Opioids Bupropion (Wellbutrin) for opioid withdrawal

[NawdybyNature]

Howdy folks,

I was curious if anyone has had any experience using Wellbutrin (bupropion) to ease opioid withdrawal symptoms. I just got prescribed bupropion xl (150mg/day) to help with apathy/motivation along with my usual daily Vyvanse (40mg/day). I currently have a fentanyl habit that I'm trying to kick, and I imagine it would make the most sense to get clean from fentanyl before introducing bupropion to my system. I have plenty of comfort meds on hand to get through the worst of the fent (Xanax, gabapentin, suboxone, Ambien, and/or loperamide). The only reason I ask is that I've come across a few anecdotal reports that suggest Wellbutrin actually helped with some of the opioid withdrawal symptoms (RLS, fatigue, anhedonia, etc.). Any knowledge would cure my curiosity and be much appreciated! Thanks!

 

[Parabolan]

Wellbutrin will help you a little bit in the energy department, at least it does for me.

I have never heard of anyone using it for opiate withdrawals, but I know people who used it upon stopping meth and they say it helped.

I see that you have some good meds to help you with withdrawal.

The only thing I am worried about is susceptibility to anxiety, especially when you are trying to kick a habit.

 

[paranoid android]

Ive used it after i kicked opiatyes and it does help alot with the lack of energy and shit you get during paws

 

[Dextro .45]

Clonidine 0.1mg absolutely Paramount
Pregabalin 150-300mg
Diazepam 5-10mg
Cannabis Indica 5mg oil
Ketamine (thin little lines)

Bupropion is……meh no real dopaminergic properties, more NET activity

TRUE Amphetamines work for opioid withdrawal in combination with the cocktail above

Ritalin 20mg IR / Dexedrine 5-10mg / Adderall 5-10mg / Vyvanse 20-40mg (6-12mg d-Amph)

 

[Parabolan]

Clonidine 0.1mg absolutely Paramount
Pregabalin 150-300mg
Diazepam 5-10mg
Cannabis Indica 5mg oil
Ketamine (thin little lines)

Bupropion is……meh no real dopaminergic properties, more NET activity

TRUE Amphetamines work for opioid withdrawal in combination with the cocktail above

Ritalin 20mg IR / Dexedrine 5-10mg / Adderall 5-10mg / Vyvanse 20-40mg (6-12mg d-Amph)

You do love your amphetamines, don't you?

 

[NawdybyNature]

Wellbutrin will help you a little bit in the energy department, at least it does for me.

I have never heard of anyone using it for opiate withdrawals, but I know people who used it upon stopping meth and they say it helped.

I see that you have some good meds to help you with withdrawal.

The only thing I am worried about is susceptibility to anxiety, especially when you are trying to kick a habit.

Ya, the possibility of exacerbating the anxiety is the main drawback for me. I'll probably just stick with the standard comfort meds.

 

[NawdybyNature]

Clonidine 0.1mg absolutely Paramount
Pregabalin 150-300mg
Diazepam 5-10mg
Cannabis Indica 5mg oil
Ketamine (thin little lines)

Bupropion is……meh no real dopaminergic properties, more NET activity

TRUE Amphetamines work for opioid withdrawal in combination with the cocktail above

Ritalin 20mg IR / Dexedrine 5-10mg / Adderall 5-10mg / Vyvanse 20-40mg (6-12mg d-Amph)

I'm prescribed clonidine (0.2mg), what does your timeline look like for using it during withdrawal? Once a day? Every few hours? I've always heard it's an amazing comfort med but maybe I'm not taking enough of it because I haven't noticed it helping that much. I guess I'm mainly worried about the drop in blood pressure by taking too much and being even more lethargic than usual.

 

[Dextro .45]

I'm prescribed clonidine (0.2mg), what does your timeline look like for using it during withdrawal? Once a day? Every few hours? I've always heard it's an amazing comfort med but maybe I'm not taking enough of it because I haven't noticed it helping that much. I guess I'm mainly worried about the drop in blood pressure by taking too much and being even more lethargic than usual.

Taking for opioid withdrawal you’d be take 0.1mg X 3 daily for a week …then X2 daily ….then 1/2 of a scored tablet at the end of taper (2 weeks max of safely reducing). 2-3 weeks of daily usage …..and upon cessation you WILL get rebound hypertension, were just standing up too quickly you’ll see stars and feel light headed, could even fall?

Used sporadically a 0.1mg tablet once or twice a week…..no issues

I even use half a scored tablet @ 240lbs and in 30min I feel amazingly relaxed. Very fast onset. I just freaking love Clonidine lol, it has anxiolytic properties even better than some benzodiazepines and safer

 

[NawdybyNature]

Taking for opioid withdrawal you’d be take 0.1mg X 3 daily for a week …then X2 daily ….then 1/2 of a scored tablet at the end of taper (2 weeks max of safely reducing). 2-3 weeks of daily usage …..and upon cessation you WILL get rebound hypertension, were just standing up too quickly you’ll see stars and feel light headed, could even fall?

Used sporadically a 0.1mg tablet once or twice a week…..no issues

I even use half a scored tablet @ 240lbs and in 30min I feel amazingly relaxed. Very fast onset. I just freaking love Clonidine lol, it has anxiolytic properties even better than some benzodiazepines and safer

Good to know, thanks man. I always took my clonidine before bed because it would help me fall asleep quicker, whether I was in WD or not. I'll try taking it 3X daily with my other comfort meds this time.

 

[Dextro .45]

You do love your amphetamines, don't you?

Yes lol I do…I actually went 30 days without my Ritalin script. Filled few days ago along with 100 Methadone tablets and damn its just so clean, effective, and completely free of cardiovascular adverse effects

Ritalin (Methylphenidate) 40-60mg IR taken with a light fatty meal (steak & eggs) which speeds absorption, and taken with alcohol / Jin 2.oz X 3-4 drinks (Ethanol increases active d-MPH by 40% aka Focalin) Significantly enhancing euphoric subjective effects in all test subjects

0.25mg of HCL salt / per Kg of body weight - dose required to inhibit 50% of DAT dopamine transporters (causing euphoria) ED-50

After 30 days of no Ritalin I took 60mg IR with Methadone 100mg and 10.oz of Jin in 5 drinks and I was On Point ! it pleasant mood-boosting properties with clean Euphoria

Vyvanse (Lisdexamfetamine) d-Amph with its 3-hour onset / peak plasma levels 8-10h duration gave me zero pleasant feelings, Super dry mouth and trouble sleeping …even heart palpitations (my buddy too)

Ritalin with its 3-4h duration and no sleep or appetite disturbances
3-4X more active at DAT than NET, further enhanced by Ethanol 40% increase in d-MPH

 

[Parabolan]

Yes lol I do…I actually went 30 days without my Ritalin script. Filled few days ago along with 100 Methadone tablets and damn its just so clean, effective, and completely free of cardiovascular adverse effects

Ritalin (Methylphenidate) 40-60mg IR taken with a light fatty meal (steak & eggs) which speeds absorption, and taken with alcohol / Jin 2.oz X 3-4 drinks (Ethanol increases active d-MPH by 40% aka Focalin) Significantly enhancing euphoric subjective effects in all test subjects

0.25mg of HCL salt / per Kg of body weight - dose required to inhibit 50% of DAT dopamine transporters (causing euphoria) ED-50

After 30 days of no Ritalin I took 60mg IR with Methadone 100mg and 10.oz of Jin in 5 drinks and I was On Point ! it pleasant mood-boosting properties with clean Euphoria

Vyvanse (Lisdexamfetamine) d-Amph with its 3-hour onset / peak plasma levels 8-10h duration gave me zero pleasant feelings, Super dry mouth and trouble sleeping …even heart palpitations (my buddy too)

Ritalin with its 3-4h duration and no sleep or appetite disturbances
3-4X more active at DAT than NET, further enhanced by Ethanol 40% increase in d-MPH

I'm scripted dextroamphetamine 50mg ER a day. Ritalin didn't go well with my body "and mind". I take half my dose or even skip it if I do ice, which I take small amounts of when I do it.

 

[NawdybyNature]

Taking for opioid withdrawal you’d be take 0.1mg X 3 daily for a week …then X2 daily ….then 1/2 of a scored tablet at the end of taper (2 weeks max of safely reducing). 2-3 weeks of daily usage …..and upon cessation you WILL get rebound hypertension, were just standing up too quickly you’ll see stars and feel light headed, could even fall?

Used sporadically a 0.1mg tablet once or twice a week…..no issues

I even use half a scored tablet @ 240lbs and in 30min I feel amazingly relaxed. Very fast onset. I just freaking love Clonidine lol, it has anxiolytic properties even better than some benzodiazepines and safer

Thanks again for the clonidine advice btw! My buddy doesn't use BL so I figured I'd post here to get him some reassurance that it would help with his WD. He's a couple weeks clean now, so fingers crossed it sticks this time

 

[jaymsie]

I have experience with bupropion while withdrawing from opiates. They will lift your mood some, but that is about it. They will not help you with any other aspect and, in my experience, tend to exacerbate the further excitement of the CNS, which is already going haywire during opiate withdrawal.

One poster mentioned amphetamines, and in my experience, methamphetamine, although a CNS stimulant as well, actually does seem to do something against opiate withdrawal. Many old heads that I know use it generously whenever they need to cease opiate use for whatever reason. Bupropion is in the cocaine family, and try using that during opiate withdrawal and you’ll notice it gets worse. So I don’t know why but amphetamines cannot be counted out, but do you want to get clean or do you want an amphetamine addiction, or an addiction to any of the variety of things mentioned.

In my experience getting off of opiates, which was a 30 year never ending series of attempt after attempt, trying every method and cocktail of other drugs under the sun, the manner in which I finally did get clean was by the dreaded long slow taper off methadone which was the last one I was on. And although I’d tried and failed at this many times, it eventually took for me to suffer going through the actual change of heart necessary to leave my addiction behind, which was probably the hardest thing I’ve ever done, to finally make it. Now I can say I am a different person completely.

When i began my final attempt to clean up, I was homeless on the streets of Toronto, shelter living, using fetty and meth everyday. My doctor helped me by giving me the methadone, plus a daily safe supply of hydromorph - enough to be able to stop the fetty. And although it still took may attempts, I’d managed to stop the fetty, yet in order to do so, was taking two 70mg doses of the hydromorph plus the single 100 mg dose of methadone each day. I was also on gabapentin. And for the meth, we tried taking Vyvanse. Studies show that vyvanse cannot reliably be used to treat meth addiction, however acknowledge that in some few cases it seems to work, and thankfully mine was one of them.

So I kicked the illicit drugs, but then had to get off this mountain of medication and this is what I’ve spent the past 4 years doing because my doctor will only take me off by way of slow taper, without any additional medications.

Ultimately it’s your life, your journey, and your story, so don’t feel like I’m preaching at you. You do it to the best of your abilities and intentions and if it fails you make a note of what did not work for you. Eventually you will come to the truth of what you must do for success. But I do wish you the very best. We are all too good to be livin that drug life. It’s no way for a human to exist.

Be good to yourselves.

 

[Dextro .45]

Yes, Vyvanse (Lisdexamfetamine) was studied for Methamphetamine addiction …..mixed results

Vyvanse 20mg = 5.9mg of d-Amph (reaching C-Max in 3h) 8-10h duration

Bupropion (Wellbutrin) was also used for Meth addiction with some success, being a beta-ketone-amphetamine/substituded Cathinone (more of a NDRI) NET more active than DAT - which is negligible at best (dopamine increase)

Adderall XR 30mg capsules & Dexedrine Spansule 15mg X 2-3 daily (plus IR Dexedrine 5mg tablets as needed) would probably be best for Methamphetamine addiction

Vyvanse is always used because it’s a pro-drug which can’t be abused per se ……must be taken orally and slow 3h onset peak lasting long. Vyvanse 70mg (21mg d-Amph) + Bupropion 300mg XR + Pregabalin 300mg + Alprazolam 3mg XR would be ideal……but that alone carries a high abuse liability and would feel GREAT

Or just get prescription Desoxyn (d-Desoxyephedrine) - Methylamphetamine 5mg tablets lol….. 3-5 tablets daily of pharmaceutical Methamphetamine 5mg tablets - Ovation Pharmaceuticals

Adderall XR 30mg capsules + Dexedrine IR 5mg tablets as needed (5-6 daily) would be the ideal Amphetamine regiment …..plus Oxy-IR 5mg tablets (extremely euphoric opioid) and a few Xanax 2mg bars ……I absolutely love these CII Controlled Substances……like candy for adults ….too bad that beautiful angel slowly turns into the ugliest, evilest devil from hell but you’re too blind to see the changes taking place ….until it’s too late

 

[SophieJ]

I have been using wellbutrin from modafinia for quite a long to ease my withdrawal symptoms just fyi so it help you.