• N&PD Moderators: Skorpio | thegreenhand

Ketamine salts solubility

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There was a lot of shady studies going on back then.
Probably still are :unsure:

I'm sure, but who on EARTH thought that knowledge could be extracted from such a trial.

It's like the Tuskegee Syphilis Study when an effective treatment was discovered, they kept on giving people the useless medicine.

By 61 the Dopamine & NMDA hypotheses were both known so I suppose someone looked for 1 drug that caused BOTH actions to ensure that EVERY patient got sick.
 
I'm sure, but who on EARTH thought that knowledge could be extracted from such a trial.

It's like the Tuskegee Syphilis Study when an effective treatment was discovered, they kept on giving people the useless medicine.

By 61 the Dopamine & NMDA hypotheses were both known so I suppose someone looked for 1 drug that caused BOTH actions to ensure that EVERY patient got sick.
Sadly there are those who not only would, but actually do such things. I cannot for the life of me actually to understand why; but a lifetime of observation sadly admits that it is true.
 
Well.. One of the reasons people act so messed up on PCP is because they can't tell whether they're in a dream or not. And if you think your in a dream you do some fucked up things.
 
Well.. One of the reasons people act so messed up on PCP is because they can't tell whether they're in a dream or not. And if you think your in a dream you do some fucked up things.
I can absolutely verify this. I had such hallucinations that I could not distinguish from real life even though major laws of logic and or physics were broken in that state. You talk about lucid dreams.

One time I came to and I was holding the remains of a cactus I was growing, blood coming from the cuts in my hand. I did not feel any pain at all.
 
I suffer from NESD so from time to time, it DOES feel like a dream.. well, a nightmare to be truthful. I got lost outside of my OWN HOME. I tried to steal a ladies wig (your guess as good as mine) and ended up wandering around for 5 hours not recognizing a single thing,

I chanced on a friends house and was driven home... but I was BLAMED.

I hadn't taken ANY drug nor alcohol but because I COULD talk, they thought it was just a sick joke on my part. I've had them before so at least my wife believed me.

I've had 4 in 3 week including waking up in hospital where they thought I was DRUNK.

It's actually worse than a mental illness because almost nobody knows what NESD LOOKS/SOUNDS/ACTS like so this month I'm getting a medic-alert bracelet - SOMETHING bad is going to happen. Oh, and an emergency referral to a neurologist? 8 months. I won't LIVE for 8 months if this goes on.
 
To clarify: NESD is apparently "Non-Essential Symptoms of Depression"[ref]: I had never heard of such a thing.

Also, instances of bizarre behaviour on PCP are usually caused from overdoses. The way it is often distributed (a diethyl ether solution of the freebase, of unknown concentration, into which cigarettes or Cannabis joints are dipped) you have no clue what kind of a dose you are going to receive. Then, add in habitual redosing, and you have a recipe for a bad time.

If you instead use PCP or its analogues by actually measuring doses and taking it i.e. orally or intranasally it can be much more controllable and even quite fun. It is also an incredibly effective painkiller, which can explain some of the "superhuman" behaviour: you too could probably punch out a car's window, but your hand would feel awful. But if you can't really feel any of your body...
 
To clarify: NESD is apparently "Non-Essential Symptoms of Depression"[ref]: I had never heard of such a thing.

Also, instances of bizarre behaviour on PCP are usually caused from overdoses. The way it is often distributed (a diethyl ether solution of the freebase, of unknown concentration, into which cigarettes or Cannabis joints are dipped) you have no clue what kind of a dose you are going to receive. Then, add in habitual redosing, and you have a recipe for a bad time.

If you instead use PCP or its analogues by actually measuring doses and taking it i.e. orally or intranasally it can be much more controllable and even quite fun. It is also an incredibly effective painkiller, which can explain some of the "superhuman" behaviour: you too could probably punch out a car's window, but your hand would feel awful. But if you can't really feel any of your body...
How much is a normal dose of PCP anyways? I'm guessing around the same rage that 3-HO / 3-MeO-PCP fall in?
 
Yeah, anywhere from 5-20mg, typically. Although I have taken doses up to 100mg and still remained "sane" - no ripping doors off of cop cars, no cannibalism, no auto-amputations, etc.
100mg?? Crazy honestly. I've read stories where people only consume something like 15mg of either 3-HO / 3-MeO with no tolerance black out so hearing that is wild.
 
> It's called "chemical fluff" dunno who named it that
I did, back when I was NSPD mod. Chemical fluff, in the sense that any of these structures have the same value as bellybutton lint.

> As long as it's moved to Basic Chemistry - I think THAT was the mistake. Where it is confers status and that status is being ABUSED.
At the time of this thread's posting, Basic Chemistry did not exist as a forum, or it would be moved there.

> 1-bromo-1-phenyl-2-methylaminopropane
1-chloro-1-phenyl-2-methylaminopropane

Dingus, those are resp. bromoephedrine, and chloroephedrine. They don't need stupid names, and are not good drugs.
(-)-Chloroephedrine is an irreversible inhibitor of CYP2D6 so if you want codeine to stop working for a few months, give it a try.
They are also not recreational and at best act sort of like ephedrine type stimulants, increasing HR/BP.
Also, both of these are unstable, and form 1,2-dimethyl-3-phenylaziridine hydrochloride/bromide by intramolecular SN2 between the halide and the secondary nitrogen, when heated or stored for long periods of time, the bromide less stable than the chloride.

> Have Either One Of You Ever Actually Even Read PiHKAL? I'm Using The Same Methodolgy.
No, you're really not. Shulgin did more than just doodle a million silly structures and publish them. He also did not leap around randomly, throwing out different analogues of different drugs as his moods changed. Instead he conducted systematic investigations of known active products. Making analogues of mescaline (escaline, proscaline, DESOXY) helped establish the importance of the 4-position. then the discovery of 2C-D as a positional isomer of DESOXY led to the 2C-x series, and also logically the alpha-methyl analogues the DOx series.
Shulgin's research was successful because he could make and test these compounds, and using knowledge of what was most active, this helped him direct his attention towards certain structural features and allowed the creation of even more active analogues.
You will note there are not many entries in PiHKAL that are total wild flights of fancy from the others. Everything was created with some active thought. Also, Shulgin provided synthesis methods, some novel, and discussion about why he made the particular compound, anecdotes of the effects, and sometimes how the name related to the drug/structure.

You are providing: structures, and frankly totally useless "names", and... nothing else. No literature references, no logic behind why the particular compound(s) would be interesting, no discussion, no thought. Whenever prompted for clarification, you come up with unhinged bursts of nonsense, unverifiable statements of "proof", or claims that go against all existing published scientific literature.

> I tried to post some trip reports over the years, but they all got flamed so hard
Because you have no credibility to your name, and I assume every one of them was on some "novel" compound hitherto unmentioned in the literature, i.e. making all of your claims unverifiable and therefore more along the lines of creative fiction writing than an honest contribution to the pharmaceutical sciences.

> SWIM is trying to focus on the 2-iodo-4,5-mda that I'm on
You've been here how long and should know better that there is no SWIMming in here as the pool was drained last year for sanitation purposes. (The level of methamphetamine in the pool water was unacceptable, from all the tweakers urinating in it). Also, nice mixing SWIM and I in the same sentence.
Anyway, you're going to have to focus pretty hard. The bromo analogue is noted as having "amphetamine-like effects" at 350mg, but even Shulgin avoided it given the high dosage. There is no reason to believe that the iodo analogue would be any different.
And if you are really taking >300mg doses of compounds we frankly know very little about, I don't believe you have an IQ of 141, nor a particularly strong sense of self-preservation.

> N-allyl-1-(2-iodo-4,5-methylenedioxyphenyl)-2-aminopropane
Oh look, even less active.

> Se Requiere High Dosages
If you need to take 1 gram+ of a pure chemical to get an effect, it's generally not worth taking.

> I'm A Rolls Royce, Lamborghini, Blue Medina, Always Feining. Ragtop. Hooba Stank. Dub Mike. Raver. Bopper. Showstopper. Planet Rocker. Rock. Rock. Rock. Rocker.
More like a tool. You have to understand: it's posts like these, that contribute nothing at all to the discussion, that make you seem less like a credible source and more like a raving lunatic. And talk of shit like thought broadcasting doesn't help.

It really does no favours to you when you eschew plain, basic English, and instead Prefer To Always Talk In Title Case, And Often Make Comments That Do Not Logically Follow Or Relate To The Topic At Hand. It makes you look like a 14 year old who got his first AOL account.

Oh also - still waiting on some sort of substantive proof. You do have something besides just tall tales and drawings right?
 
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I didn't start out at that dose, I had developed quite a tolerance/liking for it...
 
It was quite a while ago, but I seem to recall I was doing the stuff multiple times a day everyday for months... starting at edit: doses of 2-5mg as an aqueous solution.
also, it tends to be much less body effecting than ketamine

that said even at that dosage I would be slurring my words and unsteady on my feet. It wasn't a regular experience that I repeated often...
 
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It was quite a while ago, but I seem to recall I was doing the stuff multiple times a day everyday for months... starting at 10-30mg.
also, it tends to be much less body effecting than ketamine

that said even at that dosage I would be slurring my words and unsteady on my feet. It wasn't a regular experience that I repeated often...
Was it euphoric though? I've honestly wish I could try the classic PCP but I'm honestly afraid of blacking out.
 
TL;DR

Dave, Don't You Have A 12 Step Meeting You And Sondra Could Attend Instead Of Posting Diatribes Over & Over In My Thread? Have You Thought About Maybe Picking Up A White Chip And Rededicating Your Life To Abstinence With People Who Care About That Kind Of Thing?? Thanks.

1-(3,4-methylenedioxyphenyl)-1-methoxy-2-ethylamino-3,3,3-trifluoropropane.png


CRUNKY_BREWSTER
1-(3,4-methylenedioxyphenyl)-1-methoxy-2-ethylamino-3,3,3-trifluoropropane

Innerving Innovator. Dominator. Creator. Not A Playa H8er.

1-(3,4-methylenedioxyphenyl)-3,3,3-trifluoro-2-aminopropane.png


ADDY_WILLOWOOD
1-(3,4-methylenedioxyphenyl)-3,3,3-trifluoro-2-aminopropane

Andrew Bueller's Day Off.
Look Whose Off Methylenedioxyphenyl Restriction!

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MOXLEY_DIXIE_TRIXIE
1-phenyl-2-amino-3,3,3-trifluoropropane

Finally, after a long night (3 or 4 hours) of dancing on <e-xxx>, it's time to break out the bare phenyl stimulant amphetamines @ 4 am to be a safer driver for the long drive home!
 
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