Pharmacology Latuda - how does it

[Juicewrldfan]

How does Latuda treat bipolar depression pharmacologically? I know it’s full dopamine antagonist but that’s about it nd it doesn’t sound like I want to take it. I have been taking lithium and understand that drug but this ones new to me.

I guess I just don’t understand on how blocking my dopamine and serotonin is going to improve my depression. She said it’s like vraylar which she wanted to give me first but I told her I got I think manic in vraylar and very aggressive which isn’t like me and I fear that experience again. So she gave me this and said they act very similarly.

Can anyone please help me understand how Latuda works? For BD depression.

 

[kiely]

Oh. Your'e trying so hard to get through this all. Me too.

But I l am cutting back a lot also.

Always.

 

[deficiT]

How does Latuda treat bipolar depression pharmacologically? I know it’s full dopamine antagonist but that’s about it nd it doesn’t sound like I want to take it. I have been taking lithium and understand that drug but this ones new to me.

I guess I just don’t understand on how blocking my dopamine and serotonin is going to improve my depression. She said it’s like vraylar which she wanted to give me first but I told her I got I think manic in vraylar and very aggressive which isn’t like me and I fear that experience again. So she gave me this and said they act very similarly.

Can anyone please help me understand how Latuda works? For BD depression.

Never taken it before so can't say, but just from briefly reading up about it again, its an atypical antipsychotic like risperidone or quetiapine. The difference from those being that it has none of the antihistamine and anticholinergic activity. So id think that would lessen the side effects, but basically all of those drugs can be hard to deal with physically and mentally. Pretty much all of the antipsychotics are dopamine antagonists, and this one is the same in that sense.

Im not a doctor but if youre doing well on lithium I wouldn't bother adding that. Might create more problems than it solves

 

[paranoid android]

Never taken it before so can't say, but just from briefly reading up about it again, its an atypical antipsychotic like risperidone or quetiapine. The difference from those being that it has none of the antihistamine and anticholinergic activity. So id think that would lessen the side effects, but basically all of those drugs can be hard to deal with physically and mentally. Pretty much all of the antipsychotics are dopamine antagonists, and this one is the same in that sense.

Im not a doctor but if youre doing well on lithium I wouldn't bother adding that. Might create more problems than it solves

I have taken latuda and it sucks balls. It gave me horrible akathisia. It also gave my mom akathisia when she took it. So ya fuck that shit i take zyprexa now.

I would just stay on the lithium its been used to treat bipolar for like almost a century

 

[deficiT]

I have taken latuda and it sucks balls. It gave me horrible akathisia. It also gave my mom akathisia when she took it. So ya fuck that shit i take zyprexa now.

I would just stay on the lithium its been used to treat bipolar for like almost a century

Yeah im honestly just gonna give up on ever thinking I can treat bipolar and deal with my annoying mind and personality. Ive tried all of it and they all just cause me massive problems and also just make me more depressed than ever.

 

[Juicewrldfan]

Never taken it before so can't say, but just from briefly reading up about it again, its an atypical antipsychotic like risperidone or quetiapine. The difference from those being that it has none of the antihistamine and anticholinergic activity. So id think that would lessen the side effects, but basically all of those drugs can be hard to deal with physically and mentally. Pretty much all of the antipsychotics are dopamine antagonists, and this one is the same in that sense.

Im not a doctor but if youre doing well on lithium I wouldn't bother adding that. Might create more problems than it solves

I have been hesitant to add another medication and I despise APs as a whole mainly as far as side effects. Just dirty drugs and yet I am somewhat desperate so am thinking about giving it a try. I am just desperate to stay stable and when I start feeling so depressed and for no reason I mean I was literally just blessed with a high tier leadership position at a 30b dollar company and usually that’s why I’m depressed is being out of work but I’m not anymore so it is definitely not situational. I digress—when I start feeling depressed I either can’t stop thinking about suicide and then the idea to abuse stimulants comes to mind and I get cravings. That’s the last thing I need is stimulants.

So yes, I am concerned about the risk of diabetes and cholesterol mainly. And the risk of tardive dyskinesia scares the shit out of me but I’m really trying to have a better life. I don’t want to go back to the cycles of binges on stimulants. I guess binging on stimulants is more of a health risk than the side effects of latuda, right?

I will add and say I was reading up on it some more and apparently Latuda increases serotonin synthesis so maybe that’s how it helps BD depression?

 

[Juicewrldfan]

I have taken latuda and it sucks balls. It gave me horrible akathisia. It also gave my mom akathisia when she took it. So ya fuck that shit i take zyprexa now.

I would just stay on the lithium its been used to treat bipolar for like almost a century

Yeah wild how meds affect us all so differently. The first and last time I took Zyprexa i was inpatient at the hospital for alcohol withdrawal but I was faking that to get benzodiazepines. Well the shirt of the story is that the nurse that I had knew me. I mean I partied with her before knew me and told the doctor i had bipolar disorder that I didn’t volunteer and apparently they put me on zyprexa. See I was taking kethadone and then faking alcohol withdrawal to mix benzos with it and well the dr didn’t know so they almost killed me so I was intubated and unconscious when they medicated me with Zyprexa and i hallucinated I was in the morgue dead for two weeks in the basement of the hospital. The entire time it was one big nightmare with no reprieve until they finally took me off the stores and I came out of it with a feeding tube in me and all. Apparently I aspirated and got pneumonia while in their care.

 

[MedicinalUser247]

Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl) piperazin-1-ylmethyl]-cyclohexylmethyl}-hexahydro-4,7-methano-2Hisoindole-1,3-dione hydrochloride]. Lurasidone is an azapirone derivative and acts as an antagonist of the dopamine D2 and D3 receptors, and the serotonin 5-HT2A and 5-HT7 receptors, and the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor. It has moderate-affinity antagonism at α2C-adrenergic receptors; low to very low-affinity antagonism at α1A-adrenergic α2A-adrenergic receptors. I got that information off Wikipedia. In my opinion I wouldn't take the stuff and I would take a different Antipsychotic.

 

[Juicewrldfan]

Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl) piperazin-1-ylmethyl]-cyclohexylmethyl}-hexahydro-4,7-methano-2Hisoindole-1,3-dione hydrochloride]. Lurasidone is an azapirone derivative and acts as an antagonist of the dopamine D2 and D3 receptors, and the serotonin 5-HT2A and 5-HT7 receptors, and the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor. It has moderate-affinity antagonism at α2C-adrenergic receptors; low to very low-affinity antagonism at α1A-adrenergic α2A-adrenergic receptors. I got that information off Wikipedia. In my opinion I wouldn't take the stuff and I would take a different Antipsychotic.

What makes this one different than the others as far as why one wouldn’t want to take it? I am just curious. I took sequel but it’s the worst one I’ve had imo. I liked vraylar but it made me manic and she won’t prescribe abilify because she says it’s not approved by the fda for bipolar depression who is stupid to me…sigh idk what to do. I can’t take Zyprexa because I hallucinate from it.

 

[MedicinalUser247]

I would suggest Chlorpromazine or Clozapine. Although Clozapine is structurally related to Olanzapine.

 

[Juicewrldfan]

I would suggest Chlorpromazine or Clozapine. Although Clozapine is structurally related to Olanzapine.

May I ask why you recommend those two verses Latuda? Is the first one Thorazine? The second one I never heard of until now and while I am intrigued by its pharmacology it appears to have several lethal side effect possibilities which I guess is why it’s not a first line treatment?

 

[MedicinalUser247]

I've used many Antipsychotics which include both Chlorpromazine an Clozapine. Clozapine works the best, but it's a pain in the ass dealing with all the blood tests you need to get done when you take it. And if you don't get your blood tests done the Pharmacy won't give the medication to you so your always ending up going on and off of it. I had to switch to Chlorpromazine because it's an Antipsychotic I can constantly stay on. Out of all the Neuroleptic Antipsychotics it rarely has any Extrapyramidal side effects. Unlike Haldol which has a bunch of Extrapyramidal side effects.

 

[paranoid android]

I've used many Antipsychotics which include both Chlorpromazine an Clozapine. Clozapine works the best, but it's a pain in the ass dealing with all the blood tests you need to get done when you take it. And if you don't get your blood tests done the Pharmacy won't give the medication to you so your always ending up going on and off of it. I had to switch to Chlorpromazine because it's an Antipsychotic I can constantly stay on. Out of all the Neuroleptic Antipsychotics it rarely has any Extrapyramidal side effects. Unlike Haldol which has a bunch of Extrapyramidal side effects.

I took thorazine a few times with morphine for severe pain and nausea and it worked great. Also added to the nod alot. It doesent really feel like a antipsychotic it feels more like promethazine

 

[MedicinalUser247]

I took thorazine a few times with morphine for severe pain and nausea and it worked great. Also added to the nod alot. It doesent really feel like a antipsychotic it feels more like promethazine

Yet, Chlorpromazine has a much more potent Antipsychotic effect than that of Quetiapine or Olanzapine.

 

[Smyth2]

For me, 200mg chlorpromazine is usually enough to take in the evening.

On the quetiapine I was using 300mg per evening but getting very long 12 hour sleep cycles.

However, the current medicine I am using is highest dose paliperidone depot injections.

 

[MedicinalUser247]

For me, 200mg chlorpromazine is usually enough to take in the evening.

On the quetiapine I was using 300mg per evening but getting very long 12 hour sleep cycles.

However, the current medicine I am using is highest dose paliperidone depot injections.

I would not recommend using Paliperidone to use as an Antipsychotic.

Here's the thing. Doctors won't prescribe you the best thing right off the bat. So, most likely they won't prescribe you either Chlorpromazine or Clozapine first. They are most likely to prescribe new fangled crap. If your Doctor wants to prescribe some kind of new Antipsychotic medication ask about Lumateperone instead of Lurasidone.

 

[Littana]

I would not recommend using Paliperidone to use as an Antipsychotic.

Here's the thing. Doctors won't prescribe you the best thing right off the bat. So, most likely they won't prescribe you either Chlorpromazine or Clozapine first. They are most likely to prescribe new fangled crap. If your Doctor wants to prescribe some kind of new Antipsychotic medication ask about Lumateperone instead of Lurasidone.

u wouldnt but im sure theyve tried others before ending up on high dose injectable.... not really the first aid on these kinda illnesses but sometimes necessary as many people with psychosis/delusions dont take their pills and keep getting inthe revolving doors of psych. hospitals

 

[Juicewrldfan]

Man, I can’t find anyone to explain how Latuda pharmacologically improves depression in bipolar disorder. I just don’t have enough understanding of pharmacology and neurology to understand when I read it’s pharmacology. I feel like blocking serotonin and dopamine would make you depressed.

I tried on r/askpsychiatry and no one responded. I’ve tried Quora and no one can explain how it helps bipolar depression. Does anyone know the answer? Please

 

[MedicinalUser247]

@Skorpio or @someguyontheinternet more detail is needed.

 

[someguyontheinternet]

Man, I can’t find anyone to explain how Latuda pharmacologically improves depression in bipolar disorder. I just don’t have enough understanding of pharmacology and neurology to understand when I read it’s pharmacology. I feel like blocking serotonin and dopamine would make you depressed.

I tried on r/askpsychiatry and no one responded. I’ve tried Quora and no one can explain how it helps bipolar depression. Does anyone know the answer? Please
[/Q

Honestly it isn't an easy question to answer. We don't really fully understand the causes of most mental illnesses, all we know is that a drug has shown improvement in animal models so we slowly introduce it to humans and see if it works in our population of interest. Neuroscience is still working on uncovering the basics of how the brain produces our subjective experiences including emotional states so unfortunately we usually don't have a good answer yet and sadly we still may be years away without a big breakthrough in understanding neuronal information processing and brain states