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Mental Health Coming off Invega Sustenna (Paliperidone) v3

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When people look at facts, they look at facts based on USA-based studies, which again are 100% incorrect. NEVER trust a a study based on what USA has to say. Look at country's studies that have BETTER educatiom systems, which is the entirety of CIVILIZED countries in the world. LOOK at the FACTS, America is BEHIND every country that is worth a shit in the world. USA has a shirt education system, horrible quality of life index, anerica just sucks. If you cannot come to terms with that FACT, well I am done talking to you, because facts are facts buddy
 
Theresalwaystomorrow said:
I would MUCH rather be strung out on heroin, meth, crack, benzos, etc than be given this shot, it is MUCH safer to be strung out on any of those substances than to be given this shot incorrectly, as a person who should NOT ever be on these substances.
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Exactly what goes through my mind. It’s honestly very sad how we have come to such a conclusion.
 
Hey guys let's chill on the politics and stay on the topic of invega.
 
Day 292. Week 42. Still no improvements. Smh this is sickening. There is absolutely no reason some medication should last in your system this long. I haven’t taken any antipsychotic medication since November 2018. I’m so fed up with this bullshit my patience has run out. My birthday is in 5 days and I’ve literally been in this situation since my birthday last year. A whole year with no new thoughts, emotions, or libido. I’m starting to believe this shit is permanent. It’s almost impossible to be positive at this point. I’m tired of watching everyone else live their life while I suffer. This is horrible, a bad dream that I thought would have ended by now. I can’t even smoke on 4/20. I wasn’t able too last year and it looks like I won’t be able to this year as well. I feel cursed by God. I’m miserable 24/7. This is just unfair. I really wish this wasn’t happening to me. Why man why. I just don’t understand.
 
Just had a talk with both my parents. My dad thinks I should just try to move forward (which I’ve tried a lot) and my moms thinks I’m better but to me I see no difference except the fact that I’m more on edge than I’ve ever been. I told my dad that the doctor ruined me and he tried to defend. If it wasn’t for my dad I wouldn’t have been mandatorily having to visit that doctor for 5 months on outpatient commitment. I was diagnosed last March 2018 and I’ve been in this situation since April 19, 2018. Most of my entire time living with this illness I’ve been feeling this way. I just want to be functional again and not feeling disabled. I pray about this so much, but I receive nothing. I was working on a business before all of this and haven’t been able to for a year. I dunno if my business partner will welcome my return once I (hopefully) am better. This is just so unfortunate. At the time I was a recent graduate but now time is just passing and I will never be able to get it back. I feel for anyone going through this, because this is by far the toughest thing I’ve ever been through in my life. I’m so tired of being miserable. I just want my old life back. I’m tired of being in a mental prison and feeling mind controlled. My birthday is in 5 days but I’m not even looking forward to it. This is not how life should be. Beware anyone taking this medication. I’m a living example that this stuff has lasted nearly 10 months in my system with no improvement.
 
Has anyone heard any stories of recovery after 9 months? Has anyone heard from Yeshuah?
 
Theresalwaystomorrow said:
Methamphetamine and morphine should ABSOLUTELY be legal and otc. Alcohol should be illegal, along with marijuana. They are substances that do not have to improve ANYTHING whatsoever, they only help make everything you do worse.

There is no argument to what I say. What I say is Odin's truth, these are laws that are set in stone. There is nothing anyone could possibly ever say that would sway my factual-based opinion. What I say are 100% FACTS, what you or anyone in the world says are flawed OPINIONS. do you see the difference? FACTS vs. FLAWED OPINIONS, if you do not believe what I say, look any of it up. Look up what methamphetamine, or just amphetamines in general, do to your mind and body. They make you more focused, they are performance enhancers, not the other way around.
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In a thread about antipsychotic medication, suggesting people use meth is both poor advice AND off topic.

All opinions are valid here, yours included but let's stay on the topic of invega. If there are other things you wish to discuss, such as Asatru or odinism, you should check out our philosophy and spirituality forum.
 
I usually hang out in sober living (or health and recovery?) but I venture over to the dark side to read this thread regularly.

I have never been on this drug, but I have to tell you all that you are an absolute inspiration to me. I read your struggles that take months and sometimes years to overcome and it certainly puts into perspective my 7 day detox. What you all struggle with, and make it through, is not something anyone should ever have to deal with.

I just wanted to throw out a “keep it up, you all are doing AWESOME.” And let you know how much courage and perseverance I get from reading this thread and your experiences. I have my own struggles and reading hours helps me make it through. Also, I have learned a lot about drugs like invega and certainly am more educated on the side effects.

Best of luck everyone and thank you for sharing your stories.

- VE
 
@lifeline Have you tried Wellbutrin? I got a prescription less than a week ago and I can see some improvements already and I'm only 3 months off the shot. I think it might help you too. Feels like I'm more alive and can get a hold of reality much better.

I'm going to see an endocrinologist once I can get a hold of one and ask him/her to prescribe Dostinex/cabergoline for my high prolactin/low testosterone.
I'm not 100% sure but I think cabergoline could potentially relieve many of the symptoms caused by invega. It acts as an agonist on many receptors which invega antagonizes, especially the dopamine receptors which is most likely why people don't have any motivation, libido etc. while being on invega. Though cabergoline can cause psychosis or mania but somebody has to take it for the team so I'm hoping I can get a prescription.
And since Wellbutrin only inhibits dopamine re-uptake and it has already made a difference in how I feel I'm kinda curious if a dopamine agonist could possibly make even bigger difference.

10825
 
someone who take cocaine for fight this Fucking molecule and win ? because cocaine synthétise new receptor is not a bad idea, the probleme is if i create a new receptor the risperidone antagonize the new receptor create … i need person who take cocaine ^^ we all need new receptor for metabolize this dopamine and create a Messenger chimics.
 
Hello everyone,

I am in the same situation you all are with these drugs and I have a question regarding the whole coming off them drugs.

Paliperidone binds to d2 and 5h2ta. I have read that it leaves the d2 pathway blocked and supposedly all my problems will be resolved here by taking pacitane to unblock the receptor.

What about the 5h2ta receptor? Is this not left blocked too? Maybe I will need to take an antidepressant or something too? Any insight at all would be appreciated.

Also I have been on clopixol which binds to d1 receptors. I have read that some drugs that bind with d1 and d2 bind much less with the d1 receptor than the d2. I pray that this receptor is OK.

So then, I've done my research.

Cabergoline would have been ideal as this works for both d1 and d2 receptors. Outlawed because of heart defects.

Considering going onto a low dose of clopixol. Anyone still on clopixol?

Going to be putting this on the coming off invega thread
 
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Hello everyone,

I am in the same situation you all are with these drugs and I have a question regarding the whole coming off them drugs.

Paliperidone binds to d2 and 5h2ta. I have read that it leaves the d2 pathway blocked and supposedly all my problems will be resolved here by taking pacitane to unblock the receptor.

What about the 5h2ta receptor? Is this not left blocked too? Maybe I will need to take an antidepressant or something too? Any insight at all would be appreciated.

Also I have been on clopixol which binds to d1 receptors. I have read that some drugs that bind with d1 and d2 bind much less with the d1 receptor than the d2. I pray that this receptor is OK.

So then, I've done my research.

Cabergoline would have been ideal as this works for both d1 and d2 receptors. Outlawed because of heart defects.

Considering going onto a low dose of clopixol. Anyone still on clopixol?

Going to be putting this on the coming off invega thread
 
Pacitane is a totally bullshit understand me, they Don't unblock , all of meds of the world unblock this fucking receptor, is recycling by upregulation if youre neurotransmitteur is low ( im not an expert is my research) pacitane just give a lo of neurotransmitter just that .. you have not a probleme of this, your probleme is your receptor blocked ! Understand me or not understand but anti-D Don't work ..
The idea is to recycle other receptor for the dopamine will give you euphoria just that.. Cocaine synthetize new receptor but is not the best idea and is possibly he can't work. The best meds s heal natural.. walk,run etc. if you will take the risk of meds thing a meds that have a incredible affinity of receptor ! INCREDIBLE!
Because agonist Don't work youre receptor is Fucking blocked.
How much time you suffer in this side effect ? and what side effect ?

I wish you the best, you have a deal "death or heal" because a life like that is a Fucking shit my friend
 
Antipsychotique33 said:
Because agonist Don't work youre receptor is Fucking blocked.
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The degree of activity of the target receptor in the presence of an agonist and a competitive antagonist is a function of the relative affinity each has for the active binding site and their respective concentrations. Controlling for concentration, the drug with higher affinity will occupy a greater number of receptors than the drug with lower affinity. The ability of a competitive antagonist to block the effects of an agonist can be reduced or eliminated by sufficiently increasing the concentration of the receptor agonist. Therefore, competitive antagonists do not reduce the maximum response of a receptor agonist, but do increase the agonist dosage required to achieve it.

Paliperidone acts as a competitive antagonist on all receptor sites except for the 5-HT7 receptors which are irreversibly antagonized. (this can be reversed with clozapine or by waiting for the receptors to resynthesize)
Cabergoline has more affinity for 5-HT1A, D2 and D3 receptors which means that it will occupy more receptors than paliperidone. Cabergoline's potency might be lower when there's still paliperidone left in ones system, which means that you'll need a higher dose to achieve the same effect as you would get without the presence of an antagonist.
I'm starting to feel pretty positive that cabergoline has the ability to relieve many negative symptoms caused by paliperidone. (i.e. feeling unmotivated, no energy, no libido, fast heart rate etc.)

5-HT1A receptor agonists are involved in neuromodulation. They decrease blood pressure and heart rate via a central mechanism, by inducing peripheral vasodilation, and by stimulating the vagus nerve. Vasodilation of the blood vessels in the skin via central 5-HT1A activation increases heat dissipation from the organism out into the environment, causing a decrease in body temperature. 5-HT1A receptor agonists like buspirone and flesinoxan show efficacy in relieving anxiety and depression. 5-HT1A receptor activation likely plays a significant role in the positive effects of serotonin releasing agents (SRAs) like MDMA as well. 5-HT1A receptor activation has been shown to increase dopamine release in the medial prefrontal cortex, striatum, and hippocampus, and may be useful for improving the symptoms of schizophrenia and Parkinson's disease. As mentioned above, some of the atypical antipsychotics are 5-HT1A receptor partial agonists, and this property has been shown to enhance their clinical efficacy. Enhancement of dopamine release in these areas may also play a major role in the antidepressant and anxiolytic effects seen upon postsynaptic activation of the 5-HT1A receptor.
5-HT1A receptor activation induces the secretion of various hormones including cortisol, corticosterone, adrenocorticotropic hormone (ACTH), oxytocin, prolactin, growth hormone, and β-endorphin. The receptor does not affect vasopressin or renin secretion, unlike the 5-HT2 receptors. It has been suggested that oxytocin release may contribute to the prosocial, antiaggressive, and anxiolytic properties observed upon activation of the receptor. β-Endorphin secretion may contribute to antidepressant, anxiolytic, and analgesic effects.

Other effects of 5-HT1A activation that have been observed in scientific research include:
  • Decreased aggression
  • Increased sociability
  • Decreased impulsivity
  • Inhibition of drug-seeking behavior
  • Facilitation of sex drive and arousal
  • Inhibition of penile erection
  • Diminished food intake
  • Prolongation of REM sleep latency
  • Reversal of opioid-induced respiratory depression

Another interesting thing about cabergoline, is it's ability to induce weight loss in patients with hyperprolactinemia, which basically everyone has since paliperidone blocks D2 receptors which control the release of prolactin.
At least in my case, I've gained almost 30 pounds since I got injected, which is most likely caused by hyperprolactinemia. My breasts have grown quite a bit and so has my stomach. Some of the weight gain might be due the 5-HT2C antagonism though.
Prolactin also reduces fat metabolism which is critical for us since paliperidone is fat-soluble. Cabergoline has the ability to restore normal prolactin levels in patients that are still using risperidone during the cabergoline treatment, so it will do that for us too since paliperidone is losing it's potency each day that passes.

Sauce;
https://en.wikipedia.org/wiki/5-HT1A_receptor
https://academic.oup.com/bjaed/article/4/6/181/314691
https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2003.46
https://psychonautwiki.org/wiki/Antagonist
https://www.ncbi.nlm.nih.gov/pubmed/9666865
https://www.ncbi.nlm.nih.gov/pubmed/16279371
https://www.sciencedaily.com/releases/2009/04/090402092859.htm
https://link.springer.com/article/10.1007/BF03345068
https://www.ncbi.nlm.nih.gov/pubmed/15003071
https://www.ncbi.nlm.nih.gov/pubmed/23834553
 
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Irriverssibly antagonist can't be reverse… clozapine bullshit i Don't know where you hear that but lol … Second you test that you say for say this theory… ? You try youre famous clozapine and cabergoline ?
 
Antipsychotique33 said:
Irriverssibly antagonist can't be reverse… clozapine bullshit i Don't know where you hear that but lol … Second you test that you say for say this theory… ? You try youre famous clozapine and cabergoline ?
Click to expand...
Results
The competitive (non-inactivating) antagonists clozapine and mesulergine released the wash-resistant [3H]risperidone binding to the h5-HT7 receptor. The competitive antagonists clozapine, SB269970, mianserin, cyproheptadine, mesulergine, and ICI169369 reactivated the risperidone-inactivated h5-HT7receptors in a concentration-dependent manner. The potencies for reactivation closely match the affinities of these drugs for the h5-HT7 receptor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052287/

The release of the drug into the systemic circulation begins as early as the first day of administration, and continues for up to 126 days.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413070/

I'm pretty sure that consuming clozapine in order to reverse the antagonism is pretty pointless until paliperidone has been released from the injection site, which according to the study I posted above can continue for up to 126 days.
It's been 93 days for me since the last injection so most likely there's still some paliperidone stored in my arm. I will try the clozapine out once I reach about 130 days. Only thing that bothers me atm about the 5-HT7 antagonism is the messed up circadian rhythm I have. No matter what time I go to bed I always wake up at 9AM, and can't sleep after that. I really miss sleeping til mid day.
I don't know what you meant about that famous thing, but I'm trying to get an appointment with an endocrinologist so I can try to get a prescription for the cabergoline. But for the clozapine, I'm going to wait.
And it could be that as long as you have paliperidone left in your system, not only in the injection site, but in the whole body (brain, fat tissue etc.), it would be pointless to "wash" the receptors since paliperidone will most likely just antagonize the receptors again once clozapine wears off. But for the cabergoline my hopes are up.
 
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The clozapine is also a antagonist of ht7 receptor, you unblock maybe your receptor with your theory whereas your receptor is unlocked your Fucking clozapine take in place on your receptor after the paliperidone go out, and you will blocked .. the same schema.
Cabergoline is maye a good idea but im not an expert very im just a researcher of effects of meds.. and if you try cabergoline your will are a lot of neurotransmitter dopa, seroto.. and the brain downregulate because you have a lot of neurotransmitter for your receptor.. you Don't need the down regulate but the upregulate..
Normally your brain now upregulate because youre neurotransmitter not take place in receptor and this is a theorry is supposed other scheme he can't and never upregulate.
Cocaine Synthetize new receptor because dopa need to be take in receptor but in long terme your brain down regulate, the conclusion is just create new receptor and take cocaine 2 time weekly. For create new receptor but is a Dangerous idea. I read lot of person who take mdma cocaine and feel euphoria after that.. cabergoline is a good idea but Don't take Everyday just for create a new receptor..
 
Antipsychotique33 said:
The clozapine is also a antagonist of ht7 receptor, you unblock maybe your receptor with your theory whereas your receptor is unlocked your Fucking clozapine take in place on your receptor after the paliperidone go out, and you will blocked .. the same schema.
Click to expand...
Yes that's true but clozapine's half-life is nothing compared to paliperidone palmitate, and it's not irreversible. It will antagonize the receptors but once it wears off the receptors are washed. But in my opinion it's pointless to do until most or all of paliperidone is out of our system. But even though all of paliperidone is out of the system there will still be some left in the 5-HT7 receptors until they get resynthesized, or washed out. Now that I think about it, I really think consuming clozapine won't be effective until like 200-300 days off the injection or until you feel like if not all, then most of it, is metabolized the normal way, which takes a long time.
 
Im not an expert i repeat but take clozapine is a shit very shit.. take other meds is Dangerous for your brain, you need to heal natural.. maybe agonist can help but i Don't think can do.
 
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