Opioids Sublingual methadone

[LucidSDreamr]

Lately I’ve been crushing up methadone pills into powder, scraping under my tounge with a toothbrush until it bleeds a little l, dumping a very drops of ethanol under my touge then dunking the methadone powder under my tounge.

I think it comes on faster than oral on an empty stomach.

If I dose orally even on an empty stomach I’m waiting 2 hours for a decent effect.

With the sublingual method I think it’s faster but it tastes really nasty to leave in my mouth like that l.

Is it worth it….does it seem to work faster like this for anyone?


Rectal is great and I’ll get to where I am at a 2 hour oral dose within 45 min of rectal dose.

But wondering about others experience with sublingual methadone

 

[daturetard]

I would say that is probably much less healthy than any other route excluding injection. It's essentially a subcutaneous injection by that point as, instead of actually allowing for sublingual absorption, you're cutting yourself to allow the drug into your bloodstream.

 

[LucidSDreamr]

I would say that is probably much less healthy than any other route excluding injection. It's essentially a subcutaneous injection by that point as, instead of actually allowing for sublingual absorption, you're cutting yourself to allow the drug into your bloodstream.

Insufflation is by far the worst route I’ve tried. It has a very dusty consistency and goes into the lungs like a cloud of powder and is super caustic.

If I snort it I get sharp burning pain in my lungs for a week or two.

I can try sublingual without the cutting, I usually only do the cutting with the brush if I’m really desperate for pain relief since the drug takes so long to start working.

 

[Halif2]

I can try sublingual without the cutting,

That'd be preferable because I don't think scrubbing the sensitive inside of your mouth bloody is a sustainable practice.

it tastes really nasty to leave in my mouth like that

I fucking bet it does!! That sounds brutal, but...

I’m really desperate for pain relief

...yeah, I get it.

 

[RxVeritas]

When it comes to methadone pain pills, just try to appreciate the racemic mix, and resulting 50% of your dose being the d isomer, which is what you want. If you've ever had the juice they basically ROB YOU for it, because "you're a junkie". Also because you're a junkie, none of that often times pink liquid is racemic. I forget which company but one had a ratio of 1:32 or 1:36 D:L which means that you're likely not getting a threshold dose of the d isomer that would be necessary for the euphoria and pain-killing prowess it is known for. The juice helps keep the physical withdrawals at bay, and is still very dangerous especially when combined with alcohol or other downers, but it's a racket and it's fucked how people are treated,


and the euphoria to respiratory depression ratio is SO much better in the pain pills, they're almost like a different drug and the pills should be dosed much more conservatively.

There could be some out of date info in their, but this is just stuff off the top of my head.

I'd say just eat them and enjoy them, I cannot recommend adding any additional downers or substances, but I'm a bit jealous as those go fantastically with clonazepam. Oh well.



Cheers, friend.

 

[LucidSDreamr]

When it comes to methadone pain pills, just try to appreciate the racemic mix, and resulting 50% of your dose being the d isomer, which is what you want. If you've ever had the juice they basically ROB YOU for it, because "you're a junkie". Also because you're a junkie, none of that often times pink liquid is racemic. I forget which company but one had a ratio of 1:32 or 1:36 D:L which means that you're likely not getting a threshold dose of the d isomer that would be necessary for the euphoria and pain-killing prowess it is known for. The juice helps keep the physical withdrawals at bay, and is still very dangerous especially when combined with alcohol or other downers, but it's a racket and it's fucked how people are treated,


and the euphoria to respiratory depression ratio is SO much better in the pain pills, they're almost like a different drug and the pills should be dosed much more conservatively.

There could be some out of date info in their, but this is just stuff off the top of my head.

I'd say just eat them and enjoy them, I cannot recommend adding any additional downers or substances, but I'm a bit jealous as those go fantastically with clonazepam. Oh well.



Cheers, friend.

You just shattered my illusions of a safety net that addict methadone clinics will take me when my doctor retire (he’s old) and of course no other doctor nowdays in the US will prescribe opioids for pain.

Of the addict methadone is shittier than regular methadone for pain it’s pointless for me

 

[RxVeritas]

From my understanding different formulations will vary from anywhere from 1:6 (not positive on this one) all the way to 1:30something. It depends on the manufacturer.

But yes, sorry to break the bad news. While it will definitely keep you from withdrawing, it is  far from racemic methadone.

 

[kongoman]

From my understanding different formulations will vary from anywhere from 1:6 (not positive on this one) all the way to 1:30something. It depends on the manufacturer.

But yes, sorry to break the bad news. While it will definitely keep you from withdrawing, it is  far from racemic methadone.

Where did you find this info if I may ask?

 

[LucidSDreamr]

From my understanding different formulations will vary from anywhere from 1:6 (not positive on this one) all the way to 1:30something. It depends on the manufacturer.

But yes, sorry to break the bad news. While it will definitely keep you from withdrawing, it is  far from racemic methadone.

if you dose the bad isomer super high (like clinics do vs pain patients) would it at least make up for the absence of the good isomer somewhat?

Like my normal dose is only 10 mg of racemate. So if they give me 80 (or some high dose) of this shitty addict methadone it wouldn’t be equigesic?

 

[Dextro .45]

All Methadone here is racemic

Levo-Methadone is still prescribed in Germany and is the active isomer that has all desired mu-opioid agonist properties and non of the cardiovascular danger

Methadone 80mg
Levo-Methadone 40mg

...and btw, just take it orally with orange juice on an empty stomach lol, it has 80% oral bioavailability and other ROA's even IV injection doesn't have any significant advantages

I've had liquid Methadone and currently tablets .....same shit.

 

[LucidSDreamr]

All Methadone here is racemic

Levo-Methadone is still prescribed in Germany and is the active isomer that has all desired mu-opioid agonist properties and non of the cardiovascular danger

Methadone 80mg
Levo-Methadone 40mg

...and btw, just take it orally with orange juice on an empty stomach lol, it has 80% oral bioavailability and other ROA's even IV injection doesn't have any significant advantages

I've had liquid Methadone and currently tablets .....same shit.

Well you or the other guy @RxVeritas is wrong then if veritas was referring to America. I’m assuming you define "here”as America. Please correct if not.

Can’t drink citrus due to its acidity but I would think you would want to take oral methadone with something basic to deprotonate it more in the gut so it absorbs faster

Also you’ve got me dreaming of having a Levo methadone script.

I wish it could be chirally resolved in some super easy way like mixing with tartrate salts or something to have either isomer precipitate out of water.

 

[Dextro .45]

It's an expensive labor intensive process so they just synthasize the racemic molecule which is dirt cheap, Methadone HCL

Levo-Methadone has its advantages Because it's purely an mu-opioid agonist. Marketed in Germany still at half the dose as racemic

 

[LucidSDreamr]

It's an expensive labor intensive process so they just synthasize the racemic molecule which is dirt cheap, Methadone HCL

Levo-Methadone has its advantages Because it's purely an mu-opioid agonist. Marketed in Germany still at half the dose as racemic

No NMDA antagonism? Does that come from dextro methadone only

 

[Dextro .45]

Yes….NMDA Antagonist resides in dextro isomer . Levo has potent opioid activity only and doesn't carry any of the risks associated with high dose racemic, fucks with the heart beat electric impulse rhythm etc, and no NMDA antagonist activity

....just pure mu-receptor agonist

 

[RxVeritas]

Where did you find this info if I may ask?

This was told to me by a guy that I used to give rides to the methadone clinic. You could do an internet search for the labels of the bottles it comes in. Idk, I think he knew what he was talking about. He got 1 weeks worth of take homes (which in his state apparently requires 365 consecutive days of participation.

His dose was 140mg, he would give me one for driving him.

The best thing about it was the long half life, but so many people in my area died by mixing it with benzos and alcohol, because while you  do get euphoria, you get way more respiratory depression.



When I contrast my many, many experiences with this pink juice to the 10mg methadone hydrochloride tablets which were  much harder to come by, they were vastly different. At that point in my life I wasn't a daily opiate user, but selling weed gave me access to a lot of people, and almost any drug I could desire (there are a couple unicorns out there still...) and so it wasn't uncommon for us to get OC80s (he original ones, then later the shitty ones), Dilaudid, and a few times oxymorphone.

I usually split the dose with a friend, and had a nice day just smoking weed and adventuring/doing what people do, but would occasionally take the full dose myself. I had a prescription for 6mg clonazepam daily at the time, so with timing that correctly and some strong cannabis I could absolutely catch a long, long, but not qualitatively as good as the previously mentioned drugs, less euphoric quasi-nod state for most of the day.

With the tablets I took 40mg in the same fashion and was nodding out  hard.

It's not good to mix benzos and opiates, the increased respiratory depression may potentially kill you.

I no longer live like this. That being said, I have very fond memories of the sweet treats that were the little white 10mg tablets, whereas the pink juice was a good way to kill a day, but they are very different formulations and experiences.

 

[LucidSDreamr]

This was told to me by a guy that I used to give rides to the methadone clinic. You could do an internet search for the labels of the bottles it comes in. Idk, I think he knew what he was talking about.

I definitely need to search for this non racemic nonenantiopure bad methadone you’re talking about because it’s the first I’ve heard of it.

Any does the undesired D enantiomer have any mu agonist activity at all, it must have some. I how strong is its mu agonism relative to the opposite, good enantiomer?

 

[RxVeritas]

I definitely need to search for this non racemic nonenantiopure bad methadone you’re talking about because it’s the first I’ve heard of it.

Any does the undesired D enantiomer have any mu agonist activity at all, it must have some. I how strong is its mu agonism relative to the opposite, good enantiomer?

Could you please rephrase the question?

 

[LucidSDreamr]

Could you please rephrase the question?

Does the bad isomer have any mu opioid agonist activity at all? If so how much relative to the good isomer.

Thanks.