Mental Health Coming off Invega (Paliperidone, Xeplion) injections v. 7.0

[BattlingInvega]

A month or so ago he was talking about how he tried to jump in front of a train twice and was going to try again. We haven't heard from him since then

whats crazy is he was just talking about how he recovered

 

[Ayden]

When did everyone start to notice improvements if you have? Did it all come at once or gradual? I’m 2.5 months off and have only noticed I’m not losing tons of hair anymore and my erectile dysfunction has improved a bit but I can’t naturally get erections which makes no sense. Also not noticing blurry vision anymore. I’m 19.

So is the consensus that most sexual dysfunction on the male side will leave you at about 4 months which is 5 times the half life cycle meaning it’s completely out of your system. I’m just trying to get a consensus from the male side of things when improvements start to happen as I am only 40 days outside of the 2 loading shots. So I’m looking to do everything to speed up recovery. It looks like through this forum that everyone who stopped taking antipsychotics and cut out other drug use were able to cure their ED rather quickly.

I had 6 shots I’m 19. What sexual issues are you having? I don’t have the desire to have sex and can’t get natural erections 2.5 months off.

 

[CrimsonThornX]

A month or so ago he was talking about how he tried to jump in front of a train twice and was going to try again. We haven't heard from him since then

I'm still upset with myself for randomly deciding to take a break from this thread for a few weeks, I never would've imagined Merek would commit suicide during that span of time, I feel as if mabye there's a possibility I could've talked him out of it, it was the least I could try to do. The last time I spoke with him directly was back on the 8th of April when I told him I was finally able to sleep somewhat well again after not being able to do so for over 3 months, and began seeing other improvements too, his last response was even, "Glad too hear it my man, usually significant improvements are seen by month 4, you should be able to recover enough to live a good quality life again at some point the people who never recover say they haven’t had any improvements at month 4." Except that he is no longer alive for me to tell him that he was right, that I can indeed live a pretty good quality of life again.

 

[bowandsparrow]

I'm working on some writing and it's actually coming out decently and I'm staying focused. This feels like a big step towards recovering my creative faculties.

 

[RecoveryInProgress]

I'm still upset with myself for randomly deciding to take a break from this thread for a few weeks, I never would've imagined Merek would commit suicide during that span of time, I feel as if mabye there's a possibility I could've talked him out of it, it was the least I could try to do. The last time I spoke with him directly was back on the 8th of April when I told him I was finally able to sleep somewhat well again after not being able to do so for over 3 months, and began seeing other improvements too, his last response was even, "Glad too hear it my man, usually significant improvements are seen by month 4, you should be able to recover enough to live a good quality life again at some point the people who never recover say they haven’t had any improvements at month 4." Except that he is no longer alive for me to tell him that he was right, that I can indeed live a pretty good quality of life again.

I was trying to talk to him when it happened!! How do you think I did!? The whole time after I was questioning whether I said something wrong!

I'm working on some writing and it's actually coming out decently and I'm staying focused. This feels like a big step towards recovering my creative faculties.

I love this for you!

I'm still upset with myself for randomly deciding to take a break from this thread for a few weeks, I never would've imagined Merek would commit suicide during that span of time, I feel as if mabye there's a possibility I could've talked him out of it, it was the least I could try to do. The last time I spoke with him directly was back on the 8th of April when I told him I was finally able to sleep somewhat well again after not being able to do so for over 3 months, and began seeing other improvements too, his last response was even, "Glad too hear it my man, usually significant improvements are seen by month 4, you should be able to recover enough to live a good quality life again at some point the people who never recover say they haven’t had any improvements at month 4." Except that he is no longer alive for me to tell him that he was right, that I can indeed live a pretty good quality of life again.

What is it you think you could have said better than what I said?

If nobody is going to answer my threads, then I’m going to have to go somewhere else because I’m not getting any support or responses from my concerns. And it’s starting to really hurt my feelings that everyone has not been responding to me on this topic whenever I ask everyone’s input so In my logic what’s the point of staying here (again) if im literally being ignored on something I inquired about several times.

At the very least I expected maybe something. But I’m not stupid and I’m not going to just move on and pretend like everyone didn’t just flat out ignore me. And to think it’s acceptable to just allow someone already going through trauma to then experience more trauma and be ignored like that? Have some empathy!

Because no one responded, it made me think that maybe I said something wrong or I should have said something different. Please tell me. I’m really trying to just not be in a complete head spin about this and I would like to know the truth of what everyone thinks so I can not be worrying so much and can have actual honest feedback.

 

[Kaatrina]

Because no one responded, it made me think that maybe I said something wrong or I should have said something different. Please tell me. I’m really trying to just not be in a complete head spin about this and I would like to know the truth of what everyone thinks so I can not be worrying so much and can have actual honest feedback.

It's Saturday night. Not everyone is always checking the forum. No, I don't think you said anything wrong to Merek. I think it's normal to want to blame ourselves when something like that happens. I also felt like maybe I shouldn't have been so hard on him about his psychedelic use.

Don't take it so personally if someone doesn't respond to you. It's easy to lose track of who said what in the format of these forums, & a lot of people are only worried about specific information

 

[RecoveryInProgress]

It's Saturday night. Not everyone is always checking the forum. No, I don't think you said anything wrong to Merek. I think it's normal to want to blame ourselves when something like that happens. I also felt like maybe I shouldn't have been so hard on him about his psychedelic use.

Don't take it so personally if someone doesn't respond to you. It's easy to lose track of who said what in the format of these forums, & a lot of people are only worried about specific information

Thank you for replying! I was hoping I didn’t say anything wrong but did you think I actually did a good job, or should I have said things differently?

 

[CrimsonThornX]

I was trying to talk to him when it happened!! How do you think I did!? The whole time after I was questioning whether I said something wrong!

Oh my bad for not responding sooner, I wasn't even using my phone during that span of time since I was focusing on doing certain chores around the house, mainly cleaning. But yeah don't worry about taking it personally if nobody responds, I used to feel that way when people flat out ignored my questions but I assume people just simply don't have an answer or something.

But more importantly, looking back at the conversation you had with Merek back on the 10th of May, everything you did seemed fine to me, especially for being the first person to respond to him after he metioned he'd wait for the next train to arrive. If you were there during that that span of time I'd be glad of having at least tried, but I on the other hand randomly decided to stop checking these threads between the 27th of April to the 19th of May.

I'm working on some writing and it's actually coming out decently and I'm staying focused. This feels like a big step towards recovering my creative faculties.

That's good to know, earlier today I decided to volunteer for a few hours in a food donation program, which would be the first time since getting injected that I attempted to do anything of that sort. It turns out that my anhedonia has improved enough that I was able to remain motivated enough the whole time, and enjoyed it as well. Had I attempted to do this months ago I most likely would've just given up after 5 minutes or less. I believe I might be ready to start working at least part-time again so I'll start look for job openings next month, mainly because I hate the thought of having been mostly financially independent at one point pre-Invega to being a 23 year old grown-ass man living off of their parents completely now.

 

[Senior Moderator]

I'm still upset with myself for randomly deciding to take a break from this thread for a few weeks, I never would've imagined Merek would commit suicide during that span of time, I feel as if mabye there's a possibility I could've talked him out of it, it was the least I could try to do. The last time I spoke with him directly was back on the 8th of April when I told him I was finally able to sleep somewhat well again after not being able to do so for over 3 months, and began seeing other improvements too, his last response was even, "Glad too hear it my man, usually significant improvements are seen by month 4, you should be able to recover enough to live a good quality life again at some point the people who never recover say they haven’t had any improvements at month 4." Except that he is no longer alive for me to tell him that he was right, that I can indeed live a pretty good quality of life again.

I know.....I was present the whole time and I have been a moderator/senior moderator/admin on this forum for over 17 years and I have seen A LOT of cries for help, signs of suicidal intention, active suicide attempts etc during that time, and Merek's disappearance blind-sided me. He kept saying that he was doing well, he kept encouraging everyone who was struggling. I still hope every day that he is alive and just doesn't want to come back on here for whatever reasons...

Thank you for replying! I was hoping I didn’t say anything wrong but did you think I actually did a good job, or should I have said things differently?

You absolutely can not blame yourself for anything that another person does. You did the absolutely BEST you could, always believe that

 

[MephedroneCandy]

If you started antipsychotics for schizophrenia and they work, do not stop them because of cognitive deficits. An hypodopaminergic tone in most regions in the brain except the striatum which is hyperdopaminergic is normal for schizophrenia and it is responsible for the negative symptoms and partially for hallucinations. Invega exacerbates this hypodopaminergic state in favor of rebalancing striatum.
Abilify fixes it by being a partial agonist instead of antagonist, so you can try switching to it. Cognitive deficits should get better than invega, or even better than baseline. If you still want improvement you can very carefully add lisdexamphetamine to the treatment ALWAYS when you are already stable on antipsychotics. With lisdexamphetamine you can rebalance all hypodopaminergic regions and so treat all the negative symptoms of schizophrenia, while still having protection from positive symptoms by antipsychotics.

The lack of treatment for negative symptoms contributes to the reason of why some schizophrenics do still have positive symptoms when on antipsychotics. For example because the hypodopaminergic tone is associated to hearing problems, it goes in synergy with positive symptoms since the brain is forced to predict a lot aka hallucinate to understand the confused stuff it hears. but psychiatrists don't even know if they're alive, so this isn't being addressed as it should be.

Whatever you choose, I don't think just don't taking nothing is a good solution for a schizophrenic patient because there is good potential of a extremely high quality of life thanks to the right treatment.

Some source if the logical explaination isn't enough: https://www.nature.com/articles/npp2013111

 

[Mucky]

Prepare for the new ED

Yo rul if you don’t mind me asking what are your symptoms? Have you seen any improvements and how long have you been off the poison ?

 

[mura_yom_invegasucks]

If you started antipsychotics for schizophrenia and they work, do not stop them because of cognitive deficits. An hypodopaminergic tone in most regions in the brain except the striatum which is hyperdopaminergic is normal for schizophrenia and it is responsible for the negative symptoms and partially for hallucinations. Invega exacerbates this hypodopaminergic state in favor of rebalancing striatum.
Abilify fixes it by being a partial agonist instead of antagonist, so you can try switching to it. Cognitive deficits should get better than invega, or even better than baseline. If you still want improvement you can very carefully add lisdexamphetamine to the treatment ALWAYS when you are already stable on antipsychotics. With lisdexamphetamine you can rebalance all hypodopaminergic regions and so treat all the negative symptoms of schizophrenia, while still having protection from positive symptoms by antipsychotics.

The lack of treatment for negative symptoms contributes to the reason of why some schizophrenics do still have positive symptoms when on antipsychotics. For example because the hypodopaminergic tone is associated to hearing problems, it goes in synergy with positive symptoms since the brain is forced to predict a lot aka hallucinate to understand the confused stuff it hears. but psychiatrists don't even know if they're alive, so this isn't being addressed as it should be.

Whatever you choose, I don't think just don't taking nothing is a good solution for a schizophrenic patient because there is good potential of a extremely high quality of life thanks to the right treatment.

Some source if the logical explaination isn't enough: https://www.nature.com/articles/npp2013111

What do think of olanzapine as a treatment considering the effects on creativity and enthusiasm for life and hobbies? I’m taking both abilify and olanzapine and am wondering if the two in combination is a bad combination due to them combining and being to strong? So am thinking of asking if they can do one or the other. Thanks, your comment is really interesting

 

[Rulomaner]

Yo rul if you don’t mind me asking what are your symptoms? Have you seen any improvements and how long have you been off the poison ?

Ive been 4 months off abilify shots. No erections during the day. No sensitivity (thats by far the worst) I would prefer not having erections but having sensitivity than having erection when I need to but not feeling anything. Sperm is shitty. Just a few drops and if not wattery semen. This is hell mate I am sorry to tell you!
I used to practice sex everyday, and I have experience practising it in this condition. Is hell mate

 

[Rulomaner]

If you started antipsychotics for schizophrenia and they work, do not stop them because of cognitive deficits. An hypodopaminergic tone in most regions in the brain except the striatum which is hyperdopaminergic is normal for schizophrenia and it is responsible for the negative symptoms and partially for hallucinations. Invega exacerbates this hypodopaminergic state in favor of rebalancing striatum.
Abilify fixes it by being a partial agonist instead of antagonist, so you can try switching to it. Cognitive deficits should get better than invega, or even better than baseline. If you still want improvement you can very carefully add lisdexamphetamine to the treatment ALWAYS when you are already stable on antipsychotics. With lisdexamphetamine you can rebalance all hypodopaminergic regions and so treat all the negative symptoms of schizophrenia, while still having protection from positive symptoms by antipsychotics.

The lack of treatment for negative symptoms contributes to the reason of why some schizophrenics do still have positive symptoms when on antipsychotics. For example because the hypodopaminergic tone is associated to hearing problems, it goes in synergy with positive symptoms since the brain is forced to predict a lot aka hallucinate to understand the confused stuff it hears. but psychiatrists don't even know if they're alive, so this isn't being addressed as it should be.

Whatever you choose, I don't think just don't taking nothing is a good solution for a schizophrenic patient because there is good potential of a extremely high quality of life thanks to the right treatment.

Some source if the logical explaination isn't enough: https://www.nature.com/articles/npp2013111

Lisdexamphetamine? How? Abilify is partial agonist, yes, but theres a trick there. Partial agonist on PREsynaptic and antagonist on POSTsynaptic, which means you are not going to get any fucking dopamine. Why te fuck would you antagonize the post and agonize the pre, it should be the other way round for fuck shake I cant believe this scientists are so stupid!!!

 

[mura_yom_invegasucks]

Ive been 4 months off abilify shots. No erections during the day. No sensitivity (thats by far the worst) I would prefer not having erections but having sensitivity than having erection when I need to but not feeling anything. Sperm is shitty. Just a few drops and if not wattery semen. This is hell mate I am sorry to tell you!
I used to practice sex everyday, and I have experience practising it in this condition. Is hell mate

When was your last Invega injection?

 

[Rulomaner]

3 abilify injections, which for me are as bad as invega.
Last 20th March.

When was your last Invega injection?

 

[mura_yom_invegasucks]

3 abilify injections, which for me are as bad as invega.
Last 20th March.

Perhaps the ability worsened your recovery if it wasn’t that long after, when did you take Invega?

 

[MephedroneCandy]

Lisdexamphetamine? How? Abilify is partial agonist, yes, but theres a trick there. Partial agonist on PREsynaptic and antagonist on POSTsynaptic, which means you are not going to get any fucking dopamine. Why te fuck would you antagonize the post and agonize the pre, it should be the other way round for fuck shake I cant believe this scientists are so stupid!!!

What do you mean how? By eating it. Regarding aripiprazole, it is not a partial agonist just for the autoreceptor, even for brain regions that are hypodopaminergic. Infact it shows improvements compared to risperidone. Although risperidone might work better when combined with lisdexamphetamine as autoreceptor antagonism is synergical.

The best antipsychotic to take when in combination with lisdexamphetamine is something that is more selective on 5ht2a antagonism such as brexpiprazole, maybe using a small dose of haloperidol as augmentation if it is not enough. So it will inhibit dopamine neurons firing selectively on the hyperdopaminergic region and the hypodopaminergic ones can be treated with a stimulant.

 

[Rulomaner]

Perhaps the ability worsened your recovery if it wasn’t that long after, when did you take Invega?

Never invega

What do you mean how? By eating it. Regarding aripiprazole, it is not a partial agonist just for the autoreceptor, even for brain regions that are hypodopaminergic. Infact it shows improvements compared to risperidone. Although risperidone might work better when combined with lisdexamphetamine as autoreceptor antagonism is synergical.

The best antipsychotic to take when in combination with lisdexamphetamine is something that is more selective on 5ht2a antagonism such as brexpiprazole, maybe using a small dose of haloperidol as augmentation if it is not enough. So it will inhibit dopamine neurons firing selectively on the hyperdopaminergic region and the hypodopaminergic ones can be treated with a stimulant.

I dont really understand your point on autoreceptors, what do you mean? Abilify is antagonist on postsynaptic DA neurons, which means it blocks dopamine from being released, as well as risperidone thought. What I dont really understand is if taking other aps after eating lets say abilify, is going to make any changes. Just imagine they create a med that agonizes DA postsynaptic receptors, would it work? I mean, is it possible to unblock these receptors by any chance? Or is it permanent due to it being antagonized for such a long time??

What do you mean how? By eating it. Regarding aripiprazole, it is not a partial agonist just for the autoreceptor, even for brain regions that are hypodopaminergic. Infact it shows improvements compared to risperidone. Although risperidone might work better when combined with lisdexamphetamine as autoreceptor antagonism is synergical.

The best antipsychotic to take when in combination with lisdexamphetamine is something that is more selective on 5ht2a antagonism such as brexpiprazole, maybe using a small dose of haloperidol as augmentation if it is not enough. So it will inhibit dopamine neurons firing selectively on the hyperdopaminergic region and the hypodopaminergic ones can be treated with a stimulant.

I know its by eating, but many people report no effects of lisdexamp when taken along with abilify. Its obvious if u take into account abilify function…

 

[MephedroneCandy]

I dont really understand your point on autoreceptors, what do you mean? Abilify is antagonist on postsynaptic DA neurons, which means it blocks dopamine from being released, as well as risperidone thought. What I dont really understand is if taking other aps after eating lets say abilify, is going to make any changes. Just imagine they create a med that agonizes DA postsynaptic receptors, would it work? I mean, is it possible to unblock these receptors by any chance? Or is it permanent due to it being antagonized for such a long time??

The opposite happens. If you stop taking an antipsychotic you have inverse tolerance to the antagonism you had for such a long time and so it will be oversensitive.
Infact there are people who take haloperidol for like 2 weeks, stop taking it and they feel energized for a few days more than before taking it. It is a personal experience too.

I know its by eating, but many people report no effects of lisdexamp when taken along with abilify. Its obvious if u take into account abilify function…

I don't know specifically every of those cases. Maybe they were taking too much abilify (maybe the dosage that was required to treat an acute psychotic episode and not the maintenance dose) or too little lisdexamphetamine. In any case If you decide to go down this road, I have told you which antipsychotics are the most suitable.