, mild stimulant chemically unrelated to the Amphetamines (Google vintage Ritalin ads)

....all genuine Pharmaceutical dopaminergic stimulant meds from 1920/1950's to present time. Desoxyn 5mg tablets (d-Meth) still available in the US

Cocaine (illicit)
Ritalin (Methylphenidate)
Phenmetrazine (Preludin)
Benzedrine (racemic Amphetamine)
Dexedrine (d-Amphetamine)
Methedrine/Desoxyn (d-Methamphetamine)
Biphetamine (now Adderall)
Dexamyl & Desbutal (Amph/Meth + Barbiturate)
Vyvanse (Lisdexamfetamine) pro-drug to d-Amph
Benzphetamine (Didrex) pro-drug to d-Meth then d-Amph

Ritalin (Methylphenidate) is easily the safest most prescribed dopaminergic stimulant, in appropriate low therapeutic doses.

Both Phenmetrazine & Methylphenidate were highly abused compounds when pharmaceutical pure API compounding powder was available in the 70's before Phenmetrazine (Preludin) was voluntarily removed from the market due to concerns over its high abuse potential

 

[emkee_reinvented]

Ethanol with Methylphenidate forms the inactive metabolite Ritalinic Acid and l-Ethylphenidate (NOT d-Ethylphenidate, which is just as active & euphoric as Methylphenidate at inhibiting the DAT)

Ritalin is 50% dextro-threo-Methylphenidate & 50% levo-threo-Methylphenidate.

Focalin is 100% dextro-threo-Methylphenidate (the only isomer out of the possible 4 that has binding affinity to the DAT/NET) its often stated Focalin is an example of an "over engenered drug"

Ritalin (Methylphenidate) is perfectly fine as it is......

Are you sure this was Ritalin 5mg ? ....as this dose is well tolerated in small children. CIBA Pharmaceuticals marketed Ritalin in the 50/60's as a safer, mild stimulant chemically unrelated to the Amphetamines (Google vintage Ritalin ads)

....all genuine Pharmaceutical dopaminergic stimulant meds from 1920/1950's to present time. Desoxyn 5mg tablets (d-Meth) still available in the US

Cocaine (illicit)
Ritalin (Methylphenidate)
Phenmetrazine (Preludin)
Benzedrine (racemic Amphetamine)
Dexedrine (d-Amphetamine)
Methedrine/Desoxyn (d-Methamphetamine)
Biphetamine (now Adderall)
Dexamyl & Desbutal (Amph/Meth + Barbiturate)
Vyvanse (Lisdexamfetamine) pro-drug to d-Amph
Benzphetamine (Didrex) pro-drug to d-Meth then d-Amph

Ritalin (Methylphenidate) is easily the safest most prescribed dopaminergic stimulant, in appropriate low therapeutic doses.

Both Phenmetrazine & Methylphenidate were highly abused compounds when pharmaceutical pure API compounding powder was available in the 70's before Phenmetrazine (Preludin) was voluntarily removed from the market due to concerns over its high abuse potential

"Co-ingestion with Ethanol forms l-MPH not the desired d-MPH" wow quoted my own.
And yes my kinetics of MPH where extreme, so that made it basicly unuseful besides as drug.

And you "co-ingestion with Ethanol increases d-MPH (Focalin) by 40% enhancing its euphoric properties in all study participants in a medical journal study I read".

Am i missing something or you

According to some psychiatrists dextro-Amphetamine should be 1st-line treatment,
MPH 2-nd line, as it has so many disadvantages and side effects.

Btw took AminoPropanIndane [API] and its nothing to wright home about,
same for 5-AminoPropanIndole [5-IT]
But 3-Fluoro-Phenmetrazine and 2-Fluoro-Amphetamine are nice functional stims.

And Dex-Amyl & Des-Butal still available in the US,
Yeah got it your kidding. Available but never prescribed ?


"Are you sure this was Ritalin 5mg ? ....as this dose is well tolerated in small children."
Says who the kid s parents or the experts as only the first one counts.
And getting a answer out a kid they will say whatever you want em to say.

And no they come in 10 mg pills which i halved, though the ADHD corps took this very personal.
Taking a lower dose then prescribed, walking bumholes.

 

[Dextro .45]

Doctors usually use Methylphenidate as first line treatment.....then Amphetamines if not sufficient, usually lowdose mixed salts or Vyvanse now....but because it's considered more mild/gentle, Methylphenidate is first line

Is your Doctor telling you all this? No offense to doctors, but they're like car mechanics. Some know their craft like a professional, others have biases or only use one of few forms of treatment that they're comfortable with

And when Alcohol is taken with Ritalin its l-Ethylphenidate that's formed by the liver, which has very little activity at the DAT..... it's d-Ethylphenidate which is active like Ritalin. It was a popular RC phenidate stimulant on the market for years before the ban

Ethylphenidate
Isopropylphenidate
4-Fluoro Methylphenidate

If you ever research something online try to use posted studies in medical journals and other pharmaceutical/pharmacological research papers / studies etc.

Sometimes doctors don't have the precise correct information.....believe it or not. Scary but true

 

[paltatomate]

Is your Doctor telling you all this? No offense to doctors, but they're like car mechanics. Some know their craft like a professional, others have biases or only use one of few forms of treatment that they're comfortable with

this is so true.
some tell you what's wrong without even taking a look or listening to what the customer/patient has to say about symtoms. it's like they have a predefined set of stuff they need to sell/prescribe and then twist a case in a way they can use that one solution they want/need to apply.

it's always good to inform oneself about a medication, especially when it's something that you can't just drop after a certain time of use.

 

[Lauren1978]

I had a thread going on methylphenidate versus amphetamines.

After getting good perspective and trialling an amphetamine RX, I can firmly say methylphenidate works far better for me.

Releasers like amphetamine simply don't have a positive effect on me.

With that being said, ritalin, concerta, ritalin LA, and dosing;

I'd be interested to hear what works for those who use this, and what doesn't?

I'm currently using ritalin IR, which kicks well initially but that kick doesn't last. It then has about a 4 to 6 hour affect before redosing for the second half of the day is necessary.

BTW, I'm currently using it for pain and low mood brought on by said pain (dental pain, waiting for a root canal treatment or extraction).
I don't have ADHD, but fatigue, poor concentration and motivation brought on by low mood is an issue.

I get that. I do have adult ADD, and Adderall works best for me, but it was impossible to get in the EU when I lived there. So I had Concerta, which was "good enough" but not the same.
I think Adderall was better for me, (for ADD itself, and for mood and energy and yes, for chronic pain as well.) But also because there were 2 doses with Adderall (the am and the pm). If I wasn't working late on a given day, I didn't take the 2nd dose. So in the long run, I took less Adderall. I'm now working and living in a state where it's literally easier to buy a gun than to get Adderall, even if you've been on it for years.
So I take methyphenidate ER, as there's no choice. It is better than buproprion and it's better than nothing. I just don't know if breaking it up in half would help, but that's my situation.

 

[Lauren1978]

Ritalin (Methylphenidate) is AMAZING lol....considered in medical literature a "Classic Amphetamine" nearly identical in its MOA to Cocaine (both being Inverse Agonist at the monoamine transporters)

Ritalin-DAT>NET
Cocaine-DAT>SERT>>NET

Ritalin causes 3-4X more dopamine release over norepinephrine and is close to double the potency of Cocaine at the DAT (ED-50) Effective Dose to inhibit 50% of DAT - required to experience euphoric mood-boosting properties

Ritalin (Methylphenidate) is also rapid acting lasting 3-4h and has the most desirable safety profile cardiovascular speaking ....very little stress on HR & BP

I take 50mg XR capsules and IR formulation......taken with a meal it enhances/speeds absorption (oral bioavailability) and co-ingestion with Ethanol increases d-MPH (Focalin) by 40% enhancing its euphoric properties in all study participants in a medical journal study I read. Its a very effective dopaminergic stimulant with excellent safety profile.

....a little uncommon to be scripted Ritalin for dental work....they inject a numbing agent into gums and you can't feel your face for 7 hours.....then maybe, MAYBE .....TEC's (Oxycodone 5mg / Acetaminophen 325) but now weak ass T3's ohhhh 30mg of Codiene lmao. Me and my brother both had wisdom teeth removed age 15 and 13, both got Percs TEC 60 tablet jars lol.....wtf? Before the Sackler family fucked Oxycodone for the entire world, medical care, and REAL patients in genuine pain who require an effective Opioid analgesic with a set of balls......Oxycodone's only fault is its capabilities to reliably induce profound euphoric bliss.

Oxycodone (Eukadol) original German patent pre WWII stated its narcotic like euphoric properties...unlike the sleep inducing Morphine, Dilaudid, etc......Oxycodone is actually uplifting, energizing, Significantly Euphoric, and a VERY effective & potent Opioid analgesic painkiller .....Best ever. Excellent oral bioavailability and speed of onset / duration of action.

....Dilaudid & Diamorphine (super potent & rapid acting) only IV/IM/SC injection.....oral Methadone also invaluable as a long acting, potent Opioid analgesic with great oral bioavailability.

The only 2 drugs to ever give me true euphoria were oral Oxycodone & Ritalin (Methylphenidate) significant mood-boosting properties and pleasurable euphori

My opinion is bit the opposit. It does have the resemblence with Coke.
Definetly not like Amphetamines. So same goes for the HR an BP.

Both get raised a lot more by MPH then Amphetamine. YMMV.
Now is that no longer a med since they discovered the d-isomere had less side-effects.
And ime causes no Euphoria, maybe you need the levo for that.
Your dr. obliged to check anyway as thats protocol when prescribing stims.
Not that all do it, but they should.

MPH is imo trash, kiddie-Coke. Irredic kinetics, a 5 mg dose felt like a hearth attack.
And 2 hours later gone, and the if you don t keep redosing. The rebound, irritating to others.
You probably won t notice, maybe only ADHD-ers get em but only on MPH.

It stressed my hearth/ cardiovascular system and affected my appetite, big time.
And then there was a long list of side effects, btw i can sleep fine on dextro-Amphetamine.
That should be first line treatment, but isn t poor kids.

Co-ingestion with Ethanol forms l-MPH no the desired d-MPH, which is brought on the market.
For the same reason as dextro-Amphetamine. Less side effects.
So if you like the side effects then Ethanol is a good tool.

And Opiods for normal wisdom teeth removal is just saying to young people:
"You are a Pussy" no-one gets Opioids for dental work, they are not that eager for addicts.
That it outweighs profits.

well, I DREAD dental work. All drug talk aside, I can honestly say opiods were justified most of the time. I once had a dental implant in Europe and was numbed up pretty well. I got NO RX for pain, just antibiotics. A few hours later, the side of my face and jaw swelled and ached a lot. I got some OTC codeine and added that to OTC Toradol, which helped. But percocet would have been much more effective with fewer side effects. Just my .02

 

[JohnBoy2000]

Just revisiting this.

When I dosed ritalin 20 mg with even the smallest dose of mirtazapine at night, it's affect was very noticeable.

I was using mirtazapine to induce sleep through dental pain, which I've now discontinued.

So I upped to ritalin dose to 30 mg......... then 40 mg.

First it takes up to 2 hours to experience the full effect; when used with mirtazapine, full effect was felt within 1 hour.

I'm about 85 kgs, adult male, so I'm trying to figure out what dose of ritalin I would need when dosed in monotherapy, to get the same effect I did when dosing it with mirtazapine.

Maybe a trial and error process is necessary, I understand that max adult dose is 80 mg?

But in a single dose, any thoughts on the quantity necessary for a solid mood/energy boosting effect in an adult my weight?

Could up to 80 mg be required?