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  • N&PD Moderators: Skorpio | someguyontheinternet

Generic vs brand name zolpidem/Ambien

Again class action against generic Wellbutrine won, and fairly well documented... bases on fillers/biners/polymers variations and their impa t on the main FDA approved active chemical/ingredients... Fillers get a pass from FDA on generics, but must be to the aspects of Brand patented string of compounds and their grade. Class action report details it out better.

True to the above post, if it's really bad, and you can't try other mfgs, or have and none of the options work, see if a class action os in the works, or start one via a lawyer. One specifically geared toward bio-tech engineering, the may know what's in the pipeline. Food 4thought.

Asking for a pass for ti days typos... awake straight at hour 37, ugh, was originally searching how to get to sleep! (Sidetracked)
 
what5next said:
Again class action against generic Wellbutrine won, and fairly well documented... bases on fillers/biners/polymers variations and their impa t on the main FDA approved active chemical/ingredients... Fillers get a pass from FDA on generics, but must be to the aspects of Brand patented string of compounds and their grade. Class action report details it out better.
Click to expand...

The class action suit was about generic extended-release Wellbutrin.

XR formulations are always significantly more complex due to the difficulty in getting the release rate just right, especially considering the variability of factors like stomach pH, food composition, gastrointestinal motility, etc. In 2005, Purdue Pharma had to withdraw their extended-release hydromorphone capsules ("Palladone") after just a few months on the market when it was found that taking them with alcohol in your stomach led to "dose-dumping", i.e. the rapid release of a significant portion of the dose.

Yet most of the time I hear people complaining about generics it is about immediate-release drugs, like OP's zolpidem.
 
I'm not a pharmacist nor a lawyer (nor do I work for any drug companies) so I have very little to contribute to this thread in the direction that it went. If what I think I experienced was a real phenomenon I
wanted to explore the reasons for it. I did look up user reviews for many drugs and a lot of them have people complaining that the generics don't work as well, so I think to a certain extent a lot of this is in the mind. Yes stomach contents, activity, and so on all play a part. What I've been doing lately is taking the pills sublingually and they seem to be more consistent. If one manufacturer's preparation is broken down in the stomach and intestines just a little slower it can affect peak serum concentration.


An example of a drug whose generic version may not be the same- If you look at a drug like levothyroxine (for those who are hypothyroid) there are many generics that have been released. It is a widely accepted practice to keep a patient on the same preparation as there are published studies that highlight differences in the BA. If the patient has to switch the physician may retitrate the dose using lab tests for hormone values.
 
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