I mean its more of a broad generalization about life experiences than a specific scientific theory, how special an experience feels is inversely proportional to how often you do it and I think this is especially relevant for psychedelics. At the end of a summer where I've tripped often, even with proper tolerance-resetting breaks from psychedelics, the mental aspect feels diminished to me, and i think thats because I've gotten more used to thinking like that, being in that psychedelic headspace, its less of a shocker. Over time you get used to those thought patterns, you become a more experienced tripper, you've see/thought this sort of stuff before, They're PSYCHedelics, a large part of what makes them just that is how they affect you psychologically, the head high.
Maybe I'm explaining wrong, here's an example. I've tripped multiple days in a row quite a lot. I find if I take LSD day 1, the head high will be very pronounced, low-moderate visuals, but like very intense on my mind. The next day, I can take 2, 3, 4 even 5 times the dose of LSD and everything gets ramped up a ton, crazy visuals/body high, but mentally I'm probably less impaired than I was Day 1. If I take 2C-B Day 1, and then just ramp up the dose on day 2, I don't notice much difference in effects, I just had to take a higher dose.
I hear 2 weeks cited for FULL LSD tolerance reset, but if you're tripping on LSD every 2 weeks for an extended period of time, I can't see how the experience wouldn't become less special just by virtue that you go to that place often, even if the physical tolerance is technically reset. You'd probably start to be able to take (by take I mean handle with finesse) these massive LSD doses since you're having this intense mental workout every 2 weeks, and I'd be surprised if you didn't become quite unhinged tripping balls every other weekend. I have a friend who their first time taking mushrooms took ~14grams dried, and to this day, many many years later, mushrooms just don't do it for him, he'll eat 7g like its nothing and he thinks its because that first one was just so crazy. Summer 2016 I did a lot of LSD, even with 2 week breaks the whole experience started to seem mundane
Anyways, the relevance of all that to this is that with 2C-B, the profound psychedelic headspace isn't as pronounced, so it doesn't get old since it wasn't all that special (relatively speaking) to begin with. Physical tolerance is totally a thing not arguing against that, i think its fair to say psychedelics are a lot more than just a physical experience though.
