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Phenethylamines 2C-B microdosing...

Didgital

Didgital

Bluelight Crew
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Jul 22, 2018
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Colorado, USA
So after many years and many experiences, I am super open to the idea of low dose 2C-B. My friend takes it to a whole nother level, and will even take 5mg before going to work. I've told him about frequent dosing with 5HT2B receptors could be bad for heart, but it is his thing, and I've started to really appreciate his POV. I take 100mg of MDMA and 5mg of 2C-B is totally enough to add sparkles and a lot of fun. I barely feel it on its at own at 5mg, but I am curious if anyone has really much to say about frequent and low dose 2C-B.

Trying to get homie to write a synopsis is difficult, but I'm working on it :D

I rarely take more than 20mg these days. 25 is more than necessary though I do look back at my higher dose 2C-B experiences with fondness. I rarely exceed 20 mg these days, though I can do 2x 15mg doses spread over 2 hours and am fine. 32mg had me back to the wall struggling to speak. Some people really only like high dose, but I can't really relate.
 
Didgital said:
I've told him about frequent dosing with 5HT2B receptors could be bad for heart
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Yes this has scared me off ever microdosing psychedelics, Ive always tried to warn people who are really into microdosing since the consequences of 5HT2B agonism over a long period of time should terrify most people tbh. That and the fact that there are so many better options for cognitive enhancement out there.


Didgital said:
I take 100mg of MDMA and 5mg of 2C-B is totally enough to add sparkles and a lot of fun
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I really like the idea of this though and something I definetly woulda tried if I still did drugs
 
Everyone's different I guess, but 5 mg would be too much for me to take as a microdose. That's enough for walking to feel a bit strange to me and for things to start to look and feel a bit eerie. I found that 2 mg HBr was enough for a kind of "one can of beer" level of intoxication. Maybe if I had some tolerance from taking it every day, I'd want a bit more. Anyway, I thought it had some very nice if subtle effects at that level like tactile enhancement / softening of touch, anxiolysis, and a bit of emotional warmth. And of course it had way better after-effects than booze in any amount.

I'm very skeptical about dosing psychedelics more often than once per week or so. It's not just about valvulopathy but about many other unknown things and also knowledge of how chronic SSRI use leads to very different results than a single dose. I would not expect frequent microdosing to have the same long-term benefits as infrequent dosing. Perhaps there are different benefits to be had, but I don't think it's for me.

I've actually been taking a lot of phens at "micro" and "low" dose levels lately on a less frequent basis, like 1-3 weeks apart (depending on dose). I was extremely cautious when I started experimenting with psychedelics again last Fall because I believed that my body, which was quite fucked up by Long COVID, was at a much greater risk for toxicity. Like many Long COVID people including myself have (or in my case, had) considerable vascular damage. To make a long story short, I discovered that using psychedelics semi-frequently alleviates my symptoms almost entirely. By semi-frequently, I mean every 1-4 weeks or so, depending on substance, dose, and circumstance.

After 9 months of regular dosage, my health and fitness have dramatically improved, and my body seems to tolerate the effects of psychedelics much better too. My last trip on cacti was probably enough to land in the low "Shulgin range" for mescaline, and it gave me 2 weeks of freedom from symptoms while I exerted myself considerably doing heavy landscape labor. In this third week, I'm starting to see signs of trouble again and am scaling back my exertion level until I can refresh (and until the coming heat wave has run its course). Mentally, I don't really need a full trip right now, but I've been working on titrating up with 2C-T-2 and will probably munch 4 mg of it soon. Then in another few weeks, near my birthday, I'm thinking about 15 mg of 2C-I for a more "thorough" refresh and because I have so many fond memories of being on 2C-I.

I intend to titrate myself up on some other psychedelics when I get around to them, and once I'm done trying the new stuff, I'll be free to just nibble on what I want. I think I'll probably continue using the micro/low doses from time to time simply because I need a bit of a therapeutic boost but don't want to go through a full head trip. It's nice to time the full trips with special occasions, which don't necessarily align with the times I need symptom relief.
 
If I didn't state it, I'm begging roommate to write up a synopsis. Even though I have 10 years of experience and I essentially introduced it to him, at this point he has probably taken it 4x more then me.
 
Esperighanto said:
Are you looking to microdose? Try 5-8mg daily for 6-ish hours of effect. Definitely volumetrically liquid dose and sip it in a drink imo for the best results.
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Thinking about it. I have fairly tempered expectations though. I've taken 2cb so many times that I feel like I'm immune to what little headspace it has to offer, but I do like the idea of being able to micro every day without tolerance issues.

Maybe alternating 2cb and acid every other day would be a fun approach, 15ug acid one day 7mg 2cb the next day rinse and repeat for a couple of weeks...

I'll make up a tincture now and start with the 2cb tomorrow. Lions Mane matcha latte with 2cb, now there's a good way to start your work day.
 
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Day 1: 7mg 2cb
Well, I'll be, low dose 2cb might actually not be a complete waste of time. Had 7 mg mixed in with a matcha latte around 8am. Felt first alerts around 8:30 and was feeling downright giddy by 10am. No visuals but definitely enhancement. I had to go to Aldi late in the morning and was struck by how bright and vibrant everything looked, items on shelves, signs hanging from the ceiling, everything just seemed to glow. Stayed in a great mood all day. Working memory still shot though.

Day 2: 15ug LSD
9:30am with a matcha latte and the usual supplements; ashwaganda, B12, multi vitamin and a mushroom complex. Sub perceptual microdosing is such a swindle but low threshold doses are 🔥. 15-25ug is always just me having a great day, everything just looks a bit nicer smells a bit nicer tastes a bit nicer. Reality +1.

Anyway, y'all know what acid feels like. Until tomorrow then.

Day 3:
10mg 2cb+0.04ml RSO
9am with my matcha It's my day off hence the slightly higher dose. I took a further 40mg of 2cb throughout the afternoon, cos uh, I could! And I didn't have any plans for the day so why not.

Day 4:
15ug LSD in the morning 40mg 2cb in the evening. I had the house to myself and felt like tripping after work. I did bumps of ketamine throughout the evening and binge watched season 1 of the boys.

Day 5:
Slept in and feeling a bit fried after staying up until 5am the night before so taking a day off. Felt a little bit irritable during the evening. Probably just tired from being up all night rather than feeling "hungover".

Day 6:
7mg 2cb in my matcha at 8am with the usual supplements. I noticed a bit of a body high around 10am but the presence of the 2cb was a bit less noticeable than on day 1. Might be a little bit of tolerance or might just be because I was feeling a bit tired and out of sorts anyway. I also skipped breakfast because I had a morning meeting I was anxious about. By late morning I wasn't feeling any effects from the 2cb but remained in a good mood all day and had my appetite back by lunchtime. Noticed a very mild headache around 8pm, may just be dehydration.

Day 7:
15ug LSD 7:30am straight on the tongue with 0.3ml of everclear. Not a palatable way to start your day. Was a bit yawny around 9:30 but by 10 I was feeling wide more awake and had those yummy lysergamide body tingles so still no significant tolerance. Nothing else worth remarking on.

Thoughts a week in? My mood has been pretty good all week, except for that one day where I had a bit of a ketamine hangover. I don't think I've been any more productive than I would have been sober, or more creative.

But I don't feel any worse! And I don't feel my heart valves hardening yet which is also awesome. Maybe some minor HPPD, mainly in the form of noticing floaters more than normal, and a bit more burn in than usual after looking away from a bright screen for a example. Nothing's that's interfered with my day, or been noticable at all really except when sitting on the toilet or waiting for the bus, ie when there's nothing else drawing my attention I guess.

I think I'm down for keeping this up for another week. Might just stick with 2cb for 7 days straight this time instead of alternating with acid.

Week 2
Day 1: 7mg 2cb 7:30am mixed with a can of lemonade. If it wasn't already implied, I'm using a solution of 2cb HBr dissolved in vodka to dose volumetrically. Felt first alerts within an hour and by hour 2 the unmistakable hug in a mug feeling that goes hand in hand with 5HT receptors in your belly being tickled. I've been feeling tired all day because I couldn't sleep last night. Nothing else to report.

Day 2: 7mg 2cb 10am mixed in with my coffee. Couldn't sleep again last night. I doubt the micro dosing has anything to do with it though. It's been warm and humid and I've been off Elvanse for about 6 weeks so my brain is extremely itchy. I'm noticing some minor visual alterations still persisting later in the day, like the contrast has been turned up blacks are blacker and colours seem to have more depth. In the evening I nurse approximately 150mg of ketamine over a couple of hours, this too feels slightly more visual than usual.

Day 3:
7mg 2cb+0.05ml RSO 10am mixed in with my coffee. I slept better but was woken rudely and unnecessarily by a family member instead of getting up in my own time and spent most of the afternoon in a foul mood as a result. I think taking the 2cb immediately after being woken up like that actually perpetuated the odius mood. Set and setting folks. I feel like tripping this evening so I'll probably take 25mg at 7pm and go from there. I wish there were other psychedelics besides this and DMT (which I'm never in the mood for) that don't create a tolerance. I feel like taking acid really but if I do then this 2cb experiment goes out the window for at least the next week. Veering off topic now, that's all for today.

Day 4:
10am 7mg 2cb mixed in with a cup of matcha.
I did end up taking 25mg of 2cb last night which I garnished with 400mg of ketamine. Slept well but woke up with a headache which had passed by the time I had finished my matcha. I may have had breakfast a bit too soon after the 2cb because I started feeling pretty nauseous immediately after finishing it, thankfully this passed after 10 minutes or so. Still feeling pretty lazy most of the time. I did get some minor housework done but it's been a largely unproductive day. I feel like the effect of my 7mg dose was slightly less noticable today. Tolerance perhaps? I really need to lay off the ketamine as it does give me a bit of a hangover which I'm sure is offsetting the benefits of the 2cb.

Day 5:
7mg 2cb+0.03ml RSO 11am mixed in with a coffee.
Decided to put an end to this little ketamine binge by finishing my ketamine last night. I did bumps from 10pm-3am then ended the night by dropping myself into a khole. Slept great afterwards and woke up in the best mood I've been in all week. I'm hit by a wave of nausea around 1pm as I'm getting lunch ready but it passes after 5 minutes and I'm able to eat fine.

Day 6:
7mg 2cb+0.04ml RSO 10am mixed in with a matcha latte.
Put off by yesterday's nausea I wait a little bit longer before eating and taking my supplements. Sure enough the come is a lot smoother and I don't experience any nausea. Beyond that it's an unremarkable day. It's far too hot to go out so I stay in and watch a movie. By the time it has finished the 2cb has run its course, though it was barely apparent to begin with. I feel like I'm beginning to hit diminishing returns.

Day 7:
10mg 2cb+0.03ml RSO 9:30am mixed in with a matcha latte.
Slept terribly last night which was to be expected with it being the warmest day of the year so far. Today will be the last day of this little experiment.

Day 8:
20ug LSD mixed in with my coffee.
To serve as a book ender and provide perspective for comparison. I'll add my final thoughts on this little experiment, anon.
 
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Using the higher doses may have messed with your tolerance as well, I wonder if effects might remain the same if you stick with a low dose for all 7 days
 
someguyontheinternet said:
Using the higher doses may have messed with your tolerance as well, I wonder if effects might remain the same if you stick with a low dose for all 7 days
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Maybe, but I wouldn't expect much if any tolerance from 100mg over two days. I could be accumulating a bit from taking LSD every other day though. I'll try and stick with just low dose 2cb for the next 7.
 
Are you a 2C-B hard-head? Because 7 mg seems a little high compared to 15 ug LSD. Reasoning in terms of proportions, I'm inclined to think that around 2.5-3 mg 2C-B would be more comparable.

On a side note, I took 5 mg of 2C-T-2 about a week ago. I had eaten 4 hours before and been napping two of those. I think I had enough food in my stomach to slow the absorption and majorly blunt the effects such that it didn't really feel stronger than the 2.5 mg I had in June. It was qualitatively different too in a way that seemed very analogous to the "slow" cacti I've had (which I hypothesize are slow to onset and mellower in effect due to mucilage-bound mescaline being absorbed much more slowly) versus the "fast" cacti. It was a bit disappointing to not get the "rushy" feelings I like from 2C-T-2, but it was still nice and still left me with some long-term therapeutic effect.

I almost always take psychedelics on an empty stomach, often after a 12+ hour fast, so this experience was instructive as to how dramatically food can affect the absorption and apparent intensity of orally dosed psychedelics.
 
iom said:
Are you a 2C-B hard-head
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Yup. Or I've just taken it too much, hundreds of times with doses ranging from 10mg to 200mg over the last three years. 7mg feels nice without being distracting or feeling intoxicating and I don't believe sub-perceptual micro dosing has any benefits beyond placebo. Also, 7 is my lucky number :)
iom said:
almost always take psychedelics on an empty stomach, often after a 12+ hour fast, so this experience was instructive as to how dramatically food can affect the absorption and apparent intensity of orally dosed psychedelics.
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I swear by this too. Especially for 2cb as the surest way to mitigate the nausea is to have a completely empty stomach, but psychedelics in general just feel cleaner and smoother after a 12 hour fast.
 
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Shinji Ikari said:
Well, I'll be, low dose 2cb might actually not be a complete waste of time
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When I first started using 2c-b, 17 MG of the HCL salt, did not have crazy strong effect. Pushed it slowly 28mg and found 25mg was approaching too much..

I don't know if reverse tolerance is a biochemical action, but as I came to know 2c-b effect, I could recognize it at a lower dose.

I love myself some mdma, but when I really want get down, 80-100 mdma and 5-10 2cb.....very difficult to not have a good time.

2cb on its own i feel it at 10mg, I don't really feel much at 5mg. 15-20mgs is my easy comfort area but I'm def out of microdose range...
 
I am still planning on doing a proper write up on this it's just been a busy week and I've not had time to do it. The TL:Dr is that I've found low dose 2cb to have very little if any therapeutic value, while LSD can be incredibly helpful for managing the symptoms associated with ADHD, the tolerance limits it's usefulness.

I'm sitting on a gram of mescaline HCl and have another two on the way so stay tuned for my next low dose experiment. I'm looking forward to this one.
Didgital said:
When I first started using 2c-b, 17 MG of the HCL salt, did not have crazy strong effect. Pushed it slowly 28mg and found 25mg was approaching too much..
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I started out with pills which I'm hindsight were probably in the 15mg range but I can't be sure. Anyway I binged like all hell through much of 2021 and since then I do find I need higher doses than i did a few years ago to achieve the same effects. 50mg feels more like 30mg did back then.

I also find that when I'm on my elvanse (or dex) I don't tend to crave such high doses, which makes perfect sense I suppose as I'm not dopamine chasing.

Edit: do I remember reading somewhere that low doses of DXM can help lower opioid tolerance or did I just imagine that? Maybe it's similar to the reverse tolerance you experienced with 2cb. Mescaline can be funny with tolerance too, some people say there's a delay or there isn't any at all or that it's even so stronger when you use it at short intervals.
 
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