Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,108
hi everyone. through reading countless drug experiences over the years, I’ve noticed that sedative-hypnotics acting on the GABAA receptor, most commonly benzodiazepines today, have a very high likability rating. of course, other addictive drug classes like stimulants and opioids are very popular but a number of people strongly dislike them. just to clarify, I’m talking about their immediate pleasurable effect because most people who hate drugs do so because of addiction and long-term negative side-effects.
I’ve never tried any of these drug classes myself, so I can’t speak from experience. basically, I want to know if my observation is correct in that the overwhelming majority of people given a benzodiazepine like drug Will really enjoy it.
Also, I’m wondering if much of the rewarding affects of benzodiazepines actually comes from GABAA receptor potentiation simultaneously slowing down multiple brain regions, thus decreasing the general sense of awareness/consciousness which could be interpreted as a pleasant sensation.
Of course, we have to consider that most GABAAergic sedative-hypnotics provoke significant dopamine release, but so do many other drugs.
I’ve never tried any of these drug classes myself, so I can’t speak from experience. basically, I want to know if my observation is correct in that the overwhelming majority of people given a benzodiazepine like drug Will really enjoy it.
Also, I’m wondering if much of the rewarding affects of benzodiazepines actually comes from GABAA receptor potentiation simultaneously slowing down multiple brain regions, thus decreasing the general sense of awareness/consciousness which could be interpreted as a pleasant sensation.
Of course, we have to consider that most GABAAergic sedative-hypnotics provoke significant dopamine release, but so do many other drugs.