AP's that wouldn't scramble with Alpha-1, Alpha-2 receptors.

[fafner]

Hi guys, and thank you in advance. I know I'm posing a tricky question.

Long story short, my pdoc think I should stick to an AP to stabilize my mood, as classical mood stabilizers prevent me from functioning . My diagnosis is cyclothymia, even though the only mood imbalances I've ever experimented were caused by AD's (they say those could make a mood disorder surface). Well, mood imbalances: they would make me feel confused dumb and, yes, depressed. The AD's were prescribed to cope with severe anxiety and angst, but taken as a whole I wouldn't describe myself as depressed.

My problem: the atypical AP's that block the alpha-2 receptors would cause paradoxical effects: anxiety'd skyrocket, cardiac extrasystoles'd show up and in time resistant hypertension would start developing (Asenapine, Olanzapine).

Classical AP's, on the other hand, that exert a powerful blockade just on the alpha-1 receptors, would cause postural hypotension, so much so that I couldn't get on my feet without staggering and feeling like I'm on the brink of fainting (Promazine, Perphenazine).

So, I was wondering: do you know of some AP's that wouldn't scrumble with alpha receptors too much? I can just think of Amisulpiride, but I fear that would annihilate my poor sexual life for good.

Any suggestion is welcome. Thank you for reading all of this stuff.

 

[d1nach]

Have you tried posting this in the neuroscience section? You might get better responses there.

To answer your question. I haven't a clue one thing you could do is go to wiki and click on every antipsychotic and scroll down to pharmacology or mechanism and it should tell you if it effects the alpha adrenic receptors which one and how

It might give u a value in kM nM-1 the lower the number the higher the affinity for that receptor generally

 

[fafner]

Thanks for the suggestion. In fact I've already done that, and was under the impression that pharmacologosts make it out a point to hit the Alpa-1 receptor in order to sedate you, or hit the Alpha-2 to get a sort of antidepressant effect against the so called negative symptoms (these drugs seem to be designed to treat schizofrenia in the first place).

Maybe the Aripiprazole is the gentler as to Alpha receptor blockade. I'll double check, thank you.

 

[Cotcha Yankinov]

I'm curious as well if there are any particular neuroleptics/AAPs without a hypotensive effect.

 

[0_Forget]

This is just a thought, I don't know if a drug like this is currently on the market and I'm not a psychiatrist, but what about a negative allosteric modulator instead of an antagonist? That way your neurotransmitters could still bind to the affected receptors, but with reduced effectiveness. Seems like that could still have the desired effect, while having fewer side effects due to the receptors not being completely blocked.

 

[fafner]

This is just a thought, I don't know if a drug like this is currently on the market and I'm not a psychiatrist, but what about a negative allosteric modulator instead of an antagonist? That way your neurotransmitters could still bind to the affected receptors, but with reduced effectiveness. Seems like that could still have the desired effect, while having fewer side effects due to the receptors not being completely blocked.

That's a very complicated thought, unfortunately beyond my grasp. For now I can just thank you for the suggestion. I'll need to look into that.