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N&PD Moderators: Skorpio | someguyontheinternet
I Like to Draw Pictures of Random Molecules
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Organic azides do not tend to be the most stable compounds, to the point where inorganic azide salts and low-molecular weight organic azides tend to be shock-sensitive explosives.... not to mention azide salts as well as several organic azides being fairly toxic.
Trifluoromethyl groups shouldn't pose any such problem. I know of trifluoromethyl analogues of nordazepam (triflunordazepam) and clobazam (triflubazam), but these never saw market adoption, probably because you'd only see a modest increase in potency at best, while requiring a harder to obtain precursor.
Interestingly, benzos containing a trifluoroethyl group on the 1-nitrogen atom did see pharmaceutical use. One of these is halazepam (N-fluoroethyl-nordazepam), which was quickly withdrawn from the US market again because it didn't sell, however. The other and much more interesting one is quazepam. Quazepam and its metabolite 2-oxoquazepam apparently exhibit much higher selectivity for the sleep-inducing subunits of the GABA receptor than other benzos, similar to the z-drugs zolpidem and zaleplon.
This analog of caffeine is said to be 100 times more active at both the A1& A2 receptors.
During WWII the Germans needed coffee to keep their war industry going 24 hours/day. Due to the Allied embargo on coffee beans, ersatz coffee was made using synthetic caffeine. I've seen the synthesis method in an Allied intelligence report & it is not simple, beginning with relatively complex raw materials like ethyl cyanoacetate. A significant amount of German war productivity went into making synthetic coffee, as did the production of their popular soft drink, FANTA. In the case of FANTA, coloring & flavoring came from industrial byproducts because importation of the original drink syrup from Coca-Cola was also blocked..
During WWII the Germans needed coffee to keep their war industry going 24 hours/day. Due to the Allied embargo on coffee beans, ersatz coffee was made using synthetic caffeine. I've seen the synthesis method in an Allied intelligence report & it is not simple, beginning with relatively complex raw materials like ethyl cyanoacetate. A significant amount of German war productivity went into making synthetic coffee, as did the production of their popular soft drink, FANTA. In the case of FANTA, coloring & flavoring came from industrial byproducts because importation of the original drink syrup from Coca-Cola was also blocked..
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I agree with your comments on quazepam (DORAL) regards inducing sleep.
You got the linear nomenclature for halazepam wrong. See attached graphic. Intermediates derived from 2,2,2-trifluoroethanol, are commonly available on the market. The correct nomenclature is N-(2,2,2-trifluoroethyl)-.
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sekio
Bluelight Crew
I once took 80mg and it made me feel like I'd been hit by a truck while simultaneously having the flu. In retrospect it's probably a massive overdose but I was young and dumb...
40 mg is the STARTING dose for ADHD. Assuming you don't have ADHD, it may have acted like someone dropping a case of beer on your brain.
Be cautious when contemplating even small lab-scale ozonlysis. I worked in a lab where we made tens of kilos of a perfume ingredient using an industrial-scale ozonator (>$19K) & had to run the ozonolysis in ice-cold methylene chloride in 22-liter flasks. I don't think Walmart sells either CH2Cl2 or elemicin.
Because of both ambient heat & the heat of reaction, keeping those big flasks at around 0 deg C was a lot of work. The product passed & I got paid
Because of both ambient heat & the heat of reaction, keeping those big flasks at around 0 deg C was a lot of work. The product passed & I got paid
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Dresden
Bluelighter
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JacksinPA,
I already have elemicin. But as watched as I am [think permanent Saturday Night Live actor status], I am not *about* to do anything funny with it.
And I did 100mg 5-MAPB once. Hard to describe altered state of consciousness that ended in mild delirium--I desperately called my dad around 11 pm although he was just one room away. Will not voluntarily repeat.
AMP
I already have elemicin. But as watched as I am [think permanent Saturday Night Live actor status], I am not *about* to do anything funny with it.
And I did 100mg 5-MAPB once. Hard to describe altered state of consciousness that ended in mild delirium--I desperately called my dad around 11 pm although he was just one room away. Will not voluntarily repeat.
AMP
Non-benzodiazepine full Bz receptor agonist(s)
I only have access to the first page of the full journal article but this caught my eye:
For some reason I could not recover the full article through Sci-Pub.
Interesting from the SAR POV. Wonder what other analogs they produced & evaluated. Not lab-scale chemistry in any event.
I only have access to the first page of the full journal article but this caught my eye:
For some reason I could not recover the full article through Sci-Pub.
Interesting from the SAR POV. Wonder what other analogs they produced & evaluated. Not lab-scale chemistry in any event.
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According to the book QD 1 A355 no. 45 p. 117,
MP-809
Is "particularly effective in the treatment of neurotic depressions" and "is only a weak MAOI."
4-Methylindole-3-carboxaldehyde is a commercially available product.
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