AngelsandFairiesarereal
Bluelighter
- Joined
- Dec 17, 2022
- Messages
- 3,727
Wow I can really relate to what you’re saying about tramadol withdrawal vs other opioids.
-
BDD Moderators: Keif’ Richards | negrogesic
Buprenorphine is more than just an opioid
- Thread starter The Holy Quadruplty
- Start date
- Status
H1 receptor antagonists that cross the blood brain barrier do the exact opposite of what you are claiming, they decrease the activity of glutamine synthetase which is an enzyme involved in the production of GABA. This means that it actually LOWERS GABA and INCREASES the seizure threshold.
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase - PubMed
Chronic H1-antihistamine treatment produces long-lasting increase in seizure susceptibility in nonepileptic rodents after drug withdrawal and its mechanism involves impairment of GS through blocking the action of histamine.
pubmed.ncbi.nlm.nih.gov
are you serious? you say you're writing a book, essentially on the pharmacology of these substances yet you don't even have a grasp of the basics? you don't know what the gamma subunit of the GABA receptor is? this must be a joke
the gamma subunit of the GABAa receptor is specific to the synaptic form of the receptor and it is essential for forming the benzodiazepine binding site
you don't have a grasp on the things you're writing about and you refuse to cite any sources besides meta AI. quite frankly your book is going to be filled with absolute nonsense, falsehoods, and misinformation and nobody will take it seriously. I think I've tried being nice about this but your continual refusal to even go over basic published research shows that you don't care about the accuracy of your information
The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
Right, likewise, but it's hallucinating effects can be very scary/overwhelming, and sometimes Xanax can't even take the negative effect away. Well I mean it can, but can take a while for the negative effects to go away.
The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
Well that's not all there's a lot more.
It's a potent dissociative
Has some anticholinergic effects
The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
Wait.. are you saying what I think you're saying?!
It's effects on the Serotonin 2a receptor are pretty strong if I'm not mistaken.
I'm about to start a Instagram account for drug information and like especially a rare drug information like stuff that most doctors don't know and things stuff like that if anybody wants to link let me know and if you guys want to post anything on it and send it to me any stories or anything like that more about information on drugs with my voice right now. LOL
emkee_reinvented
Bluelighter
Dont think an answer of Siri (the AI of iPhone) counts as scientific research. It does give weird sometimes actually good replys. Or an copied answer of an AI reply counts right. Except when there are relevant links in the reply. Dont know how wel it atm works, is it in baby/ kids faze now?
But normally that system is shut off, way to para for a AI observing me secretly through my phone.
No idea of recent developments but like was already mentioned mumble rappers on autotune was allready way over the line. Didnt qualify as music to me. So I wonder about the other wonders of AI, the music is allready proven to be so bad. They had humans cover the AI songs, and that definetly improved them.
Last edited:
@The Holy Quadruplty if we are talking about drug facts that "even doctors don't know", I can pretty much assure you that we are that. You won't find a better resource for those answers than us right here. The BL'ers that have made us what we are today did so by collecting and validating information over the course of years... decades now. I'm not sure if you've ever been over to Advanced Drug Discussion, but some of those folks are fuckin crazy. The most-knowledgeable BL'ers in that forum would look at a thread like this as 2nd or 3rd grade level stuff. I'm not putting you down. I want you to know what we have here. If you have the questions, there are people here with the answers if you look hard enough.
There are several substances out there with these similar, I guess, auxiliary qualities. These substances are first and foremost Opioids, though they have auxiliary effects which can also play a significant role in their effects. To name a few:
Tramadol - Mu Opioid agonist/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
Tapentadol - Mu Opioid agonist/Norepinephrine Reuptake Inhibitor
Methadone - Mu Opioid agonist/N-Methyl-D-Aspartate (NMDA) Antagonist
Buprenorphine - Mu Opioid partial agonist/Delta + Kappa receptor antagonist at higher dosages/NMDA antagonist
What will happen in the course of prescribed usage, is that the physician will identify that the patient needs Opioid therapy. It might be determined that one of these medications has the potential for a small "bonus" if you will to the treatment based upon that patient's specific needs. Also, these medications might be chosen without any attention paid to their auxiliary effects.
But yes, I'll definitely agree with you that Buprenorphine is a comparatively complex drug. While the Mu receptor is the straightforward, easy to understand receptor, the Kappa and Delta receptor modulate stuff other than pain sensitivity.
Buprenorphine is a drug you can spend a lot of time learning about so enjoy.
There are several substances out there with these similar, I guess, auxiliary qualities. These substances are first and foremost Opioids, though they have auxiliary effects which can also play a significant role in their effects. To name a few:
Tramadol - Mu Opioid agonist/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
Tapentadol - Mu Opioid agonist/Norepinephrine Reuptake Inhibitor
Methadone - Mu Opioid agonist/N-Methyl-D-Aspartate (NMDA) Antagonist
Buprenorphine - Mu Opioid partial agonist/Delta + Kappa receptor antagonist at higher dosages/NMDA antagonist
What will happen in the course of prescribed usage, is that the physician will identify that the patient needs Opioid therapy. It might be determined that one of these medications has the potential for a small "bonus" if you will to the treatment based upon that patient's specific needs. Also, these medications might be chosen without any attention paid to their auxiliary effects.
But yes, I'll definitely agree with you that Buprenorphine is a comparatively complex drug. While the Mu receptor is the straightforward, easy to understand receptor, the Kappa and Delta receptor modulate stuff other than pain sensitivity.
Buprenorphine is a drug you can spend a lot of time learning about so enjoy.
Yes, maybe that's the reason it's not prescribed at All where i live. Well, basically here they will give u tramadol/oxy/fentanyl...Codein was completely pushed off the market by tramadol and other opioids by oxy and fent...They wanted to create less proconvulsive tramadol which won't be prodrug instead they made slightly less proconvulsive opioid, with shorter duration and hallucinations...As if patenting o-dsmt straight from the start won't be the best they could have done. In a few years there will be o-dsmt as a medication (it has already passed that testing phases and all) but...they probably thought that putting o-dsmt on market won't suit that " non addictive snri painkiller" bullshit so they put tramadol on the market because as a prodrug, onset is longer so no rush and in low (normal 50-100mg) dose IT will only ease your pain, maybe uplift your mood and give u some energy but that's all....Now everybody knows that tram is more potent than they thought it is because for fast cyp2d6 metabolizers it can be very potent even in low dose but 300mg + and that person, who took it would be maybe even too much high. Somebody without tolerance.
Maybe creating medication containing tramadol + some almost non-psychoactive anticonvulsant (levetiracetam) or muscle relaxants with anticonvulsant properties (tizanidine etc.) would be good idea, less seizures, and if combined with muscle relaxant better pain relief.....Tramadol is actualy quite old drug...
The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
I almost/pretty much agree with you, but if say you guys would be the 2nd best with Meta AI being 1st ONLY IF YOU KNOW HOW TO GET YOUR INFO CORRECTLY FROM IT THE Right WAY. If you want to know what I mean by that lmk, and I'll tell you.
By the way everyone I'm writing a book about harm reduction, and wellb abunch of other books, projects , cartoons other similar things, and a lot more.
Pickledlemons
Bluelighter
Please don't write a book based on things an ai bot told you....
ĐmantuNJofra
Bluelighter
Still writing posts and polluting already two pages, no offense but writing buprenorphine, nmda antagonism, there will be people who like skorpio said: without benzos or similar
Just stop please posting things: like trolling, when answered couple times with sources you are stubborn, think or try maybe PerplexityAI, or Claude if you like to play but do not listen as they or those LLMs say something like medical advices should be taken to doc with them you can hypothesize
I want to know how to get info correctly from meta AI please tell me how
...I'm pretty sure the advance has already been spent anyway 
what.......?
Psycho_Logic
Bluelight Crew
- Joined
- Aug 13, 2023
- Messages
- 305
We are currently living in a world created by human hallucinations. Are we slowly crossing into world created by AI hallucinations? The world will only get weirder and if we continue this route and don't destabilise collective dream to the point of total annihilation, we will forget that once we were humans and stabilise in the new reality (which is always collective dream/halucination) in which we will be convinced that we are AI.
"Now Once upon a time, I dreamt I was a butterfly, fluttering hither and thither, to all intents and purposes a butterfly. I was conscious only of my happiness as a butterfly, unaware that I was myself. Soon I awaked, and there I was, veritably myself again. Now I do not know whether I was then a man dreaming I was a butterfly, or whether I am now a butterfly, dreaming I am a man."
-Zhuangzi
"Now Once upon a time, I dreamt I was a butterfly, fluttering hither and thither, to all intents and purposes a butterfly. I was conscious only of my happiness as a butterfly, unaware that I was myself. Soon I awaked, and there I was, veritably myself again. Now I do not know whether I was then a man dreaming I was a butterfly, or whether I am now a butterfly, dreaming I am a man."
-Zhuangzi
ageingpartyfiend
Bluelighter
- Joined
- Mar 5, 2011
- Messages
- 7,381
I don't think one can even be "97% sure", as that makes you 'unsure' by definition
The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
Subutex is more potent NMDA antagonist than DXM.
It's effects in Serotonin 2a are not too far off than LSD.
It's effects in Serotonin 2a are not too far off than LSD.
The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
We will be ok. All ONE of us.
The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
Diphenhydramine has moderate GABA B effects similar to Gabapentin, Baclofen, and others, but just a little less strongly.
- Status