This post is filled with misinformation. Ativan is a rather short acting medication. Clonazepam has a 25 or so hour halflife but it does not have any active motabolites that I know of which stay in your system.
Diazepam and Librium are known as long acting benzodiazepines. Studies done by the NIH and the Mayo Clinic have identified several long acting metabolites of diazepam and Librium which stay in your system for up to thirty days. These motabolites include oxazapam and nordiazepam. This is why you can flag a 12 panel test 20 days after getting off diazepam and upon GC-MS anylisis oxazapam will be the first to show up.
Desmethlydiazepam is another active metabolite that has a halflife of 30-200 hours. For sources on this I would reference studies done by the Mayo Clinic but the halife of all the active motabolites are right up on Wikipedia with citations.
e and duration of action ARE NOT THE SAME THING. I am tired of saying that, when 20 or 15 minutes of research(or better yet, taking the damn medication) would prove this.
Diazepam is a fast acting benzodiazepine, like alrprazolam, though with a (typically) short duration. 2-5hrs is listed by either the manufacturer or AMA.(onset
0min, peak 1-2hrs)
It is rapidly absorbed and highly lipophillic, so it almost immediately penetrates the CNS, making it effective from for emergency situations(though even for that, they now generally preferLorazepam)
Have you ever taken Nordazepam?(desmethlydiazepam, or it’s pro-drug, Tranxene, which is quickly and almost completely converted in the stomach, before reaching small intestine)
Well, Lorne has, guess what? 200hours is a joke, and most studios put it less than that.
It is an intermediate acting benzodiazepine with a decent duration, that is longer than diszepam itself, though not as long as clonazepam, it’s hard to say cause dose dependent, though 4-8hrs later(probably up to12 with larger doses) you need a redone, similar to lorazepam.
Both clonazepam and lorazepam have very poor solubility, in comparison l to other benzos, and so they penetrate the CNS gradually, even via intravenous injection.
And, it isn’t rapidly and extensively redistributed to other body tissues, where it has no pharmacological effects, yet can delay metabolism/elimination like Valium(which is also highly protein bound)
Remember, if a drug crosses the BBB rapidly, it will quickly exit, and typically is either metabolized, or redistributed like diazepam/Valium. Clonazepam has the same t1/2 as diazepam, (Both average 30-40 hours, basically) however it has a delayed onset and extended duration.
This is because it gradually enters the CNS, and then, in turn, slowly exits, allowing it more time to activate more receptors.
Lorazepam is similar, though clonazepam tends to last longer with chronic administration, especially
You bring up Wikipedia? Check out Lorazepam’s page, it explains in detail how lorazepam lasts longer than diazepam, despite it’s T1/2.
Also, both Diazepam and Nordazepam are typically given 3-4 times per day, occasionally 5.
Didn’ Mean to seem rude, just verify you’re information before you call mine wrong; Know what I am talking about
Think about IV burpenorphine; it’s T1/2 is barely as long as oxycodone, yet (especially larger doses) last MUCH longer(although Bupe also has a longer receptor half-life, in addition to much lower water solubility, and lower lipid solubility, to some extent)
