Bomb319
Bluelighter
- Joined
- Nov 26, 2011
- Messages
- 583
And vice-versa - oversleeping increases clearance of methadone or possibly most substances? I've been on methadone maintenance since 2013 and haven't used any illegal drugs since then. The problem is that it seems to have a WILDLY different half-life in my body for which I haven't been able to consistently identify a reason. Sometimes it lasts such a short time that I can start yawning 8 hours after a dose and have disrupted, uncomfortable and fragmented sleep with vivid dreams, significant increase in sense of smell, and...well, you know...opioid withdrawal symptoms - despite taking my dose only just that morning. Other times, I can miss 2 whole days and there are few withdrawal symptoms. The ones that ARE there are typically the early ones. If I were to do that in a "low efficacy" period, I can be absolutely miserable with symptoms FAR beyond anxiety and the psychological (extreme chills and sweating, big change in sense of smell, enormous pupils, nausea and vomiting and in particular, sneezing fits. I have yet to think of a mechanism that could explain how these clear WD symptoms could only be in my head). If I feel lousy, I often won't/can't eat for a significant amount of time before I pick up my next doses. That's why I figured that a prolonged empty stomach could be the reason for this, but even THAT seems to be variable. I also take Nexium (esomeprazole) daily since the most obvious culprit seemed to be variable stomach acidity.
Yet the past several times I've been through this, I seem to be more or less OK if I've been awake all night for one or two days if I've missed doses. So far, that correlates with longer methadone effect more than any of the other potential factors I've identified. Is this just a coincidence as it was with everything else I've tried to think of, or is it actually feasible that drug clearance increases during sleep? Conversely, OVERsleeping before my dose seems to make it worse, which certainly seems to add additional evidence to this possibility. As the purpose of sleep (at least in part) is to rest, repair, eliminate toxins, etc., it doesn't seem too far-fetched.
Yet the past several times I've been through this, I seem to be more or less OK if I've been awake all night for one or two days if I've missed doses. So far, that correlates with longer methadone effect more than any of the other potential factors I've identified. Is this just a coincidence as it was with everything else I've tried to think of, or is it actually feasible that drug clearance increases during sleep? Conversely, OVERsleeping before my dose seems to make it worse, which certainly seems to add additional evidence to this possibility. As the purpose of sleep (at least in part) is to rest, repair, eliminate toxins, etc., it doesn't seem too far-fetched.
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