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N&PD Moderators: Skorpio | thegreenhand
Rectify's molecular poetry thread
- Thread starter Dresden
- Start date
Can't tell if serious or ironic.
Then again, I can't tell if Dresden named himself for the wizardly main character of the Dresden Files novels, or the German city known mostly for being thoroughly burnt-out after WW2
Re: Using a carbomethoxy group as a biostere for phenyl, it does work for remifentanil, being more than a 100 times the potency of morphine. Of course, this becomes less impressive when you consider that remifentanil is an analogue of carfentanil, which is approximately 10,000 times the potency of morphine.
Interestingly, it is also possible to replace the 4-carbomethoxy on carfentanil with a phenyl ring and get 4-phenyl-fentanyl, which is roughly 8 times the potency of fentanyl, i.e. more potent than remifentanil, but a far cry from the 100-fold increase in potency that the carbomethoxy groups confers in the 4-position. The 4-heteroaryl analogues are apparently more potent than the 4-phenyl, presumably because they are a better match for the electron distribution of the carbomethoxy.
https://en.wikipedia.org/wiki/4-Phenylfentanyl
Dresden
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The name came from the city.
I mean there's CH3CH2OH neurotoxicity and then there's HCN (g) NEUROTOXICITY, you know what I'm sayin? Nothing bad happened to the bluelighter who ate PCA.
This next one's IFFY if it doesn't work, but JIFFY if it does. Looks IFFY to me though.
(J)IFFY
Hodor,
What do you think of this?
JASON
In case of emergency, call Jason!
* * *
HODOR
Might take 100 mg. I really have ningun idea.
MISS MARIE "MS PACMAN" HANDBERRY
Might take 50mg. Una vez mas, yo no se.
TOOTY FRUITY (4-carbomethoxyphenol)
-vaginal juice extract
-topical male aphrodisiac
-used in many sunscreens
I mean there's CH3CH2OH neurotoxicity and then there's HCN (g) NEUROTOXICITY, you know what I'm sayin? Nothing bad happened to the bluelighter who ate PCA.
This next one's IFFY if it doesn't work, but JIFFY if it does. Looks IFFY to me though.
(J)IFFY
Hodor,
What do you think of this?
JASON
In case of emergency, call Jason!
* * *
HODOR
Might take 100 mg. I really have ningun idea.
MISS MARIE "MS PACMAN" HANDBERRY
Might take 50mg. Una vez mas, yo no se.
TOOTY FRUITY (4-carbomethoxyphenol)
-vaginal juice extract
-topical male aphrodisiac
-used in many sunscreens
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Limpet_Chicken
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You've read the dresden files too? like it. Have you read Jim Butcher's other series, the codex alera? worth a shot if you liked the dresden files.
But it is pretty obvious the OP of this thread is just a burnt out heap of shit. Or at least, in dire need in being hit with a fuckton of white phosphorus and a couple of thermite shells rammed up some unlikely holes he probably doesn't even know the names of. Sure as shit isn't a fuckin' wizard.
The word 'wizard' is cognate with 'wise' and probably with 'wyrd', (as in the name of the rune), dresden is just gigantic example of a broken dildo that stinks of pentaborane and who needs to be soaked in a hot, saturated solution of white phosphorus in carbon disulfide. Wait, sod that, make it carbon diselenide, because like dresden, the pentaborane is poisonous muck that fucking stinks like something rotten crawled into a pot of yoghurt, crapped it's underwear and died and needs to fucking burn. And CSe2 just stinks.
The bipedal, mammallian equivalent to a tick,a disgusting, bloated tick, dug into the head of a mangy street dog's festering diseased dick and sucking all manner of noxious bodily excretions. If it weren't for the trouble I had to go to to make the stuff safely, I'd happily tip my bottle of iodine monochloride all over him, just to see if he autoignites.His posts are getting WORSE if that is actu ally possible, it seems!
Oh, and THANKS for the books on bioisostereism.
Also, wouldn't a gem-difluoroalkene be likely to act as some less than stable molecular add-oh, at the alkene end and get metabolized to something nasty like fluorophosgene, possibly or other unpleasant entities? I've never worked with fluorophosgene, and I don't want anything to do with phosgene itself; I can't imagine fluorophosgene being pleasant.And fluoroalkenesl like that just don't look at all pleasant, I'll be making sure to read the everloving mother of crap out of those publications Just the sort of thing I've been looking for and very much appreciated.
But it is pretty obvious the OP of this thread is just a burnt out heap of shit. Or at least, in dire need in being hit with a fuckton of white phosphorus and a couple of thermite shells rammed up some unlikely holes he probably doesn't even know the names of. Sure as shit isn't a fuckin' wizard.
The word 'wizard' is cognate with 'wise' and probably with 'wyrd', (as in the name of the rune), dresden is just gigantic example of a broken dildo that stinks of pentaborane and who needs to be soaked in a hot, saturated solution of white phosphorus in carbon disulfide. Wait, sod that, make it carbon diselenide, because like dresden, the pentaborane is poisonous muck that fucking stinks like something rotten crawled into a pot of yoghurt, crapped it's underwear and died and needs to fucking burn. And CSe2 just stinks.
The bipedal, mammallian equivalent to a tick,a disgusting, bloated tick, dug into the head of a mangy street dog's festering diseased dick and sucking all manner of noxious bodily excretions. If it weren't for the trouble I had to go to to make the stuff safely, I'd happily tip my bottle of iodine monochloride all over him, just to see if he autoignites.His posts are getting WORSE if that is actu ally possible, it seems!
Oh, and THANKS for the books on bioisostereism.
Also, wouldn't a gem-difluoroalkene be likely to act as some less than stable molecular add-oh, at the alkene end and get metabolized to something nasty like fluorophosgene, possibly or other unpleasant entities? I've never worked with fluorophosgene, and I don't want anything to do with phosgene itself; I can't imagine fluorophosgene being pleasant.And fluoroalkenesl like that just don't look at all pleasant, I'll be making sure to read the everloving mother of crap out of those publications Just the sort of thing I've been looking for and very much appreciated.
You can't really gauge neurotoxicity from self-reports, unless there are obvious physiological effects (ex.: MPTP-contaminated MPPP).
Yeah, a single dose of PCA is not going to burn out every last serotonergic neuron, but if something is deliberately used for its neurotoxicity in lab animals, I'd be *very* skeptical about repeatedly using it at recreational doses.
This next one's IFFY if it doesn't work, but JIFFY if it does. Looks IFFY to me though.
(J)IFFY
I call it POP.
Because it looks like someone tried to come up with an alternate synthesis route to methadone and ended up with a dimer that should be classed as a Persistent Organic Pollutant.
Limpet_Chicken
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I don't like you, sir. [wall of text removed, as it was mostly vulgar insults -- ed]
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Bagseed
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so much NaCl in here....
more seriously, dresden has stopped using the other thread and keeps his eccentricity to this topic, how it was intended by the staff. you (l_c) coming in here to throw around insults is pretty childish and a little pathetic. keep it down and just ignore this thread if you don't like it.
more seriously, dresden has stopped using the other thread and keeps his eccentricity to this topic, how it was intended by the staff. you (l_c) coming in here to throw around insults is pretty childish and a little pathetic. keep it down and just ignore this thread if you don't like it.
Dresden
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Pomzazed, yeh ur right. It does look IFFY.
What do you think of this one?
PROPROMETHAZINE
I wanted to add a 2,3- and a 9,10- MDO moiety, but that was a byatich to name.
Limpet_Chicken,
You know, if you would start being nice and practicing a little tolerance, I might read half of your gigantic walls of text. /:
HUSSEIN
HIGDON
What do you think of this one?
PROPROMETHAZINE
I wanted to add a 2,3- and a 9,10- MDO moiety, but that was a byatich to name.
Limpet_Chicken,
You know, if you would start being nice and practicing a little tolerance, I might read half of your gigantic walls of text. /:
HUSSEIN
HIGDON
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sekio
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Limpy, if you've nothing nice to say, don't say it. Your (admittedly creative) walls-of-insult do not belong here, at least not more than one. Dresden has every right to post here, as much as you do, as long as you both play nicely in the same sandbox.
Propromethazine still looks like a diaminoethylaryl-type of H1 inverse agonist,
Also, modify HUSSEIN a bit, demethylate the phenylmethylether, and 2-4 more carbon to the tail, cyclize the N to piperidine, or better make it a N-lactan, then u will got a strong CB1/2 agonist
Also, modify HUSSEIN a bit, demethylate the phenylmethylether, and 2-4 more carbon to the tail, cyclize the N to piperidine, or better make it a N-lactan, then u will got a strong CB1/2 agonist
Dresden
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They latter two are not CB agonists, certainly not pure ones anyway. Are you familiar with promethazine? It's a sedative. I realize that likely implies H1 antagonism.
By Cronos, I apparently know a lot more than anyone gives me credit for!
"The Greatest Intelligence Seems Stupid."--Lao Tzu.
By Cronos, I apparently know a lot more than anyone gives me credit for!
"The Greatest Intelligence Seems Stupid."--Lao Tzu.
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- yes i know promethazine well, and your molecules still looks like an antihistamine despite trying to hybrid with an amphet,
It still contain 2 aryl with a linker (N) then spaces with 2 carbon then a secondary amine.
- now the antihistamines are not antagonist, they are actually inverse agonist. (They dont bind and block the real histamine, instead they bind and produce opposite signal into the cell!, thats whats called inverse agonist)
- I know your last two is intended to be a modified psychedelic phens, but u know my eyes are fast to spot the noids-familiarity lol
Dresden
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Got telepathically blessed again last night with either Higdon or Oreillyium. I'm not certain which.
Intricate, somewhat fantasmagoric, partially colored CEVs, deep relaxation. I cuddled up under my blanket on the sofa and listened to Phish. They sounded great. Praise the Lord!
Intricate, somewhat fantasmagoric, partially colored CEVs, deep relaxation. I cuddled up under my blanket on the sofa and listened to Phish. They sounded great. Praise the Lord!
