Olanzapine

[psyfiend]

I gained weight... its strange

 

[greenlight204]

I gained weight... its strange

not strange at all, olanzapine is the AP associated with the highest weight gain out of any

 

[paranoid android]

not strange at all, olanzapine is the AP associated with the highest weight gain out of any

I actually managed to lose weight on zyprexa

 

[greenlight204]

I actually managed to lose weight on zyprexa

no clue how on earth you did but good on you. I have never been so overweight like I was on that hellish drug. bulging out of my skin. ive never lost weight on any AP. what did you do specifically?

 

[Jabberwocky]

no clue how on earth you did but good on you. I have never been so overweight like I was on that hellish drug. bulging out of my skin. ive never lost weight on any AP. what did you do specifically?

Like with anything, if you spend more calories than you take in, you will lose weight. Olanzapine doesn't magically change this formula.

But olanzapine significantly raises blood sugar levels, so avoiding sugar is probably key to mitigating weight gain from 2nd gen antipsychotics. Whole foods, high protein diet. Paleo or Mediterranean diet would probably work well.

 

[paranoid android]

no clue how on earth you did but good on you. I have never been so overweight like I was on that hellish drug. bulging out of my skin. ive never lost weight on any AP. what did you do specifically?

Mostly i just cut out cola and cut back on carbs and started lifting weights again.

 

[SpiralusSancti]

When I was reading about metformin it seems it can negate olanzapine effect of gaining weight. Idk if taking it for that would be wise but there shouldn’t be any interactions.

 

[washingtonbound]

Have you had any positive experiences with olanzapine, mainly for the treatment of anxiety? Sometimes taking 5 mg will take the edge off anxiety. I wonder if taking 10 mg would increase the effect or make you too tired. I think it's commonly prescribed in in the range of 2,5 mg to 20 mg a day.

Personally I don’t recommend making a habit of taking olanzapine. I was put on it after a manic episode and dealt with some nasty weight gain, and didn’t feel like myself when on it at all. It does knock you out so I suppose that can help with anxiety but it also made me a bit agitated and definitely a bit anhedonic, even the next day. If you feel it helps you, I definitely wouldn’t exceed 5mg and only take it as needed. I’m not a psychiatrist but can tell you from personal experience it is not pleasant to be on it for long term at high doses whatsoever. Definitely be cautious with it.

 

[LongeDD]

5mg at night would give me awful pretty vivid nightmares. During the day, I didn't feel like myself. U could've told me someone died and I'd gave responded "ok"

how long were you on it?

 

[nznity]

how long were you on it?

Around 2 months, what a horrible med for real.

 

[Dreamflyer]

I tried Olanzapine and Risperidone a few times for anxiety and insomnia when my dad took it, but they just made me feel like a zombie.

 

[Deleted member 558992]

An interesting combination of this is

I was pulled off morphine, clonazepam, gabapentin and seroquel in the psych ward so nothing surprises me.



That is some bullshit though tbh i would have killed someone for some ketamine when i was in there. When it comes to being detained atleast criminals have to be charged psychiatric patients just need to be deemed unwell.

An interesting combination(?) of this are sexual offenders who are civilly committed after having completed their incarceration.

 

[Sol Andre Raz Somoza]

Yes it lowers anxiety at 2.5 in the evening half life of 30 hours I take tramadol 2 grams and clonazepam 6 mg pregabalin 75mg for week ends give a good euphoric and speedy high .. olanzapine makes me sleep and adds anti anxiety effects

 

[Mimi Bordeaux]

Have you had any positive experiences with olanzapine, mainly for the treatment of anxiety? Sometimes taking 5 mg will take the edge off anxiety. I wonder if taking 10 mg would increase the effect or make you too tired. I think it's commonly prescribed in in the range of 2,5 mg to 20 mg a day.

I only take a small dose and it seems to work in the sense that I fall asleep in minutes but I'm also on Valium so that helps no doubt.
But you can put on an extreme lot of weight on any antipsychotic
I wouldn't touch any other one earlier after being on Seroquel which for me is one of the worst drugs mankind has ever invented.
So yes and no
Hope this helps --))

 

[Flynnal]

Be careful, SUPER careful of Effexor (venlafaxine). I could have brutally killed someone whilst on that shit. I feel the same could be possible for SSRIs too. I avoid those classes of drugs. Amitryptiline is better than those for depression and anxiety, but it is toxic in O/D which can be problematic for those with depression and anxiety since both conditions increase the risk of self-harm. Amitryptiline is also better for nerve pain. I've found it helps with my ear pain and reduces it by about 30% and that's just 10mg. Baclofen is about the same, as is Lyrica, about 40% for the Lyrica. I wonder if carbamazepine would reduce it by say 65%...that would be even better...but I hear carbamazepine is ototoxic and causes hearing damage over time.

I found 60mg mirtazapine also helps with nerve pain, but it makes me eat like a pig at the trough. Not good for someone who wants to be a decent weight and feel svelte. I feel lethargic on that shit, but it sure as hell reduces nerve pain, especially in the back. And it also improves orgasms too.

 

[jambabomba]

Olanzapine destroys brain it decreases 10% grey matter from frontal lobes after one year and 20% of glial cells mass. Glial cells are very important to clean ex. Glutamate out from synaptic cleft.

Eli Lilly was so proud of its medicine and believed that mystical sickness called schizophrenia caused shrinkage of the brain but Nancy Anderson showed it was antipsychotics that causes damage to brain. Early Parkinson called 'Tardive dyskinesia' etc.

Anyway, I use small dose of Olanzapine because it raises allopregnanolone. Forget about dopamine hypothesis behind schizophrenia; when neurosteroid synthesis is blocked olanzapine and many other antipsychotics doesn't work at all. So it is gabaergic dominance that helps as 30% of neurons are gabaergic and 40% are glutamatergic and <1% or about 600 000 are dopaminergic. And what controls mesolimbic- and mesocortical dopaminergic pathways are pyramidal glutamatergic neurons and if there are GABA deficiency then those glutamatergic neurons fire too much and bombard dopaminergic neurons to work too much to create hallucinations, voices etc. But the reason is too lazy GABAergic system.

Allopregnanolone is 200x stronger than phenobarbital and about 10-100x stronger than benzodiazepines. It is endozepine; a natural benzodiazepine made from progesterone. The king of antipsychotics called Leponex or Clozapine raises allopregnanolone the most and it also has direct GABA-b agonist effect. Olanzapine raises allopregnanolone too quite a lot.

SSRI:s also raise allopregnanolone and that is the reason why they help with depression. Serotonin just causes side effects like suicidal toughts and severe anxiety through 5ht-2c and 5ht-2a which are located about 85% of glutamatergic neurons. So they cause exitotoxic damage first two weeks until those receptors start to downregulate and allopregnanolone and gabaergic tone takes over glutamatergic tone.

Anyway, SSRI:s help with depression far smaller amounts than they raise serotonin because it is allopregnanolone that helps and they raise it with very small doses.

Same thing with antipsychotics. I take Olanzapine eod 1,25-2,5mg and just because of allopregnanolone. Also amitriptyline and propranolol raises allopregnanolone.

Allopregnanolone is PAM (Positive allosteric modulator) like benzodiazepines but it acts S
as full agonist like GABA at mg doses. I eat Pregnenolone, Olanzapine, Amitriptyline and Propranolol just to raise allopregnanolone which actually helps with benzo withdrawals. 1000mg of Pregnenolone + afromentioned medicines and benzowithdrawal is made easier.

 

[BadBoy377]

Olanzapine destroys brain it decreases 10% grey matter from frontal lobes after one year and 20% of glial cells mass. Glial cells are very important to clean ex. Glutamate out from synaptic cleft.

Eli Lilly was so proud of its medicine and believed that mystical sickness called schizophrenia caused shrinkage of the brain but Nancy Anderson showed it was antipsychotics that causes damage to brain. Early Parkinson called 'Tardive dyskinesia' etc.

Anyway, I use small dose of Olanzapine because it raises allopregnanolone. Forget about dopamine hypothesis behind schizophrenia; when neurosteroid synthesis is blocked olanzapine and many other antipsychotics doesn't work at all. So it is gabaergic dominance that helps as 30% of neurons are gabaergic and 40% are glutamatergic and <1% or about 600 000 are dopaminergic. And what controls mesolimbic- and mesocortical dopaminergic pathways are pyramidal glutamatergic neurons and if there are GABA deficiency then those glutamatergic neurons fire too much and bombard dopaminergic neurons to work too much to create hallucinations, voices etc. But the reason is too lazy GABAergic system.

Allopregnanolone is 200x stronger than phenobarbital and about 10-100x stronger than benzodiazepines. It is endozepine; a natural benzodiazepine made from progesterone. The king of antipsychotics called Leponex or Clozapine raises allopregnanolone the most and it also has direct GABA-b agonist effect. Olanzapine raises allopregnanolone too quite a lot.

SSRI:s also raise allopregnanolone and that is the reason why they help with depression. Serotonin just causes side effects like suicidal toughts and severe anxiety through 5ht-2c and 5ht-2a which are located about 85% of glutamatergic neurons. So they cause exitotoxic damage first two weeks until those receptors start to downregulate and allopregnanolone and gabaergic tone takes over glutamatergic tone.

Anyway, SSRI:s help with depression far smaller amounts than they raise serotonin because it is allopregnanolone that helps and they raise it with very small doses.

Same thing with antipsychotics. I take Olanzapine eod 1,25-2,5mg and just because of allopregnanolone. Also amitriptyline and propranolol raises allopregnanolone.

Allopregnanolone is PAM (Positive allosteric modulator) like benzodiazepines but it acts S
as full agonist like GABA at mg doses. I eat Pregnenolone, Olanzapine, Amitriptyline and Propranolol just to raise allopregnanolone which actually helps with benzo withdrawals. 1000mg of Pregnenolone + afromentioned medicines and benzowithdrawal is made easier.

This is a hard read but I think I follow!

Do you know what sort of doses of propranolol raise allopregnanolone and by how much?

 

[jambabomba]

This is a hard read but I think I follow!

Do you know what sort of doses of propranolol raise allopregnanolone and by how much?

Propranolol, certain SSRI:s like Fluoxetine, Amitriptyline, Mirtazapine and many antipsychotic raises allopregnanolone.

Drugs possessing aryloxypropanamine pharmacophore, duloxetine, dapoxetine and propranolol, increase allopregnanolone in rat brain: Possible involvement of allopregnanolone in their central nervous system effects - PubMed

Allopregnanolone (AP) is a neurosteroid synthesized in the brain and a positive allosteric modulator of γ-aminobutyric acid (GABA) type A receptors. Some drugs possessing the aryloxypropanamine (AOPA) pharmacophore, such as fluoxetine, exert their central nervous system (CNS) effects by...

pubmed.ncbi.nlm.nih.gov

"Some drugs possessing the aryloxypropanamine (AOPA) pharmacophore, such as fluoxetine, exert their central nervous system (CNS) effects by increasing the brain AP. Although duloxetine (DLX), dapoxetine (DPX), atomoxetine (ATX) and propranolol (PRL) also possess the AOPA pharmacophore and are used to treat some psychiatric disorders, the capabilities of these drugs to increase the brain AP and the possible involvement of AP in their CNS effects remain to be fully elucidated. To clarify these points, we first developed a method for quantifying AP in the rat brain by liquid chromatography/electrospray ionization-tandem mass spectrometry. Analysis of the changes in the brain AP levels using this method revealed that the intraperitoneal administration of DLX (10 mg/kg), DPX (10 mg/kg) and PRL (20 mg/kg) significantly increased the brain AP (DLX: < 0.40-2.74 ng/g tissue, DPX: 1.48-3.83 ng/g tissue and PRL: < 0.40-2.09 ng/g tissue) compared to the saline administration (<0.40 ng/g tissue). These results suggested the possible involvement of the GABAergic neurosteroid, AP, in the central actions of DLX, DPX and PRL. In contrast, ATX (10 mg/kg) did not affect the AP levels in the brain. In addition, the brain and serum AP levels had a remarkably high positive correlation after the administration of DLX, DPX and PRL."

"Fluoxetine, paroxetine, and sertraline increase allopregnanolone production through increased efficiency of conversion of DHP to allopregnanolone. Fluoxetine also may have some effect through the inhibition of a competing pathway (progesterone to 20α-dihydroprogesterone)."

"Some antipsychotics, particularly olanzapine and clozapine, can increase allopregnanolone levels, which may contribute to their antipsychotic effects by modulating GABAergic neurotransmission. This effect is not seen with all antipsychotics, as risperidone and haloperidol do not appear to significantly alter allopregnanolone levels. The increase in allopregnanolone may also explain the anxiolytic-like effects of olanzapine and clozapine."
The raise of allopregnanolone was about 107% with Propranolol if I remember correctly according to some study that I didn't find right now. But if you take the precursor pregnenolone 200-1000mg with propranolol 40mg, amitriptyline 25-50mg and olanzapine 2,5mg-5mg the raise in allopregnanolone will be quite high at least when I tested that combo the gabaergic effect was stronger than 2mg of Alprazolam if I noticed correctly.
"Amitriptyline increases allopregnanolone levels by stimulating the activity of the

3α3 alpha
-HSD enzyme, which is involved in the synthesis of this neurosteroid. This effect has been observed in preclinical studies, and a reduction in allopregnanolone levels is associated with depression and other psychiatric disorders. Amitriptyline’s ability to boost allopregnanolone production is a suggested mechanism for its antidepressant and anxiolytic effects. "

"Clinical relevance: Reduced levels of allopregnanolone are found in patients with depression and anxiety disorders. The increase in allopregnanolone levels caused by antidepressants like amitriptyline may contribute to the improvement of these symptoms.
Other drugs: Other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and other tricyclic antidepressants, have also been shown to have a similar effect on allopregnanolone synthesis."

 

[BadBoy377]

Nice one, thankyou!

 

[jambabomba]

Nice one, thankyou!

I am now trying microdosing several different substances. I would like to try also Clozapine as it has so short half-life compared to ex. Olanzapine and also it has much less lower affinity to D1&D2 and also other receptors than Olanzapine. That is why they give such massive doses of it like 500mg to 750mg per day when Olanzapine is given 2,5-20mg per day..
But still, Clozapine is more effective even at lower doses because it raises allopregnanolone the most (and its antipsychotics effects can be blocked by blocking neurosteroid synthesis - mainly allopregnanolone synthesis like with Olanzapine) but what makes Clozapine the "King of neuroleptics" is not its dopamine blocking effects as it's affinity to those receptors are allmost equal to Quetiapine but Clozapine is the only neuroleptic that has direct GABA-B agonist effect + it raises the most allopregnanolone.. but allmost none of psychiatrist know this.

Baclofen (pure gaba-b agonist) would be much more safer option with some antiserotonoergic drug with some low doses of Clozapine than high dose clozapine or olanzapine that actually destroy dopaminergic pathways over time.

Anyway I am now experiencing with microdoses of Olanzapine, Quetiapine and Bupropion to try to make my dopaminergic pathways work better - and at the same time try to avoid doing damage to them as I use very low doses which will allow normal stimulation for dopaminergic systems to keep them at good condition.

Bupropion I use because I want to "reset" my nicotine tolerance and Olanzapine&Quetiapine I use because I want to get natural "dexedrine" boost for dopaminergic system through the day.

Today I tried these amounts and I also suspect even these amounts will raise allopregnanolone and especially Clozapine at dose 25-50mg will do the trick of upregulating dopaminergic system when taken by night + raises allopregnanolone and because of its short half-life (why they give it also to schizophrenic patients also during the day) it is gone by morning and leaves dopaminergic system working more efficiently than normal - maybe even over time like one would have taken dexedrine or concerta at morning. So I will try to get prescription for Clozapine but first I try these three medicines with small allmost micro doses.

Bupropion 150mg tablet weights 185mg -> 3-5mg -> Equals about 3-4mg Bupropione for sensitizing NaCh (nicotine) receptors to get high again from nicotine.

Olanzapine 5mg tablet weights 100mg -> 5-10mg -> Equals about 10ug-250ug of Olanzapine. Just to get more functional dopamine&serotonin system through the day.

Quetiapine 25mg tablet weights 100mg -> 10mg equals to 2,5mg Quetiapine (Quetiapine has allmost equal affinity to D1&D2 receptors than Clozapine so the amount with "micro dosing" can be higher than ex. With olanzapine which has affinity like Haloperidol.

Today I took all of those at morning with my normal meds of Tramadol, Gabapentin, Valium, Lorazepam, coffee, greentea and some natural stimulants.

I will report if I notice some good effects from those micro doses during the day at work.

Best regards