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Opioids Tianeptine Megathread v1

Mycophile said:
So is the consensus that Tianeptine is really not good for depression because of how horrible the WD is?

I hear that it can be used as an antidepressant and some people respond well to it, but I also keep hearing people talk about how horrible the WD is, and you are talking to someone who has disliked Kratom WD and had trouble not using too much of it, and I once heard someone in here, probably somewhere in this thread, say that if you've had problems with Kratom to NEVER touch Tianeptine.

Is this stuff really best to stay away from and not consider for usage for depression if you are the type of person to often abuse substances?
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Tianeptine is pretty great for depression if used strictly therapeutically but if someone has history of often abusing substances then it is probably a bad idea to try Tianeptine. And if that person has previous history abusing opioids then it is probably most especially a bad idea, like playing with matches in the middle of a fireworks warehouse while soaking wet from gasoline kind of bad idea.

Kratom withdrawal sucks for me, and I like kratom so I too wanna take it more than I should.... but Tianeptine? Got out of hand very quickly for me and the withdrawals are 100x worse. Kratom is benign in comparison.
 
There are several reports on the net indicating that when injected tianeptine actually causes severe necrosis, a bit like krokodil. Personally, I found tianeptine extremely underwhelming. Granted, I didn't shoot it but I have a feeling that its not worth it either.
 
Why is this thread formated so weirdly on my screen with the boxes on seperate sides of the screen instead of posts straight down? It looks much better the latter way.

Is it that way for anyone else?

Anyways, seems that NOT EVERYONE agrees that using all forms of Tianeptine in all cases is this horrible thing, and that in particular the Sulfate version rather than the sodium CAN be used for depression and anxiety with good effects and without horrible WD effects IF it is used responsibly and strictly, and some people even say it can be done with the sodium version, but I'd be much more wary there.

I still don't think I'd feel comfortable about it, but has anyone here used Tianeptine SULFATE to treat depression and/or anxiety and mood issues effectively WITHOUT it causing serious withdrawal or can they speak to the ability of some people being able to do so and how they would go about doing it?
 
Sure, If you stick to strictly therapeutic level dosing/frequency, then you won't experience those horrible withdrawals everyone talks about. I don't know what is therapeutic recommended dosage wise for the sulfate but for sodium it's 12.5mg three times a day. Sulfate is probably a little higher of a dose with less frequency, something like 25mg twice a day, but I'm only guessing here so do some research.

Can somebody use it responsibly? Of course, I think with the correct mindset going in it's totally possible for a lot of people. Probably not a good idea for addicts especially those with previous opioid issues.

I purchased Tianeptine the first time with good intentions. I enjoyed my first few therapeutic doses but unfortunately my internal addict's interest was piqued. So I tried a large dose 'just once' to see and I liked it - a lot. Soon I was taking large doses a few times a week, then daily, then every few hours. Rest is history.

I'm an addict and I give in to my urges to easily, especially with opioids. I should have known better, actually I did know better, I think in the back of my mind I I knew what would happen. So for me, it was a bad idea to get Tianeptine in the first place. For you? I don't know, you are going to have to make that decision for yourself.

Keep in mind you worked your kratom doses up very very high and eventually were using often enough to get some withdrawals when stopping. You can't do this with Tianeptine, it won't end well. The withdrawals are horrible - like heroin intensity horrible.

If you are going to use it then set strict rules: stick to strictly therapeutic doses with zero exceptions. If you break rules, then flush everything, walk away and don't look back.

Only you can make the determination whether or not this is feasible for you. It wasn't for me...
 
So I just tried converting tianeptine free acid to tianeptine sodium and am not sure if I have done it properly. This is how (maybe someone can weigh in):

Used 250mg of tianeptine free acid, 55ishmg of sodium bicarbonate (baking soda) and 80ml of water. Got the water to boiling then mixed everything in and pulse boiled at 5-10 second intervals in the microwave but it didnt react in a way that was visible like I've heard it would do. Just drank a bit of a third of the water. Eyes are heavy a few minutes after but not much else to speak of. Should it of reacted?
 
Anyone have much experience with Tianeptine Ethyl Ester Sulphate?

Been trying some of this recently, and subjectively it seems to be more mild than sulphate (Hemisulphate Monohydrate I believe is the typical sulphate version?). I've never tried sodium so can't compare to this. I've been dosing around 40mg at a time which would be on the upper end of my usual sulphate dose back when I did take this occasionally although I haven't taken any for a long time now, maybe up to a year, so I wouldn't think tolerance would be an issue. However reports on reddit and the like seem to suggest the typical dose should be a little lower... which is strange to me.

Would be very interested if anyone knows how to calculate the actual tianeptine content of this compound compared to the sulphate and sodium versions, and especially if anyone knows anything regarding the metabolism, etc...
 
I'm curious too about the ethyl ester sulphate version, hopefully somebody else has some first hand experience and can also share? Comparison to other forms, either in therapeutic or recreational doses, would be interesting.



So, I'm a pretty big fool. I finally had this beast of an addiction beat then a couple weeks ago I went and ordered some Tianeptine sodium. Damnit. WTF is wrong with me?
 
My experience with it did not feel more potent, quite the opposite. Most I took was 100mg which I believe is my max sulphate dose ever, however whereas the standard sulphate was sedating to the point that I just had to lie down for a few hours (maybe akin to a "nod", although my experience with opiates is pretty limited), I did not get this at all with ethyl ester sulphate. I actually ended up throwing away the rest of my small quantity of it having decided it was just nothing special, even quite inferior to other forms of tianeptine, and just not worth doing anymore of, especially in light of how new and unstudied it is and therefore possible safety concerns.
 
Specified said:
Hello gang,

Is it safe to take Tianeptine with a seizure history?
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"In addition, recent interesting results indicating anticonvulsant and analgesic activity of tianeptine and its possible interaction with adenosine A(1) receptors were obtained. "

Looks like it's antiseizure so it's probably safe at studied doses.
 
Saw these 2 studies when looking at long term research and how high to dose. Hope this is helpful.

"J Clin Psychiatry. 2018 Jul 3;79(4). pii: 17m11741. doi: 10.4088/JCP.17m11741.
Efficacy of Tianeptine 25-50 mg in Elderly Patients With Recurrent Major Depressive Disorder: An 8-Week Placebo- and Escitalopram-Controlled Study.

Tianeptine was well tolerated, with only minimal differences in tolerability from placebo.

CONCLUSIONS:
The present study provides robust evidence that an 8-week treatment period with tianeptine 25-50 mg is efficacious and well tolerated in depressed patients aged 65 years or older."

Looks like it's very safe up to 50 mg daily for 2 months of daily use.

"J Psychopharmacol. 2019 Apr;33(4):502-510. doi: 10.1177/0269881119826602. Epub 2019 Mar 5.
Adjunctive tianeptine treatment for bipolar disorder: A 24-week randomized, placebo-controlled, maintenance trial.

Patients in the tianeptine group showed better performance in the letter-number sequencing subtest from the Wechsler Adult Intelligence Scale at the endpoint ( p=0.014). Tianeptine was well tolerated and not associated with higher risk for manic switch compared to placebo.

CONCLUSION:
Tianeptine was not more effective than placebo in the maintenance treatment of bipolar depression. There is preliminary evidence suggesting a pro-cognitive effect of tianeptine in working memory compared to placebo."



Even for 2 years of daily use at 37.5 mg day still no problems but some nootropics effects. Impressive. I tried it up went as high as 75 mg where it was abit strong for me so I decided to hold off on it for awhile. I did try the sulfate form which is suppose to be much stronger so maybe I'll revisit the sodium salt next time.
 
Vastness said:
For the benefit of anyone else who might be reading this thread and would be quite understandably scared away... The withdrawal is not an issue if you take it in sensible doses. Some of the dosing described in this thread is absolutely insane. Admittedly the prescribed dose is a little low for many, but just a little bit higher Tianeptine can be a highly effective antidepressant and even nootropic - at least in the short term, longer term benefits are harder to quantify.

It is most definitely no more or less dangerous than any other abusable substance, if abused. I don't usually like using the word "abuse" in the context of substances, but if ever it would apply, it would be to the patterns of usage in this thread. There is nothing really that special about high dose tianeptine compared to any other drug, it's not the most euphoric, interesting, if you're looking for recreation there are many better options.

Of course everyone has their preference and for some people maybe there is something special, fair enough, I wouldn't dispute this, but my point is that the reason tianeptine is abused really has little to do with any of it's inherent qualities (except perhaps the fairly short duration, admittedly), but a lot more to do with the fact that it is cheap and easily available. Of course there's nothing unusual about this either, this is the case with almost every substance demonised and stigmatised in the public eye because of widespread problem usage. It does however result in serious negative bias as far as the actual dangers of these substances in an objective sense.
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Yeah for real. I'm amazed people are taking 10g a day of this stuff. No wonder the withdrawals are so fucking horrible!

I've used this at more sensible yet still recreational doses like 30-50mg and didn't have any serious issues with it at all. I'm not saying it's harmless, but at sensible doses there's no reason it should be as bad as the posts here paint it.
 
I ordered tianeptine. I am using amitriptyline at the moment. How strong is tianeptines serotonin effect? Has someone used it with amitriptyline or some other serotinin increasing drug and what was your experience? No excess serotonin problem with combination or..?
 
So I just saw this video on tianeptine which is apparently being called "gas station heroin".
The video reeks of overblown media bullshit, but I'm genuinely curious if people have tried or bought this "supplement" from any gas stations.
How does it compare to good Kratom leaf and extracts? How does it compare to real opioids, and is it worth giving it a try or bunk I should stay away from?

From the little bit I've read about on it, it seems to have very good anti-depressive qualities which is what interests me the most.
For the people who've tried it, what are your experiences?

 

how potent of an opiate is tianeptine, really??

How many mgs of suboxone are you on? Curious I’m on 12. Started at 24 a year me a half ago.. i started with 8 last year then i lowered it to 4 and now im on 2 but i have been trying to quit it and i have been switching to alternatives like kratom, tianeptine, tramadol etc. so its not like i...
www.bluelight.org www.bluelight.org
 
Its like a dirty oxycodone, very fiendish.

Not like kratom and much more like a traditional opioid. Oddly though it differs in that it doesnt cause significant respiratory depression unless in massive doses.

500mg of tianeptine is around 30mg of oxycodone in terms of potency. I've probably gone through a few hundred grams of it over the year. Maybe closer to 500 grams even. I liked it quite a bit and got somewhat addicted to it. I think i got sick of it because i no longer enjoy it these days. All side effects and only a shitty high.

Don't buy drugs from the gas station however. Tianeptine would be better in its pure form. But id avoid it as it is exceptionally addictive and fiendish.
 
I've been too scared to try it because I've done a lot of research on its effects and withdrawal. I already know how it'll turn out for me, and given the fact that people claim it completely ruins kratom for quite a while, that's not a path I'm exactly itching to run down Naruto-style. Never saw it covered in the media and definitely never saw it called "gas station heroin" which is absolutely ridiculous. But given the absolute state of western news I am not at all surprised.
 
500mg is a lot stronger than 30 mg oxy. Oxy is shit for me. 500mg IV felt about 200mg IV morphine.

I can't believe they sell kratom and tianeptine in gas stations. You guys will definitely ruin it for the rest of us a lot faster than if it was just left to the drug needs.
 
Tryptamite said:
500mg is a lot stronger than 30 mg oxy. Oxy is shit for me. 500mg IV felt about 200mg IV morphine.

I can't believe they sell kratom and tianeptine in gas stations. You guys will definitely ruin it for the rest of us a lot faster than if it was just left to the drug needs.
Click to expand...

Im talking about orally. Never tried it IV.
 
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