Opioids Tapentadol Megathread

[Azed]

Hey y'all, thought I would share my experience with Tapentadol. I have been using Tapentadol daily to semi-daily for around 9 months now. With doses ranging from 100mg-400mg. Most commonly doses between 100mg-200mg. Most often these doses were taken with a myriad of other substances. Almost exclusively other downers. I have taken Tapentadol with Pregabalin, Baclofen, Clonazolam, Bromazolam, Etizolam, Diclazepam, Diazepam, Clonazepam, and Carisoprodol. Often combining multiple of the previously listed substances.

I mostly took it for pain, depression/anxiety, and recreationaly. It started out originally with low doses taken weekly or bi-weekly. So in total I have taken Tapentadol for around 12 months. But eventually escalated as tolerance built. It was my crutch at the end of fall semester, it got rough for a while, but we pulled through. Left my original university that was in-person and transferred to a fully online university in the spring and quit my job as a pharmacy technician in February of 2023. Got a new job as a cable technician and loving the variety and challenge of the work so far.

Anyway, I ran out of the Tapentadol last week and I still crave it. However, I haven't decided whether to place a new order or not. The comedown from the Tapentadol is annoying with the sweating and general discomfort. But besides that it fufilled the needs I took it for. Prior to Tapentadol I had tried Kratom, but found the taste and smell to be quite repungent. I got some O-DSMT and I am still not sure how I feel about this one.

Overall, not in my opinion a "bad" drug. However, I would much rather prefer pharmaceutical opioids of higher potency. However, I have no experience with these substances and these are almost impossible to acquire at a reasonable price. I don't get anything from the street, so maybe it is for the best... There is apparent rebound anxiety and depression the day after a dose which makes me question why I event took it in the first place. I wouldn't say I'm in withdrawal, just wish I still had it in my arsenal.

Just thought I would share some of my experience with the Tapentadol. Let me know down below or DM me if you have any questions or want to talk about these substances. Or if you would like to share your experience with Tapentadol.


Best wishes to you all and stay safe out there.

 

[GetMeOutOfThisCRAP]

I would say it was "nice" but not great. However I would agree that it is one I might have to learn to use..for instance next time I'd probably jump in with 200mg straight away as the whole chasing thing was annoying. I think my codeine tolerance/my brain wanting codeine may have also ruined it slightly. Can imagine it'll be more fun next time now I know what to expect and what my dose/response feels like. New opiate dosing and redosing is always a fiddly game especially when you have cross tolerance with something else. Unlikely to get it right straight away

That's good. Its good people don't find it that addicting then. For me its the exact same as oxycodone, just a more rugged high without the feeling of purity. I could easily ruin my entire life with a constant supply of taps. Even something like tramadol is incredibly addicting and hard to control the use for. I guess some people just maintain control a little better for anything besides heroin. I find taps to be incredibly addicting once you get used to it. It could have to do with my tolerance for opioids never getting that high. Despite the long on-and-off use over the years, my tolerance never really needed that much to catch a high. A few weeks ago I had an ample supply of tapentadol. Like... A LOT. I was kind of relieved when I ran out because it was just too easy to be high all day and everyday

I'm sure people would prefer ruining their life on oxycodone or heroin, but tapentadol is known for being capable of abuse and that is referenced all over the internet. Just wanted to relay, tapentadol and many of the drugs people order online HAVE NOT been given the standard testing/FDA approval seals. You legitimately have no idea what putting tapentadol into your body could be doing. We flat out do not know if it is an unsafe opioid or not.

 

[Azed]

That's good. Its good people don't find it that addicting then. For me its the exact same as oxycodone, just a more rugged high without the feeling of purity. I could easily ruin my entire life with a constant supply of taps. Even something like tramadol is incredibly addicting and hard to control the use for. I guess some people just maintain control a little better for anything besides heroin. I find taps to be incredibly addicting once you get used to it. It could have to do with my tolerance for opioids never getting that high. Despite the long on-and-off use over the years, my tolerance never really needed that much to catch a high. A few weeks ago I had an ample supply of tapentadol. Like... A LOT. I was kind of relieved when I ran out because it was just too easy to be high all day and everyday

I'm sure people would prefer ruining their life on oxycodone or heroin, but tapentadol is known for being capable of abuse and that is referenced all over the internet. Just wanted to relay, tapentadol and many of the drugs people order online HAVE NOT been given the standard testing/FDA approval seals. You legitimately have no idea what putting tapentadol into your body could be doing. We flat out do not know if it is an unsafe opioid or not.

I agree, it was definintely too easy to get hooked on the Tapentadol. Many people in the U.S. believe that it should be less controlled (not a C2). But I think that it should remain in its current schedule until more research and testing is done.

 

[carbonhalo]

Oh crap.
It looks like my insensitivity to hallucinogens and a variety of other pharmaceuticals has struck here too.(got a thread on that)
I had slight effect from tramadol, nearly no effects from both pregabalin and Gabapentin in any dose I could titrate out of a single box and Tapentadol was the most disappointing of all.

 

[GetMeOutOfThisCRAP]

Yeah, in the US it's schedule 2 and I think I only saw it once in three years. It was brand name only it was the Nuctyna ER formulation. I've never seen the IR in the pharmacy, but that's all I got. Works great for the pain that I have in my back.

Ohhhh oh my god. So thats what "Nuctyna" was. Good to know, lol.

For people from the chronic pain perspective tapentadol's a pretty good painkiller. I doubt anyone here would find it "just as effective as oxycodone" but it does work enough to make a difference.

From the drug addict "I want fun" perspective, I'd rate it probably a 6.5/10 lol. Opioids like percocet being an 8/10 for comparison. Its still the same dead end as any, though. You'll reach a point where whatever doses you're on, it just doesn't do the same things it used to in the beginning. Someone could ruin their life off tapentadol addiction for sure.. but just not as obvious or rapidly as oxycodone addiction could.

 

[ghostfreak]

I used to get a warmth type feeling after 300mg of it but faded after a few times. Took a lot higher and felt nothing. I think I used my stash up because it was better than chucking them (but that’s me). Then bought more and they had the same effect but not getting more.

Wish i had more to be honest but trying my hardest not to order any.

 

[Azed]

WARNING: I'm sure its been said before but haven't checked the thread, if you exceed over 600 mgs in a day there is toxic effects on the liver/heart. That is the difference between this an oxycodone. There is a toxicity to the liver post 6 tablets in a day (assuming the tablets are 100 mgs each). Its very efficient, but just as addicting as any commonly abused opioid if not more.

When I last had access to Clinical Pharmacology and Micromedex I believe the max pharmaceutical dose war around 500 mg / a day. Additionally, according to the monograph for Tapentadol ER in the US it states this, "oral daily doses greater than 500 mg of NUCYNTA® Extended- Release have not been studied and, therefore, are not recommended." The monograph also states, "The CNS- and gastrointestinal symptoms are concordant with the pharmacodynamic effects of MOR agonists. In rats, adaptive
NUCYNTA® Extended-Release (tapentadol extended-release tablets) Product Monograph Page 40 of 50 changes of the liver were seen. These changes are considered to be related to the xenobiotic overload
of hepatocytes due to substantial phase II metabolism and are not regarded as a sign of overt hepatotoxicity. Additionally; there was a lack of relevant tumour formation in the liver in both rodent species (rats and mice) in the 2-year carcinogenicity studies".

In regards to your comment on cardio-toxic effects the monograph states this, "In dogs, transient prolongation of the QTc-time was observed in repeat-dose studies. The effectsincreased with dose and were significant only at the beginning of the studies. No otherelectrocardiographic findings were observed. Some late toxicity, including convulsions and deaths inrats and dogs occurred in the high dose groups with a delay of several hours following intravenous ororal administration. The cause of these deaths remained unclear, but is regarded as a result ofexaggerated pharmacodynamic effects of the compound".


Therefore, even if this monograph information is to be trusted then we must still main vigorous of our internal health.


Best Wishes and remain safe!
Azed

 

[GetMeOutOfThisCRAP]

When I last had access to Clinical Pharmacology and Micromedex I believe the max pharmaceutical dose war around 500 mg / a day. Additionally, according to the monograph for Tapentadol ER in the US it states this, "oral daily doses greater than 500 mg of NUCYNTA® Extended- Release have not been studied and, therefore, are not recommended." The monograph also states, "The CNS- and gastrointestinal symptoms are concordant with the pharmacodynamic effects of MOR agonists. In rats, adaptive
NUCYNTA® Extended-Release (tapentadol extended-release tablets) Product Monograph Page 40 of 50 changes of the liver were seen. These changes are considered to be related to the xenobiotic overload
of hepatocytes due to substantial phase II metabolism and are not regarded as a sign of overt hepatotoxicity. Additionally; there was a lack of relevant tumour formation in the liver in both rodent species (rats and mice) in the 2-year carcinogenicity studies".

In regards to your comment on cardio-toxic effects the monograph states this, "In dogs, transient prolongation of the QTc-time was observed in repeat-dose studies. The effectsincreased with dose and were significant only at the beginning of the studies. No otherelectrocardiographic findings were observed. Some late toxicity, including convulsions and deaths inrats and dogs occurred in the high dose groups with a delay of several hours following intravenous ororal administration. The cause of these deaths remained unclear, but is regarded as a result ofexaggerated pharmacodynamic effects of the compound".


Therefore, even if this monograph information is to be trusted then we must still main vigorous of our internal health.


Best Wishes and remain safe!
Azed

Okay, it is great that you located that information. Its been some time now, and I strongly dislike tapentadol--actually. It makes you really out of it in terms of brain fog and losing your train of thought typically throughout the day. It happens multiple times within a half hour before and after the effects start and fully decay. I would hate to be a chronic pain patient and perpetually prescribed tapentadol. It works decently for pain relief, but the mental aspect of the effects are more debilitating than most opioids I have ever encountered. I don't mean they make you dysfunctional, but the noticeable lack of feeling clarity with your own train of thoughts makes me realize the superiority of other opioids commonly prescribed. For instance, on percocet you can definitely be so out of it and drooling in front of people--but on reasonable doses you don't become as tired of being so out of it all the time within your own mind. For pain relief, its probably the same thing as any opioid. Your tolerance catches up to you, and then you can't surpass the unknown dose range for prolonged periods and actually know what is happening to your body. For anybody reading, the brain fog is very indescribable in words on tapentadol (but you'll know exactly what I am talking about should you try it). I don't understand what causes the symptom of losing your train of thought. Horrible in a minor way, but enough to complain about. Same with the dry skin and very dry mouth symptoms I experienced. Look much healthier off the drugs lol. Opioids never dry out my mouth or skin like tapentadol did. Unique weirdness so pick your poison if you do have legitimate pain.

 

[mdmaxanaxketamine]

Do you guys mix the taps with something? My first couple times of taking it (200mg) I had a great high and was surprisingly similar to oxy. These last couple times though at the same dose I just get the weirdest hallucinations, like someone calling my name or seeing my pets run around. The worst one is spiders, they can shoot strings at me and can be annoying and ruin the high a bit.

If you aren't mixing anything with it, what would you recommend?

 

[Azed]

Do you guys mix the taps with something? My first couple times of taking it (200mg) I had a great high and was surprisingly similar to oxy. These last couple times though at the same dose I just get the weirdest hallucinations, like someone calling my name or seeing my pets run around. The worst one is spiders, they can shoot strings at me and can be annoying and ruin the high a bit.

If you aren't mixing anything with it, what would you recommend?

I tend to mix my taps with carisoprodol. I find that carisprodol helps to reduce some of the taps stimulating effects.

In regards to the hallucinations this is quite common. I've always had visuals on tapentadol however, I haven't had anything like spiders show up. There has been plenty of times where I would catch myself responding out loud to my own internal monologue. Definitely, a weird drug to be sure.


Azed
Best wishes!

 

[mdmaxanaxketamine]

I tend to mix my taps with carisoprodol. I find that carisprodol helps to reduce some of the taps stimulating effects.

In regards to the hallucinations this is quite common. I've always had visuals on tapentadol however, I haven't had anything like spiders show up. There has been plenty of times where I would catch myself responding out loud to my own internal monologue. Definitely, a weird drug to be sure.


Azed
Best wishes!

Yeah I would have mixed it with benzos to dampen some of the NRI effects, but I've had problems with them in the past so I just avoided it and after a week long binge on Tapentadol I just flushed the rest. The hallucinations were very strong and I had the same thing happen to me all the time especially when I would try to sleep. I would toss and turn and end up responding to the craziest nod in my head out loud and felt like a crazy person. Never had such intense nods even mixing benzos & oxy. Definitely a drug that has some abuse potential, but if you have any tolerance to opiates the doses you need to get high result in way too many side effects. I prefer oxy much more.

Carisoprodol would be an interesting mix too. I've never gotten my hands on it since its such a rare drug. Would love to try carisoprodol + an opiate some day.

 

[Azed]

Yeah I would have mixed it with benzos to dampen some of the NRI effects, but I've had problems with them in the past so I just avoided it and after a week long binge on Tapentadol I just flushed the rest. The hallucinations were very strong and I had the same thing happen to me all the time especially when I would try to sleep. I would toss and turn and end up responding to the craziest nod in my head out loud and felt like a crazy person. Never had such intense nods even mixing benzos & oxy. Definitely a drug that has some abuse potential, but if you have any tolerance to opiates the doses you need to get high result in way too many side effects. I prefer oxy much more.

Carisoprodol would be an interesting mix too. I've never gotten my hands on it since its such a rare drug. Would love to try carisoprodol + an opiate some day.

There are some manufactures that even combine Carisoprodol and Tapentadol into one pill! I like to take them separately because the Carisoprodol seems to be under-dosed (especially the Pain-O-Soma brand). I would love to try Oxy, but its so damn expensive. I find Kratom and O-DSMT to be underwhelming in my opinion. I finally decided to purchase some more Tapentadol since the Flubromazepam I ordered a month or so ago appears to be bunk. Strangely enough, yesterday I took some taps after work and this morning I had no nausea when I woke up. A very welcome surprise since normally I wake up feeling sick as a dog. I'll take what I can get.


Best wishes!
Azed

 

[mdmaxanaxketamine]

There are some manufactures that even combine Carisoprodol and Tapentadol into one pill! I like to take them separately because the Carisoprodol seems to be under-dosed (especially the Pain-O-Soma brand). I would love to try Oxy, but its so damn expensive. I find Kratom and O-DSMT to be underwhelming in my opinion. I finally decided to purchase some more Tapentadol since the Flubromazepam I ordered a month or so ago appears to be bunk. Strangely enough, yesterday I took some taps after work and this morning I had no nausea when I woke up. A very welcome surprise since normally I wake up feeling sick as a dog. I'll take what I can get.


Best wishes!
Azed

Yeah I saw the red apples, but my guy only had plain taps and I haven't looked to deep into sourcing drugs via computer. Just let others do it for me. Oxy is extremely expensive though, but if you enjoy Taps you probably have a relatively low tolerance and could easily blast off with 10-20mg Oxy. Kratom and O-DSMT were honestly pretty fun and I prefer O-DSMT over Taps any day (only have done O-DSMT twice though with high dose and Kratom once with a high dose as well). I would definitely recommend trying Oxy though if you are a big fan of Taps. Once in awhile I can find some European OC80s for cheap, but American pharma pills are stupid expensive so if you do try to get American pharma the best way is to befriend someone with a script. And be very careful as well since a lot of the blue 30s are fent/RC analogue laced. I'm extremely interested in Carisoprodol I might ask my buddy if he can get some for me. Always wanted to try the "Holy Trinity" (opiate + benzo + carisoprodol).

 

[mrsopie]

Hey y'all, thought I would share my experience with Tapentadol. I have been using Tapentadol daily to semi-daily for around 9 months now. With doses ranging from 100mg-400mg. Most commonly doses between 100mg-200mg. Most often these doses were taken with a myriad of other substances. Almost exclusively other downers. I have taken Tapentadol with Pregabalin, Baclofen, Clonazolam, Bromazolam, Etizolam, Diclazepam, Diazepam, Clonazepam, and Carisoprodol. Often combining multiple of the previously listed substances.

I mostly took it for pain, depression/anxiety, and recreationaly. It started out originally with low doses taken weekly or bi-weekly. So in total I have taken Tapentadol for around 12 months. But eventually escalated as tolerance built. It was my crutch at the end of fall semester, it got rough for a while, but we pulled through. Left my original university that was in-person and transferred to a fully online university in the spring and quit my job as a pharmacy technician in February of 2023. Got a new job as a cable technician and loving the variety and challenge of the work so far.

Anyway, I ran out of the Tapentadol last week and I still crave it. However, I haven't decided whether to place a new order or not. The comedown from the Tapentadol is annoying with the sweating and general discomfort. But besides that it fufilled the needs I took it for. Prior to Tapentadol I had tried Kratom, but found the taste and smell to be quite repungent. I got some O-DSMT and I am still not sure how I feel about this one.

Overall, not in my opinion a "bad" drug. However, I would much rather prefer pharmaceutical opioids of higher potency. However, I have no experience with these substances and these are almost impossible to acquire at a reasonable price. I don't get anything from the street, so maybe it is for the best... There is apparent rebound anxiety and depression the day after a dose which makes me question why I event took it in the first place. I wouldn't say I'm in withdrawal, just wish I still had it in my arsenal.

Just thought I would share some of my experience with the Tapentadol. Let me know down below or DM me if you have any questions or want to talk about these substances. Or if you would like to share your experience with Tapentadol.


Best wishes to you all and stay safe out there.

Is this drug on a drug test?

 

[Azed]

Is this drug on a drug test?

It wouldn't be on a typical drug screen (such as for employment). However, it may still be flagged as an opioid. I would recommend caution, so tread carefully.


Best wishes!
Azed

 

[seeweed007]

How long does tapentadol stay in system? I'm in pain mgt and was flagged for tap...I stopped and drug test will be in 2 weeks. I thought it was oxycodone??

 

[Azed]

How long does tapentadol stay in system? I'm in pain mgt and was flagged for tap...I stopped and drug test will be in 2 weeks. I thought it was oxycodone??

It shouldn't stay too long as it doesn't have any significantly active metabolites. Sometimes drug tests will identify another opioid as a different one. But if it specifically flagged for tapentadol then more than likely it was indeed in your system.

95% of the drug is metabolized within 24 hours. However, the dose will effect how long it remains in your system.

Again, metabolization is not a problem as Tapentadol is processed minimally.


Best wishes!
Azes

 

[seeweed007]

Thank you Soo much it has been 12 days since last dose . And I can't screw up with pain MGMT I get all my epidural injections from them ...I tell the I'm still in pain and their answer is your at your highest dose ..
At least your answer lessened my anxiety about the tapentadol

 

[crackhead226]

This drug is pretty weird. I execpted it to be like tramadol but it was more like oxy and a benzo mixed together. Also throw in some LSD in the mix. The high was comfy but very short lived, maybe 1-2 hours and it goes and comes back in waves. I crushed 200mg, took 200mg again a few times but the first dose was the best. I won't take this drug again for a while but I imagine it could be comfy if you are sick or have some physical pain. Memory problems for sure, it makes time go faster.

 

[lolis my thesis]

Man I take methadone for pain
Tapentadol worked a charm but at about 200 mg
I would descend into a dreamlike state; I would fall unconsciouos mid sentence
completely lose my train of thought mid gesture; more like a brain fart than a total nod; then I would come to and try to recall what the fuck I was saying, without being too obviously impaired. pretty sure I was indeed obviously impaired!
I gave up my script as I would just blow thru it in a week.
If I took enough also I felt like I was floating with no sensation of having legs; but feeling wobbly like a baby giraffe in those cases.
It really made me too fucked up even compared to hydrocodone but given that ones hard to feel as strongly being on methadone too