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Stimulants How to prevent dopamine depletion from meth?

opiatekrzy said:
Meth does not cause me massive anxiety and DISGUSTING comedowns like Adderall does or even d-amp. Which is why I take meth
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If you get more of a comedown and anxiety from dexamph than meth you are probably not getting real dex or are using crazy doses. Either that or you have very interesting brain chemistry because that's certainly abnormal. Dex in particular should not give much of a comedown at all at sensible doses especially once you have a tolerance.
 
I can assure you I was getting real dex, via my doctors laptop to the pharmacy. Damp is too short lived, I fell a bit more intense in an anxiety stricken way, crashes are just worse. Why is it so hard to believe? Meth is the longer acting one with the longest half life anyways, correct?
 
Wilson Wilson said:
If you get more of a comedown and anxiety from dexamph than meth you are probably not getting real dex or are using crazy doses. Either that or you have very interesting brain chemistry because that's certainly abnormal. Dex in particular should not give much of a comedown at all at sensible doses especially once you have a tolerance.
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Even a therapeutic dose of dextroamphetamine (30mg) will eventually lead me to having a crash that is uncomfortable enough where I have to grab my klonopin bottle for relief. Yes prescribed doses...why can't people just take me for my word? I mean really, what point do I have to come out here and lie anyways? I've been on this site since I was a kid when I was 19 years old till now. Have no cruel intentions here on Bluelight.
 
opiatekrzy said:
Even a therapeutic dose of dextroamphetamine (30mg) will eventually lead me to having a crash that is uncomfortable enough where I have to grab my klonopin bottle for relief. Yes prescribed doses...why can't people just take me for my word? I mean really, what point do I have to come out here and lie anyways? I've been on this site since I was a kid when I was 19 years old till now. Have no cruel intentions here on Bluelight.
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Man no need to take it so personal, I'm just saying that is an abnormal experience that's all I meant by it. It sounds like what would happen to someone who took huge doses. The fact it happens to you at therapeutic doses makes you an outliner, that is all. Not attacking you mate.

I took multiple doses of dex today and didn't feel any anxiety or comedown or urge to reach for the benzos at all. Most people have that experience because dex is a clean stim for most.

But everyone's brains work different still.

It's like how I can bosh Xanax for months then just stop and feel no withdrawals... that's me being an outliner too.
 
Dr Jekyll said:
Not that easy given my diagnosis and economic means. My county psych is old school and doesn't want to prescribe me Adderall or Dexedrine out of fear of exacerbating my condition. The meth is just a stop-gap measure in my mind, as I will be likely seeking some private p-doc that is willing to prescribe me Adderall XR. But, as it stands, D-meth is pretty fantastic and highly economical (look up the prices on the DM for meth in the US, it's ridiculous)... The only issue is the comedown. I used to take 2-FMA, the absolute gold standard for treating ADHD; so I might go with that if my plan fails.
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You might want to look again/ more thoroughly. For a while I thought the same thing, but I've looked around and there are dirt cheap options. I'm trying the cheapest one I've found soon, not expecting much but I am really curious as to how the quality differs.
 
opiatekrzy said:
Damp is too short lived, I fell a bit more intense in an anxiety stricken way, crashes are just worse. Why is it so hard to believe?
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I second that. Tried adderal, tried vyvanse, but both just made me super amped up, jittery and generally a nightmare for my anxieties (at both low and high doses, although the high doses were so bad, that I never took more than 20mg at once ever again.) Meth always calmed me down, letting me focus on shit without much anxiety. I have generalized anxiety disorder, depression with atypical features, ADHD and social anxiety (among couple of other anxieties), if that means anything.
 
Dr Jekyll said:
Not that easy given my diagnosis and economic means. My county psych is old school and doesn't want to prescribe me Adderall or Dexedrine out of fear of exacerbating my condition. The meth is just a stop-gap measure in my mind, as I will be likely seeking some private p-doc that is willing to prescribe me Adderall XR. But, as it stands, D-meth is pretty fantastic and highly economical (look up the prices on the DM for meth in the US, it's ridiculous)... The only issue is the comedown. I used to take 2-FMA, the absolute gold standard for treating ADHD; so I might go with that if my plan fails.
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Have you tried doctor shopping
 
Dr Jekyll said:
This is the old school opinion on the matter. If you do more research, ADHD can be treated in individuals with schizophrenia or other psychotic disorders effectively with concomitant treatment with antipsychotics without exacerbating the condition. Lisdexamphetamine by Shire, is being investigated for effective treatment of negative symptoms of schizophrenia and will soon be approved for that issue.
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How soon is now?
 
Shinji Ikari said:
Ye olde thread. I'm curious how OPs attempt at self medication panned out but they haven't logged in since 2020.
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Or anyone who has commented, if their assessments have changed....

It's not "old" if the information is still relevant (which it is). No shame in commenting on "old" threads.

Thank you Bluelight for not having the site policy of "closing" threads to new replies. There is nothing I hate more! It's so counter productive & makes for a redundant & messy website. 😘
 
Taking days off from dosing helps a lot. Proper nutrition and hydration. Make sure you get rest everyday. You don’t have to sleep. But rest for a few hours.

There are supplements that are precursors for your body to produce dopamine.

The only issue is if your receptors have shut down due to over abundant dopamine levels and being bombarded constantly or at least daily.
 
xXTheGrimOneXx said:
Taking days off from dosing helps a lot. Proper nutrition and hydration. Make sure you get rest everyday. You don’t have to sleep. But rest for a few hours.

There are supplements that are precursors for your body to produce dopamine.

The only issue is if your receptors have shut down due to over abundant dopamine levels and being bombarded constantly or at least daily.
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Also look into obtaining a seroquel prescription. It helps your brain not take as much damage from the neurotoxic attributes of meth.

pubmed.ncbi.nlm.nih.gov

The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats - PubMed

Previous studies have suggested that quetiapine, a new atypical antipsychotic drug, may have beneficial effects on cognitive impairment and be a neuroprotectant in treating neurodegenerative diseases. In the present study, we investigated the therapeutic effects of chronic administration of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
With the utmost respect and genuine intentions, this must be said…the level of naivety and misinformation in these comments is staggering. Learning how to do drugs by reading the instructions on a public forum is not recommended. The internet is a wealth of knowledge
 
Dr Jekyll said:
I've been taking meth in reasonable doses (30-40mg) a day to address my ADHD. It works well for this purpose; but, I'm entering the grey territory between therapeutic doses (25mg) a day and recreational doses.

I've researched quite a fair share of ways to prevent sensitization (lithium); but, can't find any substances that would prevent persistent depletion of dopamine in nerve terminals. I have also considered selegiline; but, a study points out that its ineffective for this goal.

Any info on how to minimize the risks associated with continual methamphetamine use would be appreciated.
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I have been high for the last 11 years consistently only time I dont feel amazing is when the delivery man is late
 
zedonis said:
I have been high for the last 11 years consistently only time I dont feel amazing is when the delivery man is late
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Sounds an awful lot like you and I are two peas in a pod. I recently moved to Idaho, after falling into the self-hatred / social judgment trap attached to self medicating with meth. I did 6 months inpatient treatment, got out made the move, spent another 6 months on the verge of killing myself because frankly I have no idea “how to life” without self medicating. The level of anxiety and depression and total listlessness was insane, complete inability to create a social life, find motivation, joy, the will to live just wasn’t there… needless to say I began to self medicate again. I became instantly more productive, more motivated, more in touch with myself , my values, my goals. I started my own business, had the confidence to go out and meet people, try new things….that said my using has never been “ partying” it serves a purpose. And now I can’t find the medicine that literally keeps me from not wanting to die. It’s fucked.
 
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