Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

[sekio]

I would not worry about it. These are after all sold as pills, you're not supposed to treat them like hard candy.

 

[ghostfreak]

I actually know the smell now you’re talking about from the signature brand, it’s a weird ‘shouldn’t be there’ smell. But if concerned contact Wedinos here.

Yep got these here right now and they smell ugh like always.

 

[elgoucho9]

Glad I found this thread.

Does anyone know how effective redosing this drug is? I had 600mg before dinner and didn't get the full effect. Just had another dose after a work out hoping i catch the effect of the second dose.

 

[ĐmantuNJofra]

Glad I found this thread.

Does anyone know how effective redosing this drug is? I had 600mg before dinner and didn't get the full effect. Just had another dose after a work out hoping i catch the effect of the second dose.

No, what is the point?, that is almost like chasing the Dragon you will spike your tollerance even higher or you will binge on high doses couple of days and than diminishing returns, or mental why did I do it?

you will stretch your supply and achieve nothing if you take more on the job.
So you can try with maybe anoter 300mg or even higher if you know what you are doing meaning tollerance, don't drive, don't take another downers or if you go in that seizure mini jerks state take 5mg diazepam If you work with people try to forsee that manic state that can come with higher dosages so if you feel ok
Don't take another dose, If you feel uncomfortablle on 600mg, you shouldn't if you are nor addicted to very high dosages?


pregabalin in sweet spot and if you know where you at with meditation, or astral projection can put me in a very let's say that sometimes helps when you find another way of using med that is prescribed to you and that gose with a lot of side effects to tunnel it for expanding your awareness

patterning was somethinh I saw and could never express to anyone and it's only with pregabalin and Phenibut moreso Phenibut withdrawals that are like these forceful entries to seeing these energies or glutaminergic storm, that creates gut inflamation where well with substance abstinence chemistry of brains and body's is showing some interesting colors and patterns that I saw cause I was glued to a TV while I was in those withdrawals

Btw sorry for a little navigational turn in topic but I think there are some of you out there that experienced these and that is only with Gabapentinoid type withdrawals not benzo as much just Baclofen, GBL-H, Phenibut and pregabalin as gabapentin

stay safe and wait till you are done with work mate and then enjoy at home with another dose, you will stretch your supply and achieve nothing if you take more as you will get more from enjoying the dose from home.

 

[elgoucho9]

I'm not at work? I'm sat at home watching TV. And as i already stated i'm not using daily or addicted to this drug. I just enjoy sometimes having something to chill. I am trying to avoid benzos and other drugs.

 

[ghostfreak]

Re dosing does absolutely nothing and here I am wasting pills again. Argh. Got like 4 15 strips left so need to relax, wasted 10 300mg in last 2 hours. Great.

Anyone else feel the same?

 

[elgoucho9]

Re dosing does absolutely nothing and here I am wasting pills again. Argh. Got like 4 15 strips left so need to relax, wasted 10 300mg in last 2 hours. Great.

Anyone else feel the same?

You've had 3000mg in the last 2 hours? Surely that's getting a bit ridiculous dose wise.

Anything more than 600mg a day just started to seem quite pointless to me. Like it wasn't adding anything good to the experience.

 

[ĐmantuNJofra]

I'm not at work? I'm sat at home watching TV. And as i already stated i'm not using daily or addicted to this drug. I just enjoy sometimes having something to chill. I am trying to avoid benzos and other drugs.

OK, sorry but redosing is the thing that leads to addiction, especially with hyperbolic tolerance of pregabalin
nothing other than just anxiolitic proberties that remains with redosing

 

[cosmic charlie]

You've had 3000mg in the last 2 hours? Surely that's getting a bit ridiculous dose wise.

Anything more than 600mg a day just started to seem quite pointless to me. Like it wasn't adding anything good to the experience.

I concur once i got above 600mgs i started to get these weird side effects that really took away from the experience and made it less enjoyable. Ive found that Pregabalin should only be used one day a month in around a 600mg dose and doing so provided such a euphoric high, one of my favorites.

But even after just second day on it the magic is so much less its just not even worth it, kind of makes it anti-abusable to a degree. Was thinking about ordering another 10g of powder soon, really miss it i havent taken any in like 6-8 months if i had some now it would surely be amazing. Really loves mixing it with FXE, it was incredibly euphoric.

 

[ghostfreak]

OK, sorry but redosing is the thing that leads to addiction, especially with hyperbolic tolerance of pregabalin
nothing other than just anxiolitic proberties that remains with redosing

Yeah I was mainly doing it for the anxiolytic effects as they’re more pronounced in higher doses but the main effects diminish after 1500mg or so for me.

Addiction I keep thinking ‘am I’? But I can go for weeks or months without it and then binge it for a while. Hard to pin done this one. Prescribed it twice a day and it does help yeah, helps with anxiety great.

 

[ĐmantuNJofra]

But I can go for weeks or months without it and then binge it for a while.

Thats good and try not to be on it if you can and you do!!
dou you feel any rebound anxiety after?,,,or bettween those binges?

So it help with anxiety than that is the biggest issue that bothers me cause anxiety is hell for me, I was in some heavy pains but anxiety is the thing that makes me incapable of executing tasks, even watch TV I loose concentration......let me just rephrase that all in past sense but you get the point!

pregabalin was intended for pain which is not very very good in that as tinittus and those jerks, later it was I think became GAD mad also, but when taking for years I tend to also loose track but that is like once or two days in a row maybe twice a month break
otherwise i get very agrressive, than those frickin RLS worse than from buprenorphine, similar to benzos.

But now all may think look again horror story and it is cliche cause there are times I could easily stopped, as also fast tapers only worked on me. slow taper is just torture for what??

So do you take any med inbetween?

 

[charbucks]

Hi all

Can i just ask, has anyone taken Pregabalin with Gabapentin? Whats it like? I take the highest dose of Pregabalin and have built up tolerance. Just wondered if anyone had taken Gabapentin and Pregabalin together and if it can make you feel that happiness and motivation that Pregabalin used to? Or anything else? I cant take opiates as im on Esprinor (from opiate issues). I m getting help and accept that i have issues! Any advice would be helpful, but please be kind! Thank you in advance!

 

[Azed]

I would say that since Pregabalin in my opinion is very similar in Gabapentin at least in the receptors that they affect. I wouldn't expect you to feel much of anything from the addition of Gabapentin to your Pregabalin regiment as Pregabalin is basically Gabapentin on steroids. I am unsure how tenable it would be for yourself, but the only way that I have found in order to get the magic back is to take a reduced dose of the Pregbalin for a shorter period of time or take a break from it for a little whiles and your body will eventually reset/reduce your tolerance to the compound.

P.S. I think you may have double posted this thread.

 

[charbucks]

I would say that since Pregabalin in my opinion is very similar in Gabapentin at least in the receptors that they affect. I wouldn't expect you to feel much of anything from the addition of Gabapentin to your Pregabalin regiment as Pregabalin is basically Gabapentin on steroids. I am unsure how tenable it would be for yourself, but the only way that I have found in order to get the magic back is to take a reduced dose of the Pregbalin for a shorter period of time or take a break from it for a little whiles and your body will eventually reset/reduce your tolerance to the compound.

P.S. I think you may have double posted this thread.

Thank you so much, thats great, i really appreciate it! Do you think then that if i took Gabapentin on top of pregabalin not much would happen? Ill have to reduce/have a few days off! Do you know the effect of diazepam on pregabalin because obviously thats a benzo but pregabalin often speeds me up but then gradually makes me really tired. I suffer really badly with anxiety and whilst i am getting to the route cause, i also really need something thats going to help me...not just sedate me! Thank you so much and apologies for the double post...im not sure how to delete!

 

[Azed]

Thank you so much, thats great, i really appreciate it! Do you think then that if i took Gabapentin on top of pregabalin not much would happen? Ill have to reduce/have a few days off! Do you know the effect of diazepam on pregabalin because obviously thats a benzo but pregabalin often speeds me up but then gradually makes me really tired. I suffer really badly with anxiety and whilst i am getting to the route cause, i also really need something thats going to help me...not just sedate me! Thank you so much and apologies for the double post...im not sure how to delete!

In regards to combining the gabapentin and pregabalin... I would predict the pregabalin to be more competitive at the same receptor sites as gabapentin, such as VGCCs (voltage-gated calcium channels) and other GABA receptors sites. Since both gabapentinoids target similar receptors I can only forsee that the pregabalin would overshadow the gabapentin's affects. So I wouldn't expect the gabapentin to really do much. I wouldn't recommend combining gabapentinoids with other sedatives such as benzos. Even though these two substances are in different chemical classes and don't exactly target the same receptor sites. They will certainly potentiate one another in terms of 1+1=3. Both pregabalin, gabapentin, and benzos are all sedatives. Combining sedatives can be very dangerous and result in fatal respiratory depression. So caution advised. If you have been taking these for a whiles now you most likely have a tolerance to gabaergics. And if you are attempting to switch from pregabalin to gabapentin there is likely going to be a a cross-tolerance between the two. Meaning that once you have a tolerance to one it's likely that you will have a tolerance to the other. I would recommend tapering any of the substances that you have mentioned above in order to avoid withdrawals and other unpleasant side-effects or adverse affects as you may be either physically or psychologically dependent.

What other methods or substances have you tried previously to treat your anxiety?

However, what is most important is to identify the cause of your anxiety. Every time you use a substance you are only simply pushing off your symptoms that your suffer from without resolving them.

In terms of anxiety, I have dealt with it extensively so if you would like to talk about it sometime I am here to listen.


Best of wishes!

 

[Keif' Richards]

You'll find no kindness here @charbucks

These two drugs are extremely similar. Pregabalin (Lyrica) is approximately six times the potency of Gabapentin. This would make 100mg Pregabalin = 600mg Gabapentin. Things can become complicated as Gabapentin is highly variable in bioavailability while Pregabalin is not. Assuming you haven't made any serious dietary changes recently, than this is not important.

The big issue here is your tolerance. Gabapentinoids, of which these both are, are notorious for their fast-acting tolerance/dependence. The tolerance to the psychological effects will occur before the physical effects. Most people, myself included will tell you that you have at most, a couple of weeks of good Gabapentinoid euphoria before you start getting hit with rapaciously diminishing returns (taking 50g Gabapentinoid in a single sitting for instance).

For you to have the experience you're looking for, you would have to severely cut back on your daily dosage for a couple of weeks. If you took 3 days off, on the fourth day, you'll have some euphoria etc., but the following day will be 50% as good and the following day you'll basically be right back where you started.

If you went cold turkey; no Gabapentinoids for 4-5 days, you could probably get a few days of euphoria. The main takeaway here is that it's extremely difficult to reclaim that feeling and when you do, it's fleeting at best. The honeymoon period with any drug is always going to be the best. You can never really revisit this time and attempting to do so is usually just a maddening exercise.

 

[brokedownpalace10]

I read a different article which I don't feel like chasing down which said that there was a problem with patients combining Gabapentin and Pregabalin since it would give them euphoria(??!!). The horror.
Anyway, I like combining the two (in low dose situations, anyway) and the sum seems greater than the parts. A little greater than the parts. It's kinda like one hits things the other does not.
Nice combo, but nothing to write home to mom about.

Is there a role for combined use of gabapentin and pregabalin in pain control? Too good to be true? - PubMed

Gabapentin (Neurontin ¹ ) and pregabalin (Lyrica ² ) are first- and second-generation α2δ ligands, respectively, and are both approved for use as adjunctive therapy in pain control. Although they do not bind to gamma-aminobutyric acid (GABA) receptors they have been...

pubmed.ncbi.nlm.nih.gov

 

[AngelsandFairiesarereal]

I read a different article which I don't feel like chasing down which said that there was a problem with patients combining Gabapentin and Pregabalin since it would give them euphoria(??!!). The horror.
Anyway, I like combining the two (in low dose situations, anyway) and the sum seems greater than the parts. A little greater than the parts. It's kinda like one hits things the other does not.
Nice combo, but nothing to write home to mom about.

Is there a role for combined use of gabapentin and pregabalin in pain control? Too good to be true? - PubMed

Gabapentin (Neurontin ¹ ) and pregabalin (Lyrica ² ) are first- and second-generation α2δ ligands, respectively, and are both approved for use as adjunctive therapy in pain control. Although they do not bind to gamma-aminobutyric acid (GABA) receptors they have been...

pubmed.ncbi.nlm.nih.gov

Hey sorry if this is off topic kinda… but since you seem to have experience with both… do you think if a person didn’t like the way gabapentin felt, that there’s any chance that pregabalin would be different. I have chronic pain & tried gabapentin a while ago with hopes that it could help …. but really didn’t like how it felt. I’ve been wondering lately if I tried pregabalin if it would be better or I could tolerate it. Some stuff I read seems like they are similar but others say there are differences too. I figured I’d ask someone that has had experiences with both. I wouldn’t blame you if you couldn’t really answer since all our body chemistry’s are different

 

[brokedownpalace10]

Hey sorry if this is off topic kinda… but since you seem to have experience with both… do you think if a person didn’t like the way gabapentin felt, that there’s any chance that pregabalin would be different. I have chronic pain & tried gabapentin a while ago with hopes that it could help …. but really didn’t like how it felt. I’ve been wondering lately if I tried pregabalin if it would be better or I could tolerate it. Some stuff I read seems like they are similar but others say there are differences too. I figured I’d ask someone that has had experiences with both. I wouldn’t blame you if you couldn’t really answer since all our body chemistry’s are different

Maybe. They both can make you feel numb, but Pregabalin feels a little cleaner and more stimulating. Worth a shot anyway.

 

[JackARoe]

I agree with pregabalin being 6 times stronger than gabapentin. 300 mgs of pregabalin is my high end these days as is 1800 mgs of gabapetin. I am not sure in a taste test that I could tell the difference if I did not know. I personally like gabapentin better probably because of low tolerance and what I perceive as a gentler body high than pregabalin. But if I want to spin my head I reach for pregabalin. If I want to slightly spin my head and also have a calm body I use gabapentin.

I have been prescribed this since 2016. Never took daily or even close and I can confirm taking it once a week (or even twice) keeps the effects that I like in tact. i admit these days I usually only indulge twice a month. I also have a superstition that if I go too long without it the shoulder pain and sciatica I have been given it for will resurface. But honestly I am very happy I did not take this daily. It is much better as a utility drug.

Still waiting for that plant we will find in nature where a nice cup of tea made from it feels like gabapentin or pregabalin. I think all we have seen is synthetic gabapentinoids. But Nature will produce I am sure. I can't wait.