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2C-B usage question
- Thread starter roady05
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phenethylo J
Bluelight Crew
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He'll be fine it's not like mdma where it's a big nono to take it that close together. Also I've noticed tolerance doesn't last that long at all with 2cb.
epic11
Bluelighter
Not something to brag about.
Id actually wait a min of 2 weeks before doing 2c again. Its highly diminished if you put it that close together. Are you gonna have a big issue? Probably not. It may just not work as well.
Those friends said they were fucked after that / possibly even for life. I think one did over 200mg by accident (another story of an un-labelled water bottle)
I never did that much B at time... I do recall inhaling random amounts chasing the dragon (it's ok I had a good eye for doses mg). Maybe 60mg over few hours?
As for tolerance eye admit abusing 2c-e it for 6 months on a daily basis <<< don't do this & everytime I smoked a joint I'd hallucinate all over again
methylenedream
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This happened me from abusing 2c-i I hallucinated for around 9 months had to quit smoking weed through that time and barely smoke to this day.
Wiserthanearlier
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As long as set and setting is also considered should be fine, but waiting is better. Couple of weeks would be more healthy
2cb tolerance seems to be finicky.
unlike most classic psyches, 2cb has chronically low affinity at 5ht2a, preferring 5ht2c as the mediator of its psychedelic effect. it doesnt exhibit much cross tolerance with lsd, although there can be some as lsd has modest but not overtly notable affinity at 5ht2c also. They work perfectly fine in tandem for this reason though.
In practise it seems to work like:
If you take more 2cb while you are still on 2cb, itll have diminishing returns the longer into the experience is much like other psyches.
If you sober up from the 2cb and then say take it again the next day, youll trip fine.
This seems to hold true for around 72 hours then the tolerance kicks in hard.
2cb is also one of the substances that seems to impact in way of longer term tolerance too. I know several indivduals who more or less ruined it for themselves. It is also a Monoamine Reuptake Inhibitor, albeit a mild one, on account of its TAAR binding, so its not exactly like the classics in that regard either.
unlike most classic psyches, 2cb has chronically low affinity at 5ht2a, preferring 5ht2c as the mediator of its psychedelic effect. it doesnt exhibit much cross tolerance with lsd, although there can be some as lsd has modest but not overtly notable affinity at 5ht2c also. They work perfectly fine in tandem for this reason though.
In practise it seems to work like:
If you take more 2cb while you are still on 2cb, itll have diminishing returns the longer into the experience is much like other psyches.
If you sober up from the 2cb and then say take it again the next day, youll trip fine.
This seems to hold true for around 72 hours then the tolerance kicks in hard.
2cb is also one of the substances that seems to impact in way of longer term tolerance too. I know several indivduals who more or less ruined it for themselves. It is also a Monoamine Reuptake Inhibitor, albeit a mild one, on account of its TAAR binding, so its not exactly like the classics in that regard either.
epic11
Bluelighter
This part is untrue from my experience. Fyi. 2 week minimum break for full effects. Sure youll still notice it if you wait that short period, but its notwhere near waiting longer.
yeah fair one everyone reacts differently, some people dont even get effects from 2cb at all, some can megadose without difficulty and others are extremely sensitive. in regards to the particular part you quoted i was drawing from myself and peers experience. Iv taken 2cb 3 days in a row at a festival without having to increase dose personally and went home in a good mood.
epic11
Bluelighter
you are an enigma my man. Be careful what you spread. I dont think thats very smart HR.
The smart HR was eating two good meals every day. Also the smart HR was not drinking at all and taking mdma only on one day unlike all the other wastemen around me.
I never dosed anything for about 6 months after that.
I am putting down accurate anecdote that literally hundreds of 2cb users iv spoken to agree with. If you want to say the drug follows different rules that's fine and wholly on you but these are my experiences with the substance.
Phobos
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The thing is, being in a good mood and thinking you're ok does not mean anyone else can do the same and be fine.
If someone wants to do whatever they are free to do so, but when you recommend how to do something safely such as taking 2c-b it is more reasonable to take a break that allows a full tolerance reset.
Yeah I don't disagree with that at all I'm not talking about what was best either im just talking about what actually happened.
2cb tolerance does not follow the same rules as 5ht2a agonists.
5ht2a agonists don't even follow a strict rule that we are privy to. Everyone just says "tWo wEeKss" cos of a self reported data set that appeared here years ago averaging 2 different substances together.
Phobos
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2c B is still also a 5HT2A agonist like all classic psychedelics.
Factors that cause a drug to require a long tolerance break is how strongly receptors are activated, receptors affinities, and dosage, but individual responses will change.
I would be inclined to think that with moderate dosages of 2c-B, like 25mg or less, one week should be enough, provided that no drugs with a cross tolerance are taken before or after the 2c-B.
The fact of the matter is tolerance doesn't set in for several says and it sounds like you aren't too experienced with the substance. The above is non-specific word salad. You're hypothesising lol.
Go and please do some research 2cb has chronically low or negligible affinity at 5ht2a even as inverse agonist let alone agonist. It's effect is mediated by 5ht2c which LSD merely tickles by comparison to it's 2a affinity and that is why these substances don't heavily cross-tolerate.
I understand the point behind "give safe info", but sometimes it's dogma. And I was not advising I was stating facts. Its not wise to trip more than once a month in my opinion irrespective of substance. But just cos price harm can be reduced there doesn't mean drugs will change affinity to mould to your angle. I was talking about an incident that actually happened. I was talking about the mechanism of 2cb and the effects as many find them to be. Im only hearing hypotheticals from people atm.
Phobos
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I did my research and I did use 2c-B multiple times.
If you define that post word salad, you are the one that looks uneducated.
Nothing of it is hypothesis and all is actual fact, the only variable is that individual responses change a lot.
2c-B derives a big part of his activity from 5HT2A agonism, this is derived from actual experience with the drug and looking at the affinities of 2c-B and comparing with other drugs.
Please avoid quoting Wikipedia and go look at the actual research papers.
There is one research that says that 2c-B is an antagonist at 5HT2A, all the rest of the research available describes 2c-B as a partial agonist.
If you take a stronger 5HT2A agonist and then 2c-B before tolerance is reset, 2c-B will have very little effect.
Also 2c-B has similar potency at 5HT2C and 5HT2B, and you want to space out powerful 5HT2B agonists if you care about your heart valves.
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I’m going to throw in and also say that I haven’t noticed the same type of tolerance from 2CB that develops from other classical psychedelics.
Also, on that note, just because something works through a similar mechanism or just because a drug is in the same class as others doesn’t mean that the same principles or effects necessarily apply.
It’s very short sighted to say that just because X drug behaves one way that others, in the same or similar class, absolutely will present the same profile as well.
Also, on that note, just because something works through a similar mechanism or just because a drug is in the same class as others doesn’t mean that the same principles or effects necessarily apply.
It’s very short sighted to say that just because X drug behaves one way that others, in the same or similar class, absolutely will present the same profile as well.
Phobos
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You are right that we shouldn't assume that all 2c-X drugs behave in the same way, but I never said that I'm assuming it.
It does develop less tolerance than DOX drugs, IME, probably the fact that it has a shorter duration of action plays a role, but I can't be sure.
That 2c-B has low potency at 5HT2A is not true, it's actually stronger than 2c-E, in instance.
To define what I mean by stronger, I mean the nanomolar concentration needed to produce 50% of the maximum activity at that receptor, or the "EC50 nM" value, taking into consideration what is the Maximal activity at that site.
It is stronger at 5HT2C than it is at 5HT2A, but not in a way that it will not be very active at both sites and saying that it works in a different way compared to the rest of the phenethylamine psychedelics doesn't seem true to me.
I feels like it works in a similar way, there is cross tolerance, and the data shows that it should work in the same way.