Pyrophenidone has no NDMA ???

[Gaffy]

Seeing how close pyrophenidone and Ephenidine and its analogues are, isn't it weird it has no NDMA activity? Has it been tried at higher doses? What do you think?

 

[Gaffy]

@sekio what do you think? Adding an oxygen to the beta position renders it inactive at NMDA rceptors? Yet it is as the same place as Ketamine's ketone.. Maybe highdoses ?

 

[Gaffy]

With images:

For Ephenidine

The pyrophenidone

Pyrophenidine

 

[Rectify]

"Logic Has Nothing To Do With Drug Discovery."--Sasha Shulgin.

 

[mzm]

@sekio what do you think? Adding an oxygen to the beta position renders it inactive at NMDA rceptors? Yet it is as the same place as Ketamine's ketone.. Maybe highdoses ?

I've heard adding an oxygen at the 2' position of PCP lowers NMDA affinity and causes opioid effects. It is strange that it does not do the same for PCM or PCE.

 

[Gaffy]

I've heard adding an oxygen at the 2' position of PCP lowers NMDA affinity and causes opioid effects. It is strange that it does not do the same for PCM or PCE.

Thanks for your report